Roxane (BioDeep_00000406014)

   


代谢物信息卡片


({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}carbamoyl)methyl acetate

化学式: C19H28N2O4 (348.20489680000003)
中文名称: 醋酸罗沙替丁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2
InChI: InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23)

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents

同义名列表

4 个代谢物同义名

ROXATIDINE ACETATE; Roxane; ({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}carbamoyl)methyl acetate; Aceroxatidine;Pifatidine;Roxatidina;Roxatidine;Roxatidinum



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Xin Li, Fang Yuan, Bing Xu, Guiying Xiao, Xingming Fan, Yuan Li, Ping Zhang, Shengqing Tu. Pharmacokinetics and Bioequivalence Studies of Roxatidine Acetate Hydrochloride Sustained-Release Capsule in Healthy Chinese Subjects. Clinical pharmacology in drug development. 2022 05; 11(5):597-605. doi: 10.1002/cpdd.1053. [PMID: 34978388]
  • Hidefumi Nakamura, Hisashi Kawashima, Rieko Azuma, Ikuya Sato, Koji Nagao, Katsuhiko Miyazawa. Pharmacokinetics of the H(2) blocker roxatidine acetate hydrochloride in pediatric patients, in comparison with healthy adult volunteers. Drug metabolism and pharmacokinetics. 2012; 27(4):422-9. doi: 10.2133/dmpk.dmpk-11-rg-112. [PMID: 22293541]
  • Coleen Palileo, Jonathan D Kaunitz. Gastrointestinal defense mechanisms. Current opinion in gastroenterology. 2011 Oct; 27(6):543-8. doi: 10.1097/mog.0b013e32834b3fcb. [PMID: 21897225]
  • Kazuyoshi Hirota, Mihoko Kudo, Hiroshi Hashimoto, Tetsuya Kushikata. A marked increase in gastric fluid volume during cardiopulmonary bypass. Journal of clinical biochemistry and nutrition. 2011 Jul; 49(1):16-9. doi: 10.3164/jcbn.10-101. [PMID: 21765601]
  • Ju-Hee Ryu, Sang-Jun Choi, Heon-Woo Lee, Seung-Ki Choi, Kyung-Tae Lee. Quantification of roxatidine in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry: application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Dec; 876(1):143-7. doi: 10.1016/j.jchromb.2008.10.023. [PMID: 18977187]
  • Beom Soo Shin, Jin Won Choi, Joseph P Balthasar, Deok Ki Hong, Jung Jun Kim, Sun Dong Yoo. Determination of roxatidine in human plasma by liquid chromatography/electrospray mass spectrometry and application to a clinical pharmacokinetic study. Rapid communications in mass spectrometry : RCM. 2007; 21(3):329-35. doi: 10.1002/rcm.2838. [PMID: 17200973]
  • Kazuyoshi Hirota, Mihoko Kudo, Tetsuya Kushikata, Hiroshi Hashimoto, Akitomo Matsuki. Regular use of H2 blockers reduces the efficacy of roxatidine to control gastric pH and volume. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2005 Feb; 52(2):166-71. doi: 10.1007/bf03027723. [PMID: 15684257]
  • Kazuyoshi Tomita, Kazuki Izumi, Susumu Okabe. Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. Journal of pharmacological sciences. 2003 Nov; 93(3):321-30. doi: 10.1254/jphs.93.321. [PMID: 14646250]
  • I Yoshikawa, I Murata, K Kume, K Kanagawa, Y Hirohata, H Nakamura, M Otsuki. Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia. Alimentary pharmacology & therapeutics. 2002 Oct; 16(10):1805-9. doi: 10.1046/j.1365-2036.2002.01352.x. [PMID: 12269975]
  • M Tsutsumi, Y Ueshima, S Takase. Pharmacokinetics of roxatidine acetate in patients with chronic liver disease. Journal of gastroenterology and hepatology. 2001 Aug; 16(8):910-5. doi: 10.1046/j.1440-1746.2001.02535.x. [PMID: 11555106]
  • M Namba, E Chihara, T Ibuki, H Ashida, H Fukushima, Y Tanaka. [Clinical evaluation of roxatidine acetate hydrochlorides as a preanesthetic medication]. Masui. The Japanese journal of anesthesiology. 2001 Feb; 50(2):127-35. doi: NULL. [PMID: 11244765]
  • M Sasaki, M Nakayama, S Numazawa, T Oguro, S Honma, S Iwamura, K Tsukamoto, T Yoshida. Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes. Arzneimittel-Forschung. 2001; 51(8):651-8. doi: 10.1055/s-0031-1300096. [PMID: 11556126]
  • Y Ikeda, T Sakemi, Y Ohtsuka, M Kuwahara, N Fujisaki. Drug-related low responsiveness to recombinant human erythropoietin therapy in three patients with end-stage renal disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1997 Feb; 12(2):371-2. doi: 10.1093/ndt/12.2.371. [PMID: 9132674]
  • J G Hatlebakk, A Berstad. Pharmacokinetic optimisation in the treatment of gastro-oesophageal reflux disease. Clinical pharmacokinetics. 1996 Nov; 31(5):386-406. doi: 10.2165/00003088-199631050-00005. [PMID: 9118586]
  • N Nagai, M Furuhata, H Ogata. Drug interactions between theophylline and H2-antagonists, roxatidine acetate hydrochloride and cimetidine: pharmacokinetic analysis in rats in vivo. Biological & pharmaceutical bulletin. 1995 Nov; 18(11):1610-3. doi: 10.1248/bpb.18.1610. [PMID: 8593491]
  • U Gladziwa, S Wagner, H G Sieberth, U Klotz. Pharmacokinetics and pharmacodynamics of roxatidine in patients with renal insufficiency. British journal of clinical pharmacology. 1995 Feb; 39(2):161-7. doi: 10.1111/j.1365-2125.1995.tb04423.x. [PMID: 7742154]
  • W Beil, K F Sewing. [Effects of the histamine H2 receptor antagonist roxatidine acetate on stomach and liver alcohol dehydrogenase and serum alcohol level]. Zeitschrift fur Gastroenterologie. 1993 Nov; 31(11):643-5. doi: NULL. [PMID: 7904786]
  • K Mizunashi, Y Furukawa, K Katano, K Abe. Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans. Calcified tissue international. 1993 Jul; 53(1):21-5. doi: 10.1007/bf01352010. [PMID: 8102318]
  • D Murdoch, D McTavish. Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs. 1991 Aug; 42(2):240-60. doi: 10.2165/00003495-199142020-00006. [PMID: 1717223]
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  • E Tanaka, K Nakamura. The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous administration of three model substrates. British journal of clinical pharmacology. 1989 Aug; 28(2):171-4. doi: 10.1111/j.1365-2125.1989.tb05411.x. [PMID: 2570603]
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  • J L Burrows, K W Jolley, D J Sullivan. Determination of roxatidine in human plasma, urine and milk by capillary gas chromatography using nitrogen-selective detection. Journal of chromatography. 1988 Nov; 432(?):199-208. doi: 10.1016/s0378-4347(00)80645-3. [PMID: 2906063]
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  • K Morita, H Konishi, T Ono, H Shimakawa. A comparison of the inhibitory effects of roxatidine acetate hydrochloride and cimetidine on cytochrome P-450-mediated drug-metabolism in mouse hepatic microsomes and in man in vivo. Journal of pharmacobio-dynamics. 1987 Jul; 10(7):287-95. doi: 10.1248/bpb1978.10.287. [PMID: 2891811]
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