minaprine (BioDeep_00000408918)

   


代谢物信息卡片


minaprine

化学式: C17H22N4O (298.1794)
中文名称: 米那林二盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
InChI: InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants

同义名列表

1 个代谢物同义名

minaprine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jun Yan, Ping Luo, Yao Wu, Guandi Peng, Yini Liu, Chengrong Song, Wen Lu, Hongning Liu, Zishu Dong. Morphological and genetic differences in legs of a polygamous beetle between sexes, Glenea cantor (Coleopter: Cerambycidae: Lamiinae). PloS one. 2024; 19(2):e0297365. doi: 10.1371/journal.pone.0297365. [PMID: 38329988]
  • Yao Wu, Zhixin Li, Liangshan Ming, Zhongyan Huang, Gaochuan Zhang, Wen Lu, Hongning Liu, Zishu Dong. Observations on the ultrastructure of the oral appendages of Glenea cantor Fabricius (Coleoptera: Lamiinae). Microscopy research and technique. 2023 Dec; 86(12):1599-1609. doi: 10.1002/jemt.24395. [PMID: 37548179]
  • Tian Chen, Radhia Benmohamed, Jinho Kim, Karen Smith, Daniel Amante, Richard I Morimoto, Donald R Kirsch, Robert J Ferrante, Richard B Silverman. ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis. Journal of medicinal chemistry. 2012 Jan; 55(1):515-27. doi: 10.1021/jm2014277. [PMID: 22191331]
  • H Davi, J M Bonnet, Y Berger. Disposition of minaprine in animals and in human extensive and limited debrisoquine hydroxylators. Xenobiotica; the fate of foreign compounds in biological systems. 1992 Feb; 22(2):171-84. doi: 10.3109/00498259209046615. [PMID: 1632106]
  • O Gandolfi, P Roncada, R Dall'Olio, N Montanaro. Molecular mechanisms in the action of minaprine. Progress in neuro-psychopharmacology & biological psychiatry. 1988; 12(5):629-37. doi: 10.1016/0278-5846(88)90008-5. [PMID: 2851858]
  • N Matsuo, K Yamada, M Kumagai, M Nagashima, S Matsumoto, K Shirakawa, T Furukawa. Effects of minaprine, a novel antidepressant, on prolactin secretion in the rat. The Journal of pharmacy and pharmacology. 1988 Jan; 40(1):66-8. doi: 10.1111/j.2042-7158.1988.tb05156.x. [PMID: 2896781]
  • J Barré, G Houin, J P Jeanniot, C Coirre, J P Tillement. Binding of minaprine to human serum proteins and erythrocytes. International journal of clinical pharmacology research. 1986; 6(1):1-9. doi: NULL. [PMID: 3957500]
  • S Caccia, T Fossati, A Mancinelli. Disposition and metabolism of minaprine in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1985 Dec; 15(12):1111-9. doi: 10.3109/00498258509049105. [PMID: 4090530]
  • H Davi, A Carayon, E Marti, Y Sales, W Cautreels. Circulating and brain metabolites of minaprine in the baboon. Xenobiotica; the fate of foreign compounds in biological systems. 1985 Feb; 15(2):97-106. doi: 10.3109/00498258509045339. [PMID: 4002739]
  • H Laborit, J F Bonifacj. Effect of 3-(2-morpholinoethylamino)-4-methyl-6-phenyl pyridazine dihydrochloride (minaprine) on plasma cortisone levels of physostigmine treated rats. Research communications in chemical pathology and pharmacology. 1984 Apr; 44(1):63-7. doi: NULL. [PMID: 6729250]
  • M H Fong, A Abbiati, E Benfenati, S Caccia. Quantitative analysis of minaprine and some of its metabolites with application to kinetic studies in rats. Journal of chromatography. 1983 Mar; 259(1):141-9. doi: 10.1016/s0021-9673(01)87987-5. [PMID: 6853632]
  • H Davi, P Dupont, J P Jeanniot, R Roncucci, W Cautreels. The biotransformation of [14C]minaprine in man and five animals species. Xenobiotica; the fate of foreign compounds in biological systems. 1981 Nov; 11(11):735-47. doi: 10.3109/00498258109045877. [PMID: 6801871]