Toloxatone (BioDeep_00000408805)

   

Volatile Flavor Compounds


代谢物信息卡片


Toloxatone

化学式: C11H13NO3 (207.0895388)
中文名称: 涛洛西酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=CC=C1)N2CC(OC2=O)CO
InChI: InChI=1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AG - Monoamine oxidase a inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones

同义名列表

2 个代谢物同义名

Toloxatone; Toloxatone



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Arti Nile, Shivraj Hariram Nile, Carlos L Cespedes-Acuña, Jae-Wook Oh. Spiraeoside extracted from red onion skin ameliorates apoptosis and exerts potent antitumor, antioxidant and enzyme inhibitory effects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Aug; 154(?):112327. doi: 10.1016/j.fct.2021.112327. [PMID: 34116102]
  • Celeste De Monte, Simone Carradori, Paola Chimenti, Daniela Secci, Luisa Mannina, Francesca Alcaro, Anél Petzer, Clarina I N'Da, Maria Concetta Gidaro, Giosuè Costa, Stefano Alcaro, Jacobus P Petzer. New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies. European journal of medicinal chemistry. 2014 Jul; 82(?):164-71. doi: 10.1016/j.ejmech.2014.05.048. [PMID: 24904963]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Franco Chimenti, Filippo Cottiglia, Leonardo Bonsignore, Laura Casu, Mariano Casu, Costantino Floris, Daniela Secci, Adriana Bolasco, Paola Chimenti, Arianna Granese, Olivia Befani, Paola Turini, Stefano Alcaro, Francesco Ortuso, Giuseppe Trombetta, Alberto Loizzo, Irene Guarino. Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: extraction, biological analysis, and computational study. Journal of natural products. 2006 Jun; 69(6):945-9. doi: 10.1021/np060015w. [PMID: 16792415]
  • Charlotte Duverneuil, Geoffroy Lorin de la Grandmaison, Philippe de Mazancourt, Jean-Claude Alvarez. A high-performance liquid chromatography method with photodiode-array UV detection for therapeutic drug monitoring of the nontricyclic antidepressant drugs. Therapeutic drug monitoring. 2003 Oct; 25(5):565-73. doi: 10.1097/00007691-200310000-00005. [PMID: 14508379]
  • M L Kaltenbach, R Vistelle, G Hoizey, D Lamiable, L Zbierski. Effect of acute ethanol administration on toloxatone pharmacokinetics in rabbits. Alcoholism, clinical and experimental research. 1999 May; 23(5):885-90. doi: 10.1111/j.1530-0277.1999.tb04198.x. [PMID: 10371410]
  • S Vandel, G Bertschy, M C Perault, M Sandoz, S Bouquet, R Chakroun, S Guibert, B Vandel. Minor and clinically non-significant interaction between toloxatone and amitriptyline. European journal of clinical pharmacology. 1993; 44(1):97-9. doi: 10.1007/bf00315289. [PMID: 8436164]
  • R Vistelle, D Lamiable, M Zinsou, A Leon, M Wiczewski. Toloxatone pharmacokinetics in the plasma and cerebrospinal fluid of the rabbit. The Journal of pharmacy and pharmacology. 1992 Feb; 44(2):124-6. doi: 10.1111/j.2042-7158.1992.tb03576.x. [PMID: 1352813]
  • J Dingemanse, I Berlin, C Payan, H M Thiede, A J Puech. Comparative investigation of the effect of moclobemide and toloxatone on monoamine oxidase activity and psychometric performance in healthy subjects. Psychopharmacology. 1992; 106 Suppl(?):S68-70. doi: 10.1007/bf02246239. [PMID: 1546145]
  • I Berlin, R Zimmer, H M Thiede, C Payan, T Hergueta, L Robin, A J Puech. Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects. British journal of clinical pharmacology. 1990 Dec; 30(6):805-16. doi: 10.1111/j.1365-2125.1990.tb05445.x. [PMID: 1705137]
  • M P Schoerlin, T W Guentert. [Pharmacokinetics and metabolism of reversible MAO-A inhibitors in the human]. Psychiatrische Praxis. 1989 Aug; 16 Suppl 1(?):11-7. doi: NULL. [PMID: 2685852]
  • R Vistelle, D Lamiable, M Zinzou. Simple high-performance liquid chromatographic method for the measurement of toloxatone in rabbit cerebrospinal fluid and plasma. Journal of chromatography. 1989 May; 490(2):387-94. doi: 10.1016/s0378-4347(00)82796-6. [PMID: 2768411]
  • S Vajta, J P Le Moing, V Rovei. Reversed-phase high-performance liquid chromatographic separation of 14C-labelled toloxatone and its metabolites. Journal of chromatography. 1984 Nov; 311(2):329-37. doi: 10.1016/s0378-4347(00)84726-x. [PMID: 6520180]
  • S Vajta, J P Le Moing, V Rovei. Gas--liquid chromatographic determination of toloxatone in human plasma. Routine analysis of a wide range of drug concentrations using a nitrogen-selective detector. Journal of chromatography. 1983 May; 274(?):139-48. doi: NULL. [PMID: 6874817]
  • M S Benedetti, V Rovei, S J Dencker, A Nagy, R Johansson. Pharmacokinetics of toloxatone in man following intravenous and oral administrations. Arzneimittel-Forschung. 1982; 32(3):276-80. doi: NULL. [PMID: 7200786]