3-Methoxymorphinan (BioDeep_00000408292)

   

natural product


代谢物信息卡片


(1S,9S,10S)-4-methoxy-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-triene

化学式: C17H23NO (257.1779548)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 94.44%

分子结构信息

SMILES: COC1=CC2=C(CC3C4C2(CCCC4)CCN3)C=C1
InChI: InChI=1S/C17H23NO/c1-19-13-6-5-12-10-16-14-4-2-3-7-17(14,8-9-18-16)15(12)11-13/h5-6,11,14,16,18H,2-4,7-10H2,1H3

描述信息

D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids

同义名列表

2 个代谢物同义名

3-Methoxymorphinan; (1S,9S,10S)-4-methoxy-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-triene



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Worku Bedada, Fernando de Andrés, Ephrem Engidawork, Anton Pohanka, Olof Beck, Leif Bertilsson, Adrián Llerena, Eleni Aklillu. The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans. Journal of clinical psychopharmacology. 2015 Dec; 35(6):694-9. doi: 10.1097/jcp.0000000000000413. [PMID: 26444948]
  • Fahad Ibrahim Al-Jenoobi, Areej A Al-Thukair, Mohd Aftab Alam, Fawkeya A Abbas, Abdullah M Al-Mohizea, Khalid M Alkharfy, Saleh A Al-Suwayeh. Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects. European journal of drug metabolism and pharmacokinetics. 2015 Mar; 40(1):61-6. doi: 10.1007/s13318-014-0180-2. [PMID: 24510399]
  • Walter J Loos, Anne-Joy M de Graan, Peter de Bruijn, Ron H N van Schaik, Marianne A C van Fessem, Mei-Ho Lam, Ron H J Mathijssen, Erik A C Wiemer. Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2011 Jan; 54(2):387-94. doi: 10.1016/j.jpba.2010.08.033. [PMID: 20926215]
  • F I Al-Jenoobi, A A Al-Thukair, F A Abbas, M J Ansari, K M Alkharfy, A M Al-Mohizea, S A Al-Suwayeh, S Jamil. Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. Drug metabolism letters. 2010 Jan; 4(1):51-5. doi: 10.2174/187231210790980435. [PMID: 20201775]
  • Marios Spanakis, Ioannis S Vizirianakis, Maria Mironidou-Tzouveleki, Ioannis Niopas. A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. Biomedical chromatography : BMC. 2009 Nov; 23(11):1131-7. doi: 10.1002/bmc.1234. [PMID: 19444798]
  • Wen-Hui Tsai, Pao-Yun Cheng, Yen-Mei Lee, Min-Chen Chiu, Shyi-Shiaw Jiau, Edwin S C Wu, Mao-Hsiung Yen. Anti-inflammatory effects of LK-3, on LPS-induced sepsis in rats. The Chinese journal of physiology. 2008 Oct; 51(5):292-300. doi: . [PMID: 19175185]
  • Shyr-Yi Lin, Chien-Ho Chen, Hsiu-O Ho, Hsueh-Hui Chen, Ming-Thau Sheu. Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Nov; 859(1):141-6. doi: 10.1016/j.jchromb.2007.09.017. [PMID: 17919999]
  • Benjamin Pei-Chung Kuo, Oliver Yoa-Pu Hu, Cheng-Huei Hsiong, Li-Heng Pao, Ting-Shien Chen, Chi-Feng Hung. Single-point plasma or urine dextromethorphan method for determining CYP3A activity. Biopharmaceutics & drug disposition. 2003 Dec; 24(9):367-73. doi: 10.1002/bdd.373. [PMID: 14689465]
  • A Yu, R L Haining. Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?. Drug metabolism and disposition: the biological fate of chemicals. 2001 Nov; 29(11):1514-20. doi: . [PMID: 11602530]
  • E K Bendriss, N Markoglou, I W Wainer. High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. Journal of chromatography. B, Biomedical sciences and applications. 2001 Apr; 754(1):209-15. doi: 10.1016/s0378-4347(00)00609-5. [PMID: 11318417]
  • J S McCune, R L Hawke, E L LeCluyse, H H Gillenwater, G Hamilton, J Ritchie, C Lindley. In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. Clinical pharmacology and therapeutics. 2000 Oct; 68(4):356-66. doi: 10.1067/mcp.2000.110215. [PMID: 11061575]
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  • D I Min, Y M Ku, A Vichiendilokkul, L L Fleckenstein. A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers. Pharmacotherapy. 1999 Jun; 19(6):753-9. doi: 10.1592/phco.19.9.753.31536. [PMID: 10391422]
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