Pazufloxacin (BioDeep_00000405978)
代谢物信息卡片
Pazufloxacin
化学式: C16H15FN2O4 (318.1015802)
中文名称: 帕珠沙星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O
InChI: InChI=1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:94700
- KEGGdrug: D01153
- PubChem: 65957
- DrugBank: DB11774
- ChEMBL: CHEMBL240163
- CAS: 127046-18-8
- CAS: 127045-41-4
- MoNA: FiehnHILIC002918
- MoNA: FiehnHILIC002228
- MoNA: FiehnHILIC000660
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Makoto Kai, Ryota Tanaka, Yosuke Suzuki, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh. Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method.
Clinical biochemistry.
2021 Apr; 90(?):40-49. doi:
10.1016/j.clinbiochem.2021.01.012. [PMID: 33539809] - Kogenta Nakamura, Kazuro Ikawa, Genya Nishikawa, Ikuo Kobayashi, Masahiro Narushima, Hiroyuki Muramatsu, Shingo Morinaga, Keishi Kajikawa, Yoshiharu Kato, Masahito Watanabe, Kenji Zennami, Kent Kanao, Norifumi Morikawa, Makoto Sumitomo. Clinical pharmacokinetics and pharmacodynamic target attainment of pazufloxacin in prostate tissue: Dosing considerations for prostatitis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2017 Dec; 23(12):809-813. doi:
10.1016/j.jiac.2017.08.005. [PMID: 28923301] - Sumei Kong, Ming Liao, Yu Gu, Nan Li, Pinping Wu, Tingting Zhang, Hua He. Colorimetric recognition of pazufloxacin mesilate based on the aggregation of gold nanoparticles.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2016 Mar; 157(?):244-250. doi:
10.1016/j.saa.2016.01.013. [PMID: 26774816] - Shinnosuke Uegami, Kazuro Ikawa, Hiroki Ohge, Akira Nakashima, Norifumi Shigemoto, Norifumi Morikawa, Yoshiaki Murakami, Taijiro Sueda. Pharmacokinetics and pharmacodynamic target attainment of intravenous pazufloxacin in the bile of patients undergoing biliary pancreatic surgery.
Journal of chemotherapy (Florence, Italy).
2014 Oct; 26(5):287-92. doi:
10.1179/1973947814y.0000000167. [PMID: 24552254] - Adil Mehraj Khan, Satyavan Rampal. Effects of repeated oral administration of pazufloxacin mesylate and meloxicam on the antioxidant status in rabbits.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2014 Jul; 53(4):399-403. doi:
". [PMID: 25199097] - Yi Jiang, Hongbo Li, Lingling E, Xia Wu, Hongchen Liu. [Determination of pazufloxacin concentration in saliva, gingival crevicular fluid and serum of healthy adults using high-performance liquid chromatography].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2013 Jan; 33(1):53-6. doi:
NULL. [PMID: 23353156] - Joomi Lee, Sook Jin Seong, Mi-sun Lim, Sung Min Park, Jeonghyeon Park, Jeong Ju Seo, Hae Won Lee, Young-Ran Yoon. Single-dose pharmacokinetics and dose proportionality of intravenous pazufloxacin mesilate in healthy Korean volunteers.
Expert opinion on drug metabolism & toxicology.
2012 Aug; 8(8):921-8. doi:
10.1517/17425255.2012.688951. [PMID: 22809012] - Takeo Nomura, Kenichi Hirai, Mutsushi Yamasaki, Toru Inoue, Mika Takahashi, Takayuki Kawashima, Fuminori Sato, Hiromitsu Mimata. Efficacy of prophylactic single-dose therapy using fluoroquinolone for prostate brachytherapy.
Japanese journal of radiology.
2012 May; 30(4):317-22. doi:
10.1007/s11604-012-0053-z. [PMID: 22302294] - Satoshi Watabe, Yoshiaki Yokoyama, Kazuyuki Nakazawa, Kimikazu Shinozaki, Rika Hiraoka, Kei Takeshita, Yukio Suzuki. Simultaneous measurement of pazufloxacin, ciprofloxacin, and levofloxacin in human serum by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Jun; 878(19):1555-61. doi:
10.1016/j.jchromb.2010.04.012. [PMID: 20439169] - Xian-Gang Wang, Jia Miao, De-Rong Liang, Qin Yu, Mao-Zhi Liang, Shu-Hua Zhang. [Clinical pharmacokinetics/pharmacodynamics study on pazufloxacin methanesulphonate injection].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2009 Jul; 40(4):689-93. doi:
NULL. [PMID: 19764574] - Jahye Kim, Hisakazu Ohtani, Masayuki Tsujimoto, Yasufumi Sawada. Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Drug metabolism and pharmacokinetics.
2009; 24(2):167-74. doi:
10.2133/dmpk.24.167. [PMID: 19430173] - Sheng Lou, Wei Li, Qin Hu. Influence of cefoperazone and azithromycin on the pharmacokinetics of pazufloxacin in rats.
European journal of drug metabolism and pharmacokinetics.
2007 Oct; 32(4):219-23. doi:
10.1007/bf03191007. [PMID: 18348471] - Yaeko Watanabe, Yoshihiro Fujiue, Sintarou Yano, Satomi Shimizu, Kunio Muroki, Masao Doi, Masao Kuwabara. [Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from urine at one hospital to mainly carbapenem and fluoroquinolone drugs].
The Japanese journal of antibiotics.
2006 Apr; 59(2):65-71. doi:
. [PMID: 16805317] - Yoshikazu Ishii, Masashi Bando, Shoji Ohno, Yukihiko Sugiyama. [A travel abroad-associated case of Legionella pneumonia diagnosed by urinary antigen detection test].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
2005 Apr; 79(4):290-3. doi:
10.11150/kansenshogakuzasshi1970.79.290. [PMID: 15977568] - Akemi Shimizu, Mika Miyoshi, Masami Sugie, Jun Ueyama, Takuji Yamaguchi, Toshinobu Sasaki, Kenzo Takagi, Mingji Jin, Ken-Ichi Miyamoto, Akira Tsuji, Takaaki Hasegawa. Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats.
European journal of pharmacology.
2004 Oct; 501(1-3):151-9. doi:
10.1016/j.ejphar.2004.08.013. [PMID: 15464074] - Shilv Chen, Hongwu Ma, Huichun Zhao, Ruiqing Feng, Linpei Jin. Terbium-sensitized fluorescence method for the determination of pazufloxacin mesilate and its application.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2004 Jul; 20(7):1075-8. doi:
10.2116/analsci.20.1075. [PMID: 15293405] - Shinzaburo Minami, Rikizou Hattori, Akira Matsuda. [Pharmacological properties and expected clinical role of an injectable new quinolone antibiotic, pazufloxacin mesilate].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2003 Aug; 122(2):161-78. doi:
10.1254/fpj.122.161. [PMID: 12890902] - Kazuo Kizawa, Miyono Miyazaki, Mineko Nagasawa, Naoko Ogake, Akio Nagai, Takahiro Sanzen, Yasuhito Kawamura. [Attenuation of arbekacin-induced nephrotoxicity in rats by pazufloxacin mesilate].
The Japanese journal of antibiotics.
2003 Feb; 56(1):44-54. doi:
NULL. [PMID: 12723398] - Hiroyoshi Hayakawa, Kyoko Takagi, Yoko Fukushima Takano, Yasuhito Kawamura, Akira Tsuji. Determinant of the distribution volume at steady state for novel quinolone pazufloxacin in rats.
The Journal of pharmacy and pharmacology.
2002 Sep; 54(9):1229-36. doi:
10.1211/002235702320402071. [PMID: 12356277] - Nobuhiko Nomura, Junichi Mitsuyama, Yousuke Furuta, Hisashi Yamada, Mitsunori Nakata, Toshiko Fukuda, Hiroshi Yamada, Masahiro Takahata, Shinzaburo Minami. [In vitro and in vivo antibacterial activities of pazufloxacin mesilate, a new injectable quinolone].
The Japanese journal of antibiotics.
2002 Aug; 55(4):412-39. doi:
. [PMID: 12378871] - Mineko Nagasawa, Shozo Nakamura, Miyono Miyazaki, Yasuyuki Nojima, Hiroyoshi Hayakawa, Yasuhito Kawamura. [Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies].
The Japanese journal of antibiotics.
2002 Jun; 55(3):259-69. doi:
. [PMID: 12199110] - Yoshihito Niki, Shinsuke Watanabe, Kohichiro Yoshida, Naoyuki Miyashita, Masamitsu Nakajima, Toshiharu Matsushima. Effect of pazufloxacin mesilate on the serum concentration of theophylline.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2002 Mar; 8(1):33-6. doi:
10.1007/s101560200003. [PMID: 11957117] - H Araki, N Ogake, S Minami, Y Watanabe, H Narita, I Tamai, A Tsuji. Application of muscle microdialysis to evaluate the concentrations of the fluoroquinolones pazufloxacin and ofloxacin in the tissue interstitial fluids of rats.
The Journal of pharmacy and pharmacology.
1997 Nov; 49(11):1141-4. doi:
10.1111/j.2042-7158.1997.tb06057.x. [PMID: 9401953] - T Hasegawa, M Nadai, S Haghgoo, K Yamaki, K Takagi, T Nabeshima. Influence of a newly developed quinolone, T-3761, on pharmacokinetics of theophylline in rats.
Antimicrobial agents and chemotherapy.
1995 Sep; 39(9):2138-40. doi:
10.1128/aac.39.9.2138. [PMID: 8540732] - S Nakagawa, N Iwai, N Komae, M Nagasawa, Y Kawamura, T Kodama. [Single administration toxicity studies of T-3761 in mice, rats and dogs].
The Japanese journal of antibiotics.
1995 Jun; 48(6):754-68. doi:
NULL. [PMID: 7666580] - T Shibata, N Iwai, M Miyazaki, Y Kawamura, T Kodama. [Antigenicity study of T-3761].
The Japanese journal of antibiotics.
1995 Jun; 48(6):878-85. doi:
NULL. [PMID: 7666586] - Y Kawamura, A Nagai, K Yoshida, M Nagasawa, N Kitoh, T Kodama. [Three months oral repeated dose toxicity of T-3761 in rats].
The Japanese journal of antibiotics.
1995 Jun; 48(6):769-89. doi:
NULL. [PMID: 7666581] - H Hayakawa, K Hayashi, H Sakai, H Ishikura, H Takagi, Y Nakajima, Y Sogame. [Absorption, distribution, excretion and metabolism of [14C] T-3761 in rats and mice].
The Japanese journal of antibiotics.
1995 May; 48(5):671-85. doi:
NULL. [PMID: 7637202] - H Hayakawa, K Hayashi, K Nakafuku, Y Takano, H Takagi, Y Nakajima. [Placental transfer and mammary excretion of [14C] T-3761 in rats and mice].
The Japanese journal of antibiotics.
1995 May; 48(5):686-91. doi:
NULL. [PMID: 7637203] - S Minami, M Takahata, T Hayashi, K Kumano, Y Ikeda, T Noumi, S Takagi, N Oogake, R Tsuneda, J Maehana. [Absorption, distribution, metabolism and excretion of T-3761, a new quinolone derivative, in experimental animals].
The Japanese journal of antibiotics.
1995 May; 48(5):626-42. doi:
NULL. [PMID: 7637197] - M Tai, K Fujimaki, Y Simizu. [Determination of T-3761 in body fluids by high-performance liquid chromatography].
The Japanese journal of antibiotics.
1995 May; 48(5):621-5. doi:
NULL. [PMID: 7637196] - J Maehana, R Kitayama, Y Matsumoto, K Kumano, S Minami, T Yasuda, Y Watanabe, H Narita. [Microbiological assay method for T-3761 concentration in body fluids].
The Japanese journal of antibiotics.
1995 May; 48(5):610-20. doi:
NULL. [PMID: 7637195] - Y Fukuda, T Muratani, M Takahata, Y Fukuoka, T Yasuda, Y Watanabe, H Narita. [Mechanism of renal excretion of T-3761, a novel fluoroquinolone agent, in rabbits].
The Japanese journal of antibiotics.
1995 May; 48(5):649-55. doi:
NULL. [PMID: 7637199] - M Tai, K Demachi, Y Simizu. [Study of metabolism of T-3761 in animal].
The Japanese journal of antibiotics.
1995 May; 48(5):656-64. doi:
NULL. [PMID: 7637200] - K Furuhata, T Hiraiwa, N Terashima, H Arai, S Ono, K Hashiba, M Maekawa, K Kitamura, Y Nakada, Y Mori. [General pharmacology of T-3761, a new oral quinolone antibacterial agent (2). Effect on the respiratory and cardiovascular systems, autonomic nervous system and other functions].
The Japanese journal of antibiotics.
1995 May; 48(5):706-32. doi:
NULL. [PMID: 7637205] - R Kitayama, T Hayashi, S Minami, Y Watanabe, H Narita. [Serum protein binding of T-3761].
The Japanese journal of antibiotics.
1995 May; 48(5):643-8. doi:
NULL. [PMID: 7637198]