BENDROFLUMETHIAZIDE (BioDeep_00000408896)
Main id: BioDeep_00000001897
代谢物信息卡片
BENDROFLUMETHIAZIDE
化学式: C15H14F3N3O4S2 (421.03778000000005)
中文名称: 苄氟噻嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c(c3)ccc(c3)CC(N1)NS(=O)(=O)c(c2)c1cc(C(F)(F)F)c2S(N)(=O)=O
InChI: InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
描述信息
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:3013
- KEGG: C07758
- KEGGdrug: D00650
- PubChem: 2315
- DrugBank: DB00436
- ChEMBL: CHEMBL1684
- MeSH: Bendroflumethiazide
- CAS: 73-48-3
- MoNA: WA001809
- MoNA: WA001808
- MoNA: WA001807
- MoNA: WA001806
- MoNA: WA001805
- PubChem: 9960
- NIKKAJI: J1.428A
- RefMet: Bendroflumethiazide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Marie Cæcilie Kobel, Tommy Kjærgaard Nielsen, Ole Graumann. Acute renal failure and arterial hypertension due to subcapsular haematoma: is percutaneous drainage a feasible treatment?.
BMJ case reports.
2016 Jan; 2016(?):. doi:
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Acta physiologica Hungarica.
2014 Mar; 101(1):88-102. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
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Hypertension (Dallas, Tex. : 1979).
2012 Jun; 59(6):1104-9. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Jun; 35(6):654-60. doi:
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Amino acids.
2012 May; 42(5):1627-39. doi:
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Pediatric nephrology (Berlin, Germany).
2012 Feb; 27(2):285-93. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Jan; 45(1-2):195-200. doi:
10.1016/j.ejps.2011.11.010. [PMID: 22115868] - Yoshiteru Noutoshi, Mika Ikeda, Ken Shirasu. Diuretics prime plant immunity in Arabidopsis thaliana.
PloS one.
2012; 7(10):e48443. doi:
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Vascular health and risk management.
2012; 8(?):307-22. doi:
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Nature medicine.
2011 Oct; 17(10):1304-9. doi:
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Indian journal of pharmacology.
2011 Jul; 43(4):437-40. doi:
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BMJ case reports.
2011 May; 2011(?):. doi:
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Integrated blood pressure control.
2011; 4(?):55-71. doi:
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Vascular health and risk management.
2011; 7(?):137-41. doi:
10.2147/vhrm.s11235. [PMID: 21468174] - Subhankar Das, Edward Au, Stephen T Krazit, Kailash N Pandey. Targeted disruption of guanylyl cyclase-A/natriuretic peptide receptor-A gene provokes renal fibrosis and remodeling in null mutant mice: role of proinflammatory cytokines.
Endocrinology.
2010 Dec; 151(12):5841-50. doi:
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Canadian journal of physiology and pharmacology.
2010 Dec; 88(12):1191-201. doi:
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Vascular health and risk management.
2010 Sep; 6(?):711-22. doi:
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Analytical and bioanalytical chemistry.
2010 Apr; 396(7):2583-98. doi:
10.1007/s00216-010-3484-3. [PMID: 20155493] - Inbal Boger-Megiddo, Susan R Heckbert, Noel S Weiss, Barbara McKnight, Curt D Furberg, Kerri L Wiggins, Joseph A C Delaney, David S Siscovick, Eric B Larson, Rozenn N Lemaitre, Nicholas L Smith, Kenneth M Rice, Nicole L Glazer, Bruce M Psaty. Myocardial infarction and stroke associated with diuretic based two drug antihypertensive regimens: population based case-control study.
BMJ (Clinical research ed.).
2010 Jan; 340(?):c103. doi:
10.1136/bmj.c103. [PMID: 20100777] - Fernando Maya, José Manuel Estela, Víctor Cerdà. Interfacing on-line solid phase extraction with monolithic column multisyringe chromatography and chemiluminescence detection: An effective tool for fast, sensitive and selective determination of thiazide diuretics.
Talanta.
2010 Jan; 80(3):1333-40. doi:
10.1016/j.talanta.2009.09.033. [PMID: 20006096] - Hari K Parthasarathy, Khamis Alhashmi, Alex D McMahon, Allan D Struthers, Gordon T McInnes, Ian Ford, John M Connell, Thomas M MacDonald. Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO.
Journal of hypertension.
2010 Jan; 28(1):170-7. doi:
10.1097/hjh.0b013e328332b79b. [PMID: 20009770] - Di Zhao, Kailash N Pandey, L Gabriel Navar. ANP-mediated inhibition of distal nephron fractional sodium reabsorption in wild-type and mice overexpressing natriuretic peptide receptor.
American journal of physiology. Renal physiology.
2010 Jan; 298(1):F103-8. doi:
10.1152/ajprenal.00479.2009. [PMID: 19906950] - Maria Czarina Acelajado. Optimal management of hypertension in elderly patients.
Integrated blood pressure control.
2010; 3(?):145-53. doi:
10.2147/ibpc.s6778. [PMID: 21949630] - Keith Siau. Hypokalaemia and cardiac arrest complicating vancomycin and furosemide therapy: a case report.
Cases journal.
2009 Jul; 2(?):8244. doi:
10.4076/1757-1626-2-8244. [PMID: 19830061] - Di Zhao, Dale M Seth, L Gabriel Navar. Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice.
Hypertension (Dallas, Tex. : 1979).
2009 Jul; 54(1):120-6. doi:
10.1161/hypertensionaha.109.133785. [PMID: 19487583] - Christoph Stettler, Nicholas Witt, Robyn J Tapp, Simon Thom, Sabin Allemann, Therese Tillin, Alice Stanton, Eoin O'Brien, Neil Poulter, J Ruth Gallimore, Alun D Hughes, Nish Chaturvedi. Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy.
Diabetes care.
2009 Jun; 32(6):1098-100. doi:
10.2337/dc08-2137. [PMID: 19244088] - J N Basile. Antihypertensive therapy, new-onset diabetes, and cardiovascular disease.
International journal of clinical practice.
2009 Apr; 63(4):656-66. doi:
10.1111/j.1742-1241.2009.02009.x. [PMID: 19220522] - Alberto F Rubio-Guerra, David Castro-Serna, Cesar I Elizalde Barrera, Luz M Ramos-Brizuela. Current concepts in combination therapy for the treatment of hypertension: combined calcium channel blockers and RAAS inhibitors.
Integrated blood pressure control.
2009; 2(?):55-62. doi:
10.2147/ibpc.s6232. [PMID: 21949615] - Martin Tepel, Werner Hopfenmueller, Alexandra Scholze, Alexandra Maier, Walter Zidek. Effect of amlodipine on cardiovascular events in hypertensive haemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Nov; 23(11):3605-12. doi:
10.1093/ndt/gfn304. [PMID: 18511605] - Tord Juhlin, Bo A G Jönsson, Peter Höglund. Renal effects of aspirin are clearly dose-dependent and are of clinical importance from a dose of 160 mg.
European journal of heart failure.
2008 Sep; 10(9):892-8. doi:
10.1016/j.ejheart.2008.06.014. [PMID: 18794027] - Giovambattista Capasso, Maria Rizzo, Maria Lisa Garavaglia, Francesco Trepiccione, Miriam Zacchia, Alessandra Mugione, Patrizia Ferrari, Markus Paulmichl, Florian Lang, Johannes Loffing, Monique Carrel, Sara Damiano, Carsten A Wagner, Giuseppe Bianchi, Giuliano Meyer. Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension.
American journal of physiology. Renal physiology.
2008 Aug; 295(2):F556-67. doi:
10.1152/ajprenal.00340.2007. [PMID: 18480177] - Di Zhao, L Gabriel Navar. Acute angiotensin II infusions elicit pressure natriuresis in mice and reduce distal fractional sodium reabsorption.
Hypertension (Dallas, Tex. : 1979).
2008 Jul; 52(1):137-42. doi:
10.1161/hypertensionaha.108.111435. [PMID: 18504321] - Esther A Molenaar, Shih-Jen Hwang, Ramachandran S Vasan, Diederick E Grobbee, James B Meigs, Ralph B D'Agostino, Daniel Levy, Caroline S Fox. Burden and rates of treatment and control of cardiovascular disease risk factors in obesity: the Framingham Heart Study.
Diabetes care.
2008 Jul; 31(7):1367-72. doi:
10.2337/dc07-2413. [PMID: 18375414] - D M McLaughlin, A B Atkinson, C N Ennis, J Browne, S J Hunter, B Sheridan, P M Bell. Comparison of effects of combined ACE inhibitor and low-dose thiazide diuretic with ACE inhibitor alone on insulin action in patients with hypertension and Type 2 diabetes: a double-blind crossover study.
Diabetic medicine : a journal of the British Diabetic Association.
2008 May; 25(5):631-4. doi:
10.1111/j.1464-5491.2008.02437.x. [PMID: 18445178] - Claus Hancke, Per Andersen, Irene Hage, Ole Købke. [Serious debate on unconventional treatment, thank you].
Ugeskrift for laeger.
2008 Feb; 170(9):759; author reply 759. doi:
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Ugeskrift for laeger.
2008 Jan; 170(5):360; author reply 360. doi:
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Vascular health and risk management.
2008; 4(1):23-30. doi:
10.2147/vhrm.2008.04.01.23. [PMID: 18629377] - Marcio C Mancini, Alfredo Halpern. Orlistat in the prevention of diabetes in the obese patient.
Vascular health and risk management.
2008; 4(2):325-36. doi:
10.2147/vhrm.s6808. [PMID: 18561508] - Kamal Tolba, Detlev Belder. Fast quantitative determination of diuretic drugs in tablets and human urine by microchip electrophoresis with native fluorescence detection.
Electrophoresis.
2007 Aug; 28(16):2934-41. doi:
10.1002/elps.200600520. [PMID: 17702070] - Susan J Hood, Kevin P Taylor, Michael J Ashby, Morris J Brown. The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio.
Circulation.
2007 Jul; 116(3):268-75. doi:
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American journal of hypertension.
2007 Jun; 20(6):699-704. doi:
10.1016/j.amjhyper.2007.01.004. [PMID: 17531931] - William Stephen Waring. Delayed cardiotoxicity in chronic lithium poisoning: discrepancy between serum lithium concentrations and clinical status.
Basic & clinical pharmacology & toxicology.
2007 May; 100(5):353-5. doi:
10.1111/j.1742-7843.2007.00054.x. [PMID: 17448123] - Tord Juhlin, Leif R Erhardt, Helene Ottosson, Bo A G Jönsson, Peter Höglund. Treatments with losartan or enalapril are equally sensitive to deterioration in renal function from cyclooxygenase inhibition.
European journal of heart failure.
2007 Feb; 9(2):191-6. doi:
10.1016/j.ejheart.2006.05.015. [PMID: 16859993] - José Tuñón, José Luis Martín-Ventura, Luis Miguel Blanco-Colio, Nieves Tarín, Jesús Egido. Common pathways of hypercholesterolemia and hypertension leading to atherothrombosis: the need for a global approach in the management of cardiovascular risk factors.
Vascular health and risk management.
2007; 3(4):521-6. doi:
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Journal of chromatography. A.
2006 Dec; 1135(2):219-29. doi:
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Vascular pharmacology.
2006 May; 44(5):354-62. doi:
10.1016/j.vph.2006.01.014. [PMID: 16574496] - Xiuhan Yang, Xiaochuan Wang, Xiangmin Zhang. Indirect laser-induced fluorescence detection of diuretics separated by capillary electrophoresis.
Journal of separation science.
2006 Mar; 29(5):677-83. doi:
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Clinical drug investigation.
2006; 26(2):91-101. doi:
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Neuromuscular disorders : NMD.
2006 Jan; 16(1):39-45. doi:
10.1016/j.nmd.2005.10.005. [PMID: 16368240] - Tord Juhlin, Sven Björkman, Peter Höglund. Cyclooxygenase inhibition causes marked impairment of renal function in elderly subjects treated with diuretics and ACE-inhibitors.
European journal of heart failure.
2005 Oct; 7(6):1049-56. doi:
10.1016/j.ejheart.2004.10.005. [PMID: 16227143] - Kasper Rossing, Katrine J Schjoedt, Berit R Jensen, Frans Boomsma, Hans-Henrik Parving. Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria.
Kidney international.
2005 Sep; 68(3):1190-8. doi:
10.1111/j.1523-1755.2005.00511.x. [PMID: 16105050] - Yue Hong Pang, Li Li Yang, Shao Min Shuang, Chuan Dong, Michael Thompson. Interaction of human serum albumin with bendroflumethiazide studied by fluorescence spectroscopy.
Journal of photochemistry and photobiology. B, Biology.
2005 Aug; 80(2):139-44. doi:
10.1016/j.jphotobiol.2005.03.006. [PMID: 15916901] - Jochen Beyer, Anabelle Bierl, Frank T Peters, Hans H Maurer. Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.
Therapeutic drug monitoring.
2005 Aug; 27(4):509-20. doi:
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The British journal of general practice : the journal of the Royal College of General Practitioners.
2005 Jun; 55(515):437-43. doi:
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European journal of clinical investigation.
2003 Jan; 33(1):41-50. doi:
10.1046/j.1365-2362.2003.01103.x. [PMID: 12492451] - Arvo Haenni, Rikard Reneland, Per-Erik Andersson, Lars Lind, Hans Lithell. Skeletal muscle magnesium content is correlated with plasma glucose concentration in patients with essential hypertension treated with lisinopril or bendrofluazide.
American journal of hypertension.
2002 Aug; 15(8):735-8. doi:
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Hypertension (Dallas, Tex. : 1979).
2002 Jul; 40(1):61-6. doi:
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The Journal of pharmacology and experimental therapeutics.
2001 Oct; 299(1):307-13. doi:
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European journal of clinical investigation.
2001 Sep; 31(9):764-72. doi:
10.1046/j.1365-2362.2001.00883.x. [PMID: 11589718] - L Rejnmark, P Vestergaard, L Heickendorff, F Andreasen, L Mosekilde. Effects of thiazide- and loop-diuretics, alone or in combination, on calcitropic hormones and biochemical bone markers: a randomized controlled study.
Journal of internal medicine.
2001 Aug; 250(2):144-53. doi:
10.1046/j.1365-2796.2001.00868.x. [PMID: 11489064] - V Sanz-Nebot, I Toro, R Bergés, R Ventura, J Segura, J Barbosa. Determination and characterization of diuretics in human urine by liquid chromatography coupled to pneumatically assisted electrospray ionization mass spectrometry.
Journal of mass spectrometry : JMS.
2001 Jun; 36(6):652-7. doi:
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Journal of hypertension.
2001 Jun; 19(6):1139-47. doi:
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BMC nephrology.
2001 May; 2(?):1. doi:
10.1186/1471-2369-2-1. [PMID: 11388887] - A Greenberg. Diuretic complications.
The American journal of the medical sciences.
2000 Jan; 319(1):10-24. doi:
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