Progabide (BioDeep_00000408818)
代谢物信息卡片
Progabide
化学式: C17H16ClFN2O2 (334.0884)
中文名称: 普罗加比德
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C(=NCCCC(=O)N)C2=C(C=CC(=C2)F)O)Cl
InChI: InChI=1S/C17H16ClFN2O2/c18-12-5-3-11(4-6-12)17(21-9-1-2-16(20)23)14-10-13(19)7-8-15(14)22/h3-8,10,22H,1-2,9H2,(H2,20,23)
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AG - Fatty acid derivatives
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:135422
- KEGGdrug: D05621
- PubChem: 44115
- Metlin: METLIN85223
- DrugBank: DB00837
- ChEMBL: CHEMBL4796538
- ChEMBL: CHEMBL287631
- CAS: 104880-78-6
- CAS: 62666-20-0
- CAS: 90656-51-2
- MoNA: WA000696
- MoNA: WA000695
- MoNA: WA000694
- MoNA: WA000693
- MoNA: WA000692
- MoNA: WA000691
- MoNA: WA000690
- medchemexpress: HY-A0173
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Richard Gargiulo, Faten Suhail, Edgar V Lerma. Cardiovascular disease and chronic kidney disease.
Disease-a-month : DM.
2015 Sep; 61(9):403-13. doi:
10.1016/j.disamonth.2015.07.005. [PMID: 26328516] - Rima Nabbout, Catherine Chiron. Stiripentol: an example of antiepileptic drug development in childhood epilepsies.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.
2012 Sep; 16 Suppl 1(?):S13-7. doi:
10.1016/j.ejpn.2012.04.009. [PMID: 22695038] - W Gordon Frankle, Raymond Y Cho, N Scott Mason, Chi-Min Chen, Michael Himes, Christopher Walker, David A Lewis, Chester A Mathis, Rajesh Narendran. [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.
PloS one.
2012; 7(2):e32443. doi:
10.1371/journal.pone.0032443. [PMID: 22384252] - Kashmira J Gohil, Jagruti A Patel, Anuradha K Gajjar. Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.
Indian journal of pharmaceutical sciences.
2010 Sep; 72(5):546-56. doi:
10.4103/0250-474x.78519. [PMID: 21694984] - C Brunet, M Luyckx, M Lhermitte. Acid metabolite of progabide pharmacokinetics following single administration in the rabbit with special references to HPLC and (3H) muscimol radioreceptor assay.
European journal of drug metabolism and pharmacokinetics.
1989 Oct; 14(4):257-62. doi:
10.1007/bf03190108. [PMID: 2633919] - N M Graves, R H Fuerst, J C Cloyd, R C Brundage, T E Welty, I E Leppik. Progabide-induced changes in carbamazepine metabolism.
Epilepsia.
1988 Nov; 29(6):775-80. doi:
10.1111/j.1528-1157.1988.tb04234.x. [PMID: 3191894] - R C Thirlby, M H Stevens, A J Blair, F Petty, I L Crawford, I L Taylor, J H Walsh, M Feldman. Effect of GABA on basal and vagally mediated gastric acid secretion and hormone release in dogs.
The American journal of physiology.
1988 May; 254(5 Pt 1):G723-31. doi:
10.1152/ajpgi.1988.254.5.g723. [PMID: 2834963] - S J Munoz, R Fariello, W C Maddrey. Submassive hepatic necrosis associated with the use of progabide: a GABA receptor agonist.
Digestive diseases and sciences.
1988 Mar; 33(3):375-80. doi:
10.1007/bf01535765. [PMID: 3342728] - N M Graves, G B Holmes, I E Leppik. Compliant populations: variability in serum concentrations.
Epilepsy research. Supplement.
1988; 1(?):91-9. doi:
NULL. [PMID: 3072193] - E Benassi, G Besio, G P Bo, L Cocito, M Maffini, P Mainardi, P L Morselli, C Loeb. Preliminary observations on the activity of progabide, administered as monotherapy in complex partial seizures.
International journal of clinical pharmacology research.
1988; 8(5):353-61. doi:
NULL. [PMID: 3068161] - S Medaglini, M Filippi, S Smirne, L Ferini-Strambi, M C Giusti, A Poggi, G Comi. Effects of long-lasting antiepileptic therapy on brainstem auditory evoked potentials.
Neuropsychobiology.
1988; 19(2):104-7. doi:
10.1159/000118443. [PMID: 3147408] - H Manev, D Pericić. Progabide, a GABA mimetic drug, stimulates the secretion of plasma corticosterone in rats.
Pharmacology, biochemistry, and behavior.
1987 Dec; 28(4):443-6. doi:
10.1016/0091-3057(87)90503-x. [PMID: 3432311] - R C Brundage, J C Cloyd, I E Leppik, N M Graves, T E Welty. Effect of progabide on serum phenytoin and carbamazepine concentrations.
Clinical neuropharmacology.
1987 Dec; 10(6):545-54. doi:
10.1097/00002826-198712000-00006. [PMID: 3427561] - B K Koe, E Kondratas, L L Russo. [3H]Ro 15-1788 binding to benzodiazepine receptors in mouse brain in vivo: marked enhancement by GABA agonists and other CNS drugs.
European journal of pharmacology.
1987 Oct; 142(3):373-84. doi:
10.1016/0014-2999(87)90076-8. [PMID: 2892685] - C Hamberger, S Urien, D Essassi, B Grimaldi, J Barre, A Taiclet, J P Thenot, J P Tillement. Effect of erythrocytes and plasma protein binding on the transport of progabide and SL 75102 through the rat blood-brain barrier.
Biochemical pharmacology.
1987 Aug; 36(16):2641-5. doi:
10.1016/0006-2952(87)90545-4. [PMID: 3606664] - C Hamberger, J Barre, M Brandebourger, S Urien, A Taiclet, J P Thenot, J P Tillement. Progabide and SL 75102 binding to plasma proteins and red blood cells in humans.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Apr; 25(4):178-84. doi:
NULL. [PMID: 3583466] - N F Farraj, S S Davis, G D Parr, H N Stevens. A reversed-phase high-performance liquid chromatography assay procedure for progabide and its related metabolic derivatives.
Pharmaceutical research.
1987 Feb; 4(1):28-32. doi:
10.1023/a:1016421725650. [PMID: 3508525] - D Schmidt, K Utech. Progabide for refractory partial epilepsy: a controlled add-on trial.
Neurology.
1986 Feb; 36(2):217-21. doi:
10.1212/wnl.36.2.217. [PMID: 3511402] - V Ascalone, P Catalani, L Dal Bò. Determination of progabide and its acid metabolite in biological fluids by high-performance liquid chromatography on silica column with ultraviolet detection.
Journal of chromatography.
1985 Nov; 344(?):231-9. doi:
10.1016/s0378-4347(00)82023-x. [PMID: 4086543] - G H Fromm, C F Terrence, A S Chattha. Comparison of progabide with other antiepileptic and GABAergic drugs.
Epilepsia.
1985 Nov; 26(6):672-81. doi:
10.1111/j.1528-1157.1985.tb05710.x. [PMID: 3000759] - I Johno, M Bialer, S A Nickelson, R H Levy. Disposition of progabide and valproic acid following intraperitoneal administration in rhesus monkey.
Epilepsia.
1984 Oct; 25(5):578-85. doi:
10.1111/j.1528-1157.1984.tb03465.x. [PMID: 6434296] - J M Martínez-Lage, L Bossi, G Morales, E Martínez Vila, B Orofiamma, C Viteri. Progabide treatment in severe epilepsy: a double-blind cross-over trial versus placebo.
Epilepsia.
1984 Oct; 25(5):586-93. doi:
10.1111/j.1528-1157.1984.tb03466.x. [PMID: 6383790] - D Schmidt. Progabide as an add-on drug for epilepsy refractory to high dose antiepileptic drug therapy.
Neuroscience letters.
1984 Jun; 47(3):357-60. doi:
10.1016/0304-3940(84)90539-1. [PMID: 6382068] - P Padovani, C Deves, G Bianchetti, J P Thenot, P L Morselli. Determination of progabide and its main acid metabolite in biological fluids using high-performance liquid chromatography and electrochemical detection. Application to the measurement of blood/plasma partition ratio.
Journal of chromatography.
1984 Jun; 308(?):229-39. doi:
10.1016/s0021-9673(01)87549-x. [PMID: 6746816] - P Loiseau, L Bossi, M Guyot, B Orofiamma, P L Morselli. Double-blind crossover trial of progabide versus placebo in severe epilepsies.
Epilepsia.
1983 Dec; 24(6):703-15. doi:
10.1111/j.1528-1157.1983.tb04633.x. [PMID: 6357772] - W Yonekawa, H J Kupferberg, T Lambert. Measurement of progabide and its deaminated metabolite in plasma by high-performance liquid chromatography and electrochemical detection.
Journal of chromatography.
1983 Aug; 276(1):103-10. doi:
10.1016/s0378-4347(00)85070-7. [PMID: 6672003] - L Debeljuk, M D Díaz, V M Maines, A Seilicovich. Prolonged treatment with gamma-aminobutyric acid (GABA)-mimetic substances in prepubertal male rats.
Archives of andrology.
1983 Jun; 10(3):239-43. doi:
10.3109/01485018308987572. [PMID: 6882089] - G Gillet, J Fraisse-André, C R Lee, L G Dring, P L Morselli. Gas chromatographic method for the determination of progabide (SL 76.002) in biological fluids.
Journal of chromatography.
1982 Jun; 230(1):154-61. doi:
10.1016/s0378-4347(00)81443-7. [PMID: 7107757] - I Johno, B T Ludwick, R H Levy. Pharmacokinetic profile of progabide, a new gamma-aminobutyric acid-mimetic drug, in rhesus monkey.
Journal of pharmaceutical sciences.
1982 Jun; 71(6):633-6. doi:
10.1002/jps.2600710609. [PMID: 7097524]
