Tranilast (BioDeep_00000406048)

Chemicals and Drugs

代谢物信息卡片

2-[[3(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-benzoic acid

化学式: C18H17NO5 (327.1107)
中文名称: 曲尼司特
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC
InChI: InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000700 - Analgesics
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D018926 - Anti-Allergic Agents
Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects[1]. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells[2].
trans-Tranilast (trans-MK-341) is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis. Target: Angiotensin Receptor Tranilast has been approved in Japan and South Korea, since 1982, for the treatment of bronchial asthma, with indications for keloids and hypertrophic scar added in 1993. Tranilast is also used to treat asthma, autoimmune diseases, atopic and fibrotic pathologies, and can also inhibit angiogenesis. The antiproliferative properties of tranilast were found that tranilast elicited an inhibitory effect on fibroblast proliferation in vitro and also suppressed collagen production both in vitro and in vivo . Tranilast also reduced the release of chemical mediators from mast cells and suppressed hypersensitivity reactions. [1] Three-week-old C57Bl/10 and mdx mice received tranilast (~300 mg/kg) in their food for 9 weeks, after which fibrosis was assessed through histological analyses, and functional properties of tibialis anterior muscles were assessed in situ and diaphragm muscle strips in vitro. Tranilast administration did not significantly alter the mass of any muscles in control or mdx mice, but it decreased fibrosis in the severely affected diaphragm muscle by 31\% compared with untreated mdx mice (P< 0.05) [2].

同义名列表

7 个代谢物同义名

Tranilast; 2-[[3(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-benzoic acid; MK-341; SB 252218; trans-MK-341; trans-SB 252218; trans-Tranilast

数据库引用编号

15 个数据库交叉引用编号

ChEBI: CHEBI:92320
ChEBI: CHEBI:77572
KEGGdrug: D02027
PubChem: 5282230
Metlin: METLIN43562
DrugBank: DB07615
ChEMBL: CHEMBL415324
CAS: 70806-55-2
CAS: 53902-17-3
CAS: 53902-12-8
MoNA: FiehnHILIC003020
MoNA: FiehnHILIC002376
MoNA: FiehnHILIC000810
medchemexpress: HY-B0195
medchemexpress: HY-18706

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位		关联基因列表

文献列表

Jia-Jun Luo, Xin-Hua Chen, Peng-Ying Liang, Zean Zhao, Ting Wu, Zhong-Huang Li, Shan-He Wan, Jian Luo, Jian-Xin Pang, Jia-Jie Zhang, Yuan-Xin Tian. Mechanism of anti-hyperuricemia of isobavachin based on network pharmacology and molecular docking. Computers in biology and medicine. 2023 Feb; 155(?):106637. doi: 10.1016/j.compbiomed.2023.106637. [PMID: 36791549]
Yohei Tokita, Kimio Sugaya, Saori Nishijima, Naoko Tsuchiya, Marie Hamaguchi, Hideyuki Yamamoto. Choreito, a Kampo medicine attenuates detrusor overactivity and bladder pain symptoms in rat tranilast-induced interstitial cystitis/bladder pain syndrome-like model. Neurourology and urodynamics. 2023 01; 42(1):56-64. doi: 10.1002/nau.25095. [PMID: 36378833]
Han Bi Ji, Jae Young Hong, Cho Rim Kim, Chang Hee Min, Jae Hoon Han, Min Ji Kim, Se-Na Kim, Cheol Lee, Young Bin Choy. Microchannel-embedded implantable device with fibrosis suppression for prolonged controlled drug delivery. Drug delivery. 2022 Dec; 29(1):489-498. doi: 10.1080/10717544.2022.2032873. [PMID: 35147052]
Ali Saeedi-Boroujeni, Roohangiz Nashibi, Ata A Ghadiri, Motowo Nakajima, Shokrollah Salmanzadeh, Mohammad-Reza Mahmoudian-Sani, Mohammad Ghasem Hanafi, Asaad Sharhani, Ali Khodadadi. Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial. Archives of medical research. 2022 06; 53(4):368-377. doi: 10.1016/j.arcmed.2022.03.002. [PMID: 35339280]
N Oshitani, K Watanabe, T Sakuma, M Matsuda, Y Oyama. Tranilast, an antifibrotic agent and COVID-19-induced pulmonary fibrosis. QJM : monthly journal of the Association of Physicians. 2022 04; 115(4):249-250. doi: 10.1093/qjmed/hcac069. [PMID: 35262694]
Jingjing Wang, Wenjing Yuan, Qingqing Shen, Qipeng Wu, Zhenzhou Jiang, Wei Wu, Luyong Zhang, Xin Huang. The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate. Journal of biochemical and molecular toxicology. 2022 Apr; 36(4):e22983. doi: 10.1002/jbt.22983. [PMID: 35019195]
Fatemeh Sheikhbahaei, Seyed Noureddin Nematollahi-Mahani, Mozafar Khazaei, Mohammad Rasool Khazaei, Saeed Khazayel. Teucrium polium Extract Enhances the Anti-Angiogenic Effect of Tranilast in a Three-Dimensional Fibrin Matrix Model. Asian Pacific journal of cancer prevention : APJCP. 2021 Aug; 22(8):2471-2478. doi: 10.31557/apjcp.2021.22.8.2471. [PMID: 34452560]
Ali Saeedi-Boroujeni, Mohammad-Reza Mahmoudian-Sani, Roohangiz Nashibi, Sheyda Houshmandfar, Sima Tahmaseby Gandomkari, Ali Khodadadi. Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19. Immunopharmacology and immunotoxicology. 2021 Jun; 43(3):247-258. doi: 10.1080/08923973.2021.1925293. [PMID: 34015982]
Eslam K Fahmy, Mohamed El-Sherbiny, Eman Said, Hany A Elkattawy, Mona Qushawy, Nehal Elsherbiny. Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2. Neurotoxicology. 2021 01; 82(?):167-176. doi: 10.1016/j.neuro.2020.12.008. [PMID: 33352273]
V Quagliariello, A Bonelli, A Caronna, M C Lombari, G Conforti, M Libutti, R V Iaffaioli, M Berretta, G Botti, N Maurea. SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications?. European review for medical and pharmacological sciences. 2020 09; 24(17):9169-9171. doi: 10.26355/eurrev_202009_22867. [PMID: 32965010]
Suwen Chen, Yadong Wang, Yamu Pan, Yao Liu, Shuang Zheng, Ke Ding, Kaiyu Mu, Ye Yuan, Zhaoyang Li, Hongxian Song, Ying Jin, Jian Fu. Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis. Journal of the American Heart Association. 2020 06; 9(12):e015513. doi: 10.1161/jaha.119.015513. [PMID: 32476536]
Manar Gamal Helal, Eman Said. Tranilast attenuates methotrexate-induced renal and hepatic toxicities: Role of apoptosis-induced tissue proliferation. Journal of biochemical and molecular toxicology. 2020 May; 34(5):e22466. doi: 10.1002/jbt.22466. [PMID: 32045101]
Huilong Luo, Elisa Rossi, Bruno Saubamea, Stéphanie Chasseigneaux, Véronique Cochois, Nina Choublier, Maria Smirnova, Fabienne Glacial, Nicolas Perrière, Sandrine Bourdoulous, David M Smadja, Marie-Claude Menet, Pierre-Olivier Couraud, Salvatore Cisternino, Xavier Declèves. Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation. Molecular pharmaceutics. 2019 03; 16(3):1312-1326. doi: 10.1021/acs.molpharmaceut.8b01252. [PMID: 30721081]
Yoshiki Kojo, Hiroki Suzuki, Kouki Kato, Yuuki Kaneko, Kayo Yuminoki, Naofumi Hashimoto, Hideyuki Sato, Yoshiki Seto, Satomi Onoue. Enhanced biopharmaceutical effects of tranilast on experimental colitis model with use of self-micellizing solid dispersion technology. International journal of pharmaceutics. 2018 Jul; 545(1-2):19-26. doi: 10.1016/j.ijpharm.2018.04.053. [PMID: 29702241]
Dan-Dan Yin, Jun-Hui Luo, Zhu-Ye Zhao, Ying-Jun Liao, Ying Li. Tranilast prevents renal interstitial fibrosis by blocking mast cell infiltration in a rat model of diabetic kidney disease. Molecular medicine reports. 2018 05; 17(5):7356-7364. doi: 10.3892/mmr.2018.8776. [PMID: 29568954]
Atsushi Shiozaki, Michihiro Kudou, Daisuke Ichikawa, Hitoshi Fujiwara, Hiroki Shimizu, Takeshi Ishimoto, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Shuhei Komatsu, Kazuma Okamoto, Yoshinori Marunaka, Eigo Otsuji. Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor. Journal of gastroenterology. 2018 Feb; 53(2):197-207. doi: 10.1007/s00535-017-1338-x. [PMID: 28389731]
Wen Yang, Eboka Majolene B Sabi-Mouka, Lei Wang, Chang Shu, Yan Wang, Juefang Ding, Li Ding. Determination of tranilast in bio-samples by LC-MS/MS: Application to a pharmacokinetic and brain tissue distribution study in rats. Journal of pharmaceutical and biomedical analysis. 2018 Jan; 147(?):479-484. doi: 10.1016/j.jpba.2017.06.047. [PMID: 28774678]
Kazuhiro Tsuji, Ken Fukuda, Atsuki Fukushima. Inhibition by Tranilast of the Synergistic Induction of Degranulation and IL-13 Expression by IL-33 and FcɛRI Cross-linking in Mast Cells. Ocular immunology and inflammation. 2017 Dec; 25(6):841-843. doi: 10.1080/09273948.2016.1184285. [PMID: 27380527]
Lufen Huang, Yan Dong, Jianlin Wu, Peixun Wang, Hua Zhou, Ting Li, Liang Liu. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacological research. 2017 Nov; 125(Pt B):150-160. doi: 10.1016/j.phrs.2017.08.014. [PMID: 28867637]
Asuka Baba, Masahiro Tachi, Yutaka Ejima, Yasuhiro Endo, Hiroaki Toyama, Kazutomo Saito, Nozomu Abe, Masanori Yamauchi, Chieko Miura, Itsuro Kazama. Less contribution of mast cells to the progression of renal fibrosis in Rat kidneys with chronic renal failure. Nephrology (Carlton, Vic.). 2017 Feb; 22(2):159-167. doi: 10.1111/nep.12733. [PMID: 26840502]
Eman Said, Wagdi F Elkashef, Rania R Abdelaziz. Tranilast ameliorates cyclophosphamide-induced lung injury and nephrotoxicity. Canadian journal of physiology and pharmacology. 2016 Apr; 94(4):347-58. doi: 10.1139/cjpp-2015-0070. [PMID: 26782310]
Hiroki Suzuki, Yoshiki Kojo, Keisuke Yakushiji, Kayo Yuminoki, Naofumi Hashimoto, Satomi Onoue. Strategic application of self-micellizing solid dispersion technology to respirable powder formulation of tranilast for improved therapeutic potential. International journal of pharmaceutics. 2016 Feb; 499(1-2):255-262. doi: 10.1016/j.ijpharm.2015.12.065. [PMID: 26748364]
Asuka Baba, Masahiro Tachi, Yutaka Ejima, Yasuhiro Endo, Hiroaki Toyama, Mitsunobu Matsubara, Kazutomo Saito, Masanori Yamauchi, Chieko Miura, Itsuro Kazama. Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 38(1):15-27. doi: 10.1159/000438605. [PMID: 26741745]
Itsuro Kazama, Asuka Baba, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara, Masahiro Tachi. Mast cell involvement in the progression of peritoneal fibrosis in rats with chronic renal failure. Nephrology (Carlton, Vic.). 2015 Sep; 20(9):609-16. doi: 10.1111/nep.12489. [PMID: 25881494]
Saad Tayyab, Mohammed S Zaroog, Shevin R Feroz, Saharuddin B Mohamad, Sri Nurestri A Malek. Exploring the interaction between the antiallergic drug, tranilast and human serum albumin: Insights from calorimetric, spectroscopic and modeling studies. International journal of pharmaceutics. 2015 Aug; 491(1-2):352-8. doi: 10.1016/j.ijpharm.2015.06.042. [PMID: 26142245]
Rania R Abdelaziz, Wagdi F Elkashef, Eman Said. Tranilast reduces serum IL-6 and IL-13 and protects against thioacetamide-induced acute liver injury and hepatic encephalopathy. Environmental toxicology and pharmacology. 2015 Jul; 40(1):259-67. doi: 10.1016/j.etap.2015.06.019. [PMID: 26164743]
Songyan Wang, Bing Li, Chunguang Li, Wenpeng Cui, Lining Miao. Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy. Journal of diabetes research. 2015; 2015(?):962383. doi: 10.1155/2015/962383. [PMID: 26421309]
Xu Yong-Gang, Weng Ming-Zhe, Zhang Jin-Yan, Peng Zhi-Hai, Xu Jun-Ming. Combination of N-(3'4'-dimethoxycinnamoyl) anthranilic acid with cyclosporin A treatment preserves immunosuppressive effect and reduces the side effect of cyclosporin A in rat. European journal of pharmacology. 2014 Apr; 728(?):16-23. doi: 10.1016/j.ejphar.2014.01.055. [PMID: 24530417]
Noriaki Nagai, Yoshimasa Ito. Therapeutic effects of gel ointments containing tranilast nanoparticles on paw edema in adjuvant-induced arthritis rats. Biological & pharmaceutical bulletin. 2014; 37(1):96-104. doi: 10.1248/bpb.b13-00630. [PMID: 24389486]
Xuan Yang, Lei Feng, Changjiang Li, Yu Li. Tranilast alleviates endothelial dysfunctions and insulin resistance via preserving glutathione peroxidase 1 in rats fed a high-fat emulsion. Journal of pharmacological sciences. 2014; 124(1):18-30. doi: 10.1254/jphs.13151fp. [PMID: 24389817]
Sha-sha Li, Qi-feng Liu, Ao-lin He, Fu-rong Wu. Tranilast attenuates TGF-β1-induced epithelial-mesenchymal transition in the NRK-52E cells. Pakistan journal of pharmaceutical sciences. 2014 Jan; 27(1):51-5. doi: NULL. [PMID: 24374452]
Spencer J Williams, Steven C Zammit, Alison J Cox, David M Shackleford, Julia Morizzi, Yuan Zhang, Andrew K Powell, Richard E Gilbert, Henry Krum, Darren J Kelly. 3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy. Bioorganic & medicinal chemistry letters. 2013 Dec; 23(24):6868-73. doi: 10.1016/j.bmcl.2013.09.100. [PMID: 24169234]
Junhui Luo, Ying Li, Yang Yang, Jun Li, Lin Sun, Shaobing Duan, Hong Liu, Fuyou Liu, Yuping Liu, Yiyun Xi, Yanhua You, Hua Li. [Role and mechanism of tranilast preventing the progression of tubulointerstilial fibrosis in diabetic kidney diseases]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2013 Dec; 38(12):1233-42. doi: 10.3969/j.issn.1672-7347.2013.12.006. [PMID: 24384948]
Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. High-dose tranilast administration to rats creates interstitial cystitis-like symptoms with increased vascular permeability. Life sciences. 2013 Nov; 93(23):897-903. doi: 10.1016/j.lfs.2013.10.010. [PMID: 24157455]
Yuko Iwata, Hitomi Ohtake, Osamu Suzuki, Junichiro Matsuda, Kazuo Komamura, Shigeo Wakabayashi. Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy. Cardiovascular research. 2013 Sep; 99(4):760-8. doi: 10.1093/cvr/cvt163. [PMID: 23786999]
Peter Y Chuang, Madhav C Menon, John C He. Molecular targets for treatment of kidney fibrosis. Journal of molecular medicine (Berlin, Germany). 2013 May; 91(5):549-59. doi: 10.1007/s00109-012-0983-z. [PMID: 23179685]
Eman Said, Shehta A Said, Wagdi F Elkashef, Nariman M Gameil, Elsayed M Ammar. Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice. Inflammopharmacology. 2012 Apr; 20(2):77-87. doi: 10.1007/s10787-011-0117-1. [PMID: 22278738]
Yasuhiko Tomino. Mechanisms and interventions in peritoneal fibrosis. Clinical and experimental nephrology. 2012 Feb; 16(1):109-14. doi: 10.1007/s10157-011-0533-y. [PMID: 21935614]
Qing-Feng Sun, Ji-Guang Ding, Ji-Fang Sheng, Man-Hua Zhu, Jun-Jie Li, Zi-Ke Sheng, Xiao-Feng Tang. Novel action of 3,4-DAA ameliorating acute liver allograft injury. Cell biochemistry and function. 2011 Dec; 29(8):673-8. doi: 10.1002/cbf.1805. [PMID: 21932299]
Anne Hertenstein, Theresa Schumacher, Ulrike Litzenburger, Christiane A Opitz, Christine S Falk, Tito Serafini, Wolfgang Wick, Michael Platten. Suppression of human CD4+ T cell activation by 3,4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10. Biochemical pharmacology. 2011 Sep; 82(6):632-41. doi: 10.1016/j.bcp.2011.06.013. [PMID: 21703247]
Y Tao, L Hu, S Li, Q Liu, X Wu, D Li, P Fu, D Wei, Z Luo. Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor β/Smad pathways. Transplantation proceedings. 2011 Jun; 43(5):1985-8. doi: 10.1016/j.transproceed.2011.01.160. [PMID: 21693312]
Aymerick Eudes, Edward E K Baidoo, Fan Yang, Helcio Burd, Masood Z Hadi, F William Collins, Jay D Keasling, Dominique Loqué. Production of tranilast [N-(3',4'-dimethoxycinnamoyl)-anthranilic acid] and its analogs in yeast Saccharomyces cerevisiae. Applied microbiology and biotechnology. 2011 Feb; 89(4):989-1000. doi: 10.1007/s00253-010-2939-y. [PMID: 20972784]
Sih Min Tan, Yuan Zhang, Alison J Cox, Darren J Kelly, Weier Qi. Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 Jan; 26(1):100-10. doi: 10.1093/ndt/gfq355. [PMID: 20573806]
Yayoi Saegusa, Chiharu Sadakane, Junichi Koseki, Yoshihiro Hasegawa, Shoichiro Shindo, Hirobumi Maruyama, Yoshio Kase, Shuichi Takeda, Hiroshi Takeda, Tomohisa Hattori. Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming growth factor-β1 production. Biological & pharmaceutical bulletin. 2010; 33(10):1710-5. doi: 10.1248/bpb.33.1710. [PMID: 20930380]
Tomoki Kaneyama, Satoshi Kobayashi, Daiju Aoyagi, Takashi Ehara. Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats. Pathology. 2010; 42(6):564-73. doi: 10.3109/00313025.2010.508784. [PMID: 20854076]
Steven C Zammit, Alison J Cox, Renae M Gow, Yuan Zhang, Richard E Gilbert, Henry Krum, Darren J Kelly, Spencer J Williams. Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates. Bioorganic & medicinal chemistry letters. 2009 Dec; 19(24):7003-6. doi: 10.1016/j.bmcl.2009.09.120. [PMID: 19879136]
Y Tao, L Hu, S Li, Y Bai, Q Liu, Y Jin, D Wei, Z Luo. Tranilast attenuates chronic cyclosporine nephrotoxicity in rats. Transplantation proceedings. 2009 Dec; 41(10):4373-5. doi: 10.1016/j.transproceed.2009.09.073. [PMID: 20005402]
Ye Tao, Xin Wu, Dan-dan Li, Qi-feng Liu, Hong Bo, Xue-rong Wang. [Experimental study in renal protective effect of tranilast on rats with adriamycin nephropathy]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2008 Jan; 39(1):76-9. doi: NULL. [PMID: 18390206]
Masahito Onoda, Shigeko Inokuma, Zenro Ikezawa. [Adverse effects of chemical mediator release inhibitors]. Nihon rinsho. Japanese journal of clinical medicine. 2007 Oct; 65 Suppl 8(?):259-66. doi: NULL. [PMID: 18074547]
J J Inglis, G Criado, M Andrews, M Feldmann, R O Williams, M L Selley. The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis. Rheumatology (Oxford, England). 2007 Sep; 46(9):1428-32. doi: 10.1093/rheumatology/kem160. [PMID: 17644821]
Ying Li, Fu-You Liu, You-Ming Peng, Jun Li, Jun Chen. Mast cell, a promising therapeutic target in tubulointerstitial fibrosis. Medical hypotheses. 2007; 69(1):99-103. doi: 10.1016/j.mehy.2006.10.059. [PMID: 17257770]
Jun Soma, Kozo Sato, Harutaka Saito, Yoshinori Tsuchiya. Effect of tranilast in early-stage diabetic nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 Oct; 21(10):2795-9. doi: 10.1093/ndt/gfl325. [PMID: 16820373]
Bo Tang, Hui-Ling Liang, Li-Li Tong, Ping Li. Synthesis of ethylenediamine linked beta-cyclodextrin dimer and its analytical application for tranilast determination by spectrofluorimetry. Bioorganic & medicinal chemistry. 2006 Jun; 14(11):3947-52. doi: 10.1016/j.bmc.2006.01.049. [PMID: 16564175]
D J Kelly, Y Zhang, A J Cox, R E Gilbert. Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model. Kidney international. 2006 Jun; 69(11):1954-60. doi: 10.1038/sj.ki.5000376. [PMID: 16557218]
Qing-Yong Zhang, Jun-Bo Ge, Jun-Zhu Chen, Jian-Hua Zhu, Liang-Hui Zhang, Chu-Pak Lau, Hung-Fat Tse. Mast cell contributes to cardiomyocyte apoptosis after coronary microembolization. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2006 May; 54(5):515-23. doi: 10.1369/jhc.5a6804.2005. [PMID: 16344327]
W Qi, X Chen, S Twigg, T S Polhill, R E Gilbert, C A Pollock. Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney international. 2006 Mar; 69(6):989-95. doi: 10.1038/sj.ki.5000189. [PMID: 16528248]
Jing Lan, Jian Wang, Dan Wu, Yingwu Wang, J Paul Fawcett, Jingkai Gu. Liquid chromatographic/tandem mass spectrometric method for the quantitation of tranilast in human plasma. Rapid communications in mass spectrometry : RCM. 2006; 20(22):3309-12. doi: 10.1002/rcm.2741. [PMID: 17044126]
Hiroshi Akahori, Tsuguhito Ota, Muneyoshi Torita, Hitoshi Ando, Shuichi Kaneko, Toshinari Takamura. Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression. The Journal of pharmacology and experimental therapeutics. 2005 Aug; 314(2):514-21. doi: 10.1124/jpet.105.084772. [PMID: 15857946]
Jennifer Martin, Darren J Kelly, Sally A Mifsud, Yuan Zhang, Alison J Cox, Fiona See, Henry Krum, Jennifer Wilkinson-Berka, Richard E Gilbert. Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta. Cardiovascular research. 2005 Feb; 65(3):694-701. doi: 10.1016/j.cardiores.2004.10.041. [PMID: 15664396]
Masaki Mizuno, Hwa-Jin Chung, Ikuro Maruyama, Tadato Tani. Inhibitory effects of bezoar bovis on intimal formation and vascular smooth muscle cell proliferation in rat. The American journal of Chinese medicine. 2005; 33(3):439-47. doi: 10.1142/s0192415x05003041. [PMID: 16047561]
Darren J Kelly, Yuan Zhang, Renae Gow, Richard E Gilbert. Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model. Journal of the American Society of Nephrology : JASN. 2004 Oct; 15(10):2619-29. doi: 10.1097/01.asn.0000139066.77892.04. [PMID: 15466266]
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