Desethylamiodarone (BioDeep_00000408979)
代谢物信息卡片
Desethylamiodarone
化学式: C23H25I2NO3 (616.9923879999999)
中文名称: 去乙基胺碘酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCNCC)I
InChI: InChI=1S/C23H25I2NO3/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:180711
- PubChem: 104774
- ChEMBL: CHEMBL1600
- CAS: 83409-32-9
- MoNA: WA002809
- MoNA: WA002808
- MoNA: WA002807
- MoNA: WA002806
- MoNA: WA002805
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mikie Yamato, Kyoichi Wada, Tomohiro Hayashi, Mai Fujimoto, Kouichi Hosomi, Akira Oita, Mitsutaka Takada. Association between Serum Amiodarone and N-Desethylamiodarone Concentrations and Development of Thyroid Dysfunction.
Clinical drug investigation.
2018 Jan; 38(1):39-48. doi:
10.1007/s40261-017-0582-4. [PMID: 29080209] - Mikie Yamato, Kyoichi Wada, Mai Fujimoto, Kouichi Hosomi, Tomohiro Hayashi, Akira Oita, Mitsutaka Takada. Association between N-desethylamiodarone/amiodarone ratio and amiodarone-induced thyroid dysfunction.
European journal of clinical pharmacology.
2017 Mar; 73(3):289-296. doi:
10.1007/s00228-017-2195-5. [PMID: 28083650] - Jing-Tao Lu, Ying Cai, Feng Chen, Wei-Wei Jia, Zhe-Yi Hu, Yuan-Sheng Zhao. A Physiologically Based Pharmacokinetic Model of Amiodarone and its Metabolite Desethylamiodarone in Rats: Pooled Analysis of Published Data.
European journal of drug metabolism and pharmacokinetics.
2016 Dec; 41(6):689-703. doi:
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1990 Oct; 127(4):1656-64. doi:
10.1210/endo-127-4-1656. [PMID: 2401231] - E G Giardina, M Schneider, M L Barr. Myocardial amiodarone and desethylamiodarone concentrations in patients undergoing cardiac transplantation.
Journal of the American College of Cardiology.
1990 Oct; 16(4):943-7. doi:
10.1016/s0735-1097(10)80346-8. [PMID: 2212375] - J M Daniels, R G Leeder, J F Brien, T E Massey. Repeated amiodarone exposure in the rat: toxicity and effects on hepatic and extrahepatic monooxygenase activities.
Canadian journal of physiology and pharmacology.
1990 Sep; 68(9):1261-8. doi:
10.1139/y90-189. [PMID: 2276089] - P A Wyss, M J Moor, M H Bickel. Single-dose kinetics of tissue distribution, excretion and metabolism of amiodarone in rats.
The Journal of pharmacology and experimental therapeutics.
1990 Aug; 254(2):502-7. doi:
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The American journal of cardiology.
1990 May; 65(18):1185-91. doi:
10.1016/0002-9149(90)90971-3. [PMID: 2337027] - E Rafeiro, R G Leeder, J M Daniels, J F Brien, T E Massey. In vitro hepatic, renal, and pulmonary N-dealkylation of amiodarone.
Biochemical pharmacology.
1990 May; 39(10):1627-9. doi:
10.1016/0006-2952(90)90533-q. [PMID: 2337422] - H Abdollah, J F Brien, F J Brennan. Antiarrhythmic effect of chronic oral amiodarone treatment in dogs with myocardial infarction and reproducibly inducible sustained ventricular arrhythmias.
Journal of cardiovascular pharmacology.
1990 May; 15(5):799-807. doi:
10.1097/00005344-199005000-00016. [PMID: 1692941] - T A Plomp, R N Hauer, E O Robles de Medina. Amiodarone and desethylamiodarone concentrations in plasma and tissues of surgically treated patients on long-term oral amiodarone treatment.
In vivo (Athens, Greece).
1990 Mar; 4(2):97-100. doi:
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Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1990 Mar; 37(2):251-4. doi:
10.1007/bf03005479. [PMID: 2136324] - C N Ou, C L Rognerud, L T Duong, V L Frawley. Liquid-chromatographic determination of amiodarone and N-desethylamiodarone in serum.
Clinical chemistry.
1990 Mar; 36(3):532-4. doi:
10.1093/clinchem/36.3.532. [PMID: 2311227] - D Lamontagne, N Yamaguchi, C Lambert, J de Champlain, R Nadeau. Absence of prejunctional sympathetic effect of amiodarone in hearts of open-chest anesthetized dogs.
Canadian journal of physiology and pharmacology.
1990 Feb; 68(2):144-9. doi:
10.1139/y90-023. [PMID: 2310999] - V L Snyder, S Bandyopadhyay, J Collins, S A Gross, P Somani, L J Didio. Subcellular changes of rat myocardium after treatment with amiodarone or desethylamiodarone, studied with electron microscopy.
Journal of submicroscopic cytology and pathology.
1990 Jan; 22(1):71-8. doi:
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British journal of pharmacology.
1990 Jan; 99(1):35-40. doi:
10.1111/j.1476-5381.1990.tb14650.x. [PMID: 2331573] - P Somani, S Bandyopadhyay, J E Klaunig, S A Gross. Amiodarone- and desethylamiodarone-induced myelinoid inclusion bodies and toxicity in cultured rat hepatocytes.
Hepatology (Baltimore, Md.).
1990 Jan; 11(1):81-92. doi:
10.1002/hep.1840110115. [PMID: 2153095] - S A Beddows, S R Page, A H Taylor, R McNerney, G S Whitley, A P Johnstone, S S Nussey. Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes.
Biochemical pharmacology.
1989 Dec; 38(24):4397-403. doi:
10.1016/0006-2952(89)90648-5. [PMID: 2604742] - P T Pollak, A D Sharma, S G Carruthers. Correlation of amiodarone dosage, heart rate, QT interval and corneal microdeposits with serum amiodarone and desethylamiodarone concentrations.
The American journal of cardiology.
1989 Nov; 64(18):1138-43. doi:
10.1016/0002-9149(89)90866-7. [PMID: 2816765] - R Kannan, J S Sarma, M Guha, K Venkataraman. Tissue drug accumulation and ultrastructural changes during amiodarone administration in rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1989 Nov; 13(4):793-803. doi:
10.1016/0272-0590(89)90334-5. [PMID: 2620796] - D Paczkowski, W Popławska, M Filipek, J Podleśny. Determination of amiodarone and its metabolite desethylamiodarone in human plasma and serum.
Polish journal of pharmacology and pharmacy.
1989 Jul; 41(4):359-67. doi:
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Circulation.
1989 Jul; 80(1):34-42. doi:
10.1161/01.cir.80.1.34. [PMID: 2736754] - E Riva, D J Hearse. Anti-arrhythmic effects of amiodarone and desethylamiodarone on malignant ventricular arrhythmias arising as a consequence of ischaemia and reperfusion in the anaesthetised rat.
Cardiovascular research.
1989 Apr; 23(4):331-9. doi:
10.1093/cvr/23.4.331. [PMID: 2590914] - K Robinson, A Johnston, S Walker, J P Mulrow, W J McKenna, D W Holt. The digoxin-amiodarone interaction.
Cardiovascular drugs and therapy.
1989 Mar; 3(1):25-8. doi:
10.1007/bf01881526. [PMID: 2487521] - T J Maling, R W Siebers, C D Burgess, C Taylor, G Purdie. Individual variability of amiodarone distribution in plasma and erythrocytes: implications for therapeutic monitoring.
Therapeutic drug monitoring.
1989; 11(2):121-6. doi:
10.1097/00007691-198903000-00001. [PMID: 2718218] - M A Rochas, C Caillard, Y Coulais, A Sqalli, G Houin. High performance liquid chromatographic method for routine monitoring of amiodarone and desethylamiodarone plasma levels.
Annales de biologie clinique.
1989; 47(3):135-7. doi:
NULL. [PMID: 2712399] - H Abdollah, J F Brien, F J Brennan. Antiarrhythmic effects of desethylamiodarone in dogs with subacute myocardial infarction and inducible ventricular arrhythmias.
Journal of cardiovascular pharmacology.
1989 Jan; 13(1):37-44. doi:
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In vivo (Athens, Greece).
1989 Jan; 3(1):33-47. doi:
NULL. [PMID: 2519831] - M J Moor, P A Wyss, M H Bickel. New procedure for the high-performance liquid chromatographic determination of amiodarone and desethylamiodarone with solid-phase extraction of rat plasma and tissue samples.
Journal of chromatography.
1988 Oct; 431(2):455-60. doi:
10.1016/s0378-4347(00)83118-7. [PMID: 3243801] - R S Sheldon, L B Mitchell, H J Duff, D G Wyse, D E Manyari. Right and left ventricular function during chronic amiodarone therapy.
The American journal of cardiology.
1988 Oct; 62(10 Pt 1):736-40. doi:
10.1016/0002-9149(88)91213-1. [PMID: 3421174] - W D Spotnitz, S P Nolan, D L Kaiser, M S Dalton, J W Baker, J R Shipe, T L Matthew. The reversal of amiodarone-induced perioperative reduction in cardiac systolic reserve in dogs.
Journal of the American College of Cardiology.
1988 Sep; 12(3):757-64. doi:
10.1016/0735-1097(88)90318-x. [PMID: 3403837] - S J Connolly, R N Gupta, D Hoffert, R S Roberts. Concentration response relationships of amiodarone and desethylamiodarone.
American heart journal.
1988 Jun; 115(6):1208-13. doi:
10.1016/0002-8703(88)90010-5. [PMID: 3376838]