2-Adenylic acid (BioDeep_00000406259)
Main id: BioDeep_00000003258
PANOMIX_OTCML-2023
代谢物信息卡片
Adenosine-2-monophosphate
化学式: C10H14N5O7P (347.06308240000004)
中文名称: 腺苷2(3)-单磷酸盐混合异构体
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)OP(=O)(O)O)N
InChI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(22-23(18,19)20)6(17)4(1-16)21-10/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
描述信息
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:28223
- KEGG: C00946
- PubChem: 94136
- ChEMBL: CHEMBL57445
- MeSH: Adenosine Monophosphate
- CAS: 130-49-4
- MoNA: FiehnHILIC002444
- PubChem: 4197
- PDB-CCD: 2AM
- NIKKAJI: J10.017J
- medchemexpress: HY-124151
- KNApSAcK: 28223
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 654 - Aeromonas veronii: 10.3389/FCIMB.2020.00044
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing-Wen Xu, Si-Qi Tang, Jie Lin, Yu-Jia Li, Dan Shen, Guang-Hong Ding, Xue-Yong Shen, Li-Na Wang. NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at 'Zusanli' (ST36)-induced analgesia in ankle arthritis rats.
Brain research bulletin.
2024 Apr; 209(?):110909. doi:
10.1016/j.brainresbull.2024.110909. [PMID: 38402994] - Jiajia Yang, Jun Liu, Weiyang Kuang, Yuqi Lin, Saiyi Zhong, Supaluck Kraithong, Xiaoyong Zhang, Io Nam Wong, Riming Huang. Structural characterization and ferroptosis-related immunomodulatory of a novel exopolysaccharide isolated from marine fungus Aspergillus medius.
International journal of biological macromolecules.
2024 Apr; 265(Pt 1):130703. doi:
10.1016/j.ijbiomac.2024.130703. [PMID: 38458279] - Xuemeng Zhao, Wen Li, Xiliu Li, Zhenhua Jia, Shuishan Song, Qian Zhao. The Effect of Bacterial AHL on the Cyclic Adenosine Monophosphate Content in Plants According to High-Performance Liquid Chromatography.
Molecules (Basel, Switzerland).
2024 Feb; 29(5):. doi:
10.3390/molecules29051074. [PMID: 38474586] - Al Zahraa G Al Ashmawy, Gehan F Balata. Formulation and in vitro characterization of nanoemulsions containing remdesivir or licorice extract: A potential subcutaneous injection for coronavirus treatment.
Colloids and surfaces. B, Biointerfaces.
2024 Feb; 234(?):113703. doi:
10.1016/j.colsurfb.2023.113703. [PMID: 38096607] - Pranav Bharadwaj, Sachin M Shet, Meena Bisht, Dheeraj Kumar Sarkar, Gregory Franklin, Nataraj Sanna Kotrappanavar, Dibyendu Mondal. Suitability of Adenosine Derivatives in Improving the Activity and Stability of Cytochrome c under Stress: Insights into the Effect of Phosphate Groups.
The journal of physical chemistry. B.
2024 Jan; 128(1):86-95. doi:
10.1021/acs.jpcb.3c05996. [PMID: 38127495] - Hong Gil Lee, Seo Young Jang, Eun Yee Jie, Seung Hee Choi, Ok-Sun Park, Soon Hyung Bae, Hyun-Soon Kim, Suk Weon Kim, Geum-Sook Hwang, Pil Joon Seo. Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis.
Molecular plant.
2023 12; 16(12):1867-1870. doi:
10.1016/j.molp.2023.10.004. [PMID: 37817411] - Liu Bingbing, L I Jieru, S I Jianchao, Chen Qi, Yang Shengchang, J I Ensheng. Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 10; 43(5):906-914. doi:
10.19852/j.cnki.jtcm.20221206.004. [PMID: 37679978] - Chao Yang, Xibao Li, Jun Zhou, Caiji Gao. Autophagy contributes to positive feedback regulation of SnRK1 signaling in plants.
Autophagy.
2023 Aug; ?(?):1-3. doi:
10.1080/15548627.2023.2247741. [PMID: 37584544] - Haiyan Yang, Qiang Wang, Yuemei Xi, Wei Yu, De Xie, Hiroko Morisaki, Takayuki Morisaki, Jidong Cheng. AMPD2 plays important roles in regulating hepatic glucose and lipid metabolism.
Molecular and cellular endocrinology.
2023 Aug; ?(?):112039. doi:
10.1016/j.mce.2023.112039. [PMID: 37567359] - Mengrong Yan, Mengyuan Ma, Rong Chen, Yangzi Cao, Wei Zhang, Xiang Liu. Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology communications.
2023 Aug; 79(Pt 8):208-216. doi:
10.1107/s2053230x23005836. [PMID: 37522751] - Q Wu, Z Li, Y Zhang, K Luo, X Xu, J Li, X Peng, X Zhou. Cyclic di-AMP Rescues Porphyromonas gingivalis-Aggravated Atherosclerosis.
Journal of dental research.
2023 07; 102(7):785-794. doi:
10.1177/00220345231162344. [PMID: 37029659] - Ling Lin, Shumin Han, Zhihua Gong, Furong Ding, Zhonghua Liu, Wenjun Xiao. L-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1.
Food & function.
2023 Jun; ?(?):. doi:
10.1039/d3fo01001e. [PMID: 37338809] - Zhongsuzhi Chen, Meiying He, Yijie Zhou, Xi Chen, Hong Zhu, Bao Yang, Yueming Jiang, Hongxia Qu. Degradation of water-soluble polysaccharides in pulp of litchi during storage.
Food chemistry.
2023 Feb; 402(?):134289. doi:
10.1016/j.foodchem.2022.134289. [PMID: 36150360] - Chongxi Liu, Zhiyan Wang, Yin Chen, Yijun Yan, Lei Li, Yong-Jiang Wang, Lu Bai, Shanshan Li, Yanyan Zhang, Xiangjing Wang, Sheng-Xiong Huang, Wensheng Xiang. Guvermectin Biosynthesis Revealing the Key Role of a Phosphoribohydrolase and Structural Insight into the Active Glutamate of a Noncanonical Adenine Phosphoribosyltransferase.
ACS chemical biology.
2023 01; 18(1):102-111. doi:
10.1021/acschembio.2c00739. [PMID: 36623177] - Aniqua Tasnim Chowdhury, Md Nazmul Hasan, Fahmid H Bhuiyan, Md Qamrul Islam, Md Rakib Wazed Nayon, Md Mashiur Rahaman, Hammadul Hoque, Nurnabi Azad Jewel, Md Ashrafuzzaman, Shamsul H Prodhan. Identification, characterization of Apyrase (APY) gene family in rice (Oryza sativa) and analysis of the expression pattern under various stress conditions.
PloS one.
2023; 18(5):e0273592. doi:
10.1371/journal.pone.0273592. [PMID: 37163561] - Michelle Y Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren. CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue.
Frontiers in immunology.
2023; 14(?):1308456. doi:
10.3389/fimmu.2023.1308456. [PMID: 38264660] - Leszek A Kleczkowski, Abir U Igamberdiev. Magnesium and cell energetics: At the junction of metabolism of adenylate and non-adenylate nucleotides.
Journal of plant physiology.
2023 Jan; 280(?):153901. doi:
10.1016/j.jplph.2022.153901. [PMID: 36549033] - Xuefeng Wang, Li He, Zhiyuan Huang, Qiong Zhao, Jiangping Fan, Yang Tian, Aixiang Huang. Isolation, identification and characterization of a novel antimicrobial peptide from Moringa oleifera seeds based on affinity adsorption.
Food chemistry.
2023 Jan; 398(?):133923. doi:
10.1016/j.foodchem.2022.133923. [PMID: 35987005] - Yunda Huang, Lily Zhang, Amanda Eaton, Nonhlanhla N Mkhize, Lindsay N Carpp, Erika Rudnicki, Allan DeCamp, Michal Juraska, April Randhawa, Adrian McDermott, Julie Ledgerwood, Philip Andrew, Shelly Karuna, Srilatha Edupuganti, Nyaradzo Mgodi, Myron Cohen, Lawrence Corey, John Mascola, Peter B Gilbert, Lynn Morris, David C Montefiori. Prediction of serum HIV-1 neutralization titers of VRC01 in HIV-uninfected Antibody Mediated Prevention (AMP) trial participants.
Human vaccines & immunotherapeutics.
2022 12; 18(1):1908030. doi:
10.1080/21645515.2021.1908030. [PMID: 34213402] - Emanoelly Roberta de Carvalho Morais, Nathalia Maira Cabral de Medeiros, Francinaldo Leite da Silva, Isabel Andrade Lopes de Sousa, Izamara Gesiele Bezerra de Oliveira, Carlos Henrique Salvino Gadelha Meneses, Katia Castanho Scortecci. Redox homeostasis at SAM: a new role of HINT protein.
Planta.
2022 Dec; 257(1):12. doi:
10.1007/s00425-022-04044-5. [PMID: 36520227] - Lindsey Garnick, Christopher Bates, Andrey Massarsky, Pamela Spencer, Priyanka Sura, Andrew D Monnot, Andrew Maier. Dose and exposure route analyses inform relationships between liver steatosis and 2-amino-2-methyl-1-propanol: Implications for hazard characterization.
Journal of applied toxicology : JAT.
2022 12; 42(12):1873-1889. doi:
10.1002/jat.4308. [PMID: 35199353] - Shuhua Shen, Kungen Wang, Yihui Zhi, Yue Dong. Gypenosides counteract hepatic steatosis and intestinal barrier injury in rats with metabolic associated fatty liver disease by modulating the adenosine monophosphate activated protein kinase and Toll-like receptor 4/nuclear factor kappa B pathways.
Pharmaceutical biology.
2022 Dec; 60(1):1949-1959. doi:
10.1080/13880209.2022.2126503. [PMID: 36205541] - Xu-Dong Wen, Yao-Lei Zhang, Ling Yang, Zhen Ye, Guo-Chuan Fu, Yong-He Hu, Tao Pan, Qiao-Bo Ye. Angelica sinensis Polysaccharide and Astragalus membranaceus Polysaccharide Accelerate Liver Regeneration by Enhanced Glycolysis via Activation of JAK2/STAT3/HK2 Pathway.
Molecules (Basel, Switzerland).
2022 Nov; 27(22):. doi:
10.3390/molecules27227890. [PMID: 36431990] - Zhijun Zhou, Yu Ren, Jingxuan Yang, Mingyang Liu, Xiuhui Shi, Wenyi Luo, Kar-Ming Fung, Chao Xu, Michael S Bronze, Yuqing Zhang, Courtney W Houchen, Min Li. Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer.
Gastroenterology.
2022 11; 163(5):1281-1293.e1. doi:
10.1053/j.gastro.2022.06.058. [PMID: 35777482] - Yuwei Liu, Shen Shen, Zhimin Hao, Qing Wang, Yumei Zhang, Yulan Zhao, Yameng Tong, Fanli Zeng, Jingao Dong. Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica.
Molecular plant pathology.
2022 11; 23(11):1608-1619. doi:
10.1111/mpp.13253. [PMID: 35929228] - Juanjuan Cheng, Lieqiang Xu, Qiuxia Yu, Guoshu Lin, Xingdong Ma, Mengyao Li, Fengkun Guan, Yuhong Liu, Xiaoqi Huang, Jianhui Xie, Jiannan Chen, Ziren Su, Yucui Li. Metformin alleviates long-term high-fructose diet-induced skeletal muscle insulin resistance in rats by regulating purine nucleotide cycle.
European journal of pharmacology.
2022 Oct; 933(?):175234. doi:
10.1016/j.ejphar.2022.175234. [PMID: 36058289] - Ping-An Yao, Ke-Zhao Wei, Jia-Hua Feng, Xiao-Ning Liu, Xu Xu, Hong-Yan Cui, Xiao-Chen Zhang, Jian-Ping Gao. Sodium houttuyfonate protects against cardiac injury by regulating cardiac energy metabolism in diabetic rats.
European journal of pharmacology.
2022 Oct; 932(?):175236. doi:
10.1016/j.ejphar.2022.175236. [PMID: 36044971] - Lu Wang, Yuwei Zhang, Yafeng Ren, Xue Yang, Haijing Ben, Fulan Zhao, Sijin Yang, Li Wang, Jie Qing. Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis.
European journal of pharmacology.
2022 Oct; 932(?):175241. doi:
10.1016/j.ejphar.2022.175241. [PMID: 36058291] - Xue Mei Fang, Ying Liu, Ji Wang, Xin Zhang, Lei Wang, Li Zhang, Hong Ping Zhang, Lei Liu, Dan Huang, Dan Liu, Ke Deng, Feng Ming Luo, Hua Jing Wan, Wei Min Li, Gang Wang, Brian G Oliver. Endogenous Adenosine 5'-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations.
Lung.
2022 10; 200(5):579-589. doi:
10.1007/s00408-022-00570-x. [PMID: 36156139] - Atsuko Kitano, Toshio Norikura, Isao Matsui-Yuasa, Hiromi Shimakawa, Makoto Kamezawa, Akiko Kojima-Yuasa. Black carrot extract protects against hepatic injury through epigenetic modifications.
Journal of food biochemistry.
2022 10; 46(10):e14292. doi:
10.1111/jfbc.14292. [PMID: 35762419] - Xiao Chang, Yanhong He, Ling Wang, Chuanjin Luo, Yuntao Liu, Rong Li. Puerarin Alleviates LPS-Induced H9C2 Cell Injury by Inducing Mitochondrial Autophagy.
Journal of cardiovascular pharmacology.
2022 10; 80(4):600-608. doi:
10.1097/fjc.0000000000001315. [PMID: 35881898] - Qing Lu, Anaxi Houbaert, Qian Ma, Jingjing Huang, Lieven Sterck, Cheng Zhang, René Benjamins, Frederik Coppens, Frank Van Breusegem, Eugenia Russinova. Adenosine monophosphate deaminase modulates BIN2 activity through hydrogen peroxide-induced oligomerization.
The Plant cell.
2022 09; 34(10):3844-3859. doi:
10.1093/plcell/koac203. [PMID: 35876813] - Tomasz K Bednarski, Monika K Duda, Pawel Dobrzyn. Alterations of Lipid Metabolism in the Heart in Spontaneously Hypertensive Rats Precedes Left Ventricular Hypertrophy and Cardiac Dysfunction.
Cells.
2022 09; 11(19):. doi:
10.3390/cells11193032. [PMID: 36230994] - George Kogkos, Foteini Gkartziou, Spyridon Mourtas, Kostas K Barlos, Pavlos Klepetsanis, Kleomenis Barlos, Sophia G Antimisiaris. Liposomal Entrapment or Chemical Modification of Relaxin2 for Prolongation of Its Stability and Biological Activity.
Biomolecules.
2022 09; 12(10):. doi:
10.3390/biom12101362. [PMID: 36291571] - Hidetoshi Urakawa, Michael A Kratz, Taylor L Hancock, Rick A Armstrong. QT-AMP: Sequencing PCR amplicons from Quanti-Tray wells to analyze enterococci communities.
The Science of the total environment.
2022 Sep; 839(?):156188. doi:
10.1016/j.scitotenv.2022.156188. [PMID: 35618132] - Tobias Kruse. Function of Molybdenum Insertases.
Molecules (Basel, Switzerland).
2022 Aug; 27(17):. doi:
10.3390/molecules27175372. [PMID: 36080140] - Z X Du, Y Li, Z J Wang, D M Zhou, J H Yang. [Bioinformatics analysis of differentially expressed genes associated with chronic schistosomiasis japonica-induced hepatic fibrosis].
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control.
2022 Aug; 34(4):352-360. doi:
10.16250/j.32.1374.2022053. [PMID: 36116924] - Ahmed H Abdelazim, Sherif Ramzy. Spectrophotometric quantitative analysis of remdesivir using acid dye reagent selected by computational calculations.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Aug; 276(?):121188. doi:
10.1016/j.saa.2022.121188. [PMID: 35395463] - Chunyang Du, Yan Zhu, Yan Yang, Lin Mu, Xue Yan, Ming Wu, Chenming Zhou, Haijiang Wu, Wei Zhang, Yanhui Wu, Guoyu Zhang, Yue Hu, Yunzhuo Ren, Yonghong Shi. C1q/tumour necrosis factor-related protein-3 alleviates high-glucose-induced lipid accumulation and necroinflammation in renal tubular cells by activating the adenosine monophosphate-activated protein kinase pathway.
The international journal of biochemistry & cell biology.
2022 08; 149(?):106247. doi:
10.1016/j.biocel.2022.106247. [PMID: 35753650] - Katja Merches, Leonie Breunig, Julia Fender, Theresa Brand, Vanessa Bätz, Svenja Idel, Laxmikanth Kollipara, Yvonne Reinders, Albert Sickmann, Angela Mally, Kristina Lorenz. The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro.
Archives of toxicology.
2022 08; 96(8):2341-2360. doi:
10.1007/s00204-022-03306-1. [PMID: 35579693] - Lucio Boglione, Valentina Dodaro, Giulia Meli, Roberto Rostagno, Federica Poletti, Roberta Moglia, Bianca Bianchi, Maria Esposito, Silvio Borrè. Remdesivir treatment in hospitalized patients affected by COVID-19 pneumonia: A case-control study.
Journal of medical virology.
2022 Aug; 94(8):3653-3660. doi:
10.1002/jmv.27768. [PMID: 35411627] - Marko Lucijanic, Tomislav Cikara, Petra Bistrovic, Ivan Papic, Maja Ortner Hadziabdic, Nikolina Busic, Marina Lackovic, Natalia Cesar, Valentina Koscak, Josko Mitrovic, Bruno Barsic, Tomo Lucijanic. Remdesivir use in COVID-19 patients might predispose bacteremia, matched case-control analysis.
The Journal of infection.
2022 Aug; 85(2):174-211. doi:
10.1016/j.jinf.2022.04.045. [PMID: 35513188] - Mohsen Sedighi, Alireza Amanollahi, Omid Moradi Moghaddam, Hamed Basir Ghafouri, Seyede Elham Hoseini, Nader Tavakoli. Linear mixed model analysis to evaluate correlations between remdesivir adverse effects with age and gender of patients with mild Covid-19 pneumonia.
Journal of medical virology.
2022 Aug; 94(8):3783-3790. doi:
10.1002/jmv.27800. [PMID: 35491957] - Kevin Baudry, Félix Barbut, Séverine Domenichini, Damien Guillaumot, Mai Pham Thy, Hélène Vanacker, Wojciech Majeran, Anja Krieger-Liszkay, Emmanuelle Issakidis-Bourguet, Claire Lurin. Adenylates regulate Arabidopsis plastidial thioredoxin activities through the binding of a CBS domain protein.
Plant physiology.
2022 08; 189(4):2298-2314. doi:
10.1093/plphys/kiac199. [PMID: 35736508] - Manjit Kaur, Deepika Tiwari, Vishal Sidana, Kanya Mukhopadhyay. Remdesivir-Induced Liver Injury in a COVID-Positive Newborn.
Indian journal of pediatrics.
2022 Aug; 89(8):826. doi:
10.1007/s12098-022-04237-6. [PMID: 35583631] - Issa Haddad, Priyal Agarwal, Mohamed Hassanein. Remdesivir use in COVID-19 patients with end-stage kidney disease on intermittent hemodialysis: An absolute contraindication?.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2022 Aug; 26(4):850-851. doi:
10.1111/1744-9987.13833. [PMID: 35261170] - Marta Colaneri, Nicolò Amarasinghe, Leonardo Rezzonico, Teresa Chiara Pieri, Emilio Segalini, Margherita Sambo, Silvia Roda, Federica Meloni, Marilena Gregorini, Teresa Rampino, Stefano Pelenghi, Alessandra Ricciardi, Raffaele Bruno. Early remdesivir to prevent severe COVID-19 in recipients of solid organ transplant: a real-life study from Northern Italy.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Aug; 121(?):157-160. doi:
10.1016/j.ijid.2022.05.001. [PMID: 35533831] - Yusuke Marikawa, Vernadeth B Alarcon. Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations.
Reproductive toxicology (Elmsford, N.Y.).
2022 08; 111(?):135-147. doi:
10.1016/j.reprotox.2022.05.012. [PMID: 35605700] - Natalia Krisanova, Natalia Pozdnyakova, Artem Pastukhov, Marina Dudarenko, Oleg Shatursky, Olena Gnatyuk, Uliana Afonina, Kyrylo Pyrshev, Galina Dovbeshko, Semen Yesylevskyy, Tatiana Borisova. Amphiphilic anti-SARS-CoV-2 drug remdesivir incorporates into the lipid bilayer and nerve terminal membranes influencing excitatory and inhibitory neurotransmission.
Biochimica et biophysica acta. Biomembranes.
2022 08; 1864(8):183945. doi:
10.1016/j.bbamem.2022.183945. [PMID: 35461828] - Shijia Huang, Aolin Jia, Wen Song, Giuliana Hessler, Yonggang Meng, Yue Sun, Lina Xu, Henriette Laessle, Jan Jirschitzka, Shoucai Ma, Yu Xiao, Dongli Yu, Jiao Hou, Ruiqi Liu, Huanhuan Sun, Xiaohui Liu, Zhifu Han, Junbiao Chang, Jane E Parker, Jijie Chai. Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity.
Science (New York, N.Y.).
2022 07; 377(6605):eabq3297. doi:
10.1126/science.abq3297. [PMID: 35857645] - Ying Mei, Hui Hu, Liangjun Deng, Xiaoou Sun, Wen Tan. Therapeutic effects of isosteviol sodium on non-alcoholic fatty liver disease by regulating autophagy via Sirt1/AMPK pathway.
Scientific reports.
2022 07; 12(1):12857. doi:
10.1038/s41598-022-16119-0. [PMID: 35896572] - Jingjing Cao, Rendong Zheng, Xiaoyan Chang, Yuanyuan Zhao, Dongjian Zhang, Meng Gao, Zhiqi Yin, Cuihua Jiang, Jian Zhang. Cyclocarya paliurus triterpenoids suppress hepatic gluconeogenesis via AMPK-mediated cAMP/PKA/CREB pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 102(?):154175. doi:
10.1016/j.phymed.2022.154175. [PMID: 35609386] - Liva Checkmahomed, Julie Carbonneau, Venice Du Pont, Nicholas C Riola, Jason K Perry, Jiani Li, Bastien Paré, Shawn M Simpson, Martin A Smith, Danielle P Porter, Guy Boivin. In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance.
Antimicrobial agents and chemotherapy.
2022 Jul; 66(7):e0019822. doi:
10.1128/aac.00198-22. [PMID: 35708323] - Jonathan Fintzi, Tyler Bonnett, Daniel A Sweeney, Nikhil A Huprikar, Anuradha Ganesan, Maria G Frank, Susan L F McLellan, Lori E Dodd, Pablo Tebas, Aneesh K Mehta. Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 Jul; 74(12):2209-2217. doi:
10.1093/cid/ciab712. [PMID: 34409989] - Markus Fischer, Peter Müller, Holger A Scheidt, Meike Luck. Drug-Membrane Interactions: Effects of Virus-Specific RNA-Dependent RNA Polymerase Inhibitors Remdesivir and Favipiravir on the Structure of Lipid Bilayers.
Biochemistry.
2022 Jul; 61(13):1392-1403. doi:
10.1021/acs.biochem.2c00042. [PMID: 35731976] - Andrea Giacomelli, Alessandro Cozzi-Lepri, Giacomo Casalini, Letizia Oreni, Anna Lisa Ridolfo, Spinello Antinori. Estimating the effectiveness of remdesivir on risk of COVID-19 mortality: The role of observational data.
Pharmacological research.
2022 07; 181(?):106268. doi:
10.1016/j.phrs.2022.106268. [PMID: 35605811] - Justin G Julander, Elaine Bunyan, Robert Jordan, Danielle P Porter. Remdesivir efficacy against yellow fever in a hamster model.
Antiviral research.
2022 07; 203(?):105331. doi:
10.1016/j.antiviral.2022.105331. [PMID: 35533777] - Tamer Z Attia, John M Boushra, Ahmed F Abdel Hakiem, Adel S Lashien, Deena A M Noureldeen. Spectrofluorimetric determination of the anti-Covid 19 agent, remdesivir, in vials and spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2022 Jul; 37(7):1192-1199. doi:
10.1002/bio.4274. [PMID: 35548893] - Ling Yang, I-Hsin Lin, Lie-Chwen Lin, Jeffrey W Dalley, Tung-Hu Tsai. Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats.
EBioMedicine.
2022 Jul; 81(?):104095. doi:
10.1016/j.ebiom.2022.104095. [PMID: 35671622] - Carlos K H Wong, Ivan C H Au, Wing Yiu Cheng, Kenneth K C Man, Kristy T K Lau, Lung Yi Mak, Sing Leung Lui, Matthew S H Chung, Xi Xiong, Eric H Y Lau, Benjamin J Cowling. Remdesivir use and risks of acute kidney injury and acute liver injury among patients hospitalised with COVID-19: a self-controlled case series study.
Alimentary pharmacology & therapeutics.
2022 07; 56(1):121-130. doi:
10.1111/apt.16894. [PMID: 35318694] - Takashi Ichiyama, Masamichi Komatsu, Yosuke Wada, Masayuki Hanaoka. Report of a combination of remdesivir, intravenous methylprednisolone pulse, and tocilizumab for severe coronavirus disease: 20-case series at a single institution.
Respiratory investigation.
2022 Jul; 60(4):604-606. doi:
10.1016/j.resinv.2022.04.001. [PMID: 35501265] - Jing Wang, Xin-Qiang Ni, Li-Min Li, Ying-Zhao Liao, Yao Chen, Chun-Ling Huang. [Effect of Rehmanniae Radix Praeparata on energy metabolism in prefrontal cortex of rats with attention deficit hyperactivity disorder based on "static Yin and dynamic Yang" theory].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jul; 47(13):3554-3561. doi:
10.19540/j.cnki.cjcmm.20220412.402. [PMID: 35850809] - Petra Bistrovic, Sime Manola, Marko Lucijanic. Bradycardia during remdesivir treatment might be associated with improved survival in patients with COVID-19: a retrospective cohort study on 473 patients from a tertiary centre.
Postgraduate medical journal.
2022 07; 98(1161):501-502. doi:
10.1136/postgradmedj-2021-141079. [PMID: 34876485] - Meng Yuan, Wenjuan Hu, Yingying Feng, Yue Tong, Xin Wang, Bo Tan, Hui Xu, Jia Liu. Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice.
Biomedical chromatography : BMC.
2022 Jul; 36(7):e5380. doi:
10.1002/bmc.5380. [PMID: 35373846] - Sushmita Khadka, Karen Williams, Shantanu Solanki. Remdesivir-Associated Pancreatitis.
American journal of therapeutics.
2022 Jul; 29(4):e444-e446. doi:
10.1097/mjt.0000000000001266. [PMID: 33590992] - Andrea Tumminia, Raffaella Romano, Giuseppe Brugaletta, Roberto Scicali, Giuseppina Biondi, Rosario Oliveri, Marcello Romano, Paola Magnano San Lio. The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2022 07; 32(7):1635-1641. doi:
10.1016/j.numecd.2022.04.005. [PMID: 35508458] - E Leegwater, D J A R Moes, L B E Bosma, T H Ottens, I M van der Meer, C van Nieuwkoop, E B Wilms. Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients.
Antimicrobial agents and chemotherapy.
2022 06; 66(6):e0025422. doi:
10.1128/aac.00254-22. [PMID: 35647646] - Johannes Jungwirth, Clio Häring, Sarah König, Liane Giebeler, Heena Doshi, Christian Brandt, Stefanie Deinhardt-Emmer, Bettina Löffler, Christina Ehrhardt. D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23136880. [PMID: 35805887] - Jared Pitts, Jiani Li, Jason K Perry, Venice Du Pont, Nicholas Riola, Lauren Rodriguez, Xianghan Lu, Chaitanya Kurhade, Xuping Xie, Gregory Camus, Savrina Manhas, Ross Martin, Pei-Yong Shi, Tomas Cihlar, Danielle P Porter, Hongmei Mo, Evguenia Maiorova, John P Bilello. Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Antimicrobial agents and chemotherapy.
2022 06; 66(6):e0022222. doi:
10.1128/aac.00222-22. [PMID: 35532238] - Catherine S Nation, Akram A Da'Dara, Patrick J Skelly. NAD-catabolizing ectoenzymes of Schistosoma mansoni.
The Biochemical journal.
2022 06; 479(11):1165-1180. doi:
10.1042/bcj20210784. [PMID: 35593185] - NULL. COVID-19 update: remdesivir (Veklury) FDA-approved for children <12 years old.
The Medical letter on drugs and therapeutics.
2022 06; 64(1652):e1. doi:
NULL. [PMID: 35657368] - Rachel Beckerman, Andrea Gori, Sushanth Jeyakumar, Jakob J Malin, Roger Paredes, Pedro Póvoa, Nathaniel J Smith, Armando Teixeira-Pinto. Remdesivir for the treatment of patients hospitalized with COVID-19 receiving supplemental oxygen: a targeted literature review and meta-analysis.
Scientific reports.
2022 Jun; 12(1):9622. doi:
10.1038/s41598-022-13680-6. [PMID: 35688854] - Mathias Brands, Peter Dörmann. Two AMP-Binding Domain Proteins from Rhizophagus irregularis Involved in Import of Exogenous Fatty Acids.
Molecular plant-microbe interactions : MPMI.
2022 Jun; 35(6):464-476. doi:
10.1094/mpmi-01-22-0026-r. [PMID: 35285673] - M D Gil-Sierra, M P Briceño-Casado, E J Alegre-Del Rey, M Sánchez-Hidalgo. Efficacy of early use of remdesivir: a systematic review of subgroup analysis.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia.
2022 Jun; 35(3):249-259. doi:
10.37201/req/154.2021. [PMID: 35294145] - Peter Dovjak, Hans Jürgen Heppner. Title Not Available.
MMW Fortschritte der Medizin.
2022 06; 164(11):28. doi:
10.1007/s15006-022-1234-z. [PMID: 35650486] - Carola Ledderose, Eleftheria-Angeliki Valsami, Wolfgang G Junger. Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood.
Purinergic signalling.
2022 06; 18(2):223-239. doi:
10.1007/s11302-022-09842-w. [PMID: 35132577] - Natália Pontes Bona, Mayara Sandrielly Pereira Soares, Nathalia Stark Pedra, Luiza Spohr, Francieli da Silva Dos Santos, Alana Seixas de Farias, Fernando Lopez Alvez, Bernardo de Moraes Meine, Karina Pereira Luduvico, Roselia Maria Spanevello, Francieli Moro Stefanello. Tannic Acid Attenuates Peripheral and Brain Changes in a Preclinical Rat Model of Glioblastoma by Modulating Oxidative Stress and Purinergic Signaling.
Neurochemical research.
2022 Jun; 47(6):1541-1552. doi:
10.1007/s11064-022-03547-7. [PMID: 35178643] - Carlos K H Wong, Ivan C H Au, Wing Yiu Cheng, Kenneth K C Man, Kristy T K Lau, Lung Yi Mak, Sing Leung Lui, Matthew S H Chung, Xi Xiong, Eric H Y Lau, Benjamin J Cowling. Editorial: liver and kidney injury from remdesivir-an issue not as much as its purpose. Authors' reply.
Alimentary pharmacology & therapeutics.
2022 06; 55(11):1457-1458. doi:
10.1111/apt.16932. [PMID: 35538354] - Huancong Shi, Xiaofang Cheng, Jiacheng Peng, Hongliang Feng, Paitoon Tontiwachwuthikul, Jiawei Hu. The CO2 absorption and desorption analysis of tri-solvent MEA + EAE + AMP compared with MEA + BEA + AMP along with 'coordination effects' evaluation.
Environmental science and pollution research international.
2022 Jun; 29(27):40686-40700. doi:
10.1007/s11356-022-18792-0. [PMID: 35083697] - Susanne Rüfenacht, Pascal Gantenbein, Katia Boggian, Domenica Flury, Lukas Kern, Günter Dollenmaier, Philipp Kohler, Werner C Albrich. Remdesivir in Coronavirus Disease 2019 patients treated with anti-CD20 monoclonal antibodies: a case series.
Infection.
2022 Jun; 50(3):783-790. doi:
10.1007/s15010-022-01821-y. [PMID: 35426564] - Shireesha Vuppalanchi, Raj Vuppalanchi. Editorial: liver and kidney injury from remdesivir-an issue not as much as its purpose.
Alimentary pharmacology & therapeutics.
2022 06; 55(11):1456. doi:
10.1111/apt.16921. [PMID: 35538355] - Steve McDonald, Simon Turner, Matthew J Page, Tari Turner. Most published systematic reviews of remdesivir for COVID-19 were redundant and lacked currency.
Journal of clinical epidemiology.
2022 Jun; 146(?):22-31. doi:
10.1016/j.jclinepi.2022.02.006. [PMID: 35192923] - Irina Rajakumar, Debra L Isaac, Nowell M Fine, Brian Clarke, Linda P Ward, Rebecca J Malott, Kanti Pabbaraju, Kara Gill, Byron M Berenger, Yi-Chan Lin, David H Evans, John M Conly. Extensive environmental contamination and prolonged severe acute respiratory coronavirus-2 (SARS CoV-2) viability in immunosuppressed recent heart transplant recipients with clinical and virologic benefit with remdesivir.
Infection control and hospital epidemiology.
2022 06; 43(6):817-819. doi:
10.1017/ice.2021.89. [PMID: 33706819] - Jin Gu Yoon, Jin Sae Yoo, Jungmin Lee, Hak-Jun Hyun, Hye Seong, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Young Rong Kim, Jung Yeon Heo, Joon-Yong Bae, Chunguang Cui, Sohyun Lee, Man-Seong Park, Joon Young Song. Viable SARS-CoV-2 shedding under remdesivir and dexamethasone treatment.
The Journal of infection.
2022 06; 84(6):834-872. doi:
10.1016/j.jinf.2022.03.022. [PMID: 35351541] - Florence Ader, Maude Bouscambert-Duchamp, Maya Hites, Nathan Peiffer-Smadja, France Mentré, Charles Burdet. Final results of the DisCoVeRy trial of remdesivir for patients admitted to hospital with COVID-19.
The Lancet. Infectious diseases.
2022 06; 22(6):764-765. doi:
10.1016/s1473-3099(22)00295-x. [PMID: 35643099] - Mikael Kajova, Eliisa Kekäläinen, Veli-Jukka Anttila, Juuso Paajanen. Successful treatment with a short course of remdesivir in a case of prolonged COVID-19 in a lymphoma patient.
Infectious diseases (London, England).
2022 06; 54(6):455-459. doi:
10.1080/23744235.2022.2028896. [PMID: 35086417] - Mengchen Shi, Yu Tian, Lingyuan He, Jingdan Zhang, Xiangling Yang, Huanliang Liu. Potential roles of serum ATPase and AMPase in predicting diagnosis of colorectal cancer patients.
Bioengineered.
2022 06; 13(6):14204-14214. doi:
10.1080/21655979.2022.2084423. [PMID: 35754345] - Shan Wang, Christy Huynh, Shahidul Islam, Brian Malone, Naveed Masani, D'Andrea Joseph. Assessment of Safety of Remdesivir in Covid - 19 Patients with Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min per 1.73 m^2.
Journal of intensive care medicine.
2022 Jun; 37(6):764-768. doi:
10.1177/08850666211070521. [PMID: 34967255] - Pierluigi Russo, Evelina Tacconelli, Pier Paolo Olimpieri, Simone Celant, Antonietta Colatrella, Luca Tomassini, Giorgio Palù. Mortality in SARS-CoV-2 Hospitalized Patients Treated with Remdesivir: A Nationwide, Registry-Based Study in Italy.
Viruses.
2022 05; 14(6):. doi:
10.3390/v14061197. [PMID: 35746668] - George A Diaz, Alyssa B Christensen, Tobias Pusch, Delaney Goulet, Shu-Ching Chang, Gary L Grunkemeier, Paul A McKelvey, Ari Robicsek, Tom French, Guilford T Parsons, Glenn Doherty, Charles Laurenson, Ryan Roper, Jennifer Hadlock, Cameron J Cover, Brent Footer, Philip Robinson, Mary Micikas, Jennifer E Marfori, Charlotte Cronenweth, Yogavedya Mukkamala, Jamie Mackiewicz, Ekra Rai, Martha Dickinson Matson, Jodie Davila, Justin Rueda, Reda Tipton, Heather Algren, Brittney C Ward, Stephen Malkoski, Tyler Gluckman, Gregory B Tallman, Henry Arguinchona, Terese C Hammond, Steven Standaert, Joshua Christensen, Jose F Echaiz, Robert Choi, Daniel McClung, Albert Pacifico, Martin Fee, Farjad Sarafian, William R Berrington, Jason D Goldman. Remdesivir and Mortality in Patients With Coronavirus Disease 2019.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 05; 74(10):1812-1820. doi:
10.1093/cid/ciab698. [PMID: 34409431] - Lajos Szente, Tibor Renkecz, Dávid Sirok, János Stáhl, Gábor Hirka, István Puskás, Tamás Sohajda, Éva Fenyvesi. Comparative bioavailability study following a single dose intravenous and buccal administration of remdesivir in rabbits.
International journal of pharmaceutics.
2022 May; 620(?):121739. doi:
10.1016/j.ijpharm.2022.121739. [PMID: 35421532] - NULL. Title Not Available.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
2022 05; 194(20):E713-E723. doi:
10.1503/cmaj.211698-f. [PMID: 35609913] - Sehr Naseem-Khan, Madison B Berger, Emmett M Leddin, Yazdan Maghsoud, G Andrés Cisneros. Impact of Remdesivir Incorporation along the Primer Strand on SARS-CoV-2 RNA-Dependent RNA Polymerase.
Journal of chemical information and modeling.
2022 05; 62(10):2456-2465. doi:
10.1021/acs.jcim.2c00201. [PMID: 35435671] - . Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.
Lancet (London, England).
2022 05; 399(10339):1941-1953. doi:
10.1016/s0140-6736(22)00519-0. [PMID: 35512728] - Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Jian-Ru Qin, Qi-Hong Yan, Xia Jin, Xin-Wen Chen, Yong-Tang Zheng, Jin-Cun Zhao, Jian-Hua Wang. Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice.
Zoological research.
2022 May; 43(3):457-468. doi:
10.24272/j.issn.2095-8137.2021.469. [PMID: 35503561] - Elisabeth Mahase. Covid-19: Remdesivir has 'small effect' against death or progression to ventilation, WHO trial finds.
BMJ (Clinical research ed.).
2022 05; 377(?):o1118. doi:
10.1136/bmj.o1118. [PMID: 35508315] - Alexandra Schäfer, David R Martinez, John J Won, Rita M Meganck, Fernando R Moreira, Ariane J Brown, Kendra L Gully, Mark R Zweigart, William S Conrad, Samantha R May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T Barrett, Blake J Bleier, Roy Bannister, Joy Y Feng, John P Bilello, Tomas Cihlar, Richard L Mackman, Stephanie A Montgomery, Ralph S Baric, Timothy P Sheahan. Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Science translational medicine.
2022 05; 14(643):eabm3410. doi:
10.1126/scitranslmed.abm3410. [PMID: 35315683] - Shinya Tsuzuki, Kayoko Hayakawa, Yukari Uemura, Tomohiro Shinozaki, Nobuaki Matsunaga, Mari Terada, Setsuko Suzuki, Yusuke Asai, Koji Kitajima, Sho Saito, Gen Yamada, Taro Shibata, Masashi Kondo, Kazuo Izumi, Masayuki Hojo, Tetsuya Mizoue, Kazuhisa Yokota, Fukumi Nakamura-Uchiyama, Fumitake Saito, Wataru Sugiura, Norio Ohmagari. Effectiveness of remdesivir in hospitalized nonsevere patients with COVID-19 in Japan: A large observational study using the COVID-19 Registry Japan.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 May; 118(?):119-125. doi:
10.1016/j.ijid.2022.02.039. [PMID: 35192953] - Sabrina Wimmer, Sarai M Keestra. Public Risk-Taking and Rewards During the COVID-19 Pandemic - A Case Study of Remdesivir in the Context of Global Health Equity.
International journal of health policy and management.
2022 05; 11(5):567-578. doi:
10.34172/ijhpm.2020.166. [PMID: 32945638]
