Pilocarpine Nitrate (BioDeep_00000407612)
Secondary id: BioDeep_00000395746
natural product PANOMIX_OTCML-2023
代谢物信息卡片
Pilocarpine Nitrate
化学式: C11H17N3O5 (271.1168152)
中文名称: 硝酸毛果芸香碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 2.86%
分子结构信息
SMILES: CCC1C(COC1=O)CC2=CN=CN2C.[N+](=O)(O)[O-]
InChI: /q
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
同义名列表
1 个代谢物同义名
数据库引用编号
22 个数据库交叉引用编号
- KEGGdrug: D05478
- PubChem: 657349
- ChEMBL: CHEMBL1213136
- MeSH: Pilocarpine
- CAS: 148-72-1
- MoNA: VF-NPL-LTQ007722
- MoNA: VF-NPL-LTQ007721
- MoNA: VF-NPL-QEHF027915
- MoNA: VF-NPL-QEHF027914
- MoNA: VF-NPL-QEHF027913
- MoNA: VF-NPL-QEHF027912
- MoNA: VF-NPL-QEHF027911
- MoNA: VF-NPL-QEHF027910
- MoNA: VF-NPL-QEHF027909
- MoNA: VF-NPL-QEHF027908
- MoNA: VF-NPL-QEHF027907
- MoNA: VF-NPL-QEHF027906
- MoNA: VF-NPL-QEHF027905
- MoNA: VF-NPL-QEHF027904
- MoNA: VF-NPL-QEHF027903
- MoNA: VF-NPL-QEHF027902
- MoNA: VF-NPL-QEHF027901
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Heba Fikry, Lobna A Saleh, Faten A Mahmoud, Sara Abdel Gawad, Hadwa Ali Abd-Alkhalek. CoQ10 targeted hippocampal ferroptosis in a status epilepticus rat model.
Cell and tissue research.
2024 Jun; 396(3):371-397. doi:
10.1007/s00441-024-03880-z. [PMID: 38499882] - Hanbing Xu, Yubo Wang, Congcong Yu, Chunhong Han, Huifei Cui. Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress.
ACS chemical neuroscience.
2024 May; 15(9):1937-1947. doi:
10.1021/acschemneuro.4c00188. [PMID: 38630556] - Riccardo Lorrai, Dario Cavaterra, Sara Giammaria, Diego Sbardella, Grazia Raffaella Tundo, Alessandra Boccaccini. Eye Diseases: When the Solution Comes from Plant Alkaloids.
Planta medica.
2024 May; 90(6):426-439. doi:
10.1055/a-2283-2350. [PMID: 38452806] - Karen Paola Ramos-Riera, Luis Beltrán-Parrazal, Consuelo Morgado-Valle, Francisca Pérez-Severiano, Pablo Eliasib Martínez-Gopar, María Leonor López-Meraz. Type 2 diabetes mellitus facilitates status epilepticus in adult rats: Seizure severity, neurodegeneration, and oxidative stress.
Epilepsia open.
2024 Apr; 9(2):665-678. doi:
10.1002/epi4.12905. [PMID: 38321819] - Letícia Meier, Estevan Bruginski, Joseane Righes Marafiga, Letícia Barbieri Caus, Mayara Vendramin Pasquetti, Maria Elisa Calcagnotto, Francinete Ramos Campos. Hippocampal metabolic profile during epileptogenesis in the pilocarpine model of epilepsy.
Biomedical chromatography : BMC.
2023 Dec; ?(?):e5820. doi:
10.1002/bmc.5820. [PMID: 38154955] - Eduardo Rivadeneyra-Domínguez, Isaac Zamora-Bello, Juan Manuel Castañeda-Morales, Joel Jahaziel Díaz-Vallejo, Óscar Rosales-Sánchez, Juan Francisco Rodríguez-Landa. The standardized extract of Centella asiatica L. Urb attenuates the convulsant effect induced by lithium/pilocarpine without affecting biochemical and haematological parameters in rats.
BMC complementary medicine and therapies.
2023 Sep; 23(1):343. doi:
10.1186/s12906-023-04179-2. [PMID: 37759286] - Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu. Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking.
International journal of molecular sciences.
2023 Apr; 24(8):. doi:
10.3390/ijms24087356. [PMID: 37108518] - Amira E El-Nahas, Heba M Elbedaiwy, Inas M Masoud, Rania G Aly, Maged W Helmy, Amal H El-Kamel. Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2023 Apr; ?(?):. doi:
10.1016/j.ejpb.2023.04.008. [PMID: 37068561] - Hushuai Fan, Xiaomin Huang, Ziru Zhang, Ting Wang, Ludan Wang, Yajun Zhang. Immobilization of M3 Muscarinic Receptor to Rapidly Analyze Drug-Protein Interactions and Bioactive Components in a Natural Plant.
International journal of molecular sciences.
2023 Apr; 24(8):. doi:
10.3390/ijms24087171. [PMID: 37108332] - Maxwell Blesdel Adassi, Gwladys Temkou Ngoupaye, Francis Bray Yassi, Aurelien Fossueh Foutsop, Tatiana Diebo Kom, Elisabeth Ngo Bum. Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity.
Journal of ethnopharmacology.
2023 Mar; 303(?):115995. doi:
10.1016/j.jep.2022.115995. [PMID: 36509255] - Supriya Sharma, Anil Kumar Rana, Shubham Nilkanth Rahmatkar, Vikram Patial, Damanpreet Singh. Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model.
Journal of ethnopharmacology.
2023 Feb; ?(?):116280. doi:
10.1016/j.jep.2023.116280. [PMID: 36813245] - Chang Yu Kan, Jing Xuan H'ng, Andy Goh, Frederick Smales, Eng Lai Tan, Shiming Zhang, Mallikarjuna Rao Pichika, Abhishek Parolia. Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice.
International dental journal.
2023 Feb; 73(1):63-70. doi:
10.1016/j.identj.2022.04.011. [PMID: 35725589] - Kenjirou Ogawa, Karin Urata, Saki Maeda, Yuta Ohno, Keitaro Satoh, Yoshiyuki Yamada, Yosuke Suzuki, Yasuko Koga, Kazuhiro Sugamoto, Makiko Kawaguchi, Hisato Kunitake, Kazuo Nishiyama, Y O Goto, Takayuki Nakayama, Masao Yamasaki. Blueberry Leaf Extract Prevents Lacrimal Hyposecretion in Sjögren's Syndrome-like Model of Non-obese Diabetic Mice.
In vivo (Athens, Greece).
2023 Jan; 37(1):149-162. doi:
10.21873/invivo.13064. [PMID: 36593026] - Michaela Shishmanova-Doseva, Katerina Georgieva, Yordanka Uzunova, Lyubka Ioanidu, Milena Atanasova, Zlatina Nenchovska, Jana Tchekalarova. Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences.
International journal of molecular sciences.
2022 Oct; 23(21):. doi:
10.3390/ijms232113188. [PMID: 36361978] - Isaac Zamora-Bello, Eduardo Rivadeneyra-Domínguez, Juan Francisco Rodríguez-Landa. Anticonvulsant Effect of Turmeric and Resveratrol in Lithium/Pilocarpine-Induced Status Epilepticus in Wistar Rats.
Molecules (Basel, Switzerland).
2022 Jun; 27(12):. doi:
10.3390/molecules27123835. [PMID: 35744955] - Michele Pereira Mallmann, Fernanda Kulinski Mello, Bruna Neuberger, Karine Gabriela da Costa Sobral, Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, Mauro Schneider Oliveira. Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats.
Brain research.
2022 06; 1784(?):147883. doi:
10.1016/j.brainres.2022.147883. [PMID: 35300975] - Jian-Bo Lin, Nan-Long Lin, Xu Li, Ming-Qiang Kang. Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis.
Annals of clinical and translational neurology.
2022 06; 9(6):786-794. doi:
10.1002/acn3.51558. [PMID: 35393764] - Marwa M Nagib, Sicheng Zhang, Nelufar Yasmen, Lexiao Li, Ruida Hou, Ying Yu, Vijay K Boda, Zhongzhi Wu, Wei Li, Jianxiong Jiang. Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.
Epilepsia.
2022 04; 63(4):1003-1015. doi:
10.1111/epi.17190. [PMID: 35179226] - Wei Yang, Lijuan He. The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor.
Bioengineered.
2022 04; 13(4):8689-8698. doi:
10.1080/21655979.2022.2054596. [PMID: 35322725] - Simon Pale, Sidiki Neteydji, Germain Sotoing Taiwe, Nadège Kouemou Emegam, Elisabeth Ngo Bum. Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine.
Journal of ethnopharmacology.
2022 Mar; 286(?):114863. doi:
10.1016/j.jep.2021.114863. [PMID: 34838617] - Inas A Harb, Hend Ashour, Abeer Mostafa, Hala M El Hanbuli, Eman Hassan Nadwa. Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction.
Clinical and experimental pharmacology & physiology.
2022 03; 49(3):406-418. doi:
10.1111/1440-1681.13615. [PMID: 34796981] - Hagar N Abd Allah, Manal Abdul-Hamid, Ayman M Mahmoud, Eman S Abdel-Reheim. Melissa officinalis L. ameliorates oxidative stress and inflammation and upregulates Nrf2/HO-1 signaling in the hippocampus of pilocarpine-induced rats.
Environmental science and pollution research international.
2022 Jan; 29(2):2214-2226. doi:
10.1007/s11356-021-15825-y. [PMID: 34363578] - Akiko Tanaka, Hiroyuki Nakano, Kunio Yoneto, Chika Yoneto, Tomoyuki Furubayashi, Kei Suzuki, Azusa Okae, Takaaki Ueno, Toshiyasu Sakane. Topical Xerostomia Treatment with Hyaluronate Sheets Containing Pilocarpine.
Biological & pharmaceutical bulletin.
2022; 45(4):403-408. doi:
10.1248/bpb.b21-00763. [PMID: 35370264] - Peng Wang, Kang Ma, Lu Yang, Guodong Zhang, Mengyi Ye, Siqi Wang, Shuangshuang Wei, Zhangping Chen, Jinghai Gu, Lianxiang Zhang, Jianguo Niu, Sun Tao. Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study.
International journal of biological macromolecules.
2021 Dec; 193(Pt B):1457-1470. doi:
10.1016/j.ijbiomac.2021.10.209. [PMID: 34742844] - Tao Xiang, Xiaodan Luo, Chunmei Zeng, Sijun Li, Meigang Ma, Yuan Wu. Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis.
Brain research.
2021 12; 1772(?):147668. doi:
10.1016/j.brainres.2021.147668. [PMID: 34592245] - You Wang, Jinxian Yuan, Xinyuan Yu, Xi Liu, Changhong Tan, Yangmei Chen, Tao Xu. Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
Cell death & disease.
2021 10; 12(10):936. doi:
10.1038/s41419-021-04233-2. [PMID: 34642320] - Huifang Cao, Lichao Zhang, Zhenzhen Qu, Shuang Tian, Zhiyong Wang, Yuhang Jiang, Qian Hou, Lijing Jia, Weiping Wang. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus.
Brain research.
2021 08; 1764(?):147468. doi:
10.1016/j.brainres.2021.147468. [PMID: 33831409] - Michaela Shishmanova-Doseva, Dimitrinka Atanasova, Yordanka Uzunova, Lyubka Yoanidu, Lyudmil Peychev, Pencho Marinov, Jana Tchekalarova. Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094667. [PMID: 33925082] - Shuaishuai Xia, Ping Yang, Feng Li, Qian Yu, Weiping Kuang, Yong Zhu, Jun Lu, Huaying Wu, Liang Li, Huiyong Huang. Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons.
Journal of ethnopharmacology.
2021 Apr; 270(?):113794. doi:
10.1016/j.jep.2021.113794. [PMID: 33422654] - Chih-Sheng Yang, Sheng-Chun Chiu, Ping-Yen Liu, Sheng-Nan Wu, Ming-Chi Lai, Chin-Wei Huang. Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission.
Journal of ethnopharmacology.
2021 Apr; 269(?):113751. doi:
10.1016/j.jep.2020.113751. [PMID: 33359863] - Philip Hampel, Kerstin Römermann, Björn Gailus, Marie Johne, Birthe Gericke, Edith Kaczmarek, Wolfgang Löscher. Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Neuropharmacology.
2021 03; 185(?):108449. doi:
10.1016/j.neuropharm.2021.108449. [PMID: 33450274] - Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Emmanuel Awintiig Adakudugu, Daniel Anokwah, Lovia Serwaa Agyemang, Eric Woode, Elvis Ofori Ameyaw. The Anticonvulsant Effect of Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae).
Neural plasticity.
2021; 2021(?):5566890. doi:
10.1155/2021/5566890. [PMID: 34257639] - Aziza Rashed Al-Rafiah, Khlood Mohammed Mehdar. Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy.
Behavioural neurology.
2021; 2021(?):5549638. doi:
10.1155/2021/5549638. [PMID: 34149964] - Gary P Brennan, Sebastian Bauer, Tobias Engel, Eva M Jimenez-Mateos, Federico Del Gallo, Thomas D M Hill, Niamh M C Connolly, Lara S Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R Reschke, Norman Delanty, Jochen H M Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C Henshall. Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Neurobiology of disease.
2020 10; 144(?):105048. doi:
10.1016/j.nbd.2020.105048. [PMID: 32800995] - Ping Yang, You Qin, Yong Zhu, Feng Li, Shuai-Shuai Xia, Bin Zhou, Qin Wang, Jun Lu, Liang Li, Hui-Yong Huang. Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons.
Journal of ethnopharmacology.
2020 Sep; 259(?):112990. doi:
10.1016/j.jep.2020.112990. [PMID: 32442588] - Pedro Everson Alexandre de Aquino, Jéssica Rabelo Bezerra, Tyciane de Souza Nascimento, Juliete Tavares, Ítalo Rosal Lustosa, Adriano José Maia Chaves Filho, Melina Mottin, Danielle Macêdo Gaspar, Geanne Matos de Andrade, Kelly Rose Tavares Neves, Giuseppe Biagini, Edilberto Rocha Silveira, Glauce Socorro de Barros Viana. A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice.
International journal of molecular sciences.
2020 Jun; 21(11):. doi:
10.3390/ijms21114188. [PMID: 32545390] - Yanrong Zhang, Haiyan Zhou, Haibo Qu, Chengde Liao, Hong Jiang, Siqin Huang, Sara Natasha Ghobadi, Arsenii Telichko, Ningrui Li, Frezghi G Habte, Tim Doyle, James P Woznak, Edward H Bertram, Kevin S Lee, Max Wintermark. Effects of Non-invasive, Targeted, Neuronal Lesions on Seizures in a Mouse Model of Temporal Lobe Epilepsy.
Ultrasound in medicine & biology.
2020 05; 46(5):1224-1234. doi:
10.1016/j.ultrasmedbio.2020.01.008. [PMID: 32081583] - Chu-Xin Deng, Zhi-Bing Wu, Yi Chen, Zheng-Miao Yu. Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats.
Chinese journal of integrative medicine.
2020 Feb; 26(2):138-145. doi:
10.1007/s11655-019-2944-7. [PMID: 31093879] - G Smilin Bell Aseervatham, E Abbirami, T Sivasudha, K Ruckmani. Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice.
Metabolic brain disease.
2020 01; 35(1):159-173. doi:
10.1007/s11011-019-00501-5. [PMID: 31728889] - Florencia Chena-Becerra, Genaro Alfonso Coria-Avila, Luis Beltrán-Parrazal, Jorge Manzo, María Leonor López-Meraz. Long-term effects of status epilepticus during infancy in male rats: Sexual behavior and brain response upon exposure to sexually receptive females.
Epilepsy & behavior : E&B.
2020 01; 102(?):106676. doi:
10.1016/j.yebeh.2019.106676. [PMID: 31756620] - Chung-Yuan Hsu, Kuo-Chun Hung, Ming-Shyan Lin, Chi-Hua Ko, Yu-Sheng Lin, Tien-Hsing Chen, Chun-Yu Lin, Ying-Chou Chen. The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study.
Arthritis research & therapy.
2019 11; 21(1):251. doi:
10.1186/s13075-019-2031-7. [PMID: 31775834] - Teruhiro Fujii, Kentaro Kawasoe, Yuki Nishizawa, Jumpei Kashima, Akiko Tonooka, Akihito Ohta, Kosaku Nitta. A suspected case of drug-induced tubulointerstitial nephritis by pilocarpine hydrochloride.
CEN case reports.
2019 11; 8(4):246-251. doi:
10.1007/s13730-019-00401-8. [PMID: 31077057] - Mahin Ganjkhani, Saeed Nourozi, Reza Bigonah, Ali Rostami, Saeed Shokri. Ameliorating impacts of ginseng on the apoptosis of spermatogenic cells and sperm quality in temporal lobe epilepsy rat model treated with valproate.
Andrologia.
2019 Oct; 51(9):e13348. doi:
10.1111/and.13348. [PMID: 31243795] - Arpita Konar, Richa Gupta, Rajendra K Shukla, Bryan Maloney, Vinay K Khanna, Renu Wadhwa, Debomoy K Lahiri, Mahendra K Thakur. M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera.
Scientific reports.
2019 Sep; 9(1):13990. doi:
10.1038/s41598-019-48238-6. [PMID: 31570736] - Gerard Lee See, Ayano Sagesaka, Hiroaki Todo, Konstanty Wierzba, Kenji Sugibayashi. Pharmacokinetics and Tissue Distribution of Pilocarpine After Application to Eyelid Skin of Rats.
Journal of pharmaceutical sciences.
2019 09; 108(9):2942-2948. doi:
10.1016/j.xphs.2019.04.012. [PMID: 31002809] - Fatemeh Ebrahimi, Seyed Shahabeddin Sadr, Mehrdad Roghani, Safoura Khamse, Saeed Mohammadian Haftcheshmeh, Mojdeh Navid Hamidi, Parvaneh Mohseni-Moghaddam, Elham Zamani. Assessment of the protective effect of KN-93 drug in systemic epilepsy disorders induced by pilocarpine in male rat.
Journal of cellular biochemistry.
2019 09; 120(9):15906-15914. doi:
10.1002/jcb.28864. [PMID: 31074121] - Wenjing Tu, Sheng Qian. Anti-epileptic effect of 16-O-acetyldigitoxigenin via suppressing mTOR signaling pathway.
Cellular and molecular biology (Noisy-le-Grand, France).
2019 Jun; 65(5):59-63. doi:
10.14715/cmb/2019.65.5.10. [PMID: 31304908] - Mahshid Hosseinzadeh, Hamid Gholami Pourbadie, Fariba Khodagholi, Mahtab Daftari, Nima Naderi, Fereshteh Motamedi. Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy.
Neuroscience.
2019 06; 408(?):388-399. doi:
10.1016/j.neuroscience.2019.04.020. [PMID: 31026566] - Ya-Jun Li, Lin Wang, Bei Zhang, Fei Gao, Chun-Mei Yang. Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus.
The Journal of pharmacy and pharmacology.
2019 Mar; 71(3):390-399. doi:
10.1111/jphp.13040. [PMID: 30417405] - Xiao Hu, Jun Tang, Xiaofang Lan, Xiujuan Mi. Increased expression of DOC2A in human and rat temporal lobe epilepsy.
Epilepsy research.
2019 03; 151(?):78-84. doi:
10.1016/j.eplepsyres.2019.02.008. [PMID: 30844661] - Romildo de Albuquerque Nogueira, Daniella Tavares Pessoa, Eva Luana Almeida da Silva, Edbhergue Ventura Lola Costa. Can a hypercholesterolemic diet change the basal brain electrical activity and during status epilepticus in rats?.
Metabolic brain disease.
2019 02; 34(1):71-77. doi:
10.1007/s11011-018-0321-4. [PMID: 30259296] - Talita Matias Barbosa Cavalcante, José de Maria Albuquerque De Melo, Lia Bastos Lopes, Matheus Costa Bessa, Jéssica Gurgel Santos, Luna Costa Vasconcelos, Antônio Eufrásio Vieira Neto, Lucas Teixeira Nunes Borges, Marta Maria França Fonteles, Adriano José Maia Chaves Filho, Danielle Macêdo, Adriana Rolim Campos, Carlos Clayton Torres Aguiar, Silvânia Maria Mendes Vasconcelos. Ivabradine possesses anticonvulsant and neuroprotective action in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):2499-2512. doi:
10.1016/j.biopha.2018.11.096. [PMID: 30551511] - Hadas Han, Sara Eyal, Emma Portnoy, Aniv Mann, Miriam Shmuel, Mony Benifla, Dana Ekstein, Boris Polyak. Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain.
Current drug delivery.
2019; 16(7):637-644. doi:
10.2174/1567201816666190619122456. [PMID: 31237208] - Hongmei Dai, Peipei Wang, Huafang Mao, Xiao Mao, Shan Tan, Zhiheng Chen. Dynorphin activation of kappa opioid receptor protects against epilepsy and seizure-induced brain injury via PI3K/Akt/Nrf2/HO-1 pathway.
Cell cycle (Georgetown, Tex.).
2019 01; 18(2):226-237. doi:
10.1080/15384101.2018.1562286. [PMID: 30595095] - Supriya Sharma, Arindam G Mazumder, Anil K Rana, Vikram Patial, Damanpreet Singh. Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management.
CNS & neurological disorders drug targets.
2019; 18(7):555-565. doi:
10.2174/1871527318666190801112027. [PMID: 31368880] - Erkut Baha Bulduk, Gokhan Kurt, Sureyya Barun, Onder Aydemir, Murat Kiziltas, Murat Oktem, Turan Turhan, Pergin Atilla, Sevda Muftuoglu. The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level.
Turkish neurosurgery.
2019; 29(1):95-105. doi:
10.5137/1019-5149.jtn.22744-18.1. [PMID: 30614506] - Fang Zhao, Jia Lu, Xin Jin, Ze Wang, Yinghui Sun, Dandan Gao, Xinyu Li, Rui Liu. Comparison of response surface methodology and artificial neural network to optimize novel ophthalmic flexible nano-liposomes: Characterization, evaluation, in vivo pharmacokinetics and molecular dynamics simulation.
Colloids and surfaces. B, Biointerfaces.
2018 Dec; 172(?):288-297. doi:
10.1016/j.colsurfb.2018.08.046. [PMID: 30173096] - Edilene Gadelha de Oliveira, Aline Marquez Cardoso, Karina Paese, Karine Coradini, Clarissa Vasconcelos de Oliveira, Adriana Raffin Pohlmann, Mauro Schneider Oliveira, Sílvia Stanisçuaski Guterres, Ruy Carlos Ruver Beck. Reconstituted spray-dried phenytoin-loaded nanocapsules improve the in vivo phenytoin anticonvulsant effect and the survival time in mice.
International journal of pharmaceutics.
2018 Nov; 551(1-2):121-132. doi:
10.1016/j.ijpharm.2018.09.023. [PMID: 30218826] - Nikita Nirwan, Fouzia Siraj, Divya Vohora. Inverted-U response of lacosamide on pilocarpine-induced status epilepticus and oxidative stress in C57BL/6 mice is independent of hippocampal collapsin response mediator protein-2.
Epilepsy research.
2018 09; 145(?):93-101. doi:
10.1016/j.eplepsyres.2018.06.009. [PMID: 29935443] - Rosângela Figueiredo Mendes-da-Silva, Elian da Silva Francisco, Rubem Carlos Araújo Guedes. Pilocarpine/ascorbic acid interaction in the immature brain: Electrophysiological and oxidative effects in well-nourished and malnourished rats.
Brain research bulletin.
2018 09; 142(?):414-421. doi:
10.1016/j.brainresbull.2018.09.008. [PMID: 30232044] - Haifeng Zhang, Yajun Lian, Nanchang Xie, Yake Zheng. Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2018 08; 96(4):468-474. doi:
10.1139/bcb-2017-0102. [PMID: 29365285] - Fei Gao, Ying Gao, Fangling Meng, Chunmei Yang, Jiangfeng Fu, Yajun Li. The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus.
Basic & clinical pharmacology & toxicology.
2018 Jul; 123(1):14-20. doi:
10.1111/bcpt.12973. [PMID: 29380527] - O O Olawoye, T Ogunleye, T F Sarimiye, T O Bello. Acute angle closure following hemodialysis in a 34-year-old Nigerian female.
Nigerian journal of clinical practice.
2018 Jul; 21(7):942-944. doi:
10.4103/njcp.njcp_358_17. [PMID: 29984730] - Suianny Nayara da Silva Chaves, Gabriel Rocha Felício, Bruna Patrícia Dutra Costa, Witallo Etevaldo Araújo de Oliveira, Monica Gomes Lima-Maximino, Diógenes Henrique de Siqueira Silva, Caio Maximino. Behavioral and biochemical effects of ethanol withdrawal in zebrafish.
Pharmacology, biochemistry, and behavior.
2018 06; 169(?):48-58. doi:
10.1016/j.pbb.2018.04.006. [PMID: 29689295] - Marion Bankstahl, Heike Breuer, Ina Leiter, Martin Märkel, Pablo Bascuñana, Dominik Michalski, Frank M Bengel, Wolfgang Löscher, Martin Meier, Jens P Bankstahl, Wolfgang Härtig. Blood-Brain Barrier Leakage during Early Epileptogenesis Is Associated with Rapid Remodeling of the Neurovascular Unit.
eNeuro.
2018 May; 5(3):. doi:
10.1523/eneuro.0123-18.2018. [PMID: 29854942] - S L Souza, G Graça, A Oliva. Characterization of sweat induced with pilocarpine, physical exercise, and collected passively by metabolomic analysis.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2018 May; 24(2):187-195. doi:
10.1111/srt.12412. [PMID: 29131416] - Aniv Mann, Emma Portnoy, Hadas Han, Dorrit Inbar, Dana Blatch, Miriam Shmuel, Tamir Ben-Hur, Sara Eyal, Dana Ekstein. Folate homeostasis in epileptic rats.
Epilepsy research.
2018 05; 142(?):64-72. doi:
10.1016/j.eplepsyres.2018.03.014. [PMID: 29571151] - Mayara Lütchemeyer de Freitas, Clarissa Vasconcelos de Oliveira, Fernanda Kulinski Mello, Vinícius Rafael Funck, Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, James W Larrick, Mauro Schneider Oliveira. Na+, K+-ATPase Activating Antibody Displays in vitro and in vivo Beneficial Effects in the Pilocarpine Model of Epilepsy.
Neuroscience.
2018 05; 377(?):98-104. doi:
10.1016/j.neuroscience.2018.02.044. [PMID: 29522855] - Liu Bo-Qiang, Zhang Si-Tong, Lin Zu-Yuan, Nie Wan-Yun, Chen Bin, Lu Yuan, Li Xuyun, Mao Liangen, Chen You-Chao, Yin Xin-Zhen, Chen Zhong, Ying Xiao-Ying, Hu Wei-Wei. Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice.
Die Pharmazie.
2018 04; 73(4):207-212. doi:
10.1691/ph.2018.7310. [PMID: 29609687] - Yasser A Khadrawy, Hussein G Sawie, Eman N Hosny. Neuroprotective effect of curcumin nanoparticles against rat model of status epilepticus induced by pilocarpine.
Journal of complementary & integrative medicine.
2018 Mar; 15(3):. doi:
10.1515/jcim-2017-0117. [PMID: 29570450] - Gisele Claudine Nkamguie Nkantchoua, Jacqueline Stephanie Kameni Njapdounke, Jean Jules Fifen, Germain Sotoing Taiwe, Lucie Josiane Ojong, Antoine Kavaye Kandeda, Elisabeth Ngo Bum. Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Journal of ethnopharmacology.
2018 Feb; 212(?):18-28. doi:
10.1016/j.jep.2017.09.042. [PMID: 28986332] - Isabelle T Melo, Elisabete M Rêgo, Nassib B Bueno, Tâmara C Gomes, Suzana L Oliveira, Euclides M Trindade-Filho, Cyro R Cabral, Tacy S Machado, Jaqueline A Galvão, Terezinha R Ataide. Ketogenic Diet Based on Extra Virgin Coconut Oil Has No Effects in Young Wistar Rats With Pilocarpine-Induced Epilepsy.
Lipids.
2018 02; 53(2):251-254. doi:
10.1002/lipd.12019. [PMID: 29570799] - Youssef Bahbiti, Hammou Ammouri, Inssaf Berkiks, Aboubaker El Hessni, Ali Ouichou, Redouan Nakache, Miloud Chakit, Leila Bikjdaouene, Abdelhalem Mesfioui. Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats.
Nutritional neuroscience.
2018 Feb; 21(2):116-122. doi:
10.1080/1028415x.2016.1228492. [PMID: 27617842] - Kah Ni Tan, David Simmons, Catalina Carrasco-Pozo, Karin Borges. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration.
Journal of neurochemistry.
2018 02; 144(4):431-442. doi:
10.1111/jnc.14275. [PMID: 29222946] - Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang. Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 46(1):160-177. doi:
10.1159/000488419. [PMID: 29587280] - Wan-Hui Lin, Xiao-Feng Li, Ming-Xing Lin, Ying Zhou, Hua-Pin Huang. Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats.
Molecular medicine reports.
2017 Dec; 16(6):8245-8252. doi:
10.3892/mmr.2017.7659. [PMID: 28983622] - Xiangchang Zeng, Siyu Chen, Qing Gao, Wenjing Zong, Dejian Jiang, Guirong Zeng, Luping Zhou, Lulu Chen, Wei Luo, Jian Xiao, Bo Xiao, Dongsheng Ouyang, Kai Hu. The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.
Epilepsy research.
2017 12; 138(?):62-70. doi:
10.1016/j.eplepsyres.2017.10.011. [PMID: 29080472] - Alexey N Pronin, Qiang Wang, Vladlen Z Slepak. Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor.
Molecular pharmacology.
2017 11; 92(5):601-612. doi:
10.1124/mol.117.109678. [PMID: 28893976] - Daniella Tavares Pessoa, Eva Luana Almeida da Silva, Edbhergue Ventura Lola Costa, Romildo Albuquerque Nogueira. Effect of diet with omega-3 in basal brain electrical activity and during status epilepticus in rats.
Epilepsy research.
2017 11; 137(?):33-38. doi:
10.1016/j.eplepsyres.2017.08.014. [PMID: 28892741] - Víctor Danelon, Laura Montroull, Mariana Vallejo, José Cabrera, Alicia Agnese, María Gabriela Ortega, Daniel Mascó. An alkaloid extract obtained from Phlegmariurus Saururus induces neuroprotection after status epilepticus.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2017 Oct; 34(?):212-218. doi:
10.1016/j.phymed.2017.05.010. [PMID: 28899505] - Adriana Fernanda K Vizuete, Matheus Mittmann Hennemann, Carlos Alberto Gonçalves, Diogo Losch de Oliveira. Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats.
Neurochemical research.
2017 Oct; 42(10):2730-2742. doi:
10.1007/s11064-017-2276-y. [PMID: 28444637] - Amal M Mahfoz, Ali F Abdel-Wahab, Mohamed A Afify, Naiyer Shahzad, Ibrahim A A Ibrahim, Naser A ElSawy, Ghazi A Bamagous, Saeed S Al Ghamdi. Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Oct; 390(10):977-985. doi:
10.1007/s00210-017-1400-5. [PMID: 28687854] - Qianyun Cai, Jing Gan, Rong Luo, Yi Qu, Shiping Li, Chaomin Wan, Dezhi Mu. The role of necroptosis in status epilepticus-induced brain injury in juvenile rats.
Epilepsy & behavior : E&B.
2017 10; 75(?):134-142. doi:
10.1016/j.yebeh.2017.05.025. [PMID: 28863321] - Alexandra Robciuc, Joanna Witos, Suvi-Katriina Ruokonen, Antti H Rantamäki, Pierre-Jean Pisella, Susanne K Wiedmer, Juha M Holopainen. Pure Glaucoma Drugs Are Toxic to Immortalized Human Corneal Epithelial Cells, but They Do Not Destabilize Lipid Membranes.
Cornea.
2017 Oct; 36(10):1249-1255. doi:
10.1097/ico.0000000000001322. [PMID: 28825921] - Donato Vairo, Laurie Bruzzese, Marion Marlinge, Lea Fuster, Nabil Adjriou, Nathalie Kipson, Philippe Brunet, Jennifer Cautela, Yves Jammes, Giovanna Mottola, Stephane Burtey, Jean Ruf, Regis Guieu, Emmanuel Fenouillet. Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration.
Scientific reports.
2017 09; 7(1):11801. doi:
10.1038/s41598-017-12211-y. [PMID: 28924220] - Philip Riley, Anne-Marie Glenny, Fang Hua, Helen V Worthington. Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy.
The Cochrane database of systematic reviews.
2017 07; 7(?):CD012744. doi:
10.1002/14651858.cd012744. [PMID: 28759701] - Pascal Lösing, Cristina Elena Niturad, Merle Harrer, Christopher Meyer Zu Reckendorf, Theresa Schatz, Daniela Sinske, Holger Lerche, Snezana Maljevic, Bernd Knöll. SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model.
Molecular brain.
2017 07; 10(1):30. doi:
10.1186/s13041-017-0310-2. [PMID: 28716058] - Yi Zhang, Wendy R Kam, Yang Liu, Xiaomin Chen, David A Sullivan. Influence of Pilocarpine and Timolol on Human Meibomian Gland Epithelial Cells.
Cornea.
2017 Jun; 36(6):719-724. doi:
10.1097/ico.0000000000001181. [PMID: 28476050] - Arindam Ghosh Mazumder, Pallavi Sharma, Vikram Patial, Damanpreet Singh. Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation.
Journal of ethnopharmacology.
2017 May; 204(?):8-17. doi:
10.1016/j.jep.2017.03.060. [PMID: 28390940] - Min Xu, Peng Sun, Ying Zhang, Ci-Hang Yang, Xin Wei, Xiao-Xia Ma, Chong-Ren Yang, Kun-Ming Ni, Ying-Jun Zhang, Xiao-Ming Li. DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Scientific reports.
2017 05; 7(1):1701. doi:
10.1038/s41598-017-01734-z. [PMID: 28490750] - Priscilla Kolibea Mante, Donatus Wewura Adongo, Eric Woode. Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
BMC research notes.
2017 Apr; 10(1):167. doi:
10.1186/s13104-017-2488-x. [PMID: 28446201] - J Yankam Njiwa, N Costes, C Bouillot, S Bouvard, S Fieux, G Becker, E Levigoureux, G Kocevar, C Stamile, J B Langlois, R Bolbos, C Bonnet, L Bezin, L Zimmer, A Hammers. Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-( R)-PK11195 PET and MRI.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2017 Apr; 37(4):1251-1263. doi:
10.1177/0271678x16653615. [PMID: 27381824] - Jennifer N Pearson, Eric Warren, Li-Ping Liang, L Jackson Roberts, Manisha Patel. Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Neurobiology of disease.
2017 Feb; 98(?):88-99. doi:
10.1016/j.nbd.2016.11.011. [PMID: 27932305] - Qiong Luo, Zhen Ren, Linlin Zhu, Yiye Shao, Yangmei Xie, Yonghao Feng, Bing Li, Yinghui Chen. Involvement of microRNA-146a in the Inflammatory Response of S tatus Epilepticus Rats.
CNS & neurological disorders drug targets.
2017; 16(6):686-693. doi:
10.2174/1871527316666170505123956. [PMID: 28474544] - David Fernandes Lima, Luiza Ianny de Lima, Jefferson Almeida Rocha, Ivanilza Moreira de Andrade, Liliana Gonçalves Grazina, Caterina Villa, Liliana Meira, Leiz Maria Costa Véras, Iábita Fabiana Sousa Azevedo, Adriele Giaretta Biase, Joana Costa, Maria Beatriz P P Oliveira, Isabel Mafra, José Roberto de Souza de Almeida Leite. Seasonal change in main alkaloids of jaborandi (Pilocarpus microphyllus Stapf ex Wardleworth), an economically important species from the Brazilian flora.
PloS one.
2017; 12(2):e0170281. doi:
10.1371/journal.pone.0170281. [PMID: 28151972] - V B Karyakin, D S Vasil'ev, I A Zhuravin, A V Zaitsev, L G Magazanik. Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections.
2017 Jan; 472(1):4-7. doi:
10.1134/s0012496617010045. [PMID: 28429259] - Shu Kikuta, Yu Matsumoto, Akihito Kuboki, Tsuguhisa Nakayama, Daiya Asaka, Nobuyoshi Otori, Hiromi Kojima, Takashi Sakamoto, Kashio Akinori, Kaori Kanaya, Rumi Ueha, Ryoji Kagoya, Hironobu Nishijima, Makiko Toma-Hirano, Yayoi Kikkawa, Kenji Kondo, Koichi Tsunoda, Tempei Miyaji, Takuhiro Yamaguchi, Kazunori Kataoka, Kensaku Mori, Tatsuya Yamasoba. Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder.
Scientific reports.
2016 10; 6(?):35361. doi:
10.1038/srep35361. [PMID: 27734933] - G Smilin Bell Aseervatham, U Suryakala, Doulethunisha, S Sundaram, P Chandra Bose, T Sivasudha. Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Aug; 82(?):54-64. doi:
10.1016/j.biopha.2016.04.066. [PMID: 27470339] - Ziyan Fang, Shuda Chen, Jiaming Qin, Bao Chen, Guanzhong Ni, Ziyi Chen, Jueqian Zhou, Ze Li, Yuping Ning, Chuanbin Wu, Liemin Zhou. Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.
Biomaterials.
2016 08; 97(?):110-21. doi:
10.1016/j.biomaterials.2016.04.021. [PMID: 27162079]