MES (BioDeep_00000409348)

Main id: BioDeep_00000174600

 


代谢物信息卡片


2-(N-Morpholino)ethanesulfonic acid

化学式: C6H13NO4S (195.0565258)
中文名称: 吗啉乙磺酸, 2-(N-吗啉)乙烷磺酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1COCCN1CCS(=O)(=O)O
InChI: InChI=1S/C6H13NO4S/c8-12(9,10)6-3-7-1-4-11-5-2-7/h1-6H2,(H,8,9,10)

描述信息

COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; SXGZJKUKBWWHRA-UHFFFAOYSA-N_STSL_0145_MES_0500fmol_180419_S2_LC02_MS02_15; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.

同义名列表

2 个代谢物同义名

2-(N-Morpholino)ethanesulfonic acid; MES



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • D J Artmann, P Vrabl, R Gianordoli, W Burgstaller. Challenging the charge balance hypothesis: reconsidering buffer effect and reuptake of previously excreted organic acids by Penicillium ochrochloron. FEMS microbiology letters. 2020 02; 367(4):. doi: 10.1093/femsle/fnaa039. [PMID: 32129848]
  • William Trewby, Duncan Livesey, Kislon Voïtchovsky. Buffering agents modify the hydration landscape at charged interfaces. Soft matter. 2016 Mar; 12(9):2642-51. doi: 10.1039/c5sm02445e. [PMID: 26837938]
  • Hiroaki Mano, Tomomi Fujii, Naomi Sumikawa, Yuji Hiwatashi, Mitsuyasu Hasebe. Development of an Agrobacterium-mediated stable transformation method for the sensitive plant Mimosa pudica. PloS one. 2014; 9(2):e88611. doi: 10.1371/journal.pone.0088611. [PMID: 24533121]
  • Kaori Yoneyama, Xiaonan Xie, Hyun Il Kim, Takaya Kisugi, Takahito Nomura, Hitoshi Sekimoto, Takao Yokota, Koichi Yoneyama. How do nitrogen and phosphorus deficiencies affect strigolactone production and exudation?. Planta. 2012 Jun; 235(6):1197-207. doi: 10.1007/s00425-011-1568-8. [PMID: 22183123]
  • Takeo Aoki, Takeshi Suzuki, Haruo Hagiwara, Michio Kuwahara, Sei Sasaki, Kuniaki Takata, Toshiyuki Matsuzaki. Close association of aquaporin-2 internalization with caveolin-1. Acta histochemica et cytochemica. 2012 Apr; 45(2):139-46. doi: 10.1267/ahc.12003. [PMID: 22685356]
  • Oliver Bannach, Eva Birkmann, Elke Reinartz, Karl-Erich Jaeger, Jan P M Langeveld, Robert G Rohwer, Luisa Gregori, Linda A Terry, Dieter Willbold, Detlev Riesner. Detection of prion protein particles in blood plasma of scrapie infected sheep. PloS one. 2012; 7(5):e36620. doi: 10.1371/journal.pone.0036620. [PMID: 22567169]
  • Yasuhiro Ishimaru, Ryuichi Takahashi, Khurram Bashir, Hugo Shimo, Takeshi Senoura, Kazuhiko Sugimoto, Kazuko Ono, Masahiro Yano, Satoru Ishikawa, Tomohito Arao, Hiromi Nakanishi, Naoko K Nishizawa. Characterizing the role of rice NRAMP5 in Manganese, Iron and Cadmium Transport. Scientific reports. 2012; 2(?):286. doi: 10.1038/srep00286. [PMID: 22368778]
  • Pei-Shiue J Tsai, Ian A Brewis, Jillis van Maaren, Bart M Gadella. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. PloS one. 2012; 7(3):e32603. doi: 10.1371/journal.pone.0032603. [PMID: 22412896]
  • Nigel Hoggard, Abdelali Agouni, Nimesh Mody, Mirela Delibegovic. Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes. International journal of general medicine. 2012; 5(?):403-11. doi: 10.2147/ijgm.s25879. [PMID: 22615536]
  • Doris Pester, Renáta Milčevičová, Johann Schaffer, Eva Wilhelm, Sylvia Blümel. Erwinia amylovora expresses fast and simultaneously hrp/dsp virulence genes during flower infection on apple trees. PloS one. 2012; 7(3):e32583. doi: 10.1371/journal.pone.0032583. [PMID: 22412891]
  • Zhaohui Liu, Zengcui Zhang, Justin D Faris, Richard P Oliver, Robert Syme, Megan C McDonald, Bruce A McDonald, Peter S Solomon, Shunwen Lu, Weilin L Shelver, Steven Xu, Timothy L Friesen. The cysteine rich necrotrophic effector SnTox1 produced by Stagonospora nodorum triggers susceptibility of wheat lines harboring Snn1. PLoS pathogens. 2012 Jan; 8(1):e1002467. doi: 10.1371/journal.ppat.1002467. [PMID: 22241993]
  • Chongming Wu, Juanjuan Feng, Ran Wang, Hong Liu, Huixia Yang, Pedro L Rodriguez, Huanju Qin, Xin Liu, Daowen Wang. HRS1 acts as a negative regulator of abscisic acid signaling to promote timely germination of Arabidopsis seeds. PloS one. 2012; 7(4):e35764. doi: 10.1371/journal.pone.0035764. [PMID: 22545134]
  • Takumi Higaki, Natsumaro Kutsuna, Yoichiroh Hosokawa, Kae Akita, Kazuo Ebine, Takashi Ueda, Noriaki Kondo, Seiichiro Hasezawa. Statistical organelle dissection of Arabidopsis guard cells using image database LIPS. Scientific reports. 2012; 2(?):405. doi: 10.1038/srep00405. [PMID: 22582142]
  • Ricardo J Stein, Brian M Waters. Use of natural variation reveals core genes in the transcriptome of iron-deficient Arabidopsis thaliana roots. Journal of experimental botany. 2012 Jan; 63(2):1039-55. doi: 10.1093/jxb/err343. [PMID: 22039296]
  • Selvaraju Kanagarajan, Conny Tolf, Anneli Lundgren, Jonas Waldenström, Peter E Brodelius. Transient expression of hemagglutinin antigen from low pathogenic avian influenza A (H7N7) in Nicotiana benthamiana. PloS one. 2012; 7(3):e33010. doi: 10.1371/journal.pone.0033010. [PMID: 22442675]
  • Yoichi Shimoda, Junkyu Han, Kiyokazu Kawada, Abderrazak Smaoui, Hiroko Isoda. Metabolomics analysis of Cistus monspeliensis leaf extract on energy metabolism activation in human intestinal cells. Journal of biomedicine & biotechnology. 2012; 2012(?):428514. doi: 10.1155/2012/428514. [PMID: 22523469]
  • Hong Li Chou, Ziyu Dai, Chia Wen Hsieh, Maurice Sb Ku. High level expression of Acidothermus cellulolyticus β-1, 4-endoglucanase in transgenic rice enhances the hydrolysis of its straw by cultured cow gastric fluid. Biotechnology for biofuels. 2011 Dec; 4(?):58. doi: 10.1186/1754-6834-4-58. [PMID: 22152050]
  • Colleen Kennedy, Matthew D Nelson, Anil K Bamezai. Analysis of detergent-free lipid rafts isolated from CD4+ T cell line: interaction with antigen presenting cells promotes coalescing of lipid rafts. Cell communication and signaling : CCS. 2011 Dec; 9(1):31. doi: 10.1186/1478-811x-9-31. [PMID: 22151974]
  • Jason P Laliberte, Andrea S Weisberg, Bernard Moss. The membrane fusion step of vaccinia virus entry is cooperatively mediated by multiple viral proteins and host cell components. PLoS pathogens. 2011 Dec; 7(12):e1002446. doi: 10.1371/journal.ppat.1002446. [PMID: 22194690]
  • Slavica Matić, Riccardo Rinaldi, Vera Masenga, Emanuela Noris. Efficient production of chimeric human papillomavirus 16 L1 protein bearing the M2e influenza epitope in Nicotiana benthamiana plants. BMC biotechnology. 2011 Nov; 11(?):106. doi: 10.1186/1472-6750-11-106. [PMID: 22085463]
  • Hui Zhao, Ranran Yao, Xiaoding Cao, Gencheng Wu. Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1. Journal of neuroinflammation. 2011 Nov; 8(?):159. doi: 10.1186/1742-2094-8-159. [PMID: 22078298]
  • Ana M Fortes, Patricia Agudelo-Romero, Marta S Silva, Kashif Ali, Lisete Sousa, Federica Maltese, Young H Choi, Jerome Grimplet, José M Martinez-Zapater, Robert Verpoorte, Maria S Pais. Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. BMC plant biology. 2011 Nov; 11(?):149. doi: 10.1186/1471-2229-11-149. [PMID: 22047180]
  • Snježana Mihaljević, Sandra Radić, Nataša Bauer, Rade Garić, Branka Mihaljević, Gordana Horvat, Dunja Leljak-Levanić, Sibila Jelaska. Ammonium-related metabolic changes affect somatic embryogenesis in pumpkin (Cucurbita pepo L.). Journal of plant physiology. 2011 Nov; 168(16):1943-51. doi: 10.1016/j.jplph.2011.05.025. [PMID: 21807439]
  • Aswini Gnanasekaran, Mayya Sundukova, Arn M J M van den Maagdenberg, Elsa Fabbretti, Andrea Nistri. Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model. Molecular pain. 2011 Sep; 7(?):77. doi: 10.1186/1744-8069-7-77. [PMID: 21958474]
  • Floriane L'Haridon, Angélique Besson-Bard, Matteo Binda, Mario Serrano, Eliane Abou-Mansour, Francine Balet, Henk-Jan Schoonbeek, Stephane Hess, Ricardo Mir, José Léon, Olivier Lamotte, Jean-Pierre Métraux. A permeable cuticle is associated with the release of reactive oxygen species and induction of innate immunity. PLoS pathogens. 2011 Jul; 7(7):e1002148. doi: 10.1371/journal.ppat.1002148. [PMID: 21829351]
  • Robyn M Carey, Jan K Blusztajn, Barbara E Slack. Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC cell biology. 2011 May; 12(?):20. doi: 10.1186/1471-2121-12-20. [PMID: 21586144]
  • Colette A ten Hove, Zoltán Bochdanovits, Vera M A Jansweijer, Fenne G Koning, Lidija Berke, Gabino F Sanchez-Perez, Ben Scheres, Renze Heidstra. Probing the roles of LRR RLK genes in Arabidopsis thaliana roots using a custom T-DNA insertion set. Plant molecular biology. 2011 May; 76(1-2):69-83. doi: 10.1007/s11103-011-9769-x. [PMID: 21431781]
  • Guilan Gao, Shengchun Zhang, Chengfeng Wang, Xiang Yang, Yaqin Wang, Xiaojun Su, Jinju Du, Chengwei Yang. Arabidopsis CPR5 independently regulates seed germination and postgermination arrest of development through LOX pathway and ABA signaling. PloS one. 2011 Apr; 6(4):e19406. doi: 10.1371/journal.pone.0019406. [PMID: 21556325]
  • Atsuhiko Toyama, Hidewaki Nakagawa, Koichi Matsuda, Nobuhisa Ishikawa, Nobuoki Kohno, Yataro Daigo, Taka-Aki Sato, Yusuke Nakamura, Koji Ueda. Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer. Proteome science. 2011 Apr; 9(?):18. doi: 10.1186/1477-5956-9-18. [PMID: 21473792]
  • Worapan Pormsila, Réjane Morand, Stephan Krähenbühl, Peter C Hauser. Quantification of plasma lactate concentrations using capillary electrophoresis with contactless conductivity detection. Electrophoresis. 2011 Apr; 32(8):884-9. doi: 10.1002/elps.201000420. [PMID: 21394727]
  • Michiko Watanabe, Kouki Fujioka, Nobutake Akiyama, Hiroshi Takeyama, Noriyoshi Manabe, Kenji Yamamoto, Yoshinobu Manome. Conjugation of quantum dots and JT95 IgM monoclonal antibody for thyroid carcinoma without abolishing the specificity and activity of the antibody. IEEE transactions on nanobioscience. 2011 Mar; 10(1):30-5. doi: 10.1109/tnb.2011.2125800. [PMID: 21521661]
  • Masako Abe, Pamela A Havre, Yasuyo Urasaki, Kei Ohnuma, Chikao Morimoto, Long H Dang, Nam H Dang. Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines. BMC cancer. 2011 Feb; 11(?):51. doi: 10.1186/1471-2407-11-51. [PMID: 21284881]
  • Heather Ann Brauer, Tanya E Libby, Breeana L Mitchell, Lin Li, Chu Chen, Timothy W Randolph, Yutaka Y Yasui, Johanna W Lampe, Paul D Lampe. Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner. Nutrition journal. 2011 Jan; 10(?):11. doi: 10.1186/1475-2891-10-11. [PMID: 21272319]
  • Angela Chaparro-Garcia, Rachael C Wilkinson, Selena Gimenez-Ibanez, Kim Findlay, Michael D Coffey, Cyril Zipfel, John P Rathjen, Sophien Kamoun, Sebastian Schornack. The receptor-like kinase SERK3/BAK1 is required for basal resistance against the late blight pathogen phytophthora infestans in Nicotiana benthamiana. PloS one. 2011 Jan; 6(1):e16608. doi: 10.1371/journal.pone.0016608. [PMID: 21304602]
  • Petr Tůma, Eva Samcová, Karel Stulík. Determination of the spectrum of low molecular mass organic acids in urine by capillary electrophoresis with contactless conductivity and ultraviolet photometric detection--an efficient tool for monitoring of inborn metabolic disorders. Analytica chimica acta. 2011 Jan; 685(1):84-90. doi: 10.1016/j.aca.2010.11.007. [PMID: 21168555]
  • Anoland Garateix, Emilio Salceda, Roberto Menéndez, Erik L Regalado, Omar López, Teidy García, Ruth A Morales, Abilio Laguna, Olivier P Thomas, Enrique Soto. Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B. Molecular pain. 2011 Jan; 7(?):10. doi: 10.1186/1744-8069-7-10. [PMID: 21261973]
  • Haiyan Zhang, Liang Zhang, Bin Gao, Hai Fan, Jingbo Jin, Miguel A Botella, Liwen Jiang, Jinxing Lin. Golgi apparatus-localized synaptotagmin 2 is required for unconventional secretion in Arabidopsis. PloS one. 2011; 6(11):e26477. doi: 10.1371/journal.pone.0026477. [PMID: 22140429]
  • Nissar Ahmad Wani, Ritambhara Nada, Jyotdeep Kaur. Biochemical and molecular mechanisms of folate transport in rat pancreas; interference with ethanol ingestion. PloS one. 2011; 6(12):e28599. doi: 10.1371/journal.pone.0028599. [PMID: 22163044]
  • Likyelesh Gugsa, Jochen Kumlehn. Somatic embryogenesis and massive shoot regeneration from immature embryo explants of tef. Biotechnology research international. 2011; 2011(?):309731. doi: 10.4061/2011/309731. [PMID: 22028975]
  • Rosa Lozano-Durán, Tábata Rosas-Díaz, Ana P Luna, Eduardo R Bejarano. Identification of host genes involved in geminivirus infection using a reverse genetics approach. PloS one. 2011; 6(7):e22383. doi: 10.1371/journal.pone.0022383. [PMID: 21818318]
  • Lucas Arzola, Junxing Chen, Kittipong Rattanaporn, James M Maclean, Karen A McDonald. Transient co-expression of post-transcriptional gene silencing suppressors for increased in planta expression of a recombinant anthrax receptor fusion protein. International journal of molecular sciences. 2011; 12(8):4975-90. doi: 10.3390/ijms12084975. [PMID: 21954339]
  • Asitha T Silva, Alien Nguyen, Changming Ye, Jeanmarie Verchot, Joong Ho Moon. Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts. BMC plant biology. 2010 Dec; 10(?):291. doi: 10.1186/1471-2229-10-291. [PMID: 21192827]
  • Elena Ambrosino, Chloé Dumoulin, Eve Orlandi-Pradines, Franck Remoue, Aissatou Toure-Baldé, Adama Tall, Jean Biram Sarr, Anne Poinsignon, Cheikh Sokhna, Karine Puget, Jean-François Trape, Aurélie Pascual, Pierre Druilhe, Thierry Fusai, Christophe Rogier. A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigens. Malaria journal. 2010 Nov; 9(?):317. doi: 10.1186/1475-2875-9-317. [PMID: 21059211]
  • Johanna M S Lemons, Xiao-Jiang Feng, Bryson D Bennett, Aster Legesse-Miller, Elizabeth L Johnson, Irene Raitman, Elizabeth A Pollina, Herschel A Rabitz, Joshua D Rabinowitz, Hilary A Coller. Quiescent fibroblasts exhibit high metabolic activity. PLoS biology. 2010 Oct; 8(10):e1000514. doi: 10.1371/journal.pbio.1000514. [PMID: 21049082]
  • Ourania I Pavli, Nicholas J Panopoulos, Rob Goldbach, George N Skaracis. BNYVV-derived dsRNA confers resistance to rhizomania disease of sugar beet as evidenced by a novel transgenic hairy root approach. Transgenic research. 2010 Oct; 19(5):915-22. doi: 10.1007/s11248-010-9364-y. [PMID: 20127510]
  • Stefanie Storf, Friedhelm Pfeiffer, Kieran Dilks, Zhong Qiang Chen, Saheed Imam, Mechthild Pohlschröder. Mutational and bioinformatic analysis of haloarchaeal lipobox-containing proteins. Archaea (Vancouver, B.C.). 2010 Sep; 2010(?):. doi: 10.1155/2010/410975. [PMID: 20886060]
  • Armando S Tasistro, Liliana Picone, Miguel Cabrera. Dynamics of water soluble phosphorus from surface applied broiler litter. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2010 Aug; 45(6):572-7. doi: 10.1080/03601234.2010.493496. [PMID: 20661791]
  • Michael Pennick. Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatric disease and treatment. 2010 Jun; 6(?):317-27. doi: 10.2147/ndt.s9749. [PMID: 20628632]
  • Natalia A Ilyushina, Jon P Seiler, Jerold E Rehg, Robert G Webster, Elena A Govorkova. Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets. PLoS pathogens. 2010 May; 6(5):e1000933. doi: 10.1371/journal.ppat.1000933. [PMID: 20523902]
  • Xinlu Chen, Raymie Equi, Holly Baxter, Kyle Berk, Jin Han, Sujata Agarwal, Janice Zale. A high-throughput transient gene expression system for switchgrass (Panicum virgatum L.) seedlings. Biotechnology for biofuels. 2010 May; 3(?):9. doi: 10.1186/1754-6834-3-9. [PMID: 20459651]
  • Luís M Muñiz, Joaquín Royo, Elisa Gómez, Gaelle Baudot, Wyatt Paul, Gregorio Hueros. Atypical response regulators expressed in the maize endosperm transfer cells link canonical two component systems and seed biology. BMC plant biology. 2010 May; 10(?):84. doi: 10.1186/1471-2229-10-84. [PMID: 20459670]
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  • Peter Laverman, William J McBride, Robert M Sharkey, Annemarie Eek, Lieke Joosten, Wim J G Oyen, David M Goldenberg, Otto C Boerman. A novel facile method of labeling octreotide with (18)F-fluorine. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010 Mar; 51(3):454-61. doi: 10.2967/jnumed.109.066902. [PMID: 20150268]
  • Tsukasa Matsumoto, Masaaki Noguchi, Osamu Hayashi, Kimiko Makino, Haruki Yamada. Hochuekkito, a Kampo (traditional Japanese herbal) Medicine, Enhances Mucosal IgA Antibody Response in Mice Immunized with Antigen-entrapped Biodegradable Microparticles. Evidence-based complementary and alternative medicine : eCAM. 2010 Mar; 7(1):69-77. doi: 10.1093/ecam/nem166. [PMID: 18955273]
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  • Björn J Sieberer, Henk Kieft, Tiny Franssen-Verheijen, Anne Mie C Emons, Jan W Vos. Cell proliferation, cell shape, and microtubule and cellulose microfibril organization of tobacco BY-2 cells are not altered by exposure to near weightlessness in space. Planta. 2009 Nov; 230(6):1129-40. doi: 10.1007/s00425-009-1010-7. [PMID: 19756725]
  • Congli Wang, George Bruening, Valerie M Williamson. Determination of preferred pH for root-knot nematode aggregation using pluronic F-127 gel. Journal of chemical ecology. 2009 Oct; 35(10):1242-51. doi: 10.1007/s10886-009-9703-8. [PMID: 19838866]
  • Alexandre Tromas, Nils Braun, Philippe Muller, Tatyana Khodus, Ivan A Paponov, Klaus Palme, Karin Ljung, Ji-Young Lee, Philip Benfey, James A H Murray, Ben Scheres, Catherine Perrot-Rechenmann. The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth. PloS one. 2009 Sep; 4(9):e6648. doi: 10.1371/journal.pone.0006648. [PMID: 19777056]
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