Perospirone (BioDeep_00000405983)
代谢物信息卡片
化学式: C23H30N4O2S (426.208936)
中文名称: 哌罗匹隆
谱图信息:
最多检出来源 () 0%
Last reviewed on 2024-09-14.
Cite this Page
Perospirone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/perospirone (retrieved
2024-11-08) (BioDeep RN: BioDeep_00000405983). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
InChI: InChI=1S/C23H30N4O2S/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21/h3-4,9-10,17-18H,1-2,5-8,11-16H2/t17-,18+
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94777
- PubChem: 115368
- DrugBank: DB08922
- ChEMBL: CHEMBL1472975
- CAS: 150915-41-6
- MoNA: FiehnHILIC002236
- MoNA: FiehnHILIC000667
- medchemexpress: HY-B0731A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing Ding, Yan Zhang, Shanqi Wan, Liu Yang, Xiaohua Cui, Caiping Zhao, Suo Zhang, Zhuocheng Meng. A novel and robust analytical method for the quantification of perospirone in human plasma using an LC-MS/MS system with self-internal standard calibration.
Clinical biochemistry.
2022 Jul; 105-106(?):49-56. doi:
10.1016/j.clinbiochem.2022.04.006. [PMID: 35436467] - Kayoko Kanamitsu, Ryosuke Arakawa, Yuichi Sugiyama, Tetsuya Suhara, Hiroyuki Kusuhara. Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments.
Drug metabolism and pharmacokinetics.
2016 Dec; 31(6):395-404. doi:
10.1016/j.dmpk.2016.07.003. [PMID: 27745731] - Taro Kishi, Yuki Matsuda, Nakao Iwata. Cardiometabolic risks of blonanserin and perospirone in the management of schizophrenia: a systematic review and meta-analysis of randomized controlled trials.
PloS one.
2014; 9(2):e88049. doi:
10.1371/journal.pone.0088049. [PMID: 24505373] - Yutaro Suzuki, Kazushi Sawamura, Shin Ono, Naoki Fukui, Takuro Sugai, Junzo Watanabe, Nobuto Tsuneyama, Yoshimasa Inoue, Toshiyuki Someya. The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Aug; 34(6):830-3. doi:
10.1016/j.pnpbp.2010.03.027. [PMID: 20363276] - Ryosuke Arakawa, Hiroshi Ito, Akihiro Takano, Masaki Okumura, Hidehiko Takahashi, Harumasa Takano, Yoshiro Okubo, Tetsuya Suhara. Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects.
Psychopharmacology.
2010 May; 209(4):285-90. doi:
10.1007/s00213-010-1783-1. [PMID: 20349050] - Norio Yasui-Furukori, Hanako Furukori, Norio Sugawara, Shoko Tsuchimine, Akira Fujii, Yoshimasa Inoue, Sunao Kaneko. Prolactin fluctuation over the course of a day during treatments with three atypical antipsychotics in schizophrenic patients.
Human psychopharmacology.
2010 Apr; 25(3):236-42. doi:
10.1002/hup.1110. [PMID: 20373475] - Jian-Jun Zou, Hong-Jian Ji, Xiao-Hua Zhou, Yu-Bin Zhu, Hong-Wei Fan, Da-Wei Xiao, Qin Hu. Determination of azelnidipine by LC-ESI-MS and its application to a pharmacokinetic study in healthy Chinese volunteers.
Die Pharmazie.
2008 Aug; 63(8):568-70. doi:
NULL. [PMID: 18771003] - Ichiro Kusumi, Takuya Masui, Tsukasa Koyama. Long-term perospirone treatment with a single dose at bedtime in schizophrenia: relevant to intermittent dopamine D2 receptor antagonism.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Feb; 32(2):520-2. doi:
10.1016/j.pnpbp.2007.10.008. [PMID: 18006133] - Qian Bian, Takahiro Kato, Akira Monji, Sadayuki Hashioka, Yoshito Mizoguchi, Hideki Horikawa, Shigenobu Kanba. The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Jan; 32(1):42-8. doi:
10.1016/j.pnpbp.2007.06.031. [PMID: 17716796] - Ning Ma, Wen-Ying Liu, Huan-De Li, Yun-Gui Zhu, Bi-Kui Zhang, Feng Wang, Rong-Hua Zhu, Da-Xiong Xiang. Determination of perospirone by liquid chromatography/electrospray mass spectrometry: application to a pharmacokinetic study in healthy Chinese volunteers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Mar; 847(2):210-6. doi:
10.1016/j.jchromb.2006.10.007. [PMID: 17116433] - Yoko Tanaka, Satoshi Yoshida, Yumi Shimada, Hiroshi Ueda, Kunihiko Asai. Alteration in serum neural cell adhesion molecule in patients of schizophrenia.
Human psychopharmacology.
2007 Mar; 22(2):97-102. doi:
10.1002/hup.828. [PMID: 17266166] - Emi Ishii, Norio Otani, Masao Tsuchiya, Junko Kizu, Shinichi Ishimatsu. [Pharmacokinetics of perospirone hydrochloride at an excessive dose and changes in the serum prolactin level].
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology.
2007 Jan; 20(1):55-8. doi:
NULL. [PMID: 17319502] - Takuya Masui, Ichiro Kusumi, Yoshito Takahashi, Tsukasa Koyama. Effect of carbamazepine on the single oral dose pharmacokinetics of perospirone and its active metabolite.
Progress in neuro-psychopharmacology & biological psychiatry.
2006 Sep; 30(7):1330-3. doi:
10.1016/j.pnpbp.2006.02.012. [PMID: 16600452] - Takuya Masui, Ichiro Kusumi, Yoshito Takahashi, Tsukasa Koyama. Effects of itraconazole and tandospirone on the pharmacokinetics of perospirone.
Therapeutic drug monitoring.
2006 Feb; 28(1):73-5. doi:
10.1097/01.ftd.0000185767.59749.bb. [PMID: 16418697] - Yasuhiro Kaneda, Ichiro Kawamura, Tetsuro Ohmori. Correlation between plasma homovanillic acid levels and the response to atypical antipsychotics in male patients with schizophrenia.
Clinical neuropharmacology.
2005 Nov; 28(6):262-4. doi:
10.1097/01.wnf.0000192138.53769.43. [PMID: 16340379] - M Iwakawa, T Terao, A Soya, H Kojima, Y Inoue, N Ueda, R Yoshimura, J Nakamura. A novel antipsychotic, perospirone, has antiserotonergic and antidopaminergic effects in human brain: findings from neuroendocrine challenge tests.
Psychopharmacology.
2004 Nov; 176(3-4):407-11. doi:
10.1007/s00213-004-1905-8. [PMID: 15160263] - Norio Yasui-Furukori, Hanako Furukori, Taku Nakagami, Manabu Saito, Yoshimasa Inoue, Sunao Kaneko, Tomonori Tateishi. Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response.
Therapeutic drug monitoring.
2004 Aug; 26(4):361-5. doi:
10.1097/00007691-200408000-00004. [PMID: 15257064] - Yasuhiro Kaneda, Ichiro Kawamura, Akira Fujii, Tetsuro Ohmori. Impact of a switch from typical to atypical antipsychotic drugs on quality of life and gonadal hormones in male patients with schizophrenia.
Neuro endocrinology letters.
2004 Feb; 25(1-2):135-40. doi:
NULL. [PMID: 15159697] - Norio Yasui-Furukori, Yoshimasa Inoue, Tomonori Tateishi. Determination of a new atypical antipsychotic agent perospirone and its metabolite in human plasma by automated column-switching high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jun; 789(2):239-45. doi:
10.1016/s1570-0232(03)00067-9. [PMID: 12742115] - Takashi Togo, Eizo Iseki, Mika Shoji, Ikuo Oyama, Akihiko Kase, Hirotake Uchikado, Omi Katsuse, Kenji Kosaka. Prolactin levels in schizophrenic patients receiving perospirone in comparison to risperidone.
Journal of pharmacological sciences.
2003 Mar; 91(3):259-62. doi:
10.1254/jphs.91.259. [PMID: 12686750] - Jin Shimakura, Naoko Tani, Yoshiko Mizuno, Setsuko Komuro, Hiroshi Kanamaru. In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes.
European journal of drug metabolism and pharmacokinetics.
2003 Jan; 28(1):67-72. doi:
10.1007/bf03190869. [PMID: 14503667] - Yoshiko Mizuno, Setsuko Komuro, Hiroshi Kanamaru. Distribution of perospirone to melanin in pigmented rats.
European journal of drug metabolism and pharmacokinetics.
2003 Jan; 28(1):73-9. doi:
10.1007/bf03190870. [PMID: 14503668] - H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor.
The Biochemical journal.
1975 Dec; 152(3):601-7. doi:
10.1042/bj1520601. [PMID: 5997]