7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one (BioDeep_00000406915)

   

natural product


代谢物信息卡片


7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one

化学式: C21H22O9 (418.1263762)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 50%

分子结构信息

SMILES: C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
InChI: InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15?,17-,18-,19+,20-,21-/m1/s1



分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Meina Gao, Hui Li, Chenghao Ye, Kaixian Chen, Hualiang Jiang, Kunqian Yu. Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study. Biomolecules. 2021 10; 11(11):. doi: 10.3390/biom11111586. [PMID: 34827585]
  • Shan Jiang, Shaoping Wang, Pingping Dong, Lei Shi, Qiyan Li, Xia Wei, Peng Gao, Jiayu Zhang. A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometer. Xenobiotica; the fate of foreign compounds in biological systems. 2021 May; 51(5):564-581. doi: 10.1080/00498254.2020.1854366. [PMID: 33222601]
  • Yahang Wang, Yuanyuan Li, Hua Zhang, Leilei Zhu, Jie Zhong, Jiakai Zeng, Cong Meng, Jiasheng Wu, Tianming Wang, Rong Shi, Weian Yuan, Jian Jiang, Ping Liu, Yueming Ma. Pharmacokinetics-based comprehensive strategy to identify multiple effective components in Huangqi decoction against liver fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Apr; 84(?):153513. doi: 10.1016/j.phymed.2021.153513. [PMID: 33647776]
  • Xin-Yi Lan, Hui Yu, Qiu-Jing Chen, Shuo Zhai, Chun-Feng Zhang, Fei Li, Chong-Zhi Wang, Chun-Su Yuan. Effect of liquiritin on neuroendocrine-immune network in menopausal rat model. Phytotherapy research : PTR. 2020 Oct; 34(10):2665-2674. doi: 10.1002/ptr.6696. [PMID: 32281178]
  • Lin Zhang, Chen-Xiang Wang, Jing Wu, Tian-Yun Wang, Qiao-Qiao Zhong, Yan Du, Shuai Ji, Liang Wang, Meng-Zhe Guo, Sheng-Qiu Xu, Dao-Quan Tang. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones. Journal of ethnopharmacology. 2020 Jul; 257(?):112892. doi: 10.1016/j.jep.2020.112892. [PMID: 32320727]
  • Jina Yang, Wenbin Jin, Danyang Liu, Qisheng Zhong, Ting Zhou. Enhanced pseudotargeted analysis using a segment data dependent acquisition strategy by liquid chromatography-tandem mass spectrometry for a metabolomics study of liquiritin in the treatment of depression. Journal of separation science. 2020 Jun; 43(11):2088-2096. doi: 10.1002/jssc.202000107. [PMID: 32144949]
  • Pengcheng Huang, Yinghong Tang, Chang Li, Huifen Zhou, Li Yu, Haitong Wan, Yu He. Correlation study between the pharmacokinetics of seven main active ingredients of Mahuang decoction and its pharmacodynamics in asthmatic rats. Journal of pharmaceutical and biomedical analysis. 2020 May; 183(?):113144. doi: 10.1016/j.jpba.2020.113144. [PMID: 32070931]
  • Kang Uk Kim, Sung-Jin Lee, Inhyung Lee. Development of an Improved Menopausal Symptom-Alleviating Licorice (Glycyrrhiza uralensis) by Biotransformation Using Monascus albidulus. Journal of microbiology and biotechnology. 2020 Feb; 30(2):178-186. doi: 10.4014/jmb.1909.09037. [PMID: 31752065]
  • Jun Jiang, Shichang Xiao, Shu Yan, Jianpeng Xiao, Ximing Xu. Glycyrrhizae Radix et Rhizoma Processed by Sulfur Fumigation Damaged the Chemical Profile Accompanied by Immunosuppression and Liver Injury. BioMed research international. 2020; 2020(?):5439853. doi: 10.1155/2020/5439853. [PMID: 32090097]
  • Minwei Chen, Chaochao Zhang, Jingnan Zhang, Guoyin Kai, Bin Lu, Zhenlin Huang, Lili Ji. The involvement of DAMPs-mediated inflammation in cyclophosphamide-induced liver injury and the protection of liquiritigenin and liquiritin. European journal of pharmacology. 2019 Aug; 856(?):172421. doi: 10.1016/j.ejphar.2019.172421. [PMID: 31136760]
  • Jun-Jin Liu, Yao Cheng, Yun-Yun Shao, Zhuang-Peng Chang, Yi-Ting Guo, Xiao-Juan Feng, Ding Xu, Jing-Ping Zhang, Yan Song, Rui-Gang Hou. Comparative pharmacokinetics and metabolites study of seven major bioactive components of Shaoyao-Gancao decoction in normal and polycystic ovary syndrome rats by ultra high pressure liquid chromatography with tandem mass spectrometry. Journal of separation science. 2019 Aug; 42(15):2534-2549. doi: 10.1002/jssc.201900002. [PMID: 31144455]
  • Zilingyun Wang, Rui An, Guangli Du, Kun Liang, Guowen Li. Validation of an LC-MS/MS method for simultaneous detection of diverse components of Qinxing Qingre Zhike Granule in rat plasma and its application to pharmacokinetic study after oral administration to rats. Biomedical chromatography : BMC. 2019 Jul; 33(7):e4524. doi: 10.1002/bmc.4524. [PMID: 30821835]
  • Zhao-Guang Zheng, You-Hua Xu, Fang Liu, Ting-Ting Zhao, Rui-Xue Wang, Pei-Ying Huang, Ru-Shang Wang, An-Ping Yang, Quan Zhu. Screening bioactive components of Glycyrrhiza uralensis Fisch. with isolated perfused lung extraction and HPLC-ESI-MSn analysis. Journal of pharmaceutical and biomedical analysis. 2019 May; 169(?):127-132. doi: 10.1016/j.jpba.2019.03.007. [PMID: 30861404]
  • You Jin Han, Bitna Kang, Eun-Ju Yang, Min-Koo Choi, Im-Sook Song. Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091816. [PMID: 31083444]
  • Xinwen Lv, Yongbing Zhang, Hujin Zhang. Neuroprotective effect of Trichosanthes kirilowii cassia twig on cerebral ischemia-reperfusion injury in rats. Pakistan journal of pharmaceutical sciences. 2018 Jul; 31(4(Special)):1643-1647. doi: . [PMID: 30203753]
  • Min Zhang, Yang Deng, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang, Bi-Kui Zhang, Huan-De Li, Miao Yan. An LC-MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study. Drug testing and analysis. 2018 Feb; 10(2):262-271. doi: 10.1002/dta.2210. [PMID: 28447397]
  • Lin Zhang, Huiying Xu, Libin Zhan. Pharmacokinetic Assessments of Liquiritin, Protocatechuic Aldehyde and Rosmarinic Acid in Rat Plasma by UPLC-MS-MS After Administration of ZibuPiyin Recipe. Journal of chromatographic science. 2018 Feb; 56(2):139-146. doi: 10.1093/chromsci/bmx093. [PMID: 29186346]
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  • Yinghong Tang, Mengkai Zheng, Yu-Lin Chen, Jianzhen Chen, Yu He. Pharmacokinetic Effects of Cinnamic Acid, Amygdalin, Glycyrrhizic Acid and Liquiritin on Ephedra Alkaloids in Rats. European journal of drug metabolism and pharmacokinetics. 2017 Jun; 42(3):527-535. doi: 10.1007/s13318-016-0368-8. [PMID: 27514823]
  • Thi Thanh Hanh Nguyen, Seung-Jin Jung, Hee-Kyoung Kang, Young-Min Kim, Young-Hwan Moon, Misook Kim, Doman Kim. Production of rubusoside from stevioside by using a thermostable lactase from Thermus thermophilus and solubility enhancement of liquiritin and teniposide. Enzyme and microbial technology. 2014 Oct; 64-65(?):38-43. doi: 10.1016/j.enzmictec.2014.07.001. [PMID: 25152415]
  • Wei Zhang, Shu Jiang, Dawei Qian, Er-xin Shang, Jin-ao Duan. Effect of liquiritin on human intestinal bacteria growth: metabolism and modulation. Biomedical chromatography : BMC. 2014 Sep; 28(9):1271-7. doi: 10.1002/bmc.3160. [PMID: 24616071]
  • Chang-Li Liu, Yan Yin, Shu-Hua Zhang, Qian Li, Min Chen, Xu Guo. [Study on correlation between trace elements and active ingredient in glycyrrhizae radix et rhizome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Sep; 39(17):3335-8. doi: NULL. [PMID: 25522623]
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  • Yi-Zhu Zhang, Rui An, Jin Yuan, Yue Wang, Qing-Qing Gu, Xin-Hong Wang. [Analysis and comparison of intestinal absorption of components of Gegenqinlian decoction in different combinations based on pharmacokinetic parameters]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Oct; 48(10):1611-7. doi: . [PMID: 24417090]
  • Xiao-Xia Gao, Jie Cui, Xing-Yu Zheng, Zhen-Yu Li, Young-Hae Choi, Yu-Zhi Zhou, Jun-Sheng Tian, Jie Xing, Xiao-Jie Tan, Guan-Hua Du, Xue-Mei Qin. An investigation of the antidepressant action of xiaoyaosan in rats using ultra performance liquid chromatography-mass spectrometry combined with metabonomics. Phytotherapy research : PTR. 2013 Jul; 27(7):1074-85. doi: 10.1002/ptr.4805. [PMID: 22975930]
  • Mingjing Yi, Wei Peng, Xiaomin Chen, Junjun Wang, Yong Chen. Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo. The Journal of pharmacy and pharmacology. 2012 Nov; 64(11):1654-8. doi: 10.1111/j.2042-7158.2012.01532.x. [PMID: 23058053]
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  • Huai-Bin Zhao, Yan-Long Hong, You-Jie Wang, Lan Shen, Fei Wu, Yi Feng, Ke-Feng Ruan. [Influence of combination on the specific chromatogram of Glycyrrhiza in sini decoctions by HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Apr; 47(4):508-11. doi: ". [PMID: 22799035]
  • Lei Zhang, Lin Zhu, Yuefei Wang, Zhenzuo Jiang, Xin Chai, Yan Zhu, Xiumei Gao, Aidi Qi. Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD-MS/MS. Journal of pharmaceutical and biomedical analysis. 2012 Mar; 62(?):203-9. doi: 10.1016/j.jpba.2011.12.026. [PMID: 22264846]
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  • Ling Tong, Dandan Zhou, Jun Gao, Yonghong Zhu, He Sun, Kaishun Bi. Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2012 Jan; 58(?):58-64. doi: 10.1016/j.jpba.2011.05.001. [PMID: 22018980]
  • Chang-Seob Seo, Mee-Young Lee, Hye-Sun Lim, Su-Jeong Kim, Hyekyung Ha, Jin-Ah Lee, Hyeun-Kyoo Shin. Determination of 5-hydroxymethyl-2-furfural, albiflorin, paeoniflorin, liquiritin, ferulic acid, nodakenin, and glycyrrhizin by HPLC-PDA, and evaluation of the cytotoxicity of Palmul-tang, a traditional Korean herbal medicine. Archives of pharmacal research. 2012 Jan; 35(1):101-8. doi: 10.1007/s12272-012-0111-1. [PMID: 22297748]
  • Rong Fan, Xi Huang, Yang Wang, Xiao Chen, Ping Ren, Hui Ji, Ying Xie, Yingjin Zhang, Wei Huang, Xinjian Qiu, Zhaoqian Liu, Honghao Zhou, Lan Fan, Lichen Gao. Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):607584. doi: 10.1155/2012/607584. [PMID: 22454671]
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