Periciazine (BioDeep_00000408931)

   


代谢物信息卡片


Propericiazine (oxide)

化学式: C21H23N3OS (365.15617480000003)
中文名称: 哌噻嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
InChI: InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AC - Phenothiazines with piperidine structure
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis[1]. Pericyazine is a selective D2-dopamine receptor antagonist[2][3]. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects[4].

同义名列表

5 个代谢物同义名

Periciazine; Propericiazine (oxide); Propericiazine; RP 8909; Pericyazine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mohammad M Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S Anderson, William L Jorgensen. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2. ACS medicinal chemistry letters. 2020 Dec; 11(12):2526-2533. doi: 10.1021/acsmedchemlett.0c00521. [PMID: 33324471]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Nadezhda M Zakharova, Yury S Tarahovsky, Irina S Fadeeva, Natalia P Komelina, Maxim O Khrenov, Olga V Glushkova, Dmitry A Prokhorov, Viktor P Kutyshenko, Anatoly L Kovtun. A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats. Life sciences. 2019 Feb; 219(?):190-198. doi: 10.1016/j.lfs.2019.01.023. [PMID: 30658098]
  • Hua Lin Cai, Yang Deng, Ping Fei Fang, SiSi Cao, Zhen Yan Hou, Yan Qin Wu, Xue Jiao Chen, Miao Yan, BiKui Zhang. A sensitive LC-MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers. Journal of pharmaceutical and biomedical analysis. 2017 Feb; 135(?):67-74. doi: 10.1016/j.jpba.2016.12.007. [PMID: 28012307]
  • Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913). BMC psychiatry. 2008 Dec; 8(?):95. doi: 10.1186/1471-244x-8-95. [PMID: 19102734]
  • P B Kandagal, S S Kalanur, D H Manjunatha, J Seetharamappa. Mechanism of interaction between human serum albumin and N-alkyl phenothiazines studied using spectroscopic methods. Journal of pharmaceutical and biomedical analysis. 2008 Jun; 47(2):260-7. doi: 10.1016/j.jpba.2008.01.027. [PMID: 18313253]
  • Einosuke Tanaka, Takako Nakamura, Masaru Terada, Tatsuo Shinozuka, Chikako Hashimoto, Katsuyoshi Kurihara, Katsuya Honda. Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jul; 854(1-2):116-20. doi: 10.1016/j.jchromb.2007.04.004. [PMID: 17459789]
  • Frank M C Besag, David Berry. Interactions between antiepileptic and antipsychotic drugs. Drug safety. 2006; 29(2):95-118. doi: 10.2165/00002018-200629020-00001. [PMID: 16454538]
  • Akemi Marumo, Takeshi Kumazawa, Xiao-Pen Lee, Koichiro Fujimaki, Ayako Kuriki, Chika Hasegawa, Keizo Sato, Hiroshi Seno, Osamu Suzuki. Analysis of phenothiazines in human body fluids using disk solid-phase extraction and liquid chromatography. Journal of AOAC International. 2005 Nov; 88(6):1655-60. doi: . [PMID: 16526447]
  • José Correia de Farias Brito, Mário de Almeida Pereira Coutinho, Hermano José Falcone de Almeida, Paulo Virgolino da Nóbrega. [Wilson's disease: clinical diagnosis and 'faces of panda' signs in magnetic resonance imaging. Case report]. Arquivos de neuro-psiquiatria. 2005 Mar; 63(1):176-9. doi: 10.1590/s0004-282x2005000100034. [PMID: 15830089]
  • Akira Ohashi, Mayuko Ogiwara, Rieko Ikeda, Haruki Okada, Kousaburo Ohashi. Cloud point extraction and preconcentration for the gas chromatography of phenothiazine tranquilizers in spiked human serum. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2004 Sep; 20(9):1353-7. doi: 10.2116/analsci.20.1353. [PMID: 15478348]
  • A Hulshoff, J H Perrin. Quantitative correlations between albumin binding constants and chromatographic Rm values of phenothiazine derivatives. Journal of medicinal chemistry. 1977 Mar; 20(3):430-9. doi: 10.1021/jm00213a022. [PMID: 576620]