Alternariol methyl ether (BioDeep_00000408542)

Main id: BioDeep_00000231157

 

PANOMIX_OTCML-2023


代谢物信息卡片


Alternariol monomethyl ether

化学式: C15H12O5 (272.0684702)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=CC2=C1C3=C(C(=CC(=C3)OC)O)C(=O)O2)O
InChI: InChI=1S/C15H12O5/c1-7-3-8(16)4-12-13(7)10-5-9(19-2)6-11(17)14(10)15(18)20-12/h3-6,16-17H,1-2H3

描述信息

CONFIDENCE Reference Standard (Level 1)

同义名列表

2 个代谢物同义名

Alternariol monomethyl ether; Alternariol methyl ether



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Asmaa Mahana, Hala M Hammoda, Mona M G Saad, Mohamed M Radwan, Mahmoud A ElSohly, Doaa A Ghareeb, Fathallah M Harraz, Eman Shawky. Bio-guided isolation of potential anti-inflammatory constituents of some endophytes isolated from the leaves of ground cherry (Physalis pruinosa L.) via ex-vivo and in-silico studies. BMC complementary medicine and therapies. 2023 Apr; 23(1):103. doi: 10.1186/s12906-023-03934-9. [PMID: 37013553]
  • Nikola Puvača, Giuseppina Avantaggiato, Jordan Merkuri, Gorica Vuković, Vojislava Bursić, Magdalena Cara. Occurrence and Determination of Alternaria Mycotoxins Alternariol, Alternariol Monomethyl Ether, and Tentoxin in Wheat Grains by QuEChERS Method. Toxins. 2022 11; 14(11):. doi: 10.3390/toxins14110791. [PMID: 36422965]
  • Jiahe Fan, Shiwei Sun, Chaoyi Lv, Zhizhou Li, Mengru Guo, Yichen Yin, Hui Wang, Wei Wang. Discovery of mycotoxin alternariol as a potential lead compound targeting xanthine oxidase. Chemico-biological interactions. 2022 Jun; 360(?):109948. doi: 10.1016/j.cbi.2022.109948. [PMID: 35430257]
  • Xinyao Tang, Yiyi Chen, Xia Zhu, Yeqiu Miao, Dongxia Wang, Jing Zhang, Ruirui Li, Lishi Zhang, Jinyao Chen. Alternariol monomethyl ether toxicity and genotoxicity in male Sprague-Dawley rats: 28-Day in vivo multi-endpoint assessment. Mutation research. Genetic toxicology and environmental mutagenesis. 2022 Jan; 873(?):503435. doi: 10.1016/j.mrgentox.2021.503435. [PMID: 35094809]
  • Dongmei Jiang, Dizhe Wei, Hongtao Li, Liuqing Wang, Nan Jiang, Yunchao Li, Meng Wang. Natural occurrence of Alternaria mycotoxins in wheat and potential of reducing associated risks using magnolol. Journal of the science of food and agriculture. 2021 May; 101(7):3071-3077. doi: 10.1002/jsfa.10901. [PMID: 33124688]
  • Megha Bansal, Ishrat Jahan Saifi, Indra Dev, Aashish Kumar Sonkar, Sumita Dixit, Sheelendra Pratap Singh, Kausar Mahmood Ansari. Occurrence of Alternariol and Alternariolmonomethyl ether in edible oils: Their thermal stability and intake assessment in state of Uttar Pradesh, India. Journal of food science. 2021 Mar; 86(3):1124-1131. doi: 10.1111/1750-3841.15629. [PMID: 33580502]
  • Francesco Crudo, Georg Aichinger, Jovana Mihajlovic, Luca Dellafiora, Elisabeth Varga, Hannes Puntscher, Benedikt Warth, Chiara Dall'Asta, David Berry, Doris Marko. Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro. Archives of toxicology. 2020 10; 94(10):3541-3552. doi: 10.1007/s00204-020-02831-1. [PMID: 32623606]
  • Xiaoting Qiao, Jing Zhang, Yunjia Yang, Jie Yin, Hong Li, Yang Xing, Bing Shao. Development of a simple and rapid LC-MS/MS method for the simultaneous quantification of five Alternaria mycotoxins in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 May; 1144(?):122096. doi: 10.1016/j.jchromb.2020.122096. [PMID: 32251989]
  • Sophie Scheibenzuber, Thomas Hoffmann, Isabelle Effenberger, Wilfried Schwab, Stefan Asam, Michael Rychlik. Enzymatic Synthesis of Modified Alternaria Mycotoxins Using a Whole-Cell Biotransformation System. Toxins. 2020 04; 12(4):. doi: 10.3390/toxins12040264. [PMID: 32326012]
  • Maximilian Wenderoth, Francesca Garganese, Markus Schmidt-Heydt, Sebastian Tobias Soukup, Antonio Ippolito, Simona Marianna Sanzani, Reinhard Fischer. Alternariol as virulence and colonization factor of Alternaria alternata during plant infection. Molecular microbiology. 2019 07; 112(1):131-146. doi: 10.1111/mmi.14258. [PMID: 30947377]
  • Hannes Puntscher, Svenja Hankele, Katharina Tillmann, Eva Attakpah, Dominik Braun, Mary-Liis Kütt, Giorgia Del Favero, Georg Aichinger, Gudrun Pahlke, Harald Höger, Doris Marko, Benedikt Warth. First insights into Alternaria multi-toxin in vivo metabolism. Toxicology letters. 2019 Feb; 301(?):168-178. doi: 10.1016/j.toxlet.2018.10.006. [PMID: 30321595]
  • Bita Zaferanloo, Stephanie A Pepper, Sally A Coulthard, Christopher P F Redfern, Enzo A Palombo. Metabolites of endophytic fungi from Australian native plants as potential anticancer agents. FEMS microbiology letters. 2018 05; 365(9):. doi: 10.1093/femsle/fny078. [PMID: 29590360]
  • Yan Man, Gang Liang, Fuchao Jia, An Li, Hailong Fu, Meng Wang, Ligang Pan. Development of an Immunochromatographic Strip Test for the Rapid Detection of Alternariol Monomethyl Ether in Fruit. Toxins. 2017 04; 9(5):. doi: 10.3390/toxins9050152. [PMID: 28468234]
  • N Estiarte, A Crespo-Sempere, S Marín, V Sanchis, A J Ramos. Effect of 1-methylcyclopropene on the development of black mold disease and its potential effect on alternariol and alternariol monomethyl ether biosynthesis on tomatoes infected with Alternaria alternata. International journal of food microbiology. 2016 Nov; 236(?):74-82. doi: 10.1016/j.ijfoodmicro.2016.07.001. [PMID: 27454782]
  • Daowan Lai, Ali Wang, Yuheng Cao, Kaiyi Zhou, Ziling Mao, Xuejiao Dong, Jin Tian, Dan Xu, Jungui Dai, Yu Peng, Ligang Zhou, Yang Liu. Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22. Journal of natural products. 2016 08; 79(8):2022-31. doi: 10.1021/acs.jnatprod.6b00327. [PMID: 27441892]
  • Jingfeng Lou, Ruiting Yu, Xiaohan Wang, Ziling Mao, Linyun Fu, Yang Liu, Ligang Zhou. Alternariol 9-methyl ether from the endophytic fungus Alternaria sp. Samif01 and its bioactivities. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2016 Jan; 47(1):96-101. doi: 10.1016/j.bjm.2015.11.004. [PMID: 26887231]
  • Andreas A Hildebrand, Beate N Kohn, Erika Pfeiffer, Daniel Wefers, Manfred Metzler, Mirko Bunzel. Conjugation of the mycotoxins alternariol and alternariol monomethyl ether in tobacco suspension cells. Journal of agricultural and food chemistry. 2015 May; 63(19):4728-36. doi: 10.1021/acs.jafc.5b00806. [PMID: 25912034]
  • Panagiota Ntasiou, Charalampos Myresiotis, Sotiris Konstantinou, Euphemia Papadopoulou-Mourkidou, George S Karaoglanidis. Identification, characterization and mycotoxigenic ability of Alternaria spp. causing core rot of apple fruit in Greece. International journal of food microbiology. 2015 Mar; 197(?):22-9. doi: 10.1016/j.ijfoodmicro.2014.12.008. [PMID: 25560914]
  • Ilenia Siciliano, Giuseppe Ortu, Giovanna Gilardi, Maria Lodovica Gullino, Angelo Garibaldi. Mycotoxin production in liquid culture and on plants infected with Alternaria spp. isolated from rocket and cabbage. Toxins. 2015 Mar; 7(3):743-54. doi: 10.3390/toxins7030743. [PMID: 25751147]
  • Vanessa Mara Chapla, Maria Luiza Zeraik, Valdecir F Ximenes, Lisinéia Maria Zanardi, Márcia N Lopes, Alberto José Cavalheiro, Dulce Helena S Silva, Maria Cláudia M Young, Luiz Marcos da Fonseca, Vanderlan S Bolzani, Angela Regina Araújo. Bioactive secondary metabolites from Phomopsis sp., an endophytic fungus from Senna spectabilis. Molecules (Basel, Switzerland). 2014 May; 19(5):6597-608. doi: 10.3390/molecules19056597. [PMID: 24858094]
  • Antonio Jacinto Demuner, Luiz Cláudio Almeida Barbosa, Ana Cristina Mendes Miranda, Guilherme Carvalho Geraldo, Cleiton Moreira da Silva, Samuele Giberti, Michele Bertazzini, Giuseppe Forlani. The fungal phytotoxin alternariol 9-methyl ether and some of its synthetic analogues inhibit the photosynthetic electron transport chain. Journal of natural products. 2013 Dec; 76(12):2234-45. doi: 10.1021/np4005882. [PMID: 24245962]
  • Jovana Vučković, Marija Bodroža-Solarov, Đura Vujić, Aleksandra Bočarov-Stančić, Ferenc Bagi. The protective effect of hulls on the occurrence of Alternaria mycotoxins in spelt wheat. Journal of the science of food and agriculture. 2013 Jun; 93(8):1996-2001. doi: 10.1002/jsfa.6005. [PMID: 23255302]
  • Christine Tiessen, Markus Fehr, Christoph Schwarz, Simone Baechler, Katharina Domnanich, Ute Böttler, Gudrun Pahlke, Doris Marko. Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether. Toxicology letters. 2013 Jan; 216(1):23-30. doi: 10.1016/j.toxlet.2012.11.005. [PMID: 23154127]
  • Jun-Wei He, Guo-Dong Chen, Hao Gao, Fan Yang, Xiao-Xia Li, Tao Peng, Liang-Dong Guo, Xin-Sheng Yao. Heptaketides with antiviral activity from three endolichenic fungal strains Nigrospora sp., Alternaria sp. and Phialophora sp. Fitoterapia. 2012 Sep; 83(6):1087-91. doi: 10.1016/j.fitote.2012.05.002. [PMID: 22613072]
  • Stefania Somma, Graciela Pose, Alejandro Pardo, Giuseppina Mulè, Virginia Fernandez Pinto, Antonio Moretti, Antonio Francesco Logrieco. AFLP variability, toxin production, and pathogenicity of Alternaria species from Argentinean tomato fruits and puree. International journal of food microbiology. 2011 Feb; 145(2-3):414-9. doi: 10.1016/j.ijfoodmicro.2011.01.006. [PMID: 21303723]
  • Julia Kjer, Victor Wray, RuAngelie Edrada-Ebel, Rainer Ebel, Alexander Pretsch, Wenhan Lin, Peter Proksch. Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba. Journal of natural products. 2009 Nov; 72(11):2053-7. doi: 10.1021/np900417g. [PMID: 19835393]
  • Amal H Aly, RuAngelie Edrada-Ebel, Ine Dewi Indriani, Victor Wray, Werner E G Müller, Frank Totzke, Ute Zirrgiebel, Christoph Schächtele, Michael H G Kubbutat, W H Lin, Peter Proksch, Rainer Ebel. Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of natural products. 2008 Jun; 71(6):972-80. doi: 10.1021/np070447m. [PMID: 18494522]
  • Rodrigo F Magnani, Gezimar D De Souza, Edson Rodrigues-Filho. Analysis of alternariol and alternariol monomethyl ether on flavedo and albedo tissues of tangerines (Citrus reticulata) with symptoms of alternaria brown spot. Journal of agricultural and food chemistry. 2007 Jun; 55(13):4980-6. doi: 10.1021/jf0704256. [PMID: 17536830]
  • Birgitte Andersen, Jørn Smedsgaard, Ida Jørring, Pernille Skouboe, Lars Hagsholm Pedersen. Real-time PCR quantification of the AM-toxin gene and HPLC qualification of toxigenic metabolites from Alternaria species from apples. International journal of food microbiology. 2006 Sep; 111(2):105-11. doi: 10.1016/j.ijfoodmicro.2006.04.021. [PMID: 16890318]
  • Claudia R Pozzi, Raquel Braghini, Juliana R P Arcaro, Patricia Zorzete, Ana Lia M Israel, Ivani Otsuk Pozar, Silmar Denucci, Benedito Corrêa. Mycoflora and occurrence of alternariol and alternariol monomethyl ether in Brazilian sunflower from sowing to harvest. Journal of agricultural and food chemistry. 2005 Jul; 53(14):5824-8. doi: 10.1021/jf047884g. [PMID: 15998154]
  • G T Liu, Y Z Qian, P Zhang, Z M Dong, Z Y Shi, Y Z Zhen, J Miao, Y M Xu. Relationships between Alternaria alternata and oesophageal cancer. IARC scientific publications. 1991; ?(105):258-62. doi: ". [PMID: 1855864]
  • N Magan, G R Cayley, J Lacey. Effect of water activity and temperature on mycotoxin production by Alternaria alternata in culture and on wheat grain. Applied and environmental microbiology. 1984 May; 47(5):1113-7. doi: 10.1128/aem.47.5.1113-1117.1984. [PMID: 6540067]
  • G A Pollock, C E DiSabatino, R C Heimsch, R A Coulombe. The distribution, elimination, and metabolism of 14C-alternariol monomethyl ether. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1982; 17(2):109-24. doi: 10.1080/03601238209372306. [PMID: 7077052]