HEPES (BioDeep_00000409367)
代谢物信息卡片
4-(2-HYDROXYETHYL)-1-piperazine ethanesulfonIC ACID
化学式: C8H18N2O4S (238.0987228)
中文名称: N-2-羟乙基哌嗪-N-2-乙磺酸, 4-（2-羟乙基）-1-哌嗪乙磺酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCO)CCS(=O)(=O)O
InChI: InChI=1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)
描述信息
D019995 - Laboratory Chemicals > D002021 - Buffers
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; JKMHFZQWWAIEOD-UHFFFAOYSA-N_STSL_0147_HEPES_2000fmol_180419_S2_LC02_MS02_32; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:42334
- PubChem: 23831
- ChEMBL: CHEMBL1232545
- MeSH: HEPES
- CAS: 7365-45-9
- MoNA: MoNA010752
- MoNA: MoNA010751
- MoNA: MoNA010750
- MoNA: MoNA010749
- MoNA: MoNA010748
- MoNA: MoNA010747
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rebecca L Goldman, Namratha Turuvekere Vittala Murthy, Trent P Northen, Anuranjani Balakrishnan, Sudha Chivukula, Hillary Danz, Timothy Tibbitts, Anusha Dias, Jorel Vargas, Dustin Cooper, Hardip Gopani, Angela Beaulieu, Kirill V Kalnin, Timothy Plitnik, Saswata Karmakar, Ramesh Dasari, Ryan Landis, Shrirang Karve, Frank DeRosa. Understanding structure activity relationships of Good HEPES lipids for lipid nanoparticle mRNA vaccine applications.
Biomaterials.
2023 Jul; 301(?):122243. doi:
10.1016/j.biomaterials.2023.122243. [PMID: 37480759] - Saame Raza Shaikh, Rafia Virk, Thomas E Van Dyke. Potential Mechanisms by Which Hydroxyeicosapentaenoic Acids Regulate Glucose Homeostasis in Obesity.
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2022 12; 1864(12):184055. doi:
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The Journal of biological chemistry.
2012 Mar; 287(12):9633-9. doi:
10.1074/jbc.m111.335356. [PMID: 22253434] - László Héja, Gabriella Nyitrai, Orsolya Kékesi, Arpád Dobolyi, Pál Szabó, Richárd Fiáth, István Ulbert, Borbála Pál-Szenthe, Miklós Palkovits, Julianna Kardos. Astrocytes convert network excitation to tonic inhibition of neurons.
BMC biology.
2012 Mar; 10(?):26. doi:
10.1186/1741-7007-10-26. [PMID: 22420899] - Yihui Yang, Xianmei Piao, Mingyu Zhang, Xiaodan Wang, Bing Xu, Jiuxin Zhu, Zhiwei Fang, Yunlong Hou, Yanjie Lu, Baofeng Yang. Bioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis.
Lipids in health and disease.
2012 Mar; 11(?):38. doi:
10.1186/1476-511x-11-38. [PMID: 22413998] - Natalia Stepanyants, Gavin D M Jeffries, Owe Orwar, Aldo Jesorka. Radial sizing of lipid nanotubes using membrane displacement analysis.
Nano letters.
2012 Mar; 12(3):1372-8. doi:
10.1021/nl203983e. [PMID: 22313341] - David D Lo, Jun Ling, A Holly Eckelhoefer. M cell targeting by a Claudin 4 targeting peptide can enhance mucosal IgA responses.
BMC biotechnology.
2012 Mar; 12(?):7. doi:
10.1186/1472-6750-12-7. [PMID: 22413871] - Mikhail G Shapiro, Kazuaki Homma, Sebastian Villarreal, Claus-Peter Richter, Francisco Bezanilla. Infrared light excites cells by changing their electrical capacitance.
Nature communications.
2012 Mar; 3(?):736. doi:
10.1038/ncomms1742. [PMID: 22415827] - Caterina Scuderi, Marta Valenza, Claudia Stecca, Giuseppe Esposito, Maria Rosaria Carratù, Luca Steardo. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
Journal of neuroinflammation.
2012 Mar; 9(?):49. doi:
10.1186/1742-2094-9-49. [PMID: 22405189] - Weijiao Huang, Wooyoung Choi, Wanqiu Hu, Na Mi, Qiang Guo, Meisheng Ma, Mei Liu, Yuan Tian, Peilong Lu, Feng-Liang Wang, Haiteng Deng, Lei Liu, Ning Gao, Li Yu, Yigong Shi. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein.
Cell research.
2012 Mar; 22(3):473-89. doi:
10.1038/cr.2012.24. [PMID: 22310240] - Shirin Bruderer, Päivi Aänismaa, Marie-Claude Homery, Stephanie Häusler, Kyle Landskroner, Patricia N Sidharta, Alexander Treiber, Jasper Dingemanse. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist.
The AAPS journal.
2012 Mar; 14(1):68-78. doi:
10.1208/s12248-011-9316-3. [PMID: 22189899] - Shaoqing Lei, Yanan Liu, Huimin Liu, Hong Yu, Hui Wang, Zhengyuan Xia. Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats.
Yonsei medical journal.
2012 Mar; 53(2):294-303. doi:
10.3349/ymj.2012.53.2.294. [PMID: 22318816] - Janhavi Giri, John M Tang, Christophe Wirth, Caroline M Peneff, Bob Eisenberg. Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli.
European biophysics journal : EBJ.
2012 Mar; 41(3):259-71. doi:
10.1007/s00249-011-0781-5. [PMID: 22246445] - Tae Myoung Kim, Sang-Kyung Shin, Tae-Wang Kim, So-Young Youm, Dae Joong Kim, Byeongwoo Ahn. Elm tree bark extract inhibits HepG2 hepatic cancer cell growth via pro-apoptotic activity.
Journal of veterinary science.
2012 Mar; 13(1):7-13. doi:
10.4142/jvs.2012.13.1.7. [PMID: 22437530] - Ana P Ortega-Galisteo, María Rodríguez-Serrano, Diana M Pazmiño, Dharmendra K Gupta, Luisa M Sandalio, María C Romero-Puertas. S-Nitrosylated proteins in pea (Pisum sativum L.) leaf peroxisomes: changes under abiotic stress.
Journal of experimental botany.
2012 Mar; 63(5):2089-103. doi:
10.1093/jxb/err414. [PMID: 22213812] - Ladislav Dokládal, Michal Oboril, Karel Stejskal, Zbynek Zdráhal, Nikola Ptácková, Radka Chaloupková, Jirí Damborsky, Tomás Kasparovsky, Sylvain Jeandroz, Markéta Zd'árská, Jan Lochman. Physiological and proteomic approaches to evaluate the role of sterol binding in elicitin-induced resistance.
Journal of experimental botany.
2012 Mar; 63(5):2203-15. doi:
10.1093/jxb/err427. [PMID: 22223811] - Faride Unda, Thomas Canam, Lindsay Preston, Shawn D Mansfield. Isolation and characterization of galactinol synthases from hybrid poplar.
Journal of experimental botany.
2012 Mar; 63(5):2059-69. doi:
10.1093/jxb/err411. [PMID: 22197892] - Stuart Kyle, Kier A R James, Michael J McPherson. Recombinant production of the therapeutic peptide lunasin.
Microbial cell factories.
2012 Feb; 11(?):28. doi:
10.1186/1475-2859-11-28. [PMID: 22376274] - Sonja Kössler, Charity Nofziger, Martin Jakab, Silvia Dossena, Markus Paulmichl. Curcumin affects cell survival and cell volume regulation in human renal and intestinal cells.
Toxicology.
2012 Feb; 292(2-3):123-35. doi:
10.1016/j.tox.2011.12.002. [PMID: 22178266] - Devan E Thompson, Megan D Siwicky, Roger A Moorehead. Caveolin-1 expression is elevated in claudin-low mammary tumor cells.
Cancer cell international.
2012 Feb; 12(?):6. doi:
10.1186/1475-2867-12-6. [PMID: 22356861] - Fabien Caillé, Célia S Bonnet, Frédéric Buron, Sandrine Villette, Lothar Helm, Stéphane Petoud, Franck Suzenet, Eva Tóth. Isoquinoline-based lanthanide complexes: bright NIR optical probes and efficient MRI agents.
Inorganic chemistry.
2012 Feb; 51(4):2522-32. doi:
10.1021/ic202446e. [PMID: 22233349] - Qingshan Wang, Hui Zhou, Huiming Gao, Shih-Heng Chen, Chun-Hsien Chu, Belinda Wilson, Jau-Shyong Hong. Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase.
Journal of neuroinflammation.
2012 Feb; 9(?):32. doi:
10.1186/1742-2094-9-32. [PMID: 22340895] - Jennifer A Greene, Nadia Sam-Agudu, Chandy C John, Robert O Opoka, Peter A Zimmerman, James W Kazura. Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study.
Malaria journal.
2012 Feb; 11(?):47. doi:
10.1186/1475-2875-11-47. [PMID: 22336003] - Takayuki Matsumura, Manabu Ato, Tadayoshi Ikebe, Makoto Ohnishi, Haruo Watanabe, Kazuo Kobayashi. Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
Nature communications.
2012 Feb; 3(?):678. doi:
10.1038/ncomms1677. [PMID: 22334081] - Christian M Probst, Rodrigo A Silva, Juliana P B Menezes, Tais F Almeida, Ivana N Gomes, Andréia C Dallabona, Luiz S Ozaki, Gregory A Buck, Daniela P Pavoni, Marco A Krieger, Patrícia S T Veras. A comparison of two distinct murine macrophage gene expression profiles in response to Leishmania amazonensis infection.
BMC microbiology.
2012 Feb; 12(?):22. doi:
10.1186/1471-2180-12-22. [PMID: 22321871] - Jason Jacoby, Matthew A Kreitzer, Simon Alford, Haohua Qian, Boriana K Tchernookova, Ethan R Naylor, Robert Paul Malchow. Extracellular pH dynamics of retinal horizontal cells examined using electrochemical and fluorometric methods.
Journal of neurophysiology.
2012 Feb; 107(3):868-79. doi:
10.1152/jn.00878.2011. [PMID: 22090459] - Sarah Lebeer, Ingmar J J Claes, Crina I A Balog, Geert Schoofs, Tine L A Verhoeven, Kris Nys, Ingemar von Ossowski, Willem M de Vos, Hanne L P Tytgat, Patrizia Agostinis, Airi Palva, Els J M Van Damme, André M Deelder, Sigrid C J De Keersmaecker, Manfred Wuhrer, Jos Vanderleyden. The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG.
Microbial cell factories.
2012 Feb; 11(?):15. doi:
10.1186/1475-2859-11-15. [PMID: 22297095] - Dustin E Bosch, Francis S Willard, Ravikrishna Ramanujam, Adam J Kimple, Melinda D Willard, Naweed I Naqvi, David P Siderovski. A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.
PLoS pathogens.
2012 Feb; 8(2):e1002553. doi:
10.1371/journal.ppat.1002553. [PMID: 22383884] - Yafei Qi, Ute Armbruster, Christian Schmitz-Linneweber, Etienne Delannoy, Andeol Falcon de Longevialle, Thilo Rühle, Ian Small, Peter Jahns, Dario Leister. Arabidopsis CSP41 proteins form multimeric complexes that bind and stabilize distinct plastid transcripts.
Journal of experimental botany.
2012 Feb; 63(3):1251-70. doi:
10.1093/jxb/err347. [PMID: 22090436] - Amy Huei-Yi Lee, Brenden Hurley, Corinna Felsensteiner, Carmen Yea, Wenzislava Ckurshumova, Verena Bartetzko, Pauline W Wang, Van Quach, Jennifer D Lewis, Yulu C Liu, Frederik Börnke, Stephane Angers, Andrew Wilde, David S Guttman, Darrell Desveaux. A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.
PLoS pathogens.
2012 Feb; 8(2):e1002523. doi:
10.1371/journal.ppat.1002523. [PMID: 22319451] - Pieter Vader, Leonardus J van der Aa, Johan F J Engbersen, Gert Storm, Raymond M Schiffelers. Physicochemical and biological evaluation of siRNA polyplexes based on PEGylated Poly(amido amine)s.
Pharmaceutical research.
2012 Feb; 29(2):352-61. doi:
10.1007/s11095-011-0545-z. [PMID: 21833793] - C V Musa, A Mancini, A Alfieri, G Labruna, G Valerio, A Franzese, F Pasanisi, M R Licenziati, L Sacchetti, P Buono. Four novel UCP3 gene variants associated with childhood obesity: effect on fatty acid oxidation and on prevention of triglyceride storage.
International journal of obesity (2005).
2012 Feb; 36(2):207-17. doi:
10.1038/ijo.2011.81. [PMID: 21544083] - Sol Kim, Jun Chang. Baculovirus-based Vaccine Displaying Respiratory Syncytial Virus Glycoprotein Induces Protective Immunity against RSV Infection without Vaccine-Enhanced Disease.
Immune network.
2012 Feb; 12(1):8-17. doi:
10.4110/in.2012.12.1.8. [PMID: 22536165] - Parvesh Wadhwani, Johannes Reichert, Jochen Bürck, Anne S Ulrich. Antimicrobial and cell-penetrating peptides induce lipid vesicle fusion by folding and aggregation.
European biophysics journal : EBJ.
2012 Feb; 41(2):177-87. doi:
10.1007/s00249-011-0771-7. [PMID: 22080286] - Kyu-Sang Park, Andreas Wiederkehr, Claes B Wollheim. Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2012 Feb; 16(1):71-7. doi:
10.4196/kjpp.2012.16.1.71. [PMID: 22416223] - Jagbir Singh, Deborah Michel, Jackson M Chitanda, Ronald E Verrall, Ildiko Badea. Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles.
Journal of nanobiotechnology.
2012 Feb; 10(?):7. doi:
10.1186/1477-3155-10-7. [PMID: 22296763] - P Marius, Yuk Ming Leung, T J Piggot, S Khalid, P T F Williamson. Probing the oligomeric state and interaction surfaces of Fukutin-I in dilauroylphosphatidylcholine bilayers.
European biophysics journal : EBJ.
2012 Feb; 41(2):199-207. doi:
10.1007/s00249-011-0773-5. [PMID: 22075563] - K M Habegger, B A Penque, W Sealls, L Tackett, L N Bell, E K Blue, P J Gallagher, M Sturek, M A Alloosh, H O Steinberg, R V Considine, J S Elmendorf. Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.
Diabetologia.
2012 Feb; 55(2):457-67. doi:
10.1007/s00125-011-2334-y. [PMID: 22002007] - Abel Viejo-Borbolla, Nadia Martinez-Martín, Hendrik J Nel, Patricia Rueda, Rocío Martín, Soledad Blanco, Fernando Arenzana-Seisdedos, Marcus Thelen, Padraic G Fallon, Antonio Alcamí. Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
PLoS pathogens.
2012 Feb; 8(2):e1002497. doi:
10.1371/journal.ppat.1002497. [PMID: 22319442] - Jean-Marc Routaboul, Chris Skidmore, James G Wallis, John Browse. Arabidopsis mutants reveal that short- and long-term thermotolerance have different requirements for trienoic fatty acids.
Journal of experimental botany.
2012 Feb; 63(3):1435-43. doi:
10.1093/jxb/err381. [PMID: 22140238] - Anne-Marie Boisson, Elisabeth Gout, Richard Bligny, Corinne Rivasseau. A simple and efficient method for the long-term preservation of plant cell suspension cultures.
Plant methods.
2012 Jan; 8(?):4. doi:
10.1186/1746-4811-8-4. [PMID: 22289515]