Nelfinavir (BioDeep_00000405956)
Main id: BioDeep_00000003155
代谢物信息卡片
Nelfinavir
化学式: C32H45N3O4S (567.3130610000001)
中文名称: 奈非那韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c(c(O)1)(c(C(=O)NC(C(O)CN(C(C(NC(C)(C)C)=O)4)CC(C(C4)3[H])(CCCC3)[H])CSc(c2)cccc2)ccc1)C
InChI: InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AE - Protease inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D000084762 - Viral Protease Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C97366 - HIV Protease Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:7496
- KEGG: C07257
- KEGG: C73027
- KEGGdrug: D08259
- PubChem: 64143
- DrugBank: DB00220
- ChEMBL: CHEMBL1205
- ChEMBL: CHEMBL584
- MeSH: Nelfinavir
- CAS: 159989-64-7
- MoNA: WA000760
- MoNA: WA000759
- MoNA: WA000758
- MoNA: WA000757
- MoNA: WA000756
- MoNA: WA000755
- MoNA: FiehnHILIC002876
- MoNA: FiehnHILIC002174
- MoNA: FiehnHILIC001392
- MoNA: FiehnHILIC000605
- PubChem: 9466
- PDB-CCD: 1UN
- NIKKAJI: J709.859F
- RefMet: Nelfinavir
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling, Xiangrui Jiang, Xiangyun Lu, Chuan Li, Likun Gong, Guangbo Ge, Yani Zhang, Yi Zang, Tian-Zhang Song, Xiao-Li Feng, Ren-Rong Tian, Jia Ji, Miaojin Zhu, Nanping Wu, Chunhui Wu, Zhen Wang, Yechun Xu, Cheng Peng, Min Zheng, Junling Yang, Feifei Du, Junliang Wu, Peipei Wang, Jingshan Shen, Jianliang Zhang, Yong-Tang Zheng, Hangping Yao, Weiliang Zhu. Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2.
Signal transduction and targeted therapy.
2023 04; 8(1):169. doi:
10.1038/s41392-023-01429-0. [PMID: 37095086] - Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj. In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196374. [PMID: 36234910] - Palaniyandi Umadevi, Subramanian Manivannan, Abdulkabeer Muhammed Fayad, Sreekumar Shelvy. In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection.
Journal of biomolecular structure & dynamics.
2022 07; 40(11):5053-5059. doi:
10.1080/07391102.2020.1866669. [PMID: 33372574] - Caroline S Foo, Rana Abdelnabi, Suzanne J F Kaptein, Xin Zhang, Sebastiaan Ter Horst, Raf Mols, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, Laura Vangeel, Arnab K Chatterjee, Pieter P Annaert, Patrick F Augustijns, Steven De Jonghe, Dirk Jochmans, Mieke Gouwy, Seppe Cambier, Jennifer Vandooren, Paul Proost, Christine van Laer, Birgit Weynand, Johan Neyts. HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect.
Antiviral research.
2022 06; 202(?):105311. doi:
10.1016/j.antiviral.2022.105311. [PMID: 35390430] - Jinfu Peng, Mayur K Ladumor, Jashvant D Unadkat. Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model.
Drug metabolism and disposition: the biological fate of chemicals.
2022 05; 50(5):613-623. doi:
10.1124/dmd.121.000733. [PMID: 35149540] - Desirée Bartolini, Anna Maria Stabile, Carmine Vacca, Alessandra Pistilli, Mario Rende, Antimo Gioiello, Gabriele Cruciani, Francesco Galli. Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy.
IUBMB life.
2022 01; 74(1):93-100. doi:
10.1002/iub.2537. [PMID: 34390301] - Jose Francis, Rosie Mngqibisa, Helen McIlleron, Michelle A Kendall, Xingye Wu, Kelly E Dooley, Cynthia Firnhaber, Catherine Godfrey, Susan E Cohn, Paolo Denti. A Semimechanistic Pharmacokinetic Model for Depot Medroxyprogesterone Acetate and Drug-Drug Interactions With Antiretroviral and Antituberculosis Treatment.
Clinical pharmacology and therapeutics.
2021 10; 110(4):1057-1065. doi:
10.1002/cpt.2324. [PMID: 34151439] - Lenka Besse, Andrej Besse, Sara C Stolze, Amin Sobh, Esther A Zaal, Alwin J van der Ham, Mario Ruiz, Santosh Phuyal, Lorina Büchler, Marc Sathianathan, Bogdan I Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J Thomas Hannich, Alex Loguinov, Bart Everts, Celia R Berkers, Marc Pilon, Hesso Farhan, Christopher D Vulpe, Herman S Overkleeft, Christoph Driessen. Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma.
Cancer research.
2021 09; 81(17):4581-4593. doi:
10.1158/0008-5472.can-20-3323. [PMID: 34158378] - Malina A Bakowski, Nathan Beutler, Karen C Wolff, Melanie G Kirkpatrick, Emily Chen, Tu-Trinh H Nguyen, Laura Riva, Namir Shaabani, Mara Parren, James Ricketts, Anil K Gupta, Kastin Pan, Peiting Kuo, MacKenzie Fuller, Elijah Garcia, John R Teijaro, Linlin Yang, Debashis Sahoo, Victor Chi, Edward Huang, Natalia Vargas, Amanda J Roberts, Soumita Das, Pradipta Ghosh, Ashley K Woods, Sean B Joseph, Mitchell V Hull, Peter G Schultz, Dennis R Burton, Arnab K Chatterjee, Case W McNamara, Thomas F Rogers. Drug repurposing screens identify chemical entities for the development of COVID-19 interventions.
Nature communications.
2021 06; 12(1):3309. doi:
10.1038/s41467-021-23328-0. [PMID: 34083527] - Bruce Schultz, Andrea Zaliani, Christian Ebeling, Jeanette Reinshagen, Denisa Bojkova, Vanessa Lage-Rupprecht, Reagon Karki, Sören Lukassen, Yojana Gadiya, Neal G Ravindra, Sayoni Das, Shounak Baksi, Daniel Domingo-Fernández, Manuel Lentzen, Mark Strivens, Tamara Raschka, Jindrich Cinatl, Lauren Nicole DeLong, Phil Gribbon, Gerd Geisslinger, Sandra Ciesek, David van Dijk, Steve Gardner, Alpha Tom Kodamullil, Holger Fröhlich, Manuel Peitsch, Marc Jacobs, Julia Hoeng, Roland Eils, Carsten Claussen, Martin Hofmann-Apitius. A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization.
Scientific reports.
2021 05; 11(1):11049. doi:
10.1038/s41598-021-90296-2. [PMID: 34040048] - Naoki Hosogaya, Taiga Miyazaki, Yuri Fukushige, Sachiko Takemori, Shinpei Morimoto, Hiroshi Yamamoto, Makoto Hori, Tomoya Kurokawa, Yohei Kawasaki, Michiko Hanawa, Yasuhisa Fujii, Hideki Hanaoka, Shingo Iwami, Koichi Watashi, Satoshi Yamagoe, Yoshitsugu Miyazaki, Takaji Wakita, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae, Shigeru Kohno. Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial.
Trials.
2021 Apr; 22(1):309. doi:
10.1186/s13063-021-05282-w. [PMID: 33910617] - Mohsen Sargolzaei. Effect of nelfinavir stereoisomers on coronavirus main protease: Molecular docking, molecular dynamics simulation and MM/GBSA study.
Journal of molecular graphics & modelling.
2021 03; 103(?):107803. doi:
10.1016/j.jmgm.2020.107803. [PMID: 33333424] - Hua Qu, Yi Zheng, Yuren Wang, Hongwei Li, Xiufei Liu, Xin Xiong, Linlin Zhang, Jing Gu, Gangyi Yang, Zhiming Zhu, Hongting Zheng, Qin Ouyang. The potential effects of clinical antidiabetic agents on SARS-CoV-2.
Journal of diabetes.
2021 Mar; 13(3):243-252. doi:
10.1111/1753-0407.13135. [PMID: 33210826] - Nikhil Pathak, Yun-Ti Chen, Yen-Chao Hsu, Nung-Yu Hsu, Chih-Jung Kuo, Hui Ping Tsai, Jaw-Jou Kang, Chih-Heng Huang, Sui-Yuan Chang, Yu-Hsiu Chang, Po-Huang Liang, Jinn-Moon Yang. Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing.
ACS nano.
2021 01; 15(1):857-872. doi:
10.1021/acsnano.0c07383. [PMID: 33373194] - Mohammad M Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S Anderson, William L Jorgensen. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.
ACS medicinal chemistry letters.
2020 Dec; 11(12):2526-2533. doi:
10.1021/acsmedchemlett.0c00521. [PMID: 33324471] - Krzysztof Marciniec, Artur Beberok, Paweł Pęcak, Stanisław Boryczka, Dorota Wrześniok. Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis.
Pharmacological reports : PR.
2020 Dec; 72(6):1553-1561. doi:
10.1007/s43440-020-00169-0. [PMID: 33063271] - Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, Stefano Moro. Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir.
Scientific reports.
2020 12; 10(1):20927. doi:
10.1038/s41598-020-77700-z. [PMID: 33262359] - Teruhisa S Komatsu, Noriaki Okimoto, Yohei M Koyama, Yoshinori Hirano, Gentaro Morimoto, Yousuke Ohno, Makoto Taiji. Drug binding dynamics of the dimeric SARS-CoV-2 main protease, determined by molecular dynamics simulation.
Scientific reports.
2020 10; 10(1):16986. doi:
10.1038/s41598-020-74099-5. [PMID: 33046764] - Farhana Musarrat, Vladimir Chouljenko, Achyut Dahal, Rafiq Nabi, Tamara Chouljenko, Seetharama D Jois, Konstantin G Kousoulas. The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections.
Journal of medical virology.
2020 10; 92(10):2087-2095. doi:
10.1002/jmv.25985. [PMID: 32374457] - Aleksandr Ianevski, Rouan Yao, Mona Høysæter Fenstad, Svetlana Biza, Eva Zusinaite, Tuuli Reisberg, Hilde Lysvand, Kirsti Løseth, Veslemøy Malm Landsem, Janne Fossum Malmring, Valentyn Oksenych, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Caroline H Pettersen, Tanel Tenson, Jan Egil Afset, Svein Arne Nordbø, Magnar Bjørås, Denis E Kainov. Potential Antiviral Options against SARS-CoV-2 Infection.
Viruses.
2020 06; 12(6):. doi:
10.3390/v12060642. [PMID: 32545799] - Mark Olsen, Sarah E Cook, Vanthida Huang, Niels Pedersen, Brian G Murphy. Perspectives: potential therapeutic options for SARS-CoV-2 patients based on feline infectious peritonitis strategies: central nervous system invasion and drug coverage.
International journal of antimicrobial agents.
2020 Jun; 55(6):105964. doi:
10.1016/j.ijantimicag.2020.105964. [PMID: 32251732] - Ashley Barlow, Kaitlin M Landolf, Brooke Barlow, Siu Yan Amy Yeung, Jason J Heavner, Cassidy W Claassen, Mojdeh S Heavner. Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019.
Pharmacotherapy.
2020 05; 40(5):416-437. doi:
10.1002/phar.2398. [PMID: 32259313] - Neha Agrawal, Jennifer Rowe, Jie Lan, Qigui Yu, Christine A Hrycyna, Jean Chmielewski. Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity.
Journal of medicinal chemistry.
2020 03; 63(5):2131-2138. doi:
10.1021/acs.jmedchem.9b00779. [PMID: 31505928] - Kafila Kousar, Arshia Majeed, Farkhanda Yasmin, Waqar Hussain, Nouman Rasool. Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum Computations.
BioMed research international.
2020; 2020(?):6237160. doi:
10.1155/2020/6237160. [PMID: 33102585] - Mehregan Safari, Mojtaba Shamsipur, Parvin Zohrabi, Homeira Ebrahimzadeh. Solid-phase extraction combined with dispersive liquid-liquid microextraction/HPLC-UV as a sensitive and efficient method for extraction, pre-concentration and simultaneous determination of antiretroviral drugs nevirapine, efavirenz and nelfinavir in pharmaceutical formulations and biological samples.
Journal of pharmaceutical and biomedical analysis.
2019 Mar; 166(?):95-104. doi:
10.1016/j.jpba.2019.01.003. [PMID: 30639934] - Ahizechukwu C Eke, Shelley A McCormack, Brookie M Best, Alice M Stek, Jiajia Wang, Regis Kreitchmann, David Shapiro, Elizabeth Smith, Lynne M Mofenson, Edmund V Capparelli, Mark Mirochnick. Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum.
Journal of clinical pharmacology.
2019 03; 59(3):386-393. doi:
10.1002/jcph.1331. [PMID: 30358179] - Atsushi Kambayashi, Jennifer B Dressman. Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir.
Journal of pharmaceutical sciences.
2019 Jan; 108(1):584-591. doi:
10.1016/j.xphs.2018.11.008. [PMID: 30423339] - Tejashree Belubbi, Sukhada Shevade, Vivek Dhawan, Vinay Sridhar, Anuradha Majumdar, Rute Nunes, Francisca Araújo, Bruno Sarmento, Kalpa Nagarsenker, Frank Steiniger, Alfred Fahr, Aniket Magarkar, Alex Bunker, Mangal Nagarsenker. Lipid Architectonics for Superior Oral Bioavailability of Nelfinavir Mesylate: Comparative in vitro and in vivo Assessment.
AAPS PharmSciTech.
2018 Nov; 19(8):3584-3598. doi:
10.1208/s12249-018-1156-3. [PMID: 30209788] - Kazuki Okubo, Makoto Isono, Takako Asano, Akinori Sato. Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Anticancer research.
2018 Oct; 38(10):5615-5626. doi:
10.21873/anticanres.12896. [PMID: 30275179] - Kazuki Okubo, Akinori Sato, Makoto Isono, Takako Asano, Tomohiko Asano. Nelfinavir Induces Endoplasmic Reticulum Stress and Sensitizes Renal Cancer Cells to TRAIL.
Anticancer research.
2018 Aug; 38(8):4505-4514. doi:
10.21873/anticanres.12754. [PMID: 30061216] - Leandro S Sangenito, Rubem F S Menna-Barreto, Ana Carolina Oliveira, Claudia M d'Avila-Levy, Marta H Branquinha, André L S Santos. Primary evidence of the mechanisms of action of HIV aspartyl peptidase inhibitors on Trypanosoma cruzi trypomastigote forms.
International journal of antimicrobial agents.
2018 Aug; 52(2):185-194. doi:
10.1016/j.ijantimicag.2018.03.021. [PMID: 29635008] - Dominik Abt, Andrej Besse, Lenka Sedlarikova, Marianne Kraus, Juergen Bader, Tobias Silzle, Martina Vodinska, Ondrej Slaby, Hans-Peter Schmid, Daniel Stephan Engeler, Christoph Driessen, Lenka Besse. Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir.
BJU international.
2018 04; 121(4):600-609. doi:
10.1111/bju.14083. [PMID: 29161753] - A Besse, S C Stolze, L Rasche, N Weinhold, G J Morgan, M Kraus, J Bader, H S Overkleeft, L Besse, C Driessen. Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma.
Leukemia.
2018 02; 32(2):391-401. doi:
10.1038/leu.2017.212. [PMID: 28676669] - K Yang, C Battista, J L Woodhead, S H Stahl, J T Mettetal, P B Watkins, S Q Siler, B A Howell. Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.
Clinical pharmacology and therapeutics.
2017 04; 101(4):501-509. doi:
10.1002/cpt.619. [PMID: 28074467] - Sonya VanPatten, Shan Sun, Mingzhu He, Kai Fan Cheng, Ahmad Altiti, Angelos Papatheodorou, Czeslawa Kowal, Venkatesh Jeganathan, James M Crawford, Ona Bloom, Bruce T Volpe, Christian Grant, Nathalie Meurice, Thomas R Coleman, Betty Diamond, Yousef Al-Abed. Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies.
Journal of medicinal chemistry.
2016 10; 59(19):8859-8867. doi:
10.1021/acs.jmedchem.6b00694. [PMID: 27603688] - Soren Gantt, Erin Leister, Denise L Jacobsen, Isabelle Boucoiran, Meei-Li Huang, Keith R Jerome, Gonzague Jourdain, Nicole Ngo-Giang-Huong, Sandra Burchett, Lisa Frenkel. Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy.
Journal of medical virology.
2016 Jun; 88(6):1051-8. doi:
10.1002/jmv.24420. [PMID: 26519647] - Marlene Weiß, Bernd Kost, Ingrid Renner-Müller, Eckhard Wolf, Ioannis Mylonas, Ansgar Brüning. Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells.
Cardiovascular toxicology.
2016 Jan; 16(1):90-9. doi:
10.1007/s12012-015-9314-2. [PMID: 25666561] - Krishna Kattel, Ruby Evande, Chalet Tan, Goutam Mondal, Jean L Grem, Ram I Mahato. Impact of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir in patients with pancreatic cancer.
British journal of clinical pharmacology.
2015 Aug; 80(2):267-75. doi:
10.1111/bcp.12620. [PMID: 25752914] - Z Dai, W Cai, F Hu, Y Lan, L Li, C Chung, B Caughey, K Zhang, X Tang. Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART).
Current molecular medicine.
2015; 15(10):975-9. doi:
10.2174/1566524016666151123114401. [PMID: 26592244] - Yevgeniya Kushchayeva, Kirk Jensen, Antony Recupero, John Costello, Aneeta Patel, Joanna Klubo-Gwiezdzinska, Lisa Boyle, Kenneth Burman, Vasyl Vasko. The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.
The Journal of clinical endocrinology and metabolism.
2014 May; 99(5):E734-45. doi:
10.1210/jc.2013-3369. [PMID: 24483157] - André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
10.1021/jm401963n. [PMID: 24601604] - Peng Hsiao, Jashvant D Unadkat. Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.
Molecular pharmaceutics.
2014 Feb; 11(2):436-44. doi:
10.1021/mp400396k. [PMID: 24364805] - Yu Fukuda, Kazumasa Takenaka, Alex Sparreboom, Satish B Cheepala, Chung-Pu Wu, Sean Ekins, Suresh V Ambudkar, John D Schuetz. Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.
Molecular pharmacology.
2013 Sep; 84(3):361-71. doi:
10.1124/mol.113.086967. [PMID: 23775562] - Samantha L Gerlach, Mariamawit Yeshak, Ulf Göransson, Upal Roy, Reza Izadpanah, Debasis Mondal. Cycloviolacin O2 (CyO2) suppresses productive infection and augments the antiviral efficacy of nelfinavir in HIV-1 infected monocytic cells.
Biopolymers.
2013 Sep; 100(5):471-9. doi:
10.1002/bip.22325. [PMID: 23897405] - Cho-Ming Loi, Dennis A Smith, Deepak Dalvie. Which metabolites circulate?.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
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The Cochrane database of systematic reviews.
2013 Mar; ?(3):CD005481. doi:
10.1002/14651858.cd005481.pub3. [PMID: 23543540] - Janet Pan, Michelle Mott, Bixin Xi, Ernestine Hepner, Min Guan, Kristen Fousek, Rachel Magnusson, Raechelle Tinsley, Frances Valdes, Paul Frankel, Timothy Synold, Warren A Chow. Phase I study of nelfinavir in liposarcoma.
Cancer chemotherapy and pharmacology.
2012 Dec; 70(6):791-9. doi:
10.1007/s00280-012-1961-4. [PMID: 22983015] - Mark A Wallet, Caroline M Reist, Julie C Williams, Sofia Appelberg, Giorgio L Guiulfo, Brent Gardner, John W Sleasman, Maureen M Goodenow. The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation.
Journal of leukocyte biology.
2012 Oct; 92(4):795-805. doi:
10.1189/jlb.0911447. [PMID: 22786868] - Camille Bono, Lionel Karlin, Stephanie Harel, Enguerran Mouly, Sylvaine Labaume, Lionel Galicier, Sébastien Apcher, Hélène Sauvageon, Jean-Paul Fermand, Jean-Christophe Bories, Bertrand Arnulf. The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo.
Haematologica.
2012 Jul; 97(7):1101-9. doi:
10.3324/haematol.2011.049981. [PMID: 22271897] - Raveen Parboosing, Glenn E M Maguire, Patrick Govender, Hendrik G Kruger. Nanotechnology and the treatment of HIV infection.
Viruses.
2012 04; 4(4):488-520. doi:
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2012 Apr; 54(7):995-1000. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):610-6. doi:
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AIDS research and therapy.
2012 Feb; 9(?):3. doi:
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Molecules (Basel, Switzerland).
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Retrovirology.
2012 Jan; 9(?):4. doi:
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The Southeast Asian journal of tropical medicine and public health.
2012 Jan; 43(1):78-88. doi:
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PloS one.
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AIDS research and treatment.
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PloS one.
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HIV clinical trials.
2012 Jan; 13(1):46-59. doi:
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BMC infectious diseases.
2011 Dec; 11(?):341. doi:
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Retrovirology.
2011 Dec; 8(?):97. doi:
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Journal of acquired immune deficiency syndromes (1999).
2011 Dec; 58(4):363-70. doi:
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2011 Nov; 4(4):432-9. doi:
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Clinical pharmacokinetics.
2011 Nov; 50(11):689-704. doi:
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Antimicrobial agents and chemotherapy.
2011 Nov; 55(11):5168-71. doi:
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Cancer chemotherapy and pharmacology.
2011 Nov; 68(5):1145-54. doi:
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2011 Oct; 79(2):349-56. doi:
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BMC public health.
2011 Sep; 11(?):700. doi:
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AIDS research and human retroviruses.
2011 Aug; 27(8):921-4. doi:
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BMC pediatrics.
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2011 Jul; 32(2):94-8. doi:
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Indian journal of urology : IJU : journal of the Urological Society of India.
2011 Jul; 27(3):310-9. doi:
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2011 Jul; 73(4):416-21. doi:
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2011 Jun; 39(6):1070-8. doi:
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European journal of clinical pharmacology.
2011 May; 67(5):493-506. doi:
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PloS one.
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2011 Apr; 33(2):239-43. doi:
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2011 Mar; 8(1):12-22. doi:
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PLoS medicine.
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2011 Feb; 16(2):85-92. doi:
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Journal of lipid research.
2011 Feb; 52(2):207-20. doi:
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PloS one.
2011; 6(12):e27810. doi:
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PloS one.
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PloS one.
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PloS one.
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PloS one.
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PloS one.
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2011; 6(8):e23301. doi:
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The Journal of antimicrobial chemotherapy.
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Core evidence.
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Antiviral research.
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Journal of veterinary pharmacology and therapeutics.
2010 Oct; 33(5):453-60. doi:
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2010 Sep; 3(?):325-35. doi:
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The Journal of pharmacology and experimental therapeutics.
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Analytical and bioanalytical chemistry.
2010 Sep; 398(1):319-28. doi:
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International journal of nanomedicine.
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