canrenoic acid (BioDeep_00000408841)
Secondary id: BioDeep_00000638181
代谢物信息卡片
3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoic acid
化学式: C22H30O4 (358.214398)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(C=C2[C@@](C)([C@]3([H])[C@]([H])([C@@]4([H])[C@@](C)([C@@](CCC(O)=O)(O)CC4)CC3)C=C2)CC1)=O
InChI: InChI=1S/C22H30O4/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25)/t16-,17+,18+,20+,21+,22-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000451 - Mineralocorticoid Receptor Antagonists
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C242 - Anti-Androgen
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:50156
- PubChem: 656615
- Metlin: METLIN57852
- DrugBank: DB09015
- ChEMBL: CHEMBL1616951
- LipidMAPS: LMST02030154
- MeSH: Canrenoic Acid
- CAS: 2181-04-6
- CAS: 4138-96-9
- MoNA: WA001119
- MoNA: WA001118
- MoNA: WA001117
- MoNA: WA001116
- MoNA: WA001115
- RefMet: ST 22:4;O4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rafał Dąbrowski, Paweł Syska, Justyna Mączyńska, Michał Farkowski, Stefan Sawicki, Agata Kubaszek-Kornatowska, Piotr Michałek, Ilona Kowalik, Hanna Szwed, Tomasz Hryniewiecki. Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial).
Trials.
2020 May; 21(1):397. doi:
10.1186/s13063-020-04277-3. [PMID: 32398047] - Anne D Thuesen, Stine H Finsen, Louise L Rasmussen, Ditte C Andersen, Boye L Jensen, Pernille B L Hansen. Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.
American journal of physiology. Renal physiology.
2019 08; 317(2):F254-F263. doi:
10.1152/ajprenal.00121.2018. [PMID: 31042060] - Misato Nakamura, Ayumi Eguchi, Mari Inohana, Rei Nagahara, Hirotada Murayama, Masashi Kawashima, Sayaka Mizukami, Mihoko Koyanagi, Shim-Mo Hayashi, Robert R Maronpot, Makoto Shibutani, Toshinori Yoshida. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats.
The Journal of toxicological sciences.
2018; 43(10):611-621. doi:
10.2131/jts.43.611. [PMID: 30298849] - Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Maurizio Parola. Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?.
Clinical science (London, England : 1979).
2016 Jan; 130(2):117-24. doi:
10.1042/cs20150479. [PMID: 26519424] - Javaid Iqbal, Ruth Andrew, Nicholas L Cruden, Christopher J Kenyon, Katherine A Hughes, David E Newby, Patrick W F Hadoke, Brian R Walker. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist.
The Journal of clinical endocrinology and metabolism.
2014 Mar; 99(3):915-22. doi:
10.1210/jc.2013-2049. [PMID: 24423282] - Maysa Suyagh, Ahmed F Hawwa, Paul S Collier, Jeffrey S Millership, Prashant Kole, Muriel Millar, Mike D Shields, Henry L Halliday, James C McElnay. Potassium canrenoate treatment in paediatric patients: a population pharmacokinetic study using novel dried blood spot sampling.
Journal of hypertension.
2013 Sep; 31(9):1901-8. doi:
10.1097/hjh.0b013e3283626994. [PMID: 23846862] - Miriam T Rademaker, Christopher J Charles, M Gary Nicholls, A Mark Richards. Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure.
Circulation. Heart failure.
2013 Jul; 6(4):825-32. doi:
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British journal of clinical pharmacology.
2012 Nov; 74(5):864-72. doi:
10.1111/j.1365-2125.2012.04257.x. [PMID: 22376078] - Amitava Dasgupta, Myrtle J Johnson, Tamal K Sengupta. Clinically insignificant negative interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone in new dimension vista LOCI digoxin immunoassay.
Journal of clinical laboratory analysis.
2012 May; 26(3):143-7. doi:
10.1002/jcla.21501. [PMID: 22628228] - Yasir H Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal, Mohammad Faisal. Antigenotoxic effect of the Plumbago zeylanica extract against the genotoxic damage induced by potassium canrenoate in cultured human peripheral blood lymphocytes.
Drug and chemical toxicology.
2012 Apr; 35(2):119-26. doi:
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American journal of hypertension.
2012 Feb; 25(2):243-9. doi:
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Indian journal of endocrinology and metabolism.
2011 Oct; 15 Suppl 4(?):S298-312. doi:
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American journal of physiology. Endocrinology and metabolism.
2011 Mar; 300(3):E592-9. doi:
10.1152/ajpendo.00560.2010. [PMID: 21205934] - Andrea DeFrance, David Armbruster, Diana Petty, Kelley C Cooper, Amitava Dasgupta. Abbott ARCHITECT clinical chemistry and immunoassay systems: digoxin assays are free of interferences from spironolactone, potassium canrenoate, and their common metabolite canrenone.
Therapeutic drug monitoring.
2011 Feb; 33(1):128-31. doi:
10.1097/ftd.0b013e3181fd4c30. [PMID: 21079546] - G Nasr, A Hassan, S Ahmed, A Serwah. Predictors of large volume paracantesis induced circulatory dysfunction in patients with massive hepatic ascites.
Journal of cardiovascular disease research.
2010 Jul; 1(3):136-44. doi:
10.4103/0975-3583.70914. [PMID: 21187868] - Kathleen M Knights, Kushari Bowalgaha, John O Miners. Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Jul; 38(7):1011-4. doi:
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Advanced drug delivery reviews.
2010 Jun; 62(7-8):841-54. doi:
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Journal of hypertension.
2010 May; 28(5):1044-53. doi:
10.1097/hjh.0b013e328335c381. [PMID: 20179635] - Amitava Dasgupta, Myrtle J Johnson. Effect of spironolactone, potassium canrenoate, and their common metabolite canrenone on Dimension Vista Digoxin Assay.
Journal of clinical laboratory analysis.
2010; 24(6):413-7. doi:
10.1002/jcla.20421. [PMID: 21089173] - Creagh W Breuner, Miles Orchinik. Pharmacological characterization of intracellular, membrane, and plasma binding sites for corticosterone in house sparrows.
General and comparative endocrinology.
2009 Sep; 163(1-2):214-24. doi:
10.1016/j.ygcen.2009.01.027. [PMID: 19236873] - Stefan Pilz, Andreas Tomaschitz, Vinzenz Stepan, Barbara Obermayer-Pietsch, Astrid Fahrleitner-Pammer, Natascha Schweighofer, Horst R Portugaller, Harald Sourij, Harald Dobnig, Andreas Meinitzer, Thomas R Pieber. Graz Endocrine Causes of Hypertension (GECOH) study: a diagnostic accuracy study of aldosterone to active renin ratio in screening for primary aldosteronism.
BMC endocrine disorders.
2009 Apr; 9(?):11. doi:
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Kidney & blood pressure research.
2009; 32(2):119-27. doi:
10.1159/000214439. [PMID: 19401625] - Amitava Dasgupta, Gertie Tso, Alice Wells. Effect of spironolactone, potassium canrenoate and their common metabolite canrenone on serum digoxin measurement by digoxin III, a new digoxin immunoassay.
Therapeutic drug monitoring.
2008 Dec; 30(6):744-7. doi:
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American journal of physiology. Endocrinology and metabolism.
2008 Jun; 294(6):E1011-22. doi:
10.1152/ajpendo.00721.2007. [PMID: 18349112] - Caroline Rugale, Magali Cordaillat, Albert Mimran, Bernard Jover. Time-course reduction of renal function in rats on high sodium intake: acute reversal by potassium canrenoate.
Clinical and experimental pharmacology & physiology.
2008 Apr; 35(4):412-5. doi:
10.1111/j.1440-1681.2008.04888.x. [PMID: 18307731] - Monica Minnaard-Huiban, Judith M A Emmen, Luc Roumen, Ilona P E Beugels, Géraldine M S Cohuet, Helma van Essen, Eveline Ruijters, Koen Pieterse, Peter A J Hilbers, Harry C J Ottenheijm, Ralf Plate, Marcel E de Gooyer, Jos F M Smits, J J Rob Hermans. Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.
Endocrinology.
2008 Jan; 149(1):28-31. doi:
10.1210/en.2007-0584. [PMID: 17884944] - A Corbould. Effects of spironolactone on glucose transport and interleukin-6 secretion in adipose cells of women.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2007 Dec; 39(12):915-8. doi:
10.1055/s-2007-993156. [PMID: 18075971] - Stephen Wong, Francine E Brennan, Morag J Young, Peter J Fuller, Timothy J Cole. A direct effect of aldosterone on endothelin-1 gene expression in vivo.
Endocrinology.
2007 Apr; 148(4):1511-7. doi:
10.1210/en.2006-0965. [PMID: 17218419] - Sabine Heber, Lucia Denk, Kanghong Hu, Will W Minuth. Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium.
Tissue engineering.
2007 Feb; 13(2):281-92. doi:
10.1089/ten.2006.0199. [PMID: 17518563] - Helle C Thiesson, Boye L Jensen, Claus Bistrup, Peter D Ottosen, Alison D McNeilly, Ruth Andrew, Jonathan Seckl, Ole Skøtt. Renal sodium retention in cirrhotic rats depends on glucocorticoid-mediated activation of mineralocorticoid receptor due to decreased renal 11beta-HSD-2 activity.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Jan; 292(1):R625-36. doi:
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Journal of chromatography. A.
2006 Dec; 1135(2):219-29. doi:
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Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2006 Nov; 4(11):1395-402. doi:
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Toxicological reviews.
2006; 25(4):273-81. doi:
10.2165/00139709-200625040-00007. [PMID: 17288498] - Amitava Dasgupta, Edward Kang, Pradip Datta. A new enzyme-linked chemiluminescent immunosorbent digoxin assay is virtually free from interference of spironolactone, potassium canrenoate, and their common metabolite canrenone.
Journal of clinical laboratory analysis.
2006; 20(5):204-8. doi:
10.1002/jcla.20133. [PMID: 16960898] - Pietro Di Pasquale, Sergio Cannizzaro, Sebastiano Scalzo, Gaspare Parrinello, Sergio Fasullo, Francesco Giambanco, Antonio Fatta, Salvatore Paterna. Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarction.
American heart journal.
2005 Nov; 150(5):919. doi:
10.1016/j.ahj.2005.03.032. [PMID: 16290961] - Nobuhisa Akamatsu, Yasuhiko Sugawara, Sumihito Tamura, Junichi Kaneko, Junichi Togashi, Yoji Kishi, Hiroshi Imamura, Norihiro Kokudo, Masatoshi Makuuchi. Prevention of renal impairment by continuous infusion of human atrial natriuretic peptide after liver transplantation.
Transplantation.
2005 Oct; 80(8):1093-8. doi:
10.1097/01.tp.0000178354.60959.2d. [PMID: 16278591] - Ricardo Gómez, Lucía Núñez, Ricardo Caballero, Miguel Vaquero, Juan Tamargo, Eva Delpón. Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels.
British journal of pharmacology.
2005 Sep; 146(1):146-61. doi:
10.1038/sj.bjp.0706302. [PMID: 15980874] - Jochen Beyer, Anabelle Bierl, Frank T Peters, Hans H Maurer. Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.
Therapeutic drug monitoring.
2005 Aug; 27(4):509-20. doi:
10.1097/01.ftd.0000160719.96445.91. [PMID: 16044110] - D Armanini, C Scaroni, M J Mattarello, C Fiore, N Albiger, P Sartorato. Idiopathic primary hyperaldosteronism: normalization of plasma aldosterone after one month withdrawal of long-term therapy with aldosterone-receptor antagonist potassium canrenoate.
Journal of endocrinological investigation.
2005 Mar; 28(3):236-40. doi:
10.1007/bf03345379. [PMID: 15952408] - Atsushi Sugiyama, Yoshioki Satoh, Akira Takahara, Kentaro Ando, Kai Wang, Sachiko Honsho, Yuji Nakamura, Keitaro Hashimoto. Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model.
Journal of pharmacological sciences.
2004 Dec; 96(4):436-43. doi:
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Surgical endoscopy.
2004 Oct; 18(10):1528-34. doi:
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Journal of the American College of Cardiology.
2004 Apr; 43(7):1270-5. doi:
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Biopharmaceutics & drug disposition.
2004 Jan; 25(1):21-6. doi:
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American journal of physiology. Renal physiology.
2004 Jan; 286(1):F26-37. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2003 Nov; 285(5):R981-91. doi:
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BMC psychiatry.
2003 Oct; 3(?):15. doi:
10.1186/1471-244x-3-15. [PMID: 14585110] - Pradip Datta, Amitava Dasgupta. A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone.
Therapeutic drug monitoring.
2003 Aug; 25(4):478-82. doi:
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The Journal of biological chemistry.
2003 Jun; 278(24):21639-48. doi:
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Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.
2002 Aug; 37(8):463-7. doi:
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American journal of clinical pathology.
2002 Jul; 118(1):132-40. doi:
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Journal of clinical laboratory analysis.
2002; 16(4):172-7. doi:
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Cardiovascular drugs and therapy.
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Journal of mass spectrometry : JMS.
2001 Jun; 36(6):652-7. doi:
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Journal of the American Society of Nephrology : JASN.
2001 Mar; 12(3):598-601. doi:
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American heart journal.
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Acta anaesthesiologica Scandinavica.
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American journal of physiology. Renal physiology.
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Neuroreport.
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Journal of hepatology.
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