ZILEUTON (BioDeep_00000406065)
代谢物信息卡片
ZILEUTON
化学式: C11H12N2O2S (236.0619452)
中文名称: 齐留通
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O
InChI: InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D020024 - Leukotriene Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D004791 - Enzyme Inhibitors > D016859 - Lipoxygenase Inhibitors
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1322 - Lipooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:10112
- KEGGdrug: D00414
- PubChem: 60490
- DrugBank: DB00744
- ChEMBL: CHEMBL93
- CAS: 111406-87-2
- MoNA: FiehnHILIC003060
- MoNA: FiehnHILIC002426
- MoNA: FiehnHILIC001586
- MoNA: FiehnHILIC000868
- medchemexpress: HY-14164
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rafaela das Dores Pereira, Rayane Aparecida Nonato Rabelo, Natália Fernanda de Melo Oliveira, Samuel Luiz Teixeira Porto, Ana Claudia Dos Santos Pereira Andrade, Celso M Queiroz-Junior, César Luís Nascimento Barbosa, Luiz Pedro de Souza-Costa, Felipe Rocha da Silva Santos, Fernando Bento Rodrigues Oliveira, Bárbara Luísa Vieira da Silva, Hanna L Umezu, Raquel Ferreira, Glauber S F da Silva, Jader Santos Cruz, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Fabiana Simão Machado. A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus.
Viruses.
2023 10; 15(10):. doi:
10.3390/v15102049. [PMID: 37896826] - Piyun Sun, Jinlong Zhou, Tianshu Zhao, Huiping Qi, Guibin Qian. Zileuton Ameliorates Neuronal Ferroptosis and Functional Recovery After Spinal Cord Injury.
Alternative therapies in health and medicine.
2023 Jul; 29(5):314-319. doi:
". [PMID: 37171943] - Jong-Jer Lee, Guo-Ping Chang-Chien, Sufan Lin, Yu-Ting Hsiao, Mu-Chan Ke, Alexander Chen, Tsu-Kung Lin. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration.
Oxidative medicine and cellular longevity.
2022; 2022(?):1792894. doi:
10.1155/2022/1792894. [PMID: 35251467] - Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, Alexia Ville, Ida Cerqua, Guillaume Viault, Dimitri Bréard, Simona Pace, Veronika Temml, Elena Brunner, Paul M Jordan, Marta C Marques, Konstantin Loeser, André Gollowitzer, Stephan Permann, Jana Gerstmeier, Stefan Lorkowski, Hermann Stuppner, Ulrike Garscha, Tiago Rodrigues, Gonçalo J L Bernardes, Daniela Schuster, Denis Séraphin, Pascal Richomme, Antonietta Rossi, Alexander S Mosig, Fiorentina Roviezzo, Oliver Werz, Jean-Jacques Helesbeux, Andreas Koeberle. Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Journal of medicinal chemistry.
2021 08; 64(15):11496-11526. doi:
10.1021/acs.jmedchem.1c00806. [PMID: 34279935] - Jianjun Tang, Chuang Zhang, Jingjing Lin, Peng Duan, Jian Long, Hongyan Zhu. ALOX5-5-HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation.
Cancer medicine.
2021 08; 10(15):5246-5255. doi:
10.1002/cam4.4066. [PMID: 34121352] - Renren Bai, Chuansheng Yao, Zhichao Zhong, Jiamin Ge, Ziqiang Bai, Xiangyang Ye, Tian Xie, Yuanyuan Xie. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation.
European journal of medicinal chemistry.
2021 Mar; 213(?):113165. doi:
10.1016/j.ejmech.2021.113165. [PMID: 33454546] - Miroslav Sisa, Marcela Dvorakova, Veronika Temml, Veronika Jarosova, Tomas Vanek, Premysl Landa. Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.
European journal of medicinal chemistry.
2020 Oct; 204(?):112620. doi:
10.1016/j.ejmech.2020.112620. [PMID: 32738413] - Francesca Citron, Luigi Perelli, Angela K Deem, Giannicola Genovese, Andrea Viale. Leukotrienes, a potential target for Covid-19.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 10; 161(?):102174. doi:
10.1016/j.plefa.2020.102174. [PMID: 32977289] - Chau Phi Dinh, Alexia Ville, Konstantin Neukirch, Guillaume Viault, Veronika Temml, Andreas Koeberle, Oliver Werz, Daniela Schuster, Hermann Stuppner, Pascal Richomme, Jean-Jacques Helesbeux, Denis Séraphin. Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors.
European journal of medicinal chemistry.
2020 Sep; 202(?):112518. doi:
10.1016/j.ejmech.2020.112518. [PMID: 32668380] - Ayyoub Selka, Jérémie A Doiron, Pierre Lyons, Sonia Dastous, Alison Chiasson, Marc Cormier, Sandra Turcotte, Marc E Surette, Mohamed Touaibia. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
European journal of medicinal chemistry.
2019 Oct; 179(?):347-357. doi:
10.1016/j.ejmech.2019.06.060. [PMID: 31260889] - Jan Hošek, Veronika Leláková, Pavel Bobál, Hana Pížová, Markéta Gazdová, Milan Malaník, Karolina Jakubczyk, Ondřej Veselý, Přemysl Landa, Veronika Temml, Daniela Schuster, Vilailak Prachyawarakorn, Phanruethai Pailee, Gang Ren, Filip Zpurný, Michal Oravec, Karel Šmejkal. Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.
Journal of natural products.
2019 07; 82(7):1839-1848. doi:
10.1021/acs.jnatprod.9b00081. [PMID: 31268709] - Hao Guo, Iris C Verhoek, Gerian G H Prins, Ramon van der Vlag, Petra E van der Wouden, Ronald van Merkerk, Wim J Quax, Peter Olinga, Anna K H Hirsch, Frank J Dekker. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity.
Journal of medicinal chemistry.
2019 05; 62(9):4624-4637. doi:
10.1021/acs.jmedchem.9b00212. [PMID: 30964295] - Elvira Escribano-Ferrer, Josep Queralt Regué, Xavier Garcia-Sala, Antoni Boix Montañés, Rosa M Lamuela-Raventos. In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice.
Journal of natural products.
2019 02; 82(2):177-182. doi:
10.1021/acs.jnatprod.8b00366. [PMID: 30688453] - Sun-Yee Cheung, Markus Werner, Lucia Esposito, Fabiana Troisi, Vincenza Cantone, Stefanie Liening, Stefanie König, Jana Gerstmeier, Andreas Koeberle, Rossella Bilancia, Roberta Rizza, Antonietta Rossi, Fiorentina Roviezzo, Veronika Temml, Daniela Schuster, Hermann Stuppner, Manfred Schubert-Zsilavecz, Oliver Werz, Thomas Hanke, Simona Pace. Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
European journal of medicinal chemistry.
2018 Aug; 156(?):815-830. doi:
10.1016/j.ejmech.2018.07.031. [PMID: 30053720] - Mai M Helmy, Amel A Hashim, Samar M Mouneir. Zileuton alleviates acute cisplatin nephrotoxicity: Inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis.
Prostaglandins & other lipid mediators.
2018 03; 135(?):1-10. doi:
10.1016/j.prostaglandins.2018.01.001. [PMID: 29355720] - Ramandeep Kaur, Sundeep Kaur Manjal, Ravindra K Rawal, Kapil Kumar. Recent synthetic and medicinal perspectives of tryptanthrin.
Bioorganic & medicinal chemistry.
2017 09; 25(17):4533-4552. doi:
10.1016/j.bmc.2017.07.003. [PMID: 28720329] - Mila F M Madeira, Celso M Queiroz-Junior, Jôice D Corrêa, Sílvia M C Werneck, Fabiana S Machado, Thiago M Cunha, Gustavo P Garlet, Mauro M Teixeira, Tarcília A Silva, Daniele G Souza. The role of 5-lipoxygenase in Aggregatibacter actinomycetemcomitans-induced alveolar bone loss.
Journal of clinical periodontology.
2017 Aug; 44(8):793-802. doi:
10.1111/jcpe.12755. [PMID: 28569991] - D Saul, S Gleitz, H H Nguyen, R L Kosinsky, S Sehmisch, D B Hoffmann, M Wassmann, B Menger, M Komrakova. Effect of the lipoxygenase-inhibitors baicalein and zileuton on the vertebra in ovariectomized rats.
Bone.
2017 Aug; 101(?):134-144. doi:
10.1016/j.bone.2017.04.011. [PMID: 28455215] - Tomoki Takeda, Yukiko Komiya, Takayuki Koga, Takumi Ishida, Yuji Ishii, Yasushi Kikuta, Michio Nakaya, Hitoshi Kurose, Takehiko Yokomizo, Takao Shimizu, Hiroshi Uchi, Masutaka Furue, Hideyuki Yamada. Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
The Journal of biological chemistry.
2017 06; 292(25):10586-10599. doi:
10.1074/jbc.m116.764332. [PMID: 28487374] - Zuzana Hanáková, Jan Hošek, Zsófia Kutil, Veronika Temml, Přemysl Landa, Tomáš Vaněk, Daniela Schuster, Stefano Dall'Acqua, Josef Cvačka, Ondřej Polanský, Karel Šmejkal. Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
Journal of natural products.
2017 04; 80(4):999-1006. doi:
10.1021/acs.jnatprod.6b01011. [PMID: 28322565] - Leyla Abueid, Ünal Uslu, Alev Cumbul, Ayliz Velioğlu Öğünç, Feriha Ercan, İnci Alican. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction.
Anatolian journal of cardiology.
2017 Apr; 17(4):269-275. doi:
10.14744/anatoljcardiol.2016.7248. [PMID: 27849187] - Gianna Allegrone, Federica Pollastro, Gianmaria Magagnini, Orazio Taglialatela-Scafati, Julia Seegers, Andreas Koeberle, Oliver Werz, Giovanni Appendino. The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains.
Journal of natural products.
2017 03; 80(3):731-734. doi:
10.1021/acs.jnatprod.6b01126. [PMID: 28165233] - Masanori Hijioka, Junpei Anan, Hayato Ishibashi, Yuki Kurauchi, Akinori Hisatsune, Takahiro Seki, Tomoaki Koga, Takehiko Yokomizo, Takao Shimizu, Hiroshi Katsuki. Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice.
The Journal of pharmacology and experimental therapeutics.
2017 03; 360(3):399-408. doi:
10.1124/jpet.116.238824. [PMID: 28035009] - Yaoyu Chen, Yi Shan, Min Lu, Ngoc DeSouza, Zhiru Guo, Ronald Hoffman, Aibin Liang, Shaoguang Li. Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.
Cancer research.
2017 01; 77(1):164-174. doi:
10.1158/0008-5472.can-15-2933. [PMID: 27784744] - Giovanni Pallio, Alessandra Bitto, Gabriele Pizzino, Federica Galfo, Natasha Irrera, Letteria Minutoli, Vincenzo Arcoraci, Giovanni Squadrito, Antonio Macrì, Francesco Squadrito, Domenica Altavilla. Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis.
European journal of pharmacology.
2016 Oct; 789(?):152-162. doi:
10.1016/j.ejphar.2016.07.033. [PMID: 27450484] - Martino Forino, Simona Pace, Giuseppina Chianese, Laura Santagostini, Markus Werner, Christina Weinigel, Silke Rummler, Gelsomina Fico, Oliver Werz, Orazio Taglialatela-Scafati. Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "Cascade").
Journal of natural products.
2016 Mar; 79(3):590-7. doi:
10.1021/acs.jnatprod.5b01052. [PMID: 26918635] - Przemyslaw Rzodkiewicz, Emilia Gasinska, Slawomir Maslinski, Magdalena Bujalska-Zadrozny. Antinociceptive properties of esculetin in non-inflammatory and inflammatory models of pain in rats.
Clinical and experimental pharmacology & physiology.
2015 Feb; 42(2):213-9. doi:
10.1111/1440-1681.12346. [PMID: 25425056] - Andreas P Lill, Carmen B Rödl, Dieter Steinhilber, Holger Stark, Bettina Hofmann. Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.
European journal of medicinal chemistry.
2015 Jan; 89(?):503-23. doi:
10.1016/j.ejmech.2014.10.054. [PMID: 25462262] - Carmen B Rödl, Dominik Vogt, Simon B M Kretschmer, Katja Ihlefeld, Sebastian Barzen, Astrid Brüggerhoff, Janosch Achenbach, Ewgenij Proschak, Dieter Steinhilber, Holger Stark, Bettina Hofmann. Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.
European journal of medicinal chemistry.
2014 Sep; 84(?):302-11. doi:
10.1016/j.ejmech.2014.07.025. [PMID: 25036790] - Konstantina Vougogiannopoulou, Christelle Lemus, Maria Halabalaki, Carlo Pergola, Oliver Werz, Amos B Smith, Sylvie Michel, Leandros Skaltsounis, Brigitte Deguin. One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor.
Journal of natural products.
2014 Mar; 77(3):441-5. doi:
10.1021/np401010x. [PMID: 24568174] - Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):189-211. doi:
10.1093/toxsci/kft223. [PMID: 24085192] - Phillip Pian, Edward Labovitz, Keith Hoffman, Claudia F Clavijo, Rachael Rzasa Lynn, Jeffrey L Galinkin, Alexander A Vinks, Punam Malik, Uwe Christians. Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Oct; 937(?):79-83. doi:
10.1016/j.jchromb.2013.08.014. [PMID: 24029553] - Eric K Hoobler, Charles Holz, Theodore R Holman. Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
Bioorganic & medicinal chemistry.
2013 Jul; 21(13):3894-9. doi:
10.1016/j.bmc.2013.04.016. [PMID: 23669189] - Arash Mohebati, Ginger L Milne, Xi Kathy Zhou, Anna J Duffield-Lillico, Jay O Boyle, Allison Knutson, Brian P Bosworth, Philip J Kingsley, Lawrence J Marnett, Powel H Brown, Esther G Akpa, Eva Szabo, Andrew J Dannenberg. Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers.
Cancer prevention research (Philadelphia, Pa.).
2013 Jul; 6(7):646-55. doi:
10.1158/1940-6207.capr-13-0083. [PMID: 23682075] - Pier Morin, Dean Ferguson, Luc M LeBlanc, Martin J G Hébert, Aurélie F Paré, Jacques Jean-François, Marc E Surette, Mohamed Touaibia, Miroslava Cuperlovic-Culf. NMR metabolomics analysis of the effects of 5-lipoxygenase inhibitors on metabolism in glioblastomas.
Journal of proteome research.
2013 May; 12(5):2165-76. doi:
10.1021/pr400026q. [PMID: 23557402] - San-hua Fang, Ka-na Lin, Xue-qin Huang, Yun-bi Lu, Wei-ping Zhang, Er-qing Wei. Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells.
Acta pharmacologica Sinica.
2012 Dec; 33(12):1511-7. doi:
10.1038/aps.2012.101. [PMID: 23085741] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Yi Luo, Payal Rana, Yvonne Will. Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):346-62. doi:
10.1093/toxsci/kfs208. [PMID: 22700542] - Tsugunobu Andoh, Kazunari Sakai, Masahisa Urashima, Kayo Kitazawa, Azusa Honma, Yasushi Kuraishi. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy.
Experimental eye research.
2012 May; 98(?):97-103. doi:
10.1016/j.exer.2012.03.021. [PMID: 22504036] - Martin J Edelman, Lydia Hodgson, Paula Y Rosenblatt, Robert H Christenson, Everett E Vokes, Xiaofei Wang, Robert Kratzke. CYFRA 21-1 as a prognostic and predictive marker in advanced non-small-cell lung cancer in a prospective trial: CALGB 150304.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2012 Apr; 7(4):649-54. doi:
10.1097/jto.0b013e31824a8db0. [PMID: 22425913] - Jonathan Bertin, Corinne Barat, Sylvie Méthot, Michel J Tremblay. Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous system.
Retrovirology.
2012 Jan; 9(?):4. doi:
10.1186/1742-4690-9-4. [PMID: 22236409] - Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
10.1124/dmd.111.040758. [PMID: 21965623] - Luc H Boudreau, Jacques Maillet, Luc M LeBlanc, Jacques Jean-François, Mohamed Touaibia, Nicolas Flamand, Marc E Surette. Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes.
PloS one.
2012; 7(2):e31833. doi:
10.1371/journal.pone.0031833. [PMID: 22347509] - Alexandre P Rogerio, Fernanda F Anibal. Role of leukotrienes on protozoan and helminth infections.
Mediators of inflammation.
2012; 2012(?):595694. doi:
10.1155/2012/595694. [PMID: 22577251] - Mary K McCarthy, Jason B Weinberg. Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets.
Mediators of inflammation.
2012; 2012(?):236345. doi:
10.1155/2012/236345. [PMID: 22665949] - Lisa Baumgartner, Silvio Sosa, Atanas G Atanasov, Antje Bodensieck, Nanang Fakhrudin, Julia Bauer, Giorgia Del Favero, Cristina Ponti, Elke H Heiss, Stefan Schwaiger, Angela Ladurner, Ute Widowitz, Roberto Della Loggia, Judith M Rollinger, Oliver Werz, Rudolf Bauer, Verena M Dirsch, Aurelia Tubaro, Hermann Stuppner. Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Journal of natural products.
2011 Aug; 74(8):1779-86. doi:
10.1021/np200343t. [PMID: 21800856] - William B Rizzo. The role of fatty aldehyde dehydrogenase in epidermal structure and function.
Dermato-endocrinology.
2011 Apr; 3(2):91-9. doi:
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Science translational medicine.
2011 Feb; 3(69):69ra12. doi:
10.1126/scitranslmed.3001571. [PMID: 21307302] - Prescott G Woodruff, Richard K Albert, William C Bailey, Richard Casaburi, John E Connett, John A D Cooper, Gerard J Criner, Jeffrey L Curtis, Mark T Dransfield, Meilan K Han, Sarah M Harnden, Victor Kim, Nathaniel Marchetti, Fernando J Martinez, Charlene E McEvoy, Dennis E Niewoehner, John J Reilly, Kathryn Rice, Paul D Scanlon, Steven M Scharf, Frank C Sciurba, George R Washko, Stephen C Lazarus. Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization.
COPD.
2011 Feb; 8(1):21-9. doi:
10.3109/15412555.2010.540273. [PMID: 21299475] - Zeinab Mohamed Radwan, Gamal Abdel Nasser Yamamah, Hala Hamdy Shaaban, Azza Mohamed Omar Abdel-Rahman, Amany Abdel-Ghany Ismaeil, Elham Mohamed Mostafa. Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma.
Archives of medical science : AMS.
2010 Dec; 6(6):919-25. doi:
10.5114/aoms.2010.19302. [PMID: 22427767] - Ligia A Paiva, Clarissa M Maya-Monteiro, Christianne Bandeira-Melo, Patricia M R Silva, Marcia C El-Cheikh, Anderson J Teodoro, Radovan Borojevic, Sandra A C Perez, Patricia T Bozza. Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas.
Biochimica et biophysica acta.
2010 Dec; 1801(12):1341-8. doi:
10.1016/j.bbalip.2010.08.014. [PMID: 20817008] - Xian-kun Tu, Wei-zhong Yang, Chun-hua Wang, Song-sheng Shi, Yong-liang Zhang, Chun-mei Chen, Yi-kun Yang, Chang-dan Jin, Shuai Wen. Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats.
Inflammation.
2010 Oct; 33(5):344-52. doi:
10.1007/s10753-010-9191-6. [PMID: 20204486] - Mohamed D Morsy, Ossama A Mostafa, Waleed N Hassan. A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats.
Journal of biomedical science.
2010 Jul; 17(?):55. doi:
10.1186/1423-0127-17-55. [PMID: 20609232] - Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Peng Huang, Jinsong Liu, Bingliang Fang. Oxidative stress in NSC-741909-induced apoptosis of cancer cells.
Journal of translational medicine.
2010 Apr; 8(?):37. doi:
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Toxicon : official journal of the International Society on Toxinology.
2010 Feb; 55(2-3):343-52. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Feb; 878(3-4):333-9. doi:
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Experimental dermatology.
2010 Feb; 19(2):148-50. doi:
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Journal of leukocyte biology.
2010 Feb; 87(2):323-32. doi:
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Folia neuropathologica.
2010; 48(4):283-92. doi:
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Mediators of inflammation.
2010; 2010(?):. doi:
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Journal of natural products.
2009 Oct; 72(10):1836-41. doi:
10.1021/np900374s. [PMID: 19775092] - Sudha Yadav, A K Bajaj. Management of difficult urticaria.
Indian journal of dermatology.
2009 Jul; 54(3):275-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 May; 877(14-15):1460-4. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2009 Mar; 39(3):197-204. doi:
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Prostaglandins & other lipid mediators.
2009 Jan; 88(1-2):51-61. doi:
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Current medicinal chemistry.
2009; 16(31):4066-218. doi:
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Mediators of inflammation.
2009; 2009(?):737282. doi:
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Journal of asthma and allergy.
2008 Dec; 2(?):9-16. doi:
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Cancer research.
2008 Sep; 68(18):7362-70. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2008 Sep; 33(17):2154-7. doi:
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Aviation, space, and environmental medicine.
2008 Feb; 79(2):87-93. doi:
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Chemical research in toxicology.
2007 Dec; 20(12):1854-61. doi:
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Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2007 Oct; 56(10):409-13. doi:
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Medicinal research reviews.
2007 Jul; 27(4):469-527. doi:
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The Journal of pharmacology and experimental therapeutics.
2007 Jun; 321(3):1154-60. doi:
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Molecular diagnosis & therapy.
2007; 11(2):97-104. doi:
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Current topics in medicinal chemistry.
2007; 7(3):251-63. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Jun; 41(4):1317-24. doi:
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Planta medica.
2006 Jun; 72(8):754-6. doi:
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Journal of leukocyte biology.
2006 Jun; 79(6):1234-41. doi:
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British journal of pharmacology.
2006 Jun; 148(4):553-60. doi:
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Clinical and experimental dermatology.
2006 May; 31(3):327-34. doi:
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Inflammopharmacology.
2006 Mar; 14(1-2):10-6. doi:
10.1007/s10787-006-1496-6. [PMID: 16835707] - Britt-Marie Larsson, Maria Kumlin, Britt-Marie Sundblad, Kjell Larsson, Sven-Erik Dahlén, Lena Palmberg. Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects.
Respiratory medicine.
2006 Feb; 100(2):226-37. doi:
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Journal of cellular biochemistry.
2005 Jun; 95(3):571-88. doi:
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Chest.
2005 Feb; 127(2):565-70. doi:
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Journal of leukocyte biology.
2004 Nov; 76(5):961-70. doi:
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Planta medica.
2004 Nov; 70(11):1098-100. doi:
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Circulation.
2004 Sep; 110(10):1320-5. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2004 Aug; 287(2):G408-16. doi:
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Molecular pharmacology.
2004 Aug; 66(2):220-7. doi:
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Clinical & developmental immunology.
2004 Mar; 11(1):13-21. doi:
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Chemical research in toxicology.
2004 Feb; 17(2):137-43. doi:
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British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
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American journal of hematology.
2003 Sep; 74(1):23-5. doi:
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Journal of nephrology.
2003 Jan; 16(1):85-94. doi:
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American journal of respiratory medicine : drugs, devices, and other interventions.
2003; 2(2):139-56. doi:
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Biochemical pharmacology.
2002 Dec; 64(12):1767-75. doi:
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