5,7-Dihydroxyisoflavone (BioDeep_00000407044)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


5,7-Dihydroxyisoflavone

化学式: C15H10O4 (254.057906)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 3.7%

分子结构信息

SMILES: C1(O)C=C(O)C2C(=O)C(C3=CC=CC=C3)=COC=2C=1
InChI: InChI=1S/C15H10O4/c16-10-6-12(17)14-13(7-10)19-8-11(15(14)18)9-4-2-1-3-5-9/h1-8,16-17H

描述信息

D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

5,7-Dihydroxyisoflavone



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Jose Guzman-Esquivel, Hector R Galvan-Salazar, Hannah P Guzman-Solorzano, Andrea C Cuevas-Velazquez, Jose A Guzman-Solorzano, Karen A Mokay-Ramirez, Brenda A Paz-Michel, Efren Murillo-Zamora, Josuel Delgado-Enciso, Valery Melnikov, Osiris G Delgado-Enciso, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Fabian Rojas-Larios, Mireya Walle-Guillen, Citlaly B Cardenas-Aguilar, Oscar Beas-Guzman, Daniel Chaviano-Conesa, Hossana S Garcia-Garcia, Ivan Delgado-Enciso. Efficacy of the use of mefenamic acid combined with standard medical care vs. standard medical care alone for the treatment of COVID‑19: A randomized double‑blind placebo‑controlled trial. International journal of molecular medicine. 2022 Mar; 49(3):. doi: 10.3892/ijmm.2022.5084. [PMID: 35029292]
  • Dounia Sid, Milad Baitiche, Zineb Elbahri, Ferhat Djerboua, Mokhtar Boutahala, Zouhair Bouaziz, Marc Le Borgne. Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec; 36(1):605-617. doi: 10.1080/14756366.2020.1869225. [PMID: 33557644]
  • Yan Rong, Tony K L Kiang. Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification. Toxicology and applied pharmacology. 2021 08; 425(?):115553. doi: 10.1016/j.taap.2021.115553. [PMID: 33915121]
  • Rami Ayoub, Qais Jarrar, Dalia Ali, Said Moshawih, Yazun Jarrar, Muhammad Hakim, Zainul Zakaria. Synthesis of Novel Esters of Mefenamic Acid with Pronounced Anti-nociceptive Effects and a Proposed Activity on GABA, Opioid and Glutamate Receptors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Aug; 163(?):105865. doi: 10.1016/j.ejps.2021.105865. [PMID: 33979659]
  • Fatemeh Darvishnejad, Jahan Bakhsh Raoof, Milad Ghani. In-situ synthesis of nanocubic cobalt oxide @ graphene oxide nanocomposite reinforced hollow fiber-solid phase microextraction for enrichment of non-steroidal anti-inflammatory drugs from human urine prior to their quantification via high-performance liquid chromatography-ultraviolet detection. Journal of chromatography. A. 2021 Mar; 1641(?):461984. doi: 10.1016/j.chroma.2021.461984. [PMID: 33611121]
  • Ernesto Callegari, Jian Lin, Susanna Tse, Theunis C Goosen, Vaishali Sahasrabudhe. Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid. CPT: pharmacometrics & systems pharmacology. 2021 02; 10(2):127-136. doi: 10.1002/psp4.12581. [PMID: 33314761]
  • Hadis Shahrahmani, Masumeh Ghazanfarpour, Nasim Shahrahmani, Fatemeh Abdi, Robert D E Sewell, Mahmoud Rafieian-Kopaei. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis. Journal of complementary & integrative medicine. 2021 Jan; 18(2):261-269. doi: 10.1515/jcim-2019-0212. [PMID: 34187122]
  • Zahra Jafari, Mohammad Reza Hadjmohammadi. A banana peel/silicon glue coated stir bar for extraction of aspirin, diclofenac, ibuprofen and mefenamic acid followed by high performance liquid chromatography-UV detection. Analytical methods : advancing methods and applications. 2020 09; 12(36):4429-4437. doi: 10.1039/d0ay01332c. [PMID: 32853301]
  • Milad Ghani. Nanocrystalline cellulose as a biotemplate for preparation of porous titania thin film as a sorbent for thin film microextraction of ketorolac, meloxicam, diclofenac and mefenamic acid. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1142(?):122039. doi: 10.1016/j.jchromb.2020.122039. [PMID: 32163902]
  • Qais Bashir Jarrar, Muhammad Nazrul Hakim, Zainul Amiruddin Zakaria, Manraj Singh Cheema, Said Moshawih. Renal ultrastructural alterations induced by various preparations of mefenamic acid. Ultrastructural pathology. 2020 Jan; 44(1):130-140. doi: 10.1080/01913123.2020.1717705. [PMID: 31967489]
  • Hmed Ben-Nasr, Kamilia Ksouda, Bahira Harrabi, Serria Turki Hammami, Khaled Zeghal, Hanen Affes. Pediatric liver failure following mefenamic acid associated to herbal auto-medication: A case report. Therapie. 2019 12; 74(6):677-680. doi: 10.1016/j.therap.2019.04.001. [PMID: 31635831]
  • Tianlang Zhang, Junlang Qiu, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. Uptake of pharmaceuticals acts as an abiotic stress and triggers variation of jasmonates in Malabar spinach (Basella alba. L). Chemosphere. 2019 Dec; 236(?):124711. doi: 10.1016/j.chemosphere.2019.124711. [PMID: 31549668]
  • Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram. Application of hydrophobic deep eutectic solvent as the carrier for ferrofluid: A novel strategy for pre-concentration and determination of mefenamic acid in human urine samples by high performance liquid chromatography under experimental design optimization. Talanta. 2019 Sep; 202(?):526-530. doi: 10.1016/j.talanta.2019.05.027. [PMID: 31171217]
  • Yang Li, Yingmin Liao, Youfang Huang, Ziwen Ye, Xiaojia Huang. Dual functional monomers modified magnetic adsorbent for the enrichment of non-steroidal anti-inflammatory drugs in water and urine samples. Talanta. 2019 Aug; 201(?):496-502. doi: 10.1016/j.talanta.2019.04.043. [PMID: 31122456]
  • Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon. A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1122-1123(?):49-57. doi: 10.1016/j.jchromb.2019.05.023. [PMID: 31153131]
  • Z Raisi Dehkordi, M Rafieian-Kopaei, F S Hosseini-Baharanchi. A double-blind controlled crossover study to investigate the efficacy of salix extract on primary dysmenorrhea. Complementary therapies in medicine. 2019 Jun; 44(?):102-109. doi: 10.1016/j.ctim.2019.04.002. [PMID: 31126541]
  • Shahram Seidi, Sasan Eshghi Sanàti. Nickel-iron layered double hydroxide nanostructures for micro solid phase extraction of nonsteroidal anti-inflammatory drugs, followed by quantitation by HPLC-UV. Mikrochimica acta. 2019 04; 186(5):297. doi: 10.1007/s00604-019-3419-4. [PMID: 31016399]
  • Nagaraj P Shetti, Deepti S Nayak, Shweta J Malode, Raghava Reddy Kakarla, Shyam S Shukla, Tejraj M Aminabhavi. Sensors based on ruthenium-doped TiO2 nanoparticles loaded into multi-walled carbon nanotubes for the detection of flufenamic acid and mefenamic acid. Analytica chimica acta. 2019 Mar; 1051(?):58-72. doi: 10.1016/j.aca.2018.11.041. [PMID: 30661620]
  • Alketa Tarushi, George D Geromichalos, Dimitris P Kessissoglou, George Psomas. Manganese coordination compounds of mefenamic acid: In vitro screening and in silico prediction of biological activity. Journal of inorganic biochemistry. 2019 01; 190(?):1-14. doi: 10.1016/j.jinorgbio.2018.09.017. [PMID: 30312777]
  • Mukesh Kumar, Dilpreet Singh, Neena Bedi. Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile. Therapeutic delivery. 2019 01; 10(1):21-36. doi: 10.4155/tde-2018-0053. [PMID: 30730824]
  • Yazun Jarrar, Qais Jarrar, Mohammad Abu-Shalhoob, Abdulqader Abed, Esra'a Sha'ban. Relative Expression of Mouse Udp-glucuronosyl Transferase 2b1 Gene in the Livers, Kidneys, and Hearts: The Influence of Nonsteroidal Anti-inflammatory Drug Treatment. Current drug metabolism. 2019; 20(11):918-923. doi: 10.2174/1389200220666191115103310. [PMID: 31733637]
  • Ian Cook, Ting Wang, Thomas S Leyh. Isoform-specific therapeutic control of sulfonation in humans. Biochemical pharmacology. 2019 01; 159(?):25-31. doi: 10.1016/j.bcp.2018.11.010. [PMID: 30423313]
  • Hamid Asiabi, Yadollah Yamini, Maryam Shamsayei. Development of electrochemically controlled packed-in-tube solid phase microextraction method for sensitive analysis of acidic drugs in biological samples. Talanta. 2018 Aug; 185(?):80-88. doi: 10.1016/j.talanta.2018.03.058. [PMID: 29759253]
  • Esra Dilek, Sema Caglar, Kübra Erdogan, Bülent Caglar, Onur Sahin. Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity. Journal of biochemical and molecular toxicology. 2018 Apr; 32(4):e22043. doi: 10.1002/jbt.22043. [PMID: 29512227]
  • Somayeh Arghavani-Beydokhti, Maryam Rajabi, Alireza Asghari. Coupling of two centrifugeless ultrasound-assisted dispersive solid/liquid phase microextractions as a highly selective, clean, and efficient method for determination of ultra-trace amounts of non-steroidal anti-inflammatory drugs in complicated matrices. Analytica chimica acta. 2018 Jan; 997(?):67-79. doi: 10.1016/j.aca.2017.10.005. [PMID: 29149996]
  • Siok Yean Tan, Mei Mei Wong, Angela Lu Wun Tiew, Yai Wen Choo, Suat Hun Lim, Ing Hong Ooi, Pilar Modamio, Cecilia Fernández, Eduardo L Mariño, Ignacio Segarra. Sunitinib DDI with paracetamol, diclofenac, mefenamic acid and ibuprofen shows sex-divergent effects on the tissue uptake and distribution pattern of sunitinib in mice. Cancer chemotherapy and pharmacology. 2016 10; 78(4):709-18. doi: 10.1007/s00280-016-3120-9. [PMID: 27495788]
  • Khanzada Atta Ur Rehman Khan, Muhammad Naeem, Afif Ali, Nisar Ur Rehman, Zarqa Nawaz, Muhammad Rouf Akram, Jawad Ahmad Khan. ASSESSMENT OF GUAR AND XANTHAN GUM BASED FLOATING DRUG DELIVERY SYSTEM CONTAINING MEFENAMIC ACID. Acta poloniae pharmaceutica. 2016 Sep; 73(5):1287-1297. doi: ". [PMID: 29638069]
  • Sofia Tsiliou, Lida-Aikaterini Kefala, Antonios G Hatzidimitriou, Dimitris P Kessissoglou, Franc Perdih, Athanasios N Papadopoulos, Iztok Turel, George Psomas. Cobalt(II) complexes with non-steroidal anti-inflammatory drugs and α-diimines. Journal of inorganic biochemistry. 2016 07; 160(?):125-39. doi: 10.1016/j.jinorgbio.2015.12.015. [PMID: 26775611]
  • Hussin A Rothan, Hirbod Bahrani, Ammar Y Abdulrahman, Zulqarnain Mohamed, Teow Chong Teoh, Shatrah Othman, Nurshamimi Nor Rashid, Noorsaadah A Rahman, Rohana Yusof. Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo. Antiviral research. 2016 Mar; 127(?):50-6. doi: 10.1016/j.antiviral.2016.01.006. [PMID: 26794398]
  • Khadige Abadian, Zohreh Keshavarz, Faraz Mojab, Hamid Alavi Majd, Nazari Mohamad Abbasi. Comparison the effect of mefenamic acid and Teucrium polium on the severity and systemic symptoms of dysmenorrhea. Complementary therapies in clinical practice. 2016 Feb; 22(?):12-5. doi: 10.1016/j.ctcp.2015.09.003. [PMID: 26850798]
  • Asif Husain, Priyanka Ahuja, Aftab Ahmad, Shah A Khan. Synthesis, Biological Evaluation and Pharmacokinetic Studies of Mefenamic Acid - N-Hydroxymethylsuccinimide Ester Prodrug as Safer NSAID. Medicinal chemistry (Shariqah (United Arab Emirates)). 2016; 12(6):585-91. doi: 10.2174/1573406412666160107113548. [PMID: 26740206]
  • Sophia Yui Kau Fong, Yufeng Zhang, Yin Cheong Wong, Limin Zhou, Quanbin Han, Zhong Zuo. Identification and disposition of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo. Biopharmaceutics & drug disposition. 2015 Nov; 36(8):529-51. doi: 10.1002/bdd.1964. [PMID: 26109199]
  • Valentina Manzo, Karla Ulisse, Inés Rodríguez, Eduardo Pereira, Pablo Richter. A molecularly imprinted polymer as the sorptive phase immobilized in a rotating disk extraction device for the determination of diclofenac and mefenamic acid in wastewater. Analytica chimica acta. 2015 Aug; 889(?):130-7. doi: 10.1016/j.aca.2015.07.038. [PMID: 26343435]
  • Sophia Yui Kau Fong, Yin Cheong Wong, Chen Xie, Zhong Zuo. Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats. Journal of ethnopharmacology. 2015 Jul; 170(?):106-16. doi: 10.1016/j.jep.2015.04.036. [PMID: 25980420]
  • Marjan Ahmad Shirvani, Narges Motahari-Tabari, Abbas Alipour. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Archives of gynecology and obstetrics. 2015 Jun; 291(6):1277-81. doi: 10.1007/s00404-014-3548-2. [PMID: 25399316]
  • Hamid Abedi, Homeira Ebrahimzadeh. Electromembrane-surrounded solid-phase microextraction coupled to ion mobility spectrometry for the determination of nonsteroidal anti-inflammatory drugs: A rapid screening method in complicated matrices. Journal of separation science. 2015 May; 38(8):1358-64. doi: 10.1002/jssc.201401350. [PMID: 25655267]
  • Xanthippi Totta, Aikaterini A Papadopoulou, Antonios G Hatzidimitriou, Athanasios Papadopoulos, George Psomas. Synthesis, structure and biological activity of nickel(II) complexes with mefenamato and nitrogen-donor ligands. Journal of inorganic biochemistry. 2015 Apr; 145(?):79-93. doi: 10.1016/j.jinorgbio.2015.01.009. [PMID: 25660964]
  • Eva Kupetz, Heike Bunjes. Lipid nanoparticles: drug localization is substance-specific and achievable load depends on the size and physical state of the particles. Journal of controlled release : official journal of the Controlled Release Society. 2014 Sep; 189(?):54-64. doi: 10.1016/j.jconrel.2014.06.007. [PMID: 24933601]
  • Khawla Kammoun, Faical Jarraya, Saloua Makni, Lobna Ben Mahmoud, Mahmoud Kharrat, Mohamed Ben Hmida, Khaled Zeghal, Tahia Boudawara, Jamil Hachicha. Ciprofloxacin-induced crystal nephropathy. Iranian journal of kidney diseases. 2014 May; 8(3):240-2. doi: NULL. [PMID: 24878949]
  • Chenrui Li, Sophia Yui Kau Fong, Qibing Mei, Ge Lin, Zhong Zuo. Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact. Pharmaceutical biology. 2014 Mar; 52(3):291-7. doi: 10.3109/13880209.2013.834366. [PMID: 24102566]
  • Farangis Sharifi, Masoumeh Simbar, Faraz Mojab, Hamid Alavi Majd. Comparison of the effects of Matricaria chamomila (Chamomile) extract and mefenamic acid on the intensity of premenstrual syndrome. Complementary therapies in clinical practice. 2014 Feb; 20(1):81-8. doi: 10.1016/j.ctcp.2013.09.002. [PMID: 24439651]
  • Asadollah Beiraghi, Kamyar Pourghazi, Mitra Amoli-Diva, Akbar Razmara. Magnetic solid phase extraction of mefenamic acid from biological samples based on the formation of mixed hemimicelle aggregates on Fe(3)O(4) nanoparticles prior to its HPLC-UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jan; 945-946(?):46-52. doi: 10.1016/j.jchromb.2013.11.039. [PMID: 24321760]
  • Ross W Sullivan, Matthew Ryzewski, Michael G Holland, Jeanna M Marraffa. Compounded ointment results in severe toxicity in a pediatric patient. Pediatric emergency care. 2013 Nov; 29(11):1220-2. doi: 10.1097/pec.0b013e3182aa4748. [PMID: 24196095]
  • Alketa Tarushi, Zoi Karaflou, Jakob Kljun, Iztok Turel, George Psomas, Athanasios N Papadopoulos, Dimitris P Kessissoglou. Antioxidant capacity and DNA-interaction studies of zinc complexes with a non-steroidal anti-inflammatory drug, mefenamic acid. Journal of inorganic biochemistry. 2013 Nov; 128(?):85-96. doi: 10.1016/j.jinorgbio.2013.07.013. [PMID: 23948577]
  • Kamal Shah, Sushant K Shrivastava, Pradeep Mishra. Synthesis, kinetics and pharmacological evaluation of mefenamic acid mutual prodrug. Acta poloniae pharmaceutica. 2013 Sep; 70(5):905-11. doi: . [PMID: 24147370]
  • S Kasichayanula, X Liu, S C Griffen, F P Lacreta, D W Boulton. Effects of rifampin and mefenamic acid on the pharmacokinetics and pharmacodynamics of dapagliflozin. Diabetes, obesity & metabolism. 2013 Mar; 15(3):280-3. doi: 10.1111/dom.12024. [PMID: 23061428]
  • Samer Khalaf, Fuad Al-Rimawi, Mustafa Khamis, Shlomo Nir, Sabino A Bufo, Laura Scrano, Gennaro Mecca, Rafik Karaman. Efficiency of membrane technology, activated charcoal, and a micelle-clay complex for removal of the acidic pharmaceutical mefenamic acid. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2013; 48(13):1655-62. doi: 10.1080/10934529.2013.815475. [PMID: 23947703]
  • J A Murillo Pulgarín, A Alañón Molina, F Martínez Ferreras. Simultaneous determination of mefenamic and tolfenamic acids in real samples by terbium-sensitized luminescence. Journal of fluorescence. 2012 Nov; 22(6):1483-92. doi: 10.1007/s10895-012-1085-6. [PMID: 22752433]
  • Taro Kojima, Kenjirou Higashi, Toyofumi Suzuki, Kazuo Tomono, Kunikazu Moribe, Keiji Yamamoto. Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with EUDRAGIT(®) EPO. Pharmaceutical research. 2012 Oct; 29(10):2777-91. doi: 10.1007/s11095-011-0655-7. [PMID: 22219167]
  • Guliz Armagan, Lutfiye Kanit, Ayfer Yalcin. Effects of non-steroidal antiinflammatory drugs on D-serine-induced oxidative stress in vitro. Drug and chemical toxicology. 2012 Oct; 35(4):393-8. doi: 10.3109/01480545.2011.633086. [PMID: 22486999]
  • Mahadeo Mahadik, Sunil Dhaneshwar, Ravindra Bhavsar. A high performance liquid chromatography-tandem mass spectrometric method for the determination of mefenamic acid in human plasma: application to pharmacokinetic study. Biomedical chromatography : BMC. 2012 Oct; 26(10):1137-42. doi: 10.1002/bmc.1755. [PMID: 22275128]
  • Guliz Armagan, Ezgi Turunc, Lutfiye Kanit, Ayfer Yalcin. Neuroprotection by mefenamic acid against D-serine: involvement of oxidative stress, inflammation and apoptosis. Free radical research. 2012 Jun; 46(6):726-39. doi: 10.3109/10715762.2012.669836. [PMID: 22369458]
  • Mohamed A Etman, Ragwa M Farid, Aly H Nada, Abdel-Azim R Ebian. In vitro/in vivo correlation of fast release mephenamic acid microspheres in humans. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2012; 21(3):223-7. doi: 10.1159/000333558. [PMID: 22116543]
  • Filitsa Dimiza, Stella Fountoulaki, Athanasios N Papadopoulos, Christos A Kontogiorgis, Vassilis Tangoulis, Catherine P Raptopoulou, Vassilis Psycharis, Aris Terzis, Dimitris P Kessissoglou, George Psomas. Non-steroidal antiinflammatory drug-copper(II) complexes: structure and biological perspectives. Dalton transactions (Cambridge, England : 2003). 2011 Sep; 40(34):8555-68. doi: 10.1039/c1dt10714c. [PMID: 21805007]
  • Arun Rasheed, C K Ashok Kumar. Tyrosine and glycine derivatives as potential prodrugs: design, synthesis, and pharmacological evaluation of amide derivatives of mefenamic acid. Journal of enzyme inhibition and medicinal chemistry. 2010 Dec; 25(6):804-11. doi: 10.3109/14756360903468163. [PMID: 20578977]
  • J Yu, K S Han, G Lee, M J Paik, K R Kim. Enantiomeric composition analysis of pranoprofen in equine plasma and urine by chiral liquid chromatography-tandem mass spectrometry in selected reaction monitoring mode. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Dec; 878(31):3249-54. doi: 10.1016/j.jchromb.2010.10.002. [PMID: 21036111]
  • Filitsa Dimiza, Athanasios N Papadopoulos, Vassilis Tangoulis, Vassilis Psycharis, Catherine P Raptopoulou, Dimitris P Kessissoglou, George Psomas. Biological evaluation of non-steroidal anti-inflammatory drugs-cobalt(II) complexes. Dalton transactions (Cambridge, England : 2003). 2010 May; 39(19):4517-28. doi: 10.1039/b927472c. [PMID: 20372735]
  • Satoshi Endo, Toshiyuki Matsunaga, Midori Soda, Kazuo Tajima, Hi-Tai Zhao, Ossama El-Kabbani, Akira Hara. Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid. Biological & pharmaceutical bulletin. 2010; 33(5):886-90. doi: 10.1248/bpb.33.886. [PMID: 20460771]
  • Irene M Villaseñor, Arlyn C Sanchez. Menthalactone, a new analgesic from Mentha cordifolia Opiz. Leaves. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2009 Nov; 64(11-12):809-12. doi: 10.1515/znc-2009-11-1209. [PMID: 20158150]
  • Suzanne Habjan, Robert J Vandenberg. Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids. Neurochemical research. 2009 Oct; 34(10):1738-47. doi: 10.1007/s11064-009-9983-y. [PMID: 19444608]
  • Khodakrami Nahid, Moatar Fariborz, Ghahiri Ataolah, Shahdan Solokian. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. Journal of midwifery & women's health. 2009 Sep; 54(5):401-404. doi: 10.1016/j.jmwh.2008.12.006. [PMID: 19720342]
  • Dasandi Bhavesh, Sanjay Shah. Determination of fenofibric acid in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry: application to a bioequivalence study. Biomedical chromatography : BMC. 2009 Sep; 23(9):922-8. doi: 10.1002/bmc.1203. [PMID: 19353730]
  • Tayyebeh Madrakian, Abbas Afkhami, Masoumeh Mohammadnejad. Second-order advantage applied to simultaneous spectrofluorimetric determination of paracetamol and mefenamic acid in urine samples. Analytica chimica acta. 2009 Jul; 645(1-2):25-9. doi: 10.1016/j.aca.2009.05.002. [PMID: 19481626]
  • Ozge Surmeli Onay, Hale Sakalli Erçoban, Umut Selda Bayrakci, Engin Melek, Nurcan Cengiz, Esra Baskin. Acute, reversible nonoliguric renal failure in two children associated with analgesic-antipyretic drugs. Pediatric emergency care. 2009 Apr; 25(4):263-6. doi: 10.1097/pec.0b013e31819e38d4. [PMID: 19369842]
  • Giti Ozgoli, Marjan Goli, Fariborz Moattar. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. Journal of alternative and complementary medicine (New York, N.Y.). 2009 Feb; 15(2):129-32. doi: 10.1089/acm.2008.0311. [PMID: 19216660]
  • Soyab A Patel, Felicity Currie, Nalin Thakker, Royston Goodacre. Spatial metabolic fingerprinting using FT-IR spectroscopy: investigating abiotic stresses on Micrasterias hardyi. The Analyst. 2008 Dec; 133(12):1707-13. doi: 10.1039/b809441a. [PMID: 19082073]
  • Ana Rita M Silva, Fátima C M Portugal, J M F Nogueira. Advances in stir bar sorptive extraction for the determination of acidic pharmaceuticals in environmental water matrices Comparison between polyurethane and polydimethylsiloxane polymeric phases. Journal of chromatography. A. 2008 Oct; 1209(1-2):10-6. doi: 10.1016/j.chroma.2008.08.103. [PMID: 18805538]
  • Koichi Omura, Takashi Nakazawa, Takahiro Sato, Takashi Iwanaga, Osamu Nagata. Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor. Drug metabolism and disposition: the biological fate of chemicals. 2007 Dec; 35(12):2143-8. doi: 10.1124/dmd.107.017251. [PMID: 17761779]
  • Hany Ibrahim, Alexandre Boyer, Jalloul Bouajila, François Couderc, Françoise Nepveu. Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 857(1):59-66. doi: 10.1016/j.jchromb.2007.07.008. [PMID: 17646136]
  • Wing Lam, Cho-Ming Loi, James Atherton, Wayne Stolle, John Easter, Abdul Mutlib. Application of in-line liquid chromatography-accurate radioisotope counting-mass spectrometry (LC-ARC-MS) to evaluate metabolic profile of [3H]-mefenamic acid in rat plasma. Drug metabolism letters. 2007 Aug; 1(3):179-88. doi: 10.2174/187231207781369771. [PMID: 19356041]
  • Gregory S Walker, James Atherton, Jonathan Bauman, Christopher Kohl, Wing Lam, Michael Reily, Zhen Lou, Abdul Mutlib. Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy. Chemical research in toxicology. 2007 Jun; 20(6):876-86. doi: 10.1021/tx600297u. [PMID: 17536843]
  • Paraskevi Gaganis, John O Miners, Kathleen M Knights. Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7. Biochemical pharmacology. 2007 May; 73(10):1683-91. doi: 10.1016/j.bcp.2007.01.030. [PMID: 17343829]
  • Louise Cole, Charles Heard. Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effect. International journal of pharmaceutics. 2007 Mar; 333(1-2):10-6. doi: 10.1016/j.ijpharm.2006.09.047. [PMID: 17088033]
  • O A H Jones, N Voulvoulis, J N Lester. The occurrence and removal of selected pharmaceutical compounds in a sewage treatment works utilising activated sludge treatment. Environmental pollution (Barking, Essex : 1987). 2007 Feb; 145(3):738-44. doi: 10.1016/j.envpol.2005.08.077. [PMID: 16891046]
  • André Rätzer Künzel, Manuel Haschke, Christian Surber, J Thomas Lambrecht. [Mefenamic acid and other non-steroidal anti-inflammatory agents in dental practice. A review of the literature]. Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia. 2007; 117(1):12-8. doi: NULL. [PMID: 17330662]
  • Susanne Vogt, Annekathrin Mehlig, Patrick Hunziker, André Scholer, Julia Jung, Ana Baranda González, Wolfgang Weinmann, Stephan Marsch. Survival of severe amlodipine intoxication due to medical intensive care. Forensic science international. 2006 Sep; 161(2-3):216-20. doi: 10.1016/j.forsciint.2006.02.051. [PMID: 16872774]
  • V Modaress Nejad, M Asadipour. Comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. 2006 May; 12(3-4):423-7. doi: ". [PMID: 17037712]
  • A Muñoz de la Peña, A Espinosa Mansilla, N Mora Díez, D Bohoyo Gil, A C Olivieri, G M Escandar. Second-order calibration of excitation-emission matrix fluorescence spectra for the determination of N-phenylanthranilic acid derivatives. Applied spectroscopy. 2006 Mar; 60(3):330-8. doi: 10.1366/000370206776342643. [PMID: 16608576]
  • P Komericki, E Arbab, R Grims, B Kränke, W Aberer. Tryptase as severity marker in drug provocation tests. International archives of allergy and immunology. 2006; 140(2):164-9. doi: 10.1159/000092556. [PMID: 16601354]
  • A Espinosa-Mansilla, A Muñoz de la Peña, F Cañada-Cañada, D González Gómez. Determinations of fluoroquinolones and nonsteroidal anti-inflammatory drugs in urine by extractive spectrophotometry and photoinduced spectrofluorimetry using multivariate calibration. Analytical biochemistry. 2005 Dec; 347(2):275-86. doi: 10.1016/j.ab.2005.09.032. [PMID: 16289005]
  • Manoj G Tyagi, S Thirumalai Velu, Gota S Vikram. Renal humoral modulation of skeletal muscle tone in mice: implications for 'the pulmonary-renal cascade'. Indian journal of physiology and pharmacology. 2005 Oct; 49(4):403-10. doi: . [PMID: 16579393]
  • A Tauxe-Wuersch, L F De Alencastro, D Grandjean, J Tarradellas. Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. Water research. 2005 May; 39(9):1761-72. doi: 10.1016/j.watres.2005.03.003. [PMID: 15899274]
  • Masaya Fukuda, Kiyoyuki Kitaichi, Fumie Abe, Yohei Fujimoto, Kenji Takagi, Kenzo Takagi, Tsuneo Morishima, Takaaki Hasegawa. Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice. Journal of pharmacological sciences. 2005 Apr; 97(4):525-32. doi: 10.1254/jphs.fp0040752. [PMID: 15821337]
  • M S Y Khan, M Akhter. Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid. Die Pharmazie. 2005 Feb; 60(2):110-4. doi: NULL. [PMID: 15739898]
  • M A E Buylaert, J A Schifferli. [Acute renal failure--"a well meant present from a friend"]. Therapeutische Umschau. Revue therapeutique. 2004 Dec; 61(12):725-7. doi: 10.1024/0040-5930.61.12.725. [PMID: 15651168]
  • N Somchit, F Sanat, E H Gan, I A W Shahrin, A Zuraini. Liver injury induced by the non-steroidal anti-inflammatory drug mefenamic acid. Singapore medical journal. 2004 Nov; 45(11):530-2. doi: . [PMID: 15510325]
  • Irene M Villaseñor, Arlyn P Canlas, Karen M Faustino, Katherine G Plana. Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves. Journal of ethnopharmacology. 2004 May; 92(1):53-6. doi: 10.1016/j.jep.2004.01.017. [PMID: 15099847]
  • Mohammad-Reza Rouini, Ali Asadipour, Yalda Hoseinzadeh Ardakani, Fakhredin Aghdasi. Liquid chromatography method for determination of mefenamic acid in human serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Feb; 800(1-2):189-92. doi: 10.1016/j.jchromb.2003.09.063. [PMID: 14698254]
  • B Namavar Jahromi, A Tartifizadeh, S Khabnadideh. Comparison of fennel and mefenamic acid for the treatment of primary dysmenorrhea. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2003 Feb; 80(2):153-7. doi: 10.1016/s0020-7292(02)00372-7. [PMID: 12566188]
  • Irene M Villaseñor, Jennifer Angelada, Arlyn P Canlas, Deborah Echegoyen. Bioactivity studies on beta-sitosterol and its glucoside. Phytotherapy research : PTR. 2002 Aug; 16(5):417-21. doi: 10.1002/ptr.910. [PMID: 12203259]
  • Vimon Tantishaiyakul, Kamonthip Wiwattanawongsa, Sirirat Pinsuwan, Srirat Kasiwong, Narubodee Phadoongsombut, Sanae Kaewnopparat, Nattha Kaewnopparat, Yon Rojanasakul. Characterization of mefenamic acid-guaiacol ester: stability and transport across Caco-2 cell monolayers. Pharmaceutical research. 2002 Jul; 19(7):1013-8. doi: 10.1023/a:1016470523923. [PMID: 12180533]
  • H Weiss, A Amberger, M Widschwendter, R Margreiter, D Ofner, P Dietl. Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. International journal of cancer. 2001 Jun; 92(6):877-82. doi: 10.1002/ijc.1280. [PMID: 11351310]
  • R Sinniah, W C Lye. Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. Clinical nephrology. 2001 Mar; 55(3):254-8. doi: . [PMID: 11316248]
  • T K Nguyen, D K Obatomi, P H Bach. Increased urinary uronic acid excretion in experimentally-induced renal papillary necrosis in rats. Renal failure. 2001 Jan; 23(1):31-42. doi: 10.1081/jdi-100001281. [PMID: 11256527]
  • M Vietri, A Pietrabissa, R Spisni, F Mosca, G M Pacifici. Differential inhibition of hepatic and duodenal sulfation of (-)-salbutamol and minoxidil by mefenamic acid. European journal of clinical pharmacology. 2000 Sep; 56(6-7):477-9. doi: 10.1007/s002280000168. [PMID: 11049010]
  • E Mikami, T Goto, T Ohno, H Matsumoto, K Inagaki, H Ishihara, M Nishida. Simultaneous analysis of anthranilic acid derivatives in pharmaceuticals and human urine by high-performance liquid chromatography with isocratic elution. Journal of chromatography. B, Biomedical sciences and applications. 2000 Jul; 744(1):81-9. doi: 10.1016/s0378-4347(00)00233-4. [PMID: 10985569]
  • M Vietri, C De Santi, A Pietrabissa, F Mosca, G M Pacifici. Fenamates and the potent inhibition of human liver phenol sulphotransferase. Xenobiotica; the fate of foreign compounds in biological systems. 2000 Feb; 30(2):111-6. doi: 10.1080/004982500237712. [PMID: 10718119]
  • R F Halliwell, P Thomas, D Patten, C H James, A Martinez-Torres, R Miledi, T G Smart. Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. The European journal of neuroscience. 1999 Aug; 11(8):2897-905. doi: 10.1046/j.1460-9568.1999.00709.x. [PMID: 10457186]
  • P H Whiting, K Tisocki, G M Hawksworth. Human renal medullary interstitial cells and analgesic nephropathy. Renal failure. 1999 May; 21(3-4):387-92. doi: 10.3109/08860229909085102. [PMID: 10416217]