Levosulpiride (BioDeep_00000405881)

   


代谢物信息卡片


Levosulpiride

化学式: C15H23N3O4S (341.1409198)
中文名称: (S)-(-)-舒必利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC
InChI: InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AL - Benzamides
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class.

同义名列表

3 个代谢物同义名

Levosulpiride; RV-12309; S-(-)-Sulpiride



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar. Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention. Indian journal of pharmacology. 2024 Jan; 56(1):4-9. doi: 10.4103/ijp.ijp_555_23. [PMID: 38454582]
  • Summaira Maqsood, Fakhar Ud Din, Saif Ullah Khan, Ehsan Elahi, Zakir Ali, Humzah Jamshaid, Alam Zeb, Tunazza Nadeem, Wajed Ahmed, Salman Khan, Han Gon Choi. Levosulpiride-loaded nanostructured lipid carriers for brain delivery with antipsychotic and antidepressant effects. Life sciences. 2022 Dec; 311(Pt B):121198. doi: 10.1016/j.lfs.2022.121198. [PMID: 36396112]
  • Erwin Chiquete, Liz Toapanta-Yanchapaxi, José Jesús Aceves-Buendía, Eduardo Ruiz-Ruiz, Elizabeth Rodríguez-Perea, Salvador Durán-Coyote, Carlos Cantú-Brito. Levosulpiride Relieved Persistent Hiccups in a Patient With COVID-19 and Vascular Cognitive Impairment. Clinical neuropharmacology. 2021 Sep; 44(5):186-188. doi: 10.1097/wnf.0000000000000459. [PMID: 34238784]
  • Carlos D Nuñez-Amaro, Aura Ileana Moreno-Vega, Elva Adan-Castro, Magdalena Zamora, Renata Garcia-Franco, Paulina Ramirez-Neria, Marlon Garcia-Roa, Yolanda Villalpando, Juan Pablo Robles, Gabriela Ramirez-Hernandez, Mariana Lopez, Jorge Sanchez, Ellery Lopez-Star, Thomas Bertsch, Gonzalo Martinez de la Escalera, Ma Ludivina Robles-Osorio, Jakob Triebel, Carmen Clapp. Levosulpiride Increases the Levels of Prolactin and Antiangiogenic Vasoinhibin in the Vitreous of Patients with Proliferative Diabetic Retinopathy. Translational vision science & technology. 2020 08; 9(9):27. doi: 10.1167/tvst.9.9.27. [PMID: 32879783]
  • Nadra Khaleeq, Fakhar-Ud Din, Anam Sajjad Khan, Samreen Rabia, Junaid Dar, Gul Majid Khan. Development of levosulpiride-loaded solid lipid nanoparticles and their in vitro and in vivo comparison with commercial product. Journal of microencapsulation. 2020 Mar; 37(2):160-169. doi: 10.1080/02652048.2020.1713242. [PMID: 31916886]
  • Beata Łebkowska-Wieruszewska, Giovanni Barsotti, Francesco Camillo, Alessandra Rota, Duccio Panzani, Amnart Poapolathep, Andrzej Lisowski, Mario Giorgi. Pharmacokinetics of levosulpiride after single-dose administration in goats (Capra hircus) by different routes of administration. Journal of veterinary pharmacology and therapeutics. 2019 Jul; 42(4):440-446. doi: 10.1111/jvp.12786. [PMID: 31206720]
  • Fakhar-Ud-Din, Gul Majid Khan. Development and characterisation of levosulpiride-loaded suppositories with improved bioavailability in vivo. Pharmaceutical development and technology. 2019 Jan; 24(1):63-69. doi: 10.1080/10837450.2017.1419256. [PMID: 29251521]
  • Simona De Gregori, Laura Cipollina, Annalisa De Silvestri, Marianna Ventura, Roberta Michelini, Monica Morosini, Michela Montagna, Carmine Tinelli, Mario Regazzi, Mariadelfina Molinaro, Roberto Imberti. Bioequivalence of a New Oral Levosulpiride Formulation Compared With a Standard One in Healthy Volunteers. Therapeutic drug monitoring. 2017 04; 39(2):118-123. doi: 10.1097/ftd.0000000000000380. [PMID: 28196046]
  • Mingzhen Xu, Ying Zhou, Yang Ni, Xiaomeng He, Huqun Li, Haseeb Sattar, Hui Chen, Weiyong Li. Tolerability and Pharmacokinetic Comparison of Oral, Intramuscular, and Intravenous Administration of Levosulpiride After Single and Multiple Dosing in Healthy Chinese Volunteers. Clinical therapeutics. 2015 Nov; 37(11):2458-67. doi: 10.1016/j.clinthera.2015.08.024. [PMID: 26404395]
  • Juan J Sebastián-Domingo. [Integrative medicine in the management of functional dyspepsia. Role of the herbal preparation STW5]. Gastroenterologia y hepatologia. 2014 Apr; 37(4):256-61. doi: 10.1016/j.gastrohep.2013.10.001. [PMID: 24314790]
  • Krzysztof Ciszowski, Dorota Szpak, Jolanta Wilimowska, Barbara Groszek. [Sulpiride poisoning--case report confirmed with the quantitative determination of the xenobiotic serum level]. Przeglad lekarski. 2011; 68(8):506-9. doi: . [PMID: 22010451]
  • Prasad B Phapale, Hae Won Lee, Mi-Sun Lim, Sook Jin Seong, Eun-Hee Kim, Jeonghyeon Park, Miran Lee, Sung-Kyu Hwang, Young-Ran Yoon. Liquid chromatography-tandem mass spectrometry quantification of levosulpiride in human plasma and its application to bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Aug; 878(24):2280-5. doi: 10.1016/j.jchromb.2010.06.036. [PMID: 20656570]
  • H Y Cho, H D Yoo, Y B Lee. Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of levosulpiride in healthy subjects. Neuroscience. 2010 Aug; 169(1):378-87. doi: 10.1016/j.neuroscience.2010.04.065. [PMID: 20438811]
  • Jin-Hee Park, Yoo-Sin Park, Si-Youn Rhim, Hyun-Jin Kim, Ok-Hwa Jhee, Yun-Sik Lee, Min-Ho Lee, Leslie M Shaw, Ju-Seop Kang. Rapid quantification of levosulpiride in human plasma using RP-HPLC-MS/MS for pharmacokinetic and bioequivalence study. Biomedical chromatography : BMC. 2009 Dec; 23(12):1350-6. doi: 10.1002/bmc.1260. [PMID: 19488984]
  • Hye Won Lee, Hye Young Ji, Hoe Yoon Kim, Eun-Seok Park, Kang Choon Lee, Hye Suk Lee. Determination of metoclopramide in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jun; 877(18-19):1716-20. doi: 10.1016/j.jchromb.2009.04.027. [PMID: 19442594]
  • Ma Soledad García, Joaquín A Ortuño, Ma Isabel Albero, Mustafa Salem Abuherba. Development of membrane selective electrode for determination of the antipsychotic sulpiride in pharmaceuticals and urine. Sensors (Basel, Switzerland). 2009; 9(6):4309-22. doi: 10.3390/s90604309. [PMID: 22408528]
  • F Demarosi, M Tarozzi, G Lodi, L Canegallo, L Rimondini, A Sardella. The effect of levosulpiride in burning mouth syndrome. Minerva stomatologica. 2007 Jan; 56(1-2):21-6. doi: NULL. [PMID: 17287703]
  • In Bok Paek, Ya Moon, Hye Young Ji, Hui-Hyun Kim, Hye Won Lee, Yong-Bok Lee, Hye Suk Lee. Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of levosulpiride in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Oct; 809(2):345-50. doi: 10.1016/j.jchromb.2004.07.005. [PMID: 15315786]
  • Su-Eon Jin, Eunmi Ban, Yang-Bae Kim, Chong-Kook Kim. Development of HPLC method for the determination of levosulpiride in human plasma. Journal of pharmaceutical and biomedical analysis. 2004 Jun; 35(4):929-36. doi: 10.1016/j.jpba.2004.02.024. [PMID: 15193738]
  • H Y Cho, J D Moon, Y B Lee. Pharmacokinetics and bioequivalence evaluation of 2 levosulpiride preparations after a single oral dose in healthy male Korean volunteers. International journal of clinical pharmacology and therapeutics. 2004 Mar; 42(3):174-80. doi: NULL. [PMID: 15049438]
  • Hea-Young Cho, Yong-Bok Lee. Improvement and validation of a liquid chromatographic method for the determination of levosulpiride in human serum and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Nov; 796(2):243-51. doi: 10.1016/j.jchromb.2003.07.009. [PMID: 14581065]
  • S Patel, S Patel, R Marwood, F Emms, D Marston, P D Leeson, N R Curtis, J J Kulagowski, S B Freedman. Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor. Molecular pharmacology. 1996 Dec; 50(6):1658-64. doi: NULL. [PMID: 8967990]
  • C Mansi, V Savarino, S Vigneri, D Perilli, P Melga, L Sciabà, D De Martini, G S Mela. Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis. The American journal of gastroenterology. 1995 Nov; 90(11):1989-93. doi: NULL. [PMID: 7485007]
  • A Mucci, G Nolfe, M Maj. Levosulpiride: a review of its clinical use in psychiatry. Pharmacological research. 1995 Feb; 31(2):95-101. doi: 10.1016/1043-6618(95)80053-0. [PMID: 7596960]