PHOLCODINE (BioDeep_00000408842)
代谢物信息卡片
PHOLCODINE
化学式: C23H30N2O4 (398.220546)
中文名称: 福尔可定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OCCN6CCOCC6)OC3C(C=C4)O
InChI: InChI=1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16-,17+,18-,22-,23-/m0/s1
描述信息
R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants > R05DA - Opium alkaloids and derivatives
A morphinane alkaloid that is a derivative of morphine with a 2-morpholinoethyl group at the 3-position.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:53579
- KEGGdrug: D07385
- PubChem: 5311356
- Metlin: METLIN1933
- DrugBank: DB09209
- ChEMBL: CHEMBL2105224
- CAS: 509-67-1
- MoNA: WA001123
- MoNA: WA001122
- MoNA: WA001121
- MoNA: WA001120
- MetaboLights: MTBLC53579
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vedrana Bulat, Robert Likic, Nives Pondeljak, Marija Delas Azdajic. Pholcodine-induced Stevens-Johnson syndrome in a patient with COVID-19.
Postgraduate medical journal.
2022 07; 98(1161):499-500. doi:
10.1136/postgradmedj-2021-139892. [PMID: 33879549] - Heba Elmansi, Fathalla Belal, Galal Magdy. Determination of pholcodine alone or in combination with ephedrine in human plasma using fluorescence spectroscopy.
Scientific reports.
2022 06; 12(1):9372. doi:
10.1038/s41598-022-13194-1. [PMID: 35672340] - Marie Epain, Nathalie Cartiser, Fabien Bévalot, Laurent Fanton. Toxicological detection of pholcodine in blood, urine and hair in three cases of fatal intoxication.
Forensic science international.
2021 Oct; 327(?):110975. doi:
10.1016/j.forsciint.2021.110975. [PMID: 34478894] - Nastaran Jafari Delouei, Ali Mokhtari, Mohammad Reza Jamali. Determination of pholcodine in syrups and human plasma using the chemiluminescence system of tris(1,10 phenanthroline)ruthenium(II) and acidic Ce(IV).
Luminescence : the journal of biological and chemical luminescence.
2017 May; 32(3):387-393. doi:
10.1002/bio.3191. [PMID: 27501419] - E Florvaag, S G O Johansson. The Pholcodine Case. Cough Medicines, IgE-Sensitization, and Anaphylaxis: A Devious Connection.
The World Allergy Organization journal.
2012 Jul; 5(7):73-8. doi:
10.1097/wox.0b013e318261eccc. [PMID: 23283141] - Anne Dick, Rodney Ford. Cholinergic and oxidative stress mechanisms in sudden infant death syndrome.
Acta paediatrica (Oslo, Norway : 1992).
2009 Nov; 98(11):1768-75. doi:
10.1111/j.1651-2227.2009.01476.x. [PMID: 19706020] - Thomas Berg, Elsa Lundanes, Asbjørg S Christophersen, Dag Helge Strand. Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Feb; 877(4):421-32. doi:
10.1016/j.jchromb.2008.12.052. [PMID: 19144579] - Veronica Santos, Karin Jannet Vera López, Luciana Moraes Santos, Mauricio Yonamine, Maria José Carvalho Carmona, Silvia Regina Cavani Jorge Santos. Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period.
Clinics (Sao Paulo, Brazil).
2008 Jun; 63(3):307-14. doi:
10.1590/s1807-59322008000300004. [PMID: 18568238] - T Harboe, S G O Johansson, E Florvaag, H Oman. Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents.
Allergy.
2007 Dec; 62(12):1445-50. doi:
10.1111/j.1398-9995.2007.01554.x. [PMID: 17983379] - E Florvaag, S G O Johansson, H Oman, T Harboe, A Nopp. Pholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot study.
Allergy.
2006 Jan; 61(1):49-55. doi:
10.1111/j.1398-9995.2005.00933.x. [PMID: 16364156] - E Florvaag, S G O Johansson, H Oman, L Venemalm, F Degerbeck, T Dybendal, M Lundberg. Prevalence of IgE antibodies to morphine. Relation to the high and low incidences of NMBA anaphylaxis in Norway and Sweden, respectively.
Acta anaesthesiologica Scandinavica.
2005 Apr; 49(4):437-44. doi:
10.1111/j.1399-6576.2004.00591.x. [PMID: 15777289] - V Cirimele, S Etienne, M Villain, B Ludes, P Kintz. Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens.
Forensic science international.
2004 Jul; 143(2-3):153-6. doi:
10.1016/j.forsciint.2004.02.035. [PMID: 15240036] - V Cirimele, P Kintz, S Lohner, B Ludes. Enzyme immunoassay validation for the detection of buprenorphine in urine.
Journal of analytical toxicology.
2003 Mar; 27(2):103-5. doi:
10.1093/jat/27.2.103. [PMID: 12670004] - C Meadway, S George, R Braithwaite. Interpretation of GC-MS opiate results in the presence of pholcodine.
Forensic science international.
2002 Jun; 127(1-2):131-5. doi:
10.1016/s0379-0738(01)00643-0. [PMID: 12098537] - A Leino, J Saarimies, M Grönholm, P Lillsunde. Comparison of eight commercial on-site screening devices for drugs-of-abuse testing.
Scandinavian journal of clinical and laboratory investigation.
2001 Jul; 61(4):325-31. doi:
10.1080/00365510152379067. [PMID: 11465347] - K Laine, K T Kivistö, P Ojala-Karlsson, P J Neuvonen. Effect of activated charcoal on the pharmacokinetics of pholcodine, with special reference to delayed charcoal ingestion.
Therapeutic drug monitoring.
1997 Feb; 19(1):46-50. doi:
10.1097/00007691-199702000-00008. [PMID: 9029746] - M Krogh, A S Christophersen, K E Rasmussen. Automated sample preparation by on-line dialysis and trace enrichment. Analysis of morphine, 6-monoacetylmorphine, codeine, ethylmorphine and pholcodine in plasma and whole blood by capillary gas chromatography and capillary gas chromatography-mass spectrometry.
Journal of chromatography.
1993 Nov; 621(1):41-8. doi:
. [PMID: 8308086] - A T Andresen, M Krogh, K E Rasmussen. On-line dialysis and weak cation-exchange enrichment of dialysate. Automated high-performance liquid chromatography of pholcodine in human plasma and whole blood.
Journal of chromatography.
1992 Nov; 582(1-2):123-30. doi:
10.1016/0378-4347(92)80310-m. [PMID: 1491030] - M Johansen, F Tønnesen, K E Rasmussen. Column-switching high-performance liquid chromatographic detection of pholcodine and its metabolites in urine with fluorescence and electrochemical detection.
Journal of chromatography.
1992 Jan; 573(2):283-8. doi:
10.1016/0378-4347(92)80130-i. [PMID: 1601961] - M Johansen, K E Rasmussen, A S Christophersen, B Skuterud. Metabolic study of pholcodine in urine using enzyme multiplied immunoassay technique (EMIT) and capillary gas chromatography.
Acta pharmaceutica Nordica.
1991; 3(2):91-4. doi:
NULL. [PMID: 1910552] - H H Maurer, C F Fritz. Toxicological detection of pholcodine and its metabolites in urine and hair using radio immunoassay, fluorescence polarisation immunoassay, enzyme immunoassay, and gas chromatography-mass spectrometry.
International journal of legal medicine.
1990 Dec; 104(1):43-6. doi:
10.1007/bf01816483. [PMID: 11453092] - M Johansen, K E Rasmussen, A S Christophersen. Determination of pholcodine and its metabolites in urine by capillary gas chromatography.
Journal of chromatography.
1990 Nov; 532(2):277-84. doi:
10.1016/s0378-4347(00)83778-0. [PMID: 2084125] - H H Maurer, C F Fritz. Metabolism of pholcodine in man.
Arzneimittel-Forschung.
1990 May; 40(5):564-6. doi:
NULL. [PMID: 2383296] - H H Maurer, C F Fritz. [Forensic-toxicologic detection of pholcodine in urine and hair].
Beitrage zur gerichtlichen Medizin.
1990; 48(?):37-9. doi:
NULL. [PMID: 2241818] - Z R Chen, F Bochner, A Somogyi. Pharmacokinetics of pholcodine in healthy volunteers: single and chronic dosing studies.
British journal of clinical pharmacology.
1988 Oct; 26(4):445-53. doi:
10.1111/j.1365-2125.1988.tb03404.x. [PMID: 3190994] - J W Findlay, A S Fowle, R F Butz, E C Jones, B C Weatherley, R M Welch, J Posner. Comparative disposition of codeine and pholcodine in man after single oral doses.
British journal of clinical pharmacology.
1986 Jul; 22(1):61-71. doi:
10.1111/j.1365-2125.1986.tb02881.x. [PMID: 3741728] - R F Butz, E C Jones, R M Welch, J W Findlay. Pharmacokinetics and O-dealkylation of morphine-3-alkyl ethers in the rat. A radioimmunoassay study.
Drug metabolism and disposition: the biological fate of chemicals.
1983 Sep; 11(5):481-8. doi:
. [PMID: 6138235] - G Svenneby, E Wedege, R L Karlsen. Pholcodine interference in the immunoassay for opiates in urine.
Forensic science international.
1983 May; 21(3):223-6. doi:
10.1016/0379-0738(83)90126-3. [PMID: 6347841]