artenimol (BioDeep_00000407807)
natural product
代谢物信息卡片
(3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
化学式: C15H24O5 (284.1624)
中文名称: (3R,5AS,6R,8AS,9R,12R,12AR)-十氢-3,6,9-三甲基-3,12-环氧-12H-吡喃并[4,3-J]-1,2-苯并二氧杂卓-10-醇
谱图信息:
最多检出来源 Homo sapiens(natural_products) 100%
分子结构信息
SMILES: CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C
InChI: InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13-,14-,15-/m1/s1
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BE - Artemisinin and derivatives, plain
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:207229
- PubChem: 6918483
- DrugBank: DB11638
- ChEMBL: CHEMBL25164
- CAS: 131175-87-6
- MoNA: VF-NPL-LTQ006276
- MoNA: VF-NPL-LTQ006275
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Denis Ponomarev, Maria Lvova, Viatcheslav Mordvinov, Irina Chidunchi, Alexander Dushkin, Damira Avgustinovich. Anti-Opisthorchis felineus effects of artemisinin derivatives: An in vitro study.
Acta tropica.
2024 Jun; 254(?):107196. doi:
10.1016/j.actatropica.2024.107196. [PMID: 38521124] - Yanping Li, Haoyi Sun, Caihong Bai, Youfan Hu, Jingyi Tang, Yuxi Zhang, Jilan Chen, Zhanqiong Zhong, Yuping He, Kaifeng Hu, Jiahui Yang. Dihydroartemisinin inhibits tumor progress via blocking ROR1-induced STAT3-activation in non-small cell lung cancer.
International immunopharmacology.
2024 May; 133(?):112157. doi:
10.1016/j.intimp.2024.112157. [PMID: 38678671] - Liu-Gen Li, Xing-Chun Peng, Zi-Yi Yang, Ning Han, Chang-Long Gou, Jun Shi, Li-Li Yu, Nan-Nan Chen, Ting-Ting Yu, Tong-Fei Li, Xian-Yu Li, Jun Hu. Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage.
Scientific reports.
2024 05; 14(1):11704. doi:
10.1038/s41598-024-62126-8. [PMID: 38778121] - Pamela Weathers, Melissa Towler, Bushra Hafeez Kiani, David Dolivo, Tanja Dominko. Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts to Artemisia sp., Artemisinin, and Its Derivatives.
Molecules (Basel, Switzerland).
2024 May; 29(9):. doi:
10.3390/molecules29092107. [PMID: 38731597] - Xing Wan, Can Li, Yue Hao Tan, Shi Qi Zuo, Feng Mei Deng, Jing Sun, Yi Lun Liu. Dihydroartemisinin eliminates senescent cells by promoting autophagy-dependent ferroptosis via AMPK/mTOR signaling pathway.
Cell biology international.
2024 May; 48(5):726-736. doi:
10.1002/cbin.12143. [PMID: 38439187] - Jie Ji, Ziqi Cheng, Jie Zhang, Jianye Wu, Xuanfu Xu, Chuanyong Guo, Jiao Feng. Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway.
Journal of cellular and molecular medicine.
2024 Apr; 28(8):e18335. doi:
10.1111/jcmm.18335. [PMID: 38652216] - Yan Luo, Jiaxing Zhang, Yue Jiao, Hao Huang, Liangshan Ming, Yunlei Song, Yanlong Niu, Xiaolu Tang, Liwei Liu, Yi Li, Yumao Jiang. Dihydroartemisinin abolishes cisplatin-induced nephrotoxicity in vivo.
Journal of natural medicines.
2024 Mar; 78(2):439-454. doi:
10.1007/s11418-024-01783-5. [PMID: 38351420] - Chong-Zhi Wang, Chunping Wan, Cang-Hai Li, Guo-Gang Liang, Yun Luo, Chun-Feng Zhang, Qi-Hui Zhang, Qinge Ma, Angela H Wang, Mallory Lager, Ting-Liang Jiang, Lifei Hou, Chun-Su Yuan. Ruthenium-dihydroartemisinin complex: a promising new compound for colon cancer prevention via G1 cell cycle arrest, apoptotic induction, and adaptive immune regulation.
Cancer chemotherapy and pharmacology.
2024 Jan; ?(?):. doi:
10.1007/s00280-023-04623-7. [PMID: 38191768] - Jiao Wang, Jin Zhang, Zeyu Guo, Hui Hua, Hongying Zhang, Yongliang Liu, Yangfu Jiang. Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 122(?):155156. doi:
10.1016/j.phymed.2023.155156. [PMID: 37897861] - Xueyan Zhang, Hua Liu, Na Li, Jiayang Li, Meng Wang, Xiaoliang Ren. A (Traditional Chinese Medicine) TCM-Inspired Doxorubicin Resistance Reversing Strategy: Preparation, Characterization, and Application of a Co-loaded pH-Sensitive Liposome.
AAPS PharmSciTech.
2023 Sep; 24(7):181. doi:
10.1208/s12249-023-02630-8. [PMID: 37697172] - Hua Liu, Yi Liu, Na Li, Guo-Qin Zhang, Meng Wang. [Ginsenoside Rg_3 based liposomes target delivery of dihydroartemisinin and paclitaxel for treatment of triple-negative breast cancer].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jul; 48(13):3472-3484. doi:
10.19540/j.cnki.cjcmm.20230410.301. [PMID: 37474984] - Jingsong Lu, Jing Yu, Wensheng Xie, Zhenhu Guo, Xiaohan Gao, Ying Li, Ziqing Zhang, Zeping Jin, Abdul Fahad, Shenglei Che, Lingyun Zhao, Yen Wei. Acidity-Triggered Charge-Convertible Conjugated Polymer for Dihydroartemisinin Delivery and Tumor-Specific Chemo-Photothermal Therapy.
ACS applied bio materials.
2023 06; 6(6):2303-2313. doi:
10.1021/acsabm.3c00169. [PMID: 37190932] - Shanshan Shi, Yanhong Gong, Hailiang Hu, Shuai Peng, Ju Liu. Topical Dihydroartemisinin Improves Wound Healing in Diabetic Mice.
Journal of plastic surgery and hand surgery.
2023 Jun; 58(?):26-32. doi:
10.2340/jphs.v58.5775. [PMID: 37314293] - Wen Cui, Zheng Xue, Ling-Ling Zhao, Ying Li, Jian-Qing Mi. [Effect of a Novel Dihydroartemisinin Dimer Containing Nitrogen Atoms SM 1044 on Apoptosis of Human Leukemia Cell Line NB4-R1].
Zhongguo shi yan xue ye xue za zhi.
2023 Jun; 31(3):659-665. doi:
10.19746/j.cnki.issn.1009-2137.2023.03.007. [PMID: 37356923] - Shaohuan Liu, Shu Wang, Dan Xu, Bowen Pan, Linzhi Chen, Shijia Zhao, Zhi Xu, Wei Zhou. Novel ester tethered dihydroartemisinin-3-(oxime/thiosemicarbazide)isatin hybrids as potential anti-breast cancer agents: Synthesis, in vitro cytotoxicity and structure-activity relationship.
Drug development research.
2023 May; ?(?):. doi:
10.1002/ddr.22078. [PMID: 37165798] - Dandan Huang, Dafen Xu, Wenxin Chen, Ruimei Wu, Yujuan Wen, Ailin Liu, Liqing Lin, Xinhua Lin, Xuewen Wang. Fe-MnO2 nanosheets loading dihydroartemisinin for ferroptosis and immunotherapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 May; 161(?):114431. doi:
10.1016/j.biopha.2023.114431. [PMID: 36827713] - Sheng Huan, Sumin Sun, Shilian Song, Jin Dai, Guining Zhu, Yanling Zhong, Yihao Ji, Shizhong Zheng, Guoping Yin. Dihydroartemisinin inhibits the activation and proliferation of hepatic stellate cells by regulating miR‑29b‑3p.
International journal of molecular medicine.
2023 May; 51(5):. doi:
10.3892/ijmm.2023.5243. [PMID: 37026504] - Yingjie Wang, Fangmin Chen, Huiling Zhou, Lujia Huang, Jiayi Ye, Xiaoying Liu, Weizhong Sheng, Weidong Gao, Haijun Yu, Feng Wang. Redox Dyshomeostasis with Dual Stimuli-Activatable Dihydroartemisinin Nanoparticles to Potentiate Ferroptotic Therapy of Pancreatic Cancer.
Small methods.
2023 05; 7(5):e2200888. doi:
10.1002/smtd.202200888. [PMID: 36446643] - Camilla Valente Pires, Jenna Oberstaller, Chengqi Wang, Debora Casandra, Min Zhang, Jyotsna Chawla, Swamy Rakesh Adapa, Thomas D Otto, Michael T Ferdig, Julian C Rayner, Rays H Y Jiang, John H Adams. Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins.
Microbiology spectrum.
2023 Apr; ?(?):e0501422. doi:
10.1128/spectrum.05014-22. [PMID: 37067430] - Zhi Xu, Bowen Pan, Linzhi Chen, Dan Xu. Design, synthesis, and in vitro cytotoxicity evaluation of novel dihydroartemisinin-isatin hybrids tethered via different length of esters as potential anti-breast cancer agents.
Fitoterapia.
2023 Apr; 166(?):105436. doi:
10.1016/j.fitote.2023.105436. [PMID: 36693438] - Ning Han, Zi-Yi Yang, Zhong-Xiong Xie, Hua-Zhen Xu, Ting-Ting Yu, Qi-Rui Li, Liu-Gen Li, Xing-Chun Peng, Xiao-Xin Yang, Jun Hu, Xiang Xu, Xiao Chen, Mei-Fang Wang, Tong-Fei Li. Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Apr; 112(?):154682. doi:
10.1016/j.phymed.2023.154682. [PMID: 36739636] - Yawei Li, Wei Zhang, Naiyuan Shi, Wenqing Li, Junxia Bi, Xianmin Feng, Nianqiu Shi, Wenhe Zhu, Zhigang Xie. Self-assembly and self-delivery of the pure nanodrug dihydroartemisinin for tumor therapy and mechanism analysis.
Biomaterials science.
2023 Mar; 11(7):2478-2485. doi:
10.1039/d2bm01949c. [PMID: 36763165] - Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Luis J Montaner, Ian Tietjen, Vicky M Avery, Rohan A Davis. Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations.
Journal of natural products.
2023 03; 86(3):557-565. doi:
10.1021/acs.jnatprod.2c01041. [PMID: 36799121] - Zhi Xu, Xiaoyan Zhang, Jie Liu, Shijia Zhao, Junna Liu, Wei Zhou. Design, Synthesis, and Biological Evaluation of Novel Amyl Ester Tethered Dihydroartemisinin-Isatin Hybrids as Potent Anti-Breast Cancer Agents.
Chemistry & biodiversity.
2023 Mar; 20(3):e202201257. doi:
10.1002/cbdv.202201257. [PMID: 36808231] - Jingfeng Yu, Sihan Sheng, Xiaosu Zou, Zhengwu Shen. Dihydroartemisinin-ursodeoxycholic acid conjugate is a potential treatment agent for inflammatory bowel disease.
International immunopharmacology.
2023 Feb; 117(?):109918. doi:
10.1016/j.intimp.2023.109918. [PMID: 36842236] - Sakaewan Ounjaijean, Voravuth Somsak. Synergistic antimalarial treatment of Plasmodium berghei infection in mice with dihydroartemisinin and Gymnema inodorum leaf extract.
BMC complementary medicine and therapies.
2023 Jan; 23(1):20. doi:
10.1186/s12906-023-03850-y. [PMID: 36690988] - Yiyi Hu, Xuetao Peng, Guoping Du, Yingji Zhai, Xingbo Xiong, Xiaoliang Luo. Dihydroartemisinin ameliorates the liver steatosis in metabolic associated fatty liver disease mice by attenuating the inflammation and oxidative stress and promoting autophagy.
Acta cirurgica brasileira.
2023; 38(?):e385023. doi:
10.1590/acb385023. [PMID: 37851788] - Jing Zhang, Yang Li, Ji-Guo Wang, Jing-Yu Feng, Guo-Dong Huang, Chang-Guo Luo. Dihydroartemisinin Affects STAT3/DDA1 Signaling Pathway and Reverses Breast Cancer Resistance to Cisplatin.
The American journal of Chinese medicine.
2023; 51(2):445-459. doi:
10.1142/s0192415x23500234. [PMID: 36891981] - Dancan M Wakoli, Bartholomew N Ondigo, Douglas O Ochora, Joseph G Amwoma, Winnie Okore, Edwin W Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H Opot, Agnes C Cheruiyot, Dennis Juma, Amanda Roth, Benhards R Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M Akala. Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs.
BMC medicine.
2022 11; 20(1):448. doi:
10.1186/s12916-022-02652-2. [PMID: 36397090] - Yanfen Yao, Hong Wang, Jing Xu, Feng Gao, Wei Cao. The Anti-Breast Cancer Activity of Dihydroartemisinin-5-methylisatin Hybrids Tethered via Different Carbon Spacers.
Molecules (Basel, Switzerland).
2022 Nov; 27(22):. doi:
10.3390/molecules27227994. [PMID: 36432095] - Guan-Zheng Lu, Yan-Jun Yang, Mao-Mao Zhu, Jun Liu, Jing Zhao, Xiao-Bin Jia, Xiang-Jun Zhu, Liang Feng. [Pharmacodynamic substances and mechanism of action of Xiaoer Chiqiao Qingre Granules in treatment of acute upper respiratory tract infection in children].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Nov; 47(21):5717-5734. doi:
10.19540/j.cnki.cjcmm.20220614.302. [PMID: 36471990] - Umi Cahyaningsih, Siti Sa'diah, Wasrin Syafii, Rita Kartika Sari, Abdul Jafar Maring, Arifin Budiman Nugraha. Antimalarial Efficacy of Aqueous Extract of Strychnos ligustrina and Its Combination with Dihydroartemisinin and Piperaquine Phosphate (DHP) against Plasmodium berghei Infection.
The Korean journal of parasitology.
2022 Oct; 60(5):339-344. doi:
10.3347/kjp.2022.60.5.339. [PMID: 36320110] - Wei Zhou, Min-Min Chen, Hui-Ling Liu, Zi-Lin Si, Wen-Hui Wu, Hong Jiang, Lin-Xiao Wang, Nosratola D Vaziri, Xiao-Fei An, Ke Su, Cheng Chen, Ning-Hua Tan, Zhi-Hao Zhang. Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.
Acta pharmacologica Sinica.
2022 Oct; 43(10):2609-2623. doi:
10.1038/s41401-022-00898-3. [PMID: 35347248] - Joyce Hernandez Maldonado, Oliver Grundmann. Drug-Drug Interactions of Artemisinin-Based Combination Therapies in Malaria Treatment: A Narrative Review of the Literature.
Journal of clinical pharmacology.
2022 10; 62(10):1197-1205. doi:
10.1002/jcph.2073. [PMID: 35543380] - Fuhong Liu, Jing Liu, Hongjie Xiang, Zongguo Sun, Yan Li, Xiao Li, Yanjun Liu, Ju Liu. Dihydroartemisinin protects blood-brain barrier permeability during sepsis by inhibiting the transcription factor SNAI1.
Clinical and experimental pharmacology & physiology.
2022 09; 49(9):979-987. doi:
10.1111/1440-1681.13683. [PMID: 35651290] - Jibo Li, Yongsong Bai, Kaidi Ma, Zhongshuai Ren, Jianping Li, Jing Zhang, Anshan Shan. Dihydroartemisinin alleviates deoxynivalenol induced liver apoptosis and inflammation in piglets.
Ecotoxicology and environmental safety.
2022 Aug; 241(?):113811. doi:
10.1016/j.ecoenv.2022.113811. [PMID: 35772362] - Haijian Cai, Shiqian Fan, Luqiong Cai, Lin Zhu, Zhucheng Zhao, Yaozhe Li, Yizhu Yao, Xiaoying Huang, Liangxing Wang. Dihydroartemisinin Attenuates Hypoxia-Induced Pulmonary Hypertension Through the ELAVL2/miR-503/PI3K/AKT Axis.
Journal of cardiovascular pharmacology.
2022 07; 80(1):95-109. doi:
10.1097/fjc.0000000000001271. [PMID: 35512032] - Clifford G Banda, Dumisile Nkosi, Elizabeth Allen, Lesley Workman, Mwayiwawo Madanitsa, Marumbo Chirwa, Mayamiko Kapulula, Sharon Muyaya, Steven Munharo, Lubbe Wiesner, Kamija S Phiri, Victor Mwapasa, Feiko O Ter Kuile, Gary Maartens, Karen I Barnes. Effect of dihydroartemisinin/piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1733-1737. doi:
10.1093/jac/dkac081. [PMID: 35288747] - Xiao-Xin Yang, Xiang Xu, Mei-Fang Wang, Hua-Zhen Xu, Xing-Chun Peng, Ning Han, Ting-Ting Yu, Liu-Gen Li, Qi-Rui Li, Xiao Chen, Yu Wen, Tong-Fei Li. A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin.
Journal of nanobiotechnology.
2022 May; 20(1):230. doi:
10.1186/s12951-022-01455-0. [PMID: 35568865] - Shuo Li, Wenhui Xu, Huajing Wang, Tian Tang, Ji Ma, Zhao Cui, Hang Shi, Ting Qin, Hongying Zhou, Lanfang Li, Tingliang Jiang, Canghai Li. Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112742. doi:
10.1016/j.biopha.2022.112742. [PMID: 35228063] - Chong-Zhi Wang, Chunping Wan, Yun Luo, Chun-Feng Zhang, Qi-Hui Zhang, Lina Chen, Zhi Liu, Daniel H Wang, Mallory Lager, Cang-Hai Li, Ting-Liang Jiang, Lifei Hou, Chun-Su Yuan. Effects of dihydroartemisinin, a metabolite of artemisinin, on colon cancer chemoprevention and adaptive immune regulation.
Molecular biology reports.
2022 Apr; 49(4):2695-2709. doi:
10.1007/s11033-021-07079-1. [PMID: 35040004] - Yuxi Zhang, Yi Wang, Yanping Li, Cong Huang, Xiaoqian Xiao, Zhanqiong Zhong, Jingyi Tang, Haolan Lu, Yibei Tang, Jiahui Yang. Dihydroartemisinin and artesunate inhibit aerobic glycolysis via suppressing c-Myc signaling in non-small cell lung cancer.
Biochemical pharmacology.
2022 04; 198(?):114941. doi:
10.1016/j.bcp.2022.114941. [PMID: 35149053] - Min Shen, Mei Guo, Yujia Li, Yingqian Wang, Yangling Qiu, Jiangjuan Shao, Feng Zhang, Xuefen Xu, Guoping Yin, Shijun Wang, Anping Chen, Zili Zhang, Shizhong Zheng. m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells.
Free radical biology & medicine.
2022 03; 182(?):246-259. doi:
10.1016/j.freeradbiomed.2022.02.028. [PMID: 35248719] - Xiaolan You, Xingyu Jiang, Chuanmeng Zhang, Kejia Jiang, Xiaojun Zhao, Ting Guo, Xiaowei Zhu, Jingjing Bao, Hongmei Dou. Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling.
Aging.
2022 02; 14(3):1110-1127. doi:
10.18632/aging.203874. [PMID: 35120332] - Liyuan Hao, Yinglin Guo, Qing Peng, Zhiqin Zhang, Jingmin Ji, Yiwei Liu, Yu Xue, Caige Li, Kangning Zheng, Xinli Shi. Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Feb; 96(?):153913. doi:
10.1016/j.phymed.2021.153913. [PMID: 35026515] - Xiaoqian Xiao, Yanping Li, Yi Wang, Yuxi Zhang, Jilan Chen, Weiwei Liu, Jingyi Tang, Fuping Yue, Jiahui Yang. Dihydroartemisinin inhibits Lewis Lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway.
International immunopharmacology.
2022 Feb; 103(?):108427. doi:
10.1016/j.intimp.2021.108427. [PMID: 34922249] - Ibrahim Malami, Aisha Muktar Bunza, Alhassan Muhammad Alhassan, Aliyu Muhammad, Ibrahim Babangida Abubakar, Abdulmajeed Yunusa, Peter M Waziri, Imaobong C Etti. Dihydroartemisinin as a potential drug candidate for cancer therapy: a structural-based virtual screening for multitarget profiling.
Journal of biomolecular structure & dynamics.
2022 02; 40(3):1347-1362. doi:
10.1080/07391102.2020.1824811. [PMID: 32964804] - Zhao Cui, Huajing Wang, Shuo Li, Tingting Qin, Hang Shi, Ji Ma, Lanfang Li, Guihua Yu, Tingliang Jiang, Canghai Li. Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism.
Journal of pharmacological sciences.
2022 Jan; 148(1):73-85. doi:
10.1016/j.jphs.2021.09.008. [PMID: 34924133] - Tong Xia, Sihao Liu, Ge Xu, Siji Zhou, Ziguo Luo. Dihydroartemisinin induces cell apoptosis through repression of UHRF1 in prostate cancer cells.
Anti-cancer drugs.
2022 01; 33(1):e113-e124. doi:
10.1097/cad.0000000000001156. [PMID: 34387595] - Hailong Gong, Mingjun Gao, Yuancai Lin, Jinliang Liu, Zhiwen Hu, Jing Liu. TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.
Oxidative medicine and cellular longevity.
2022; 2022(?):7843863. doi:
10.1155/2022/7843863. [PMID: 36164395] - Chime Salome Amarachi, Anthony Amaechi Attama, Godswill Chukwunweike Onunkwo. Assessment of the Anti-Malarial Properties of Dihydroartemisinin- Piperaquine Phosphate Solid Lipid-Based Tablets.
Recent advances in anti-infective drug discovery.
2022; 17(2):103-117. doi:
10.2174/2772434417666220606105822. [PMID: 35670344] - Baojiang Chen, Chen Li, Guizhen Chang, Huan Wang. Dihydroartemisinin targets fibroblast growth factor receptor 1 (FGFR1) to inhibit interleukin 17A (IL-17A)-induced hyperproliferation and inflammation of keratinocytes.
Bioengineered.
2022 01; 13(1):1530-1540. doi:
10.1080/21655979.2021.2021701. [PMID: 35006038] - Xiaosu Zou, Chang Liu, Congcong Li, Rong Fu, Wei Xu, Hongzhu Bian, Xun Dong, Xiaozhen Zhao, Zhenye Xu, Jinghua Zhang, Zhengwu Shen. Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
European journal of medicinal chemistry.
2021 Dec; 225(?):113754. doi:
10.1016/j.ejmech.2021.113754. [PMID: 34399390] - Mengyu Chen, Yuexin Cui, Wenyan Hao, Yueyue Fan, Jingqiu Zhang, Qianqian Liu, Mingrui Jiang, Yang Yang, Yingzi Wang, Chunsheng Gao. Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy.
Drug delivery.
2021 Dec; 28(1):2241-2255. doi:
10.1080/10717544.2021.1992038. [PMID: 34668811] - Xianjing Hu, Sarwat Fatima, Minting Chen, Tao Huang, Yuen Wa Chen, Ruihong Gong, Hoi Leong Xavier Wong, Rongmin Yu, Liyan Song, Hiu Yee Kwan, Zhaoxiang Bian. Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level.
Cell death & disease.
2021 11; 12(11):1053. doi:
10.1038/s41419-021-04247-w. [PMID: 34741022] - Zhiwei Wang, Mingxing Li, Yuanfeng Liu, Zhentao Qiao, Tao Bai, Ling Yang, Bo Liu. Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression.
Oncology reports.
2021 Nov; 46(5):. doi:
10.3892/or.2021.8191. [PMID: 34558645] - Yanping Li, Xiaoqian Xiao, Huili Wang, Qi Zhou, Zhao Jin, Yuxi Zhang, Yi Wang, Fuping Yue, Shiyi Zhou, Jiahui Yang. Integrating network pharmacology and experimental models to investigate the mechanisms of dihydroartemisinin in preventing NSCLC progression via mTOR/HIF-1α signaling.
European journal of pharmacology.
2021 Oct; 909(?):174411. doi:
10.1016/j.ejphar.2021.174411. [PMID: 34390710] - Sina Bader, Julia Wilmers, Teona Ontikatze, Violetta Ritter, Verena Jendrossek, Justine Rudner. Loss of pro-apoptotic Bax and Bak increases resistance to dihydroartemisinin-mediated cytotoxicity in normoxia but not in hypoxia in HCT116 colorectal cancer cells.
Free radical biology & medicine.
2021 10; 174(?):157-170. doi:
10.1016/j.freeradbiomed.2021.08.012. [PMID: 34403740] - Rui Li, Hanlin Yin, Juan Wang, Dongyi He, Qingran Yan, Liangjing Lu. Dihydroartemisinin alleviates skin fibrosis and endothelial dysfunction in bleomycin-induced skin fibrosis models.
Clinical rheumatology.
2021 Oct; 40(10):4269-4277. doi:
10.1007/s10067-021-05765-w. [PMID: 34013490] - Siwei Xia, Zhimin Wang, Li Chen, Yuanyuan Zhou, Yang Li, Shijun Wang, Anping Chen, Xuefen Xu, Jiangjuan Shao, Zili Zhang, Shanzhong Tan, Feng Zhang, Shizhong Zheng. Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal.
Biochemical pharmacology.
2021 10; 192(?):114730. doi:
10.1016/j.bcp.2021.114730. [PMID: 34400125] - Zili Zhang, Xian Wang, Zilong Wang, Zhiyue Zhang, Yashi Cao, Zonghui Wei, Jiangjuan Shao, Anping Chen, Feng Zhang, Shizhong Zheng. Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells.
BioFactors (Oxford, England).
2021 Sep; 47(5):801-818. doi:
10.1002/biof.1764. [PMID: 34129254] - Cong You, Jun Yu, Guangjiong Qin, JinPeng Yang, Chunlei Yang, Guoyuan Hu. Homogenate Extraction of Dihydroartemisinin from Artemisia Hedinii and Its Antifungal Activity.
Journal of AOAC International.
2021 Aug; 104(4):1206-1212. doi:
10.1093/jaoacint/qsab010. [PMID: 33484255] - Xueting Cai, Jing Miao, Rongwei Sun, Sainan Wang, Miguel Angel Molina-Vila, Imane Chaib, Rafael Rosell, Peng Cao. Dihydroartemisinin overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer.
Pharmacological research.
2021 08; 170(?):105701. doi:
10.1016/j.phrs.2021.105701. [PMID: 34087353] - Daniel J Watson, Lizahn Laing, Liezl Gibhard, Ho Ning Wong, Richard K Haynes, Lubbe Wiesner. Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether.
Antimicrobial agents and chemotherapy.
2021 07; 65(8):e0099021. doi:
10.1128/aac.00990-21. [PMID: 34097488] - Jing Du, Xu Wang, Yanchun Li, Xueying Ren, Yi Zhou, Wanye Hu, Chaoting Zhou, Qiangan Jing, Chen Yang, Luyang Wang, Huanjuan Li, Lijuan Fang, Yonglie Zhou, Xiangmin Tong, Ying Wang. DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.
Cell death & disease.
2021 07; 12(7):705. doi:
10.1038/s41419-021-03996-y. [PMID: 34262021] - M S Nair, Y Huang, D A Fidock, S J Polyak, J Wagoner, M J Towler, P J Weathers. Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants.
Journal of ethnopharmacology.
2021 Jun; 274(?):114016. doi:
10.1016/j.jep.2021.114016. [PMID: 33716085] - Guoying Zhang, Na Li, Yongjuan Tong, Peilin Li, Haotian Han, Qihan Song, Bin Yang, Lei Cui. Artemisinin derivatives inhibit adipogenic differentiation of 3T3-L1 preadipocytes through upregulation of CHOP.
Biochemical and biophysical research communications.
2021 06; 557(?):309-315. doi:
10.1016/j.bbrc.2021.04.013. [PMID: 33894419] - Fanfan Wang, Ming Li, Cong Lin, Sha Jin, Hongyuan Li, Yuyuan Lu, Hengshan Wang, Hongshuang Wang, Xiaohui Wang. Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity.
Bioorganic & medicinal chemistry.
2021 06; 39(?):116131. doi:
10.1016/j.bmc.2021.116131. [PMID: 33852975] - Sina Bader, Julia Wilmers, Martin Pelzer, Verena Jendrossek, Justine Rudner. Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation.
Free radical biology & medicine.
2021 05; 168(?):44-54. doi:
10.1016/j.freeradbiomed.2021.03.024. [PMID: 33775773] - Yepu He, Liyu Xu, Yanbing Li, Yinying Tang, Shuwen Rao, Rongtian Lin, Zhijun Liu, Heru Chen. Synergistic integration of dihydro-artemisinin with γ-aminobutyric acid results in a more potential anti-depressant.
Bioorganic chemistry.
2021 05; 110(?):104769. doi:
10.1016/j.bioorg.2021.104769. [PMID: 33677247] - Hui Li, Haisheng Chen, Wenna Shi, Jing Shi, Jupeng Yuan, Cunxian Duan, Qing Fan, Yuguo Liu. A novel use for an old drug: resistance reversal in Candida albicans by combining dihydroartemisinin with fluconazole.
Future microbiology.
2021 05; 16(?):461-469. doi:
10.2217/fmb-2020-0148. [PMID: 33960815] - Yan Chen, Tingjun Tao, Weiliang Wang, Botao Yang, Xushan Cha. Dihydroartemisinin attenuated the symptoms of mice model of systemic lupus erythematosus by restoring the Treg/Th17 balance.
Clinical and experimental pharmacology & physiology.
2021 04; 48(4):626-633. doi:
10.1111/1440-1681.13461. [PMID: 33469936] - Fengyun Dong, Xinghai Zhao, Jianning Wang, Xin Huang, Xiao Li, Liang Zhang, Haixin Dong, Fuhong Liu, Mengge Fan. Dihydroartemisinin inhibits the expression of von Willebrand factor by downregulation of transcription factor ERG in endothelial cells.
Fundamental & clinical pharmacology.
2021 Apr; 35(2):321-330. doi:
10.1111/fcp.12622. [PMID: 33107067] - Xiaoyuan Wang, Junpeng Wu, Haiyang Zhang, Bei Sun, Renping Huang. Dihydroartemisinin ameliorates balloon injury-induced neointimal formation through suppressing autophagy in vascular smooth muscle cells.
Biological chemistry.
2021 03; 402(4):451-460. doi:
10.1515/hsz-2020-0233. [PMID: 33938177] - Ryan Arey, Brad Reisfeld. Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling.
Antimicrobial agents and chemotherapy.
2021 02; 65(3):. doi:
10.1128/aac.02280-20. [PMID: 33361307] - Nathalia Grazzia, Sinésio Boaventura, Vera Lucia Garcia, Fernanda R Gadelha, Danilo C Miguel. Dihydroartemisinin, an active metabolite of artemisinin, interferes with Leishmania braziliensis mitochondrial bioenergetics and survival.
Parasitology research.
2021 Feb; 120(2):705-713. doi:
10.1007/s00436-020-07019-1. [PMID: 33415404] - Qiong Luo, Suyun Zhang, Donghuan Zhang, Rui Feng, Nan Li, Wujin Chen, Xiangqi Chen, Sheng Yang. Effects and Mechanisms of Anlotinib and Dihydroartemisinin Combination Therapy in Ameliorating Malignant Biological Behavior of Gastric Cancer Cells.
Current pharmaceutical biotechnology.
2021; 22(4):523-533. doi:
10.2174/1389201021666200623132803. [PMID: 32576126] - Liqing Chai, Rongrong Wang, Yan Wang, Wenju Guo, Ning Li, Hengtong Zuo, Yidan Wang, Danyu Duan, Guolian Ren, Bin Zheng, Ruili Wang, Shuqiu Zhang. Auto-Induction of Intestinal First-Pass Effect Related Time-Dependent Pharmacokinetics of Artemisinin Rather than Dihydroartemisinin.
Journal of pharmaceutical sciences.
2021 01; 110(1):458-466. doi:
10.1016/j.xphs.2020.09.023. [PMID: 32976901] - Ying Su, Danli Zhao, Chun Jin, Zhanghao Li, Sumin Sun, Siwei Xia, Yuxin Zhang, Zili Zhang, Feng Zhang, Xuefen Xu, Jiangjuan Shao, Biyun Zhang, Shizhong Zheng. Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO.
Oxidative medicine and cellular longevity.
2021; 2021(?):3456725. doi:
10.1155/2021/3456725. [PMID: 34925691] - Junying Gao, Fengqiu Ma, Xingjie Wang, Guorong Li. Combination of dihydroartemisinin and resveratrol effectively inhibits cancer cell migration via regulation of the DLC1/TCTP/Cdc42 pathway.
Food & function.
2020 Nov; 11(11):9573-9584. doi:
10.1039/d0fo00996b. [PMID: 33150340] - Huanhuan Wang, Xueting Yao, Teng Wang, Shuai Yan, Ji Jiang, Fengchun Zhang, Junfeng Liu, Duo Gao, Zhanguo Ma, Qian Zhao, Dongyang Liu, Pei Hu. Application of LC-MS/MS method for determination of dihydroartemisin in human plasma in a pharmacokinetic study.
Bioanalysis.
2020 Nov; 12(22):1635-1646. doi:
10.4155/bio-2020-0224. [PMID: 33118839] - Zhan Min-Xia, D U Wei, L I Heng-Hua, Luo Jin-Ping, Mei Xiao-Li, T U Ru-Xia, Zhang Li. [Effects of combination of dihydroartemisinin and Huobahua on expression of p-p38 MAPK and ICAM-1 in mice with delayed-type hypersensitivity].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Nov; 45(22):5561-5566. doi:
10.19540/j.cnki.cjcmm.20200708.401. [PMID: 33350219] - Rongji Ma, Wenjuan Qin, Yuanmao Xie, Ziwei Han, Shuojie Li, Yufeng Jiang, Hailong Lv. Dihydroartemisinin induces ER stress-dependent apoptosis of Echinococcus protoscoleces in vitro.
Acta biochimica et biophysica Sinica.
2020 Oct; 52(10):1140-1147. doi:
10.1093/abbs/gmaa101. [PMID: 33085744] - Bingqi Yang, Xueliang Gao, Yunchao Sun, Jianing Zhao, Jie Chen, Limin Gao, Li Zhao, Yongzhang Li. Dihydroartemisinin alleviates high glucose-induced vascular smooth muscle cells proliferation and inflammation by depressing the miR-376b-3p/KLF15 pathway.
Biochemical and biophysical research communications.
2020 09; 530(3):574-580. doi:
10.1016/j.bbrc.2020.07.095. [PMID: 32753318] - Rajabu Hussein Mnkugwe, Omary Minzi, Safari Kinung'hi, Appolinary Kamuhabwa, Eleni Aklillu. Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial.
PLoS neglected tropical diseases.
2020 09; 14(9):e0008619. doi:
10.1371/journal.pntd.0008619. [PMID: 32966290] - Yu Yu, Jingfeng Yu, Xiaosu Zou, Wei Xu, Jinghua Zhang, Hongzhu Bian, Xun Dong, Zhengwu Shen. Studies on the stereoselective synthesis and immunosuppressive activity of dihydroartemisinin-O-glycoside derivatives.
Bioorganic & medicinal chemistry letters.
2020 08; 30(16):127338. doi:
10.1016/j.bmcl.2020.127338. [PMID: 32631539] - Yanyan Liu, Yanhong Yang, Yuting Lei, Lanxiang Yang, Xueying Zhang, Jian Yuan, Zili Lei. Effects of dihydroartemisinin on the gut microbiome of mice.
Molecular medicine reports.
2020 08; 22(2):707-714. doi:
10.3892/mmr.2020.11165. [PMID: 32468008] - Zhi-Min Wang, Si-Wei Xia, Tian Zhang, Zhen-Yi Wang, Xiang Yang, Jun Kai, Xu-Dong Cheng, Jiang-Juan Shao, Shan-Zhong Tan, An-Ping Chen, Shi-Jun Wang, Feng Zhang, Zi-Li Zhang, Shi-Zhong Zheng. LncRNA-H19 induces hepatic stellate cell activation via upregulating alcohol dehydrogenase III-mediated retinoic acid signals.
International immunopharmacology.
2020 Jul; 84(?):106470. doi:
10.1016/j.intimp.2020.106470. [PMID: 32304991] - Zili Lei, Yanhong Yang, Shaomin Liu, Yuting Lei, Lanxiang Yang, Xueying Zhang, Wanwan Liu, Huijuan Wu, Changyuan Yang, Jiao Guo. Dihydroartemisinin ameliorates dextran sulfate sodium induced inflammatory bowel diseases in mice.
Bioorganic chemistry.
2020 07; 100(?):103915. doi:
10.1016/j.bioorg.2020.103915. [PMID: 32450383] - Renxin Yi, Handong Wang, Chulei Deng, Xinyue Wang, Lei Yao, Wenhao Niu, Maoxing Fei, Wangdui Zhaba. Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition.
Bioscience reports.
2020 06; 40(6):. doi:
10.1042/bsr20193314. [PMID: 32452511] - Ruiting Wu, Yan Gao, Jiaqin Wu, Chunli Wang, Li Yang. Semi-synthetic product dihydroartemisinin inhibited fibronectin-1 and integrin-β1 and interfered with the migration of HCCLM6 cells via PI3K-AKT pathway.
Biotechnology letters.
2020 Jun; 42(6):917-926. doi:
10.1007/s10529-020-02839-8. [PMID: 32072334] - Chunying Hou, Dongqing Guo, Xue Yu, Shuyan Wang, Tianhua Liu. TMT-based proteomics analysis of the anti-hepatocellular carcinoma effect of combined dihydroartemisinin and sorafenib.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Jun; 126(?):109862. doi:
10.1016/j.biopha.2020.109862. [PMID: 32120157] - Ting Zhang, Yiwei Zhang, Ning Jiang, Xu Zhao, Xiaoyu Sang, Na Yang, Ying Feng, Ran Chen, Qijun Chen. Dihydroartemisinin regulates the immune system by promotion of CD8+ T lymphocytes and suppression of B cell responses.
Science China. Life sciences.
2020 May; 63(5):737-749. doi:
10.1007/s11427-019-9550-4. [PMID: 31290095] - Zhong-Yuan Zheng, Li-Na Chen, Ting Yang, Hui Liu, Shui-Qing Qu, Yuan-Min Yang, Yu-Jie Li, Shu-Qiu Zhang. [Method for rapid synchronization of different growth cycles of Plasmodium falciparum in vitro and application in differential gene expression profile of 3D7 after dihydroartemisinin treatment].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 May; 45(10):2454-2463. doi:
10.19540/j.cnki.cjcmm.20191031.401. [PMID: 32495606] - Jittra Kornsakulkarn, Somporn Palasarn, Wilunda Choowong, Tienthong Thongpanchang, Nattawut Boonyuen, Rattaket Choeyklin, Thitiya Boonpratuang, Masahiko Isaka, Chawanee Thongpanchang. Antimalarial 9-Methoxystrobilurins, Oudemansins, and Related Polyketides from Cultures of Basidiomycete Favolaschia Species.
Journal of natural products.
2020 04; 83(4):905-917. doi:
10.1021/acs.jnatprod.9b00647. [PMID: 32193929] - Yuting Gao, Miaomiao Cui, Sijin Zhong, Chenyao Feng, Alexander Kenechukwu Nwobodo, Bin Chen, Yuanjian Song, Yulan Wang. Dihydroartemisinin ameliorates LPS-induced neuroinflammation by inhibiting the PI3K/AKT pathway.
Metabolic brain disease.
2020 04; 35(4):661-672. doi:
10.1007/s11011-020-00533-2. [PMID: 32152798] - Ming Xia, Di Liu, Xiaofang Tang, Yexin Liu, Haiyang Liu, Yu Liu, Guochun Chen, Hong Liu. Dihydroartemisinin inhibits the proliferation of IgAN mesangial cells through the mTOR signaling pathway.
International immunopharmacology.
2020 Mar; 80(?):106125. doi:
10.1016/j.intimp.2019.106125. [PMID: 31931362] - Sa'ad T Abdullahi, Julius O Soyinka, Adeniyi Olagunju, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Markus Winterberg, Joel Tarning, Andrew Owen, Saye Khoo. CYP2B6*6 Genotype Specific Differences in Artemether-Lumefantrine Disposition in Healthy Volunteers.
Journal of clinical pharmacology.
2020 03; 60(3):351-360. doi:
10.1002/jcph.1527. [PMID: 31549442] - Chu Xuan Anh, Marina Chavchich, Geoffrey W Birrell, Karin Van Breda, Thomas Travers, Kerryn Rowcliffe, Anton R Lord, G Dennis Shanks, Michael D Edstein. Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.01441-19. [PMID: 31907186]
