Raclopride (BioDeep_00000406006)

   


代谢物信息卡片


3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide

  化学式: C15H20Cl2N2O3 (346.0851)
中文名称: 雷氯必利
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN1CCCC1CNC(=O)C2=C(C(=CC(=C2OC)Cl)Cl)O
InChI: InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1


描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Raclopride is a dopamine D2/D3 receptor antagonist with potential antipsychotic effects. Raclopride binds to D2 and D3 receptors with Kis of 1.8 nM and 3.5 nM, respectively[1][2].

同义名列表

43 个代谢物同义名

Raclopride; Tox21_110961_1; (-)-(S)-3,5-Dichlor-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamid; (-)-(S)-3,5-Dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamide; (-)-raclopride; (S)-3,5-DICHLORO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE; (S)-3,5-DICHLORO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-6-HYDROXY-O-ANISAMIDE; (S)-3,5-dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide; (S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide; (S)-3,5-Dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-6-methoxybenzamide; (S)3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide; [3H]-raclopride; [3H]raclopride; 3,5-Dichloro-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide; 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide (raclopride); 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide(Raclopride); 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide; 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide; 3,5-dichloro-N-{[(2s)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide; Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-methoxy-; Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-6-methoxy-, (-)-; BPBio1_001215; C11, Raclopride; C15H20Cl2N2O3; GTPL94; PDSP1_000924; Racloprida; Racloprida [Spanish]; RACLOPRIDE (MART.); Raclopride [INN:BAN]; RACLOPRIDE [INN]; RACLOPRIDE [MART.]; RACLOPRIDE [WHO-DD]; Raclopride C11; raclopride c11 injection; Raclopride;3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide; Raclopridum; Raclopridum (Latin); Raclopridum [Latin]; S-(-)-raclopride; S-raclopride; S(-)-RACLOPRIDE L-TARTRATE; Tox21_110961



数据库引用编号

14 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Xuenan Wang, Min Li, Jinlu Xie, Dadian Chen, Xiwen Geng, Shuang Sun, Bo Liu, Min Wang. Beta band modulation by dopamine D2 receptors in the primary motor cortex and pedunculopontine nucleus in a rat model of Parkinson's disease. Brain research bulletin. 2022 04; 181(?):121-128. doi: 10.1016/j.brainresbull.2022.01.012. [PMID: 35077843]
  • Peter Manza, Ehsan Shokri-Kojori, Corinde E Wiers, Danielle Kroll, Dana Feldman, Katherine McPherson, Erin Biesecker, Evan Dennis, Allison Johnson, Andrew Kelleher, Song Qu, Dardo Tomasi, Gene-Jack Wang, Nora D Volkow. Sex differences in methylphenidate-induced dopamine increases in ventral striatum. Molecular psychiatry. 2022 02; 27(2):939-946. doi: 10.1038/s41380-021-01294-9. [PMID: 34707237]
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  • Anna Schildt, Erik F J de Vries, Antoon T M Willemsen, Bruno Lima Giacobbo, Rodrigo Moraga-Amaro, Jürgen W A Sijbesma, Aren van Waarde, Vesna Sossi, Rudi A J O Dierckx, Janine Doorduin. Effect of Dopamine D2 Receptor Antagonists on [18F]-FEOBV Binding. Molecular pharmaceutics. 2020 03; 17(3):865-872. doi: 10.1021/acs.molpharmaceut.9b01129. [PMID: 32011892]
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