Physostigmine salicylate (BioDeep_00000407611)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

Physostigmine salicylate

化学式: C22H27N3O5 (413.19506120000005)
中文名称: 水杨酸毒扁豆碱
谱图信息: 最多检出来源 Viridiplantae(plant) 86.24%

分子结构信息

SMILES: CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.C1=CC=C(C(=C1)C(=O)O)O
InChI: /m1./s1

描述信息

C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4].

同义名列表

3 个代谢物同义名

Physostigmine salicylate; Eserine (salicylate); Physostigmine (salicylate)

数据库引用编号

23 个数据库交叉引用编号

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

40685 - Salix: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Nadine Pinder, Johannes B Zimmermann, Silke Gastine, Gudrun Würthwein, Georg Hempel, Thomas Bruckner, Torsten Hoppe-Tichy, Markus A Weigand, Stefanie Swoboda. Continuous infusion of physostigmine in patients with perioperative septic shock: A pharmacokinetic/pharmacodynamic study with population pharmacokinetic modeling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Oct; 118(?):109318. doi: 10.1016/j.biopha.2019.109318. [PMID: 31398669]
Johannes B Zimmermann, Nadine Pinder, Thomas Bruckner, Monika Lehmann, Johann Motsch, Thorsten Brenner, Torsten Hoppe-Tichy, Stefanie Swoboda, Markus A Weigand, Stefan Hofer. Adjunctive use of physostigmine salicylate (Anticholium®) in perioperative sepsis and septic shock: study protocol for a randomized, double-blind, placebo-controlled, monocentric trial (Anticholium® per Se). Trials. 2017 Nov; 18(1):530. doi: 10.1186/s13063-017-2231-x. [PMID: 29126416]
Jian Yan, Lirong Sun, Guisheng Wu, Ping Yi, Fumei Yang, Lin Zhou, Xianmin Zhang, Zhongrong Li, Xiaosheng Yang, Huairong Luo, Minghua Qiu. Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives. Bioorganic & medicinal chemistry. 2009 Oct; 17(19):6937-41. doi: 10.1016/j.bmc.2009.08.017. [PMID: 19726199]
R Whelpton, T Moore. Sensitive liquid chromatographic method for physostigmine in biological fluids using dual-electrode electrochemical detection. Journal of chromatography. 1985 Jun; 341(2):361-71. doi: 10.1016/s0378-4347(00)84049-9. [PMID: 4030986]
W Klein-Schwartz, G M Oderda. Jimsonweed intoxication in adolescents and young adults. American journal of diseases of children (1960). 1984 Aug; 138(8):737-9. doi: 10.1001/archpedi.1984.02140460029010. [PMID: 6741888]
S C Risch. beta-Endorphin hypersecretion in depression: possible cholinergic mechanisms. Biological psychiatry. 1982 Oct; 17(10):1071-9. doi: NULL. [PMID: 6293594]