Ergothioneine (BioDeep_00000405812)
Main id: BioDeep_00000018451
PANOMIX_OTCML-2023
代谢物信息卡片
L-(+)-ERGOTHIONEINE
化学式: C9H15N3O2S (229.088493)
中文名称: 麦角硫因, (S)-ALPHA-羧基-N,N,N-三甲基-2-巯基-1H-咪唑-4-乙铵 内盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+](C)(C)C(CC1=CNC(=S)N1)C(=O)[O-]
InChI: InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1
描述信息
A L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine synthesized by bacteria and fungi with antioxidant properties. It is found ubiquitously in plants and animals and is present in many human foodstuffs.
D020011 - Protective Agents > D000975 - Antioxidants
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 60
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity[1][2].
Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
同义名列表
2 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:82707
- ChEBI: CHEBI:4828
- PubChem: 5351619
- Metlin: METLIN53
- ChEMBL: CHEMBL5209630
- MeSH: Ergothioneine
- CAS: 497-30-3
- CAS: 58511-63-0
- MoNA: UA006001
- MoNA: FiehnHILIC001918
- MoNA: FiehnHILIC001176
- MoNA: FiehnHILIC000336
- MetaboLights: MTBLC4828
- RefMet: Ergothioneine
- medchemexpress: HY-N1914
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Robert J Hondal. Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine.
Current opinion in chemical biology.
2023 May; 75(?):102328. doi:
10.1016/j.cbpa.2023.102328. [PMID: 37236134] - Yuting Zhang, Guizhu Cao, Xiaonan Li, Zhongyun Piao. Effects of Exogenous Ergothioneine on Brassica rapa Clubroot Development Revealed by Transcriptomic Analysis.
International journal of molecular sciences.
2023 Mar; 24(7):. doi:
10.3390/ijms24076380. [PMID: 37047350] - Dirk Gründemann, Lea Hartmann, Svenja Flögel. The ergothioneine transporter (ETT): substrates and locations, an inventory.
FEBS letters.
2022 May; 596(10):1252-1269. doi:
10.1002/1873-3468.14269. [PMID: 34958679] - Robert B Beelman, Allen T Phillips, John P Richie, Djibril M Ba, Sjoerd W Duiker, Michael D Kalaras. Health consequences of improving the content of ergothioneine in the food supply.
FEBS letters.
2022 05; 596(10):1231-1240. doi:
10.1002/1873-3468.14268. [PMID: 34954825] - William J Behof, Clayton A Whitmore, Justin R Haynes, Adam J Rosenberg, Mohammed N Tantawy, Todd E Peterson, Fiona E Harrison, Robert B Beelman, Printha Wijesinghe, Joanne A Matsubara, Wellington Pham. Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer's disease.
FEBS letters.
2022 05; 596(10):1279-1289. doi:
10.1002/1873-3468.14303. [PMID: 35100442] - Li Wang, Yang Wang, Jianghua Li, Guocheng DU, Zhen Kang. [Construction and optimization of ergothioneine-producing Escherichia coli].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2022 Feb; 38(2):796-806. doi:
10.13345/j.cjb.210166. [PMID: 35234399] - Lan Pang, Ting Wang, Qian Liao, Yanfen Cheng, Di Wang, Jingjing Li, Chaomei Fu, Chen Zhang, Jinming Zhang. Protective role of ergothioneine isolated from Pleurotus ostreatus against dextran sulfate sodium-induced ulcerative colitis in rat model.
Journal of food science.
2022 Jan; 87(1):415-426. doi:
10.1111/1750-3841.15982. [PMID: 34873706] - Ayobami Dare, Ahmed A Elrashedy, Mahendra L Channa, Anand Nadar. Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats.
Cardiovascular & hematological agents in medicinal chemistry.
2022; 20(2):133-147. doi:
10.2174/1871525719666210809122541. [PMID: 34370646] - Jaeyoung Choi, Eunsu Song, Hyeeun Gwon, Eunju Song, Michael D Kalaras, Robert B Beelman, Jinah Hwang. Aqueous Extracts of Pleurotus ostreatus and Hericium erinaceus Protect against Ultraviolet A-Induced Damage in Human Dermal Fibroblasts.
International journal of medicinal mushrooms.
2022; 24(2):63-74. doi:
10.1615/intjmedmushrooms.2021042348. [PMID: 35446523] - Liu-Yun Wu, Irwin K Cheah, Joyce Ruifen Chong, Yuek Ling Chai, Jia Yun Tan, Saima Hilal, Henri Vrooman, Christopher P Chen, Barry Halliwell, Mitchell K P Lai. Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia.
Free radical biology & medicine.
2021 12; 177(?):201-211. doi:
10.1016/j.freeradbiomed.2021.10.019. [PMID: 34673145] - Sahar Abdalkarim Salih, Hossein Daghigh-Kia, Mahdieh Mehdipour, Abouzar Najafi. Does ergothioneine and thawing temperatures improve rooster semen post-thawed quality?.
Poultry science.
2021 Oct; 100(10):101405. doi:
10.1016/j.psj.2021.101405. [PMID: 34464932] - William J Behof, Clayton A Whitmore, Justin R Haynes, Adam J Rosenberg, Mohammed N Tantawy, Todd E Peterson, Fiona E Harrison, Robert B Beelman, Wellington Pham. A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications.
Scientific reports.
2021 09; 11(1):18450. doi:
10.1038/s41598-021-97925-w. [PMID: 34531467] - Ayobami Dare, Mahendra L Channa, Anand Nadar. L-ergothioneine and its combination with metformin attenuates renal dysfunction in type-2 diabetic rat model by activating Nrf2 antioxidant pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111921. doi:
10.1016/j.biopha.2021.111921. [PMID: 34346315] - Samir A Salama, Gamil M Abd-Allah, Ahmed M Mohamadin, Mostafa M Elshafey, Hesham S Gad. Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase.
Life sciences.
2021 Aug; 278(?):119572. doi:
10.1016/j.lfs.2021.119572. [PMID: 33964294] - Shohei Makiishi, Kengo Furuichi, Yuta Yamamura, Keisuke Sako, Yasuyuki Shinozaki, Tadashi Toyama, Shinji Kitajima, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Tomoko Hirose-Sugiura, Shuichi Kaneko, Yukio Kato, Takashi Wada. Carnitine/organic cation transporter 1 precipitates the progression of interstitial fibrosis through oxidative stress in diabetic nephropathy in mice.
Scientific reports.
2021 04; 11(1):9093. doi:
10.1038/s41598-021-88724-4. [PMID: 33907247] - Daniel Lam-Sidun, Kia M Peters, Nica M Borradaile. Mushroom-Derived Medicine? Preclinical Studies Suggest Potential Benefits of Ergothioneine for Cardiometabolic Health.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22063246. [PMID: 33806754] - Sally Shuxian Koh, Samantha Chia-Yi Ooi, Natalie Man-Yin Lui, Cao Qiong, Leona Ting-Yuke Ho, Irwin Kee-Mun Cheah, Barry Halliwell, Deron R Herr, Wei-Yi Ong. Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury.
Neuromolecular medicine.
2021 03; 23(1):184-198. doi:
10.1007/s12017-020-08620-4. [PMID: 33067719] - Stefano Fornasaro, Elisa Gurian, Sofia Pagarin, Elena Genova, Gabriele Stocco, Giuliana Decorti, Valter Sergo, Alois Bonifacio. Ergothioneine, a dietary amino acid with a high relevance for the interpretation of label-free surface enhanced Raman scattering (SERS) spectra of many biological samples.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Feb; 246(?):119024. doi:
10.1016/j.saa.2020.119024. [PMID: 33049471] - Noritaka Nakamichi, Shunsuke Nakao, Misa Nishiyama, Yuka Takeda, Takahiro Ishimoto, Yusuke Masuo, Satoshi Matsumoto, Makoto Suzuki, Yukio Kato. Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice.
Current molecular pharmacology.
2021; 14(2):220-233. doi:
10.2174/1874467213666200212102710. [PMID: 32048982] - Julia Tschirka, Markus Bach, Ilmars Kisis, Julia Lemmen, Mark Jean Gnoth, Dirk Gründemann. Transporter tandems: precise tools for normalizing active transporter in the plasma membrane.
The Biochemical journal.
2020 11; 477(21):4191-4206. doi:
10.1042/bcj20200666. [PMID: 33073844] - Misa Nishiyama, Noritaka Nakamichi, Tomoyuki Yoshimura, Yusuke Masuo, Tomoe Komori, Takahiro Ishimoto, Jun-Ichi Matsuo, Yukio Kato. Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice.
Neurochemical research.
2020 Nov; 45(11):2664-2678. doi:
10.1007/s11064-020-03118-8. [PMID: 32844295] - Yoshiki Matsuda, Nobuyuki Ozawa, Takiko Shinozaki, Ken-Ichi Wakabayashi, Kosuke Suzuki, Yusuke Kawano, Iwao Ohtsu, Yoshitaka Tatebayashi. Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances.
Translational psychiatry.
2020 05; 10(1):170. doi:
10.1038/s41398-020-0855-1. [PMID: 32467627] - Einar Smith, Filip Ottosson, Sophie Hellstrand, Ulrika Ericson, Marju Orho-Melander, Céline Fernandez, Olle Melander. Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease.
Heart (British Cardiac Society).
2020 05; 106(9):691-697. doi:
10.1136/heartjnl-2019-315485. [PMID: 31672783] - Rachel D Williamson, Fergus P McCarthy, Samprikta Manna, Emer Groarke, Douglas B Kell, Louise C Kenny, Cathal M McCarthy. L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model.
Hypertension (Dallas, Tex. : 1979).
2020 02; 75(2):561-568. doi:
10.1161/hypertensionaha.119.13929. [PMID: 31865793] - Pachara Thananurak, Napapach Chuaychu-Noo, Aurore Thélie, Yupin Phasuk, Thevin Vongpralub, Elisabeth Blesbois. Different concentrations of cysteamine, ergothioneine, and serine modulate quality and fertilizing ability of cryopreserved chicken sperm.
Poultry science.
2020 Feb; 99(2):1185-1198. doi:
10.1016/j.psj.2019.10.040. [PMID: 32029149] - Aude-Claire Morillon, Rachel D Williamson, Philip N Baker, Douglas B Kell, Louise C Kenny, Jane A English, Fergus P McCarthy, Cathal McCarthy. Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia.
PloS one.
2020; 15(3):e0230977. doi:
10.1371/journal.pone.0230977. [PMID: 32231385] - Robert B Beelman, Michael D Kalaras, Allen T Phillips, John P Richie. Is ergothioneine a 'longevity vitamin' limited in the American diet?.
Journal of nutritional science.
2020; 9(?):e52. doi:
10.1017/jns.2020.44. [PMID: 33244403] - Raquel G Loreto, David P Hughes. The metabolic alteration and apparent preservation of the zombie ant brain.
Journal of insect physiology.
2019 10; 118(?):103918. doi:
10.1016/j.jinsphys.2019.103918. [PMID: 31400384] - Nayara Alves Chaves, Thiago Geronimo Pires Alegria, Lucas Souza Dantas, Luis Eduardo Soares Netto, Sayuri Miyamoto, Claudia Regina Bonini Domingos, Danilo Grünig Humberto da Silva. Impaired antioxidant capacity causes a disruption of metabolic homeostasis in sickle erythrocytes.
Free radical biology & medicine.
2019 09; 141(?):34-46. doi:
10.1016/j.freeradbiomed.2019.05.034. [PMID: 31163255] - Jade Pahila, Yuki Ishikawa, Toshiaki Ohshima. Effects of Ergothioneine-Rich Mushroom Extract on the Oxidative Stability of Astaxanthin in Liposomes.
Journal of agricultural and food chemistry.
2019 Mar; 67(12):3491-3501. doi:
10.1021/acs.jafc.9b00485. [PMID: 30789726] - Yoshiko Fujitani, Kabir Md Alamgir, Akio Tani. Ergothioneine production using Methylobacterium species, yeast, and fungi.
Journal of bioscience and bioengineering.
2018 Dec; 126(6):715-722. doi:
10.1016/j.jbiosc.2018.05.021. [PMID: 29910189] - Barry Halliwell, Irwin K Cheah, Richard M Y Tang. Ergothioneine - a diet-derived antioxidant with therapeutic potential.
FEBS letters.
2018 10; 592(20):3357-3366. doi:
10.1002/1873-3468.13123. [PMID: 29851075] - Kentaro Nishida, Kazuya Takeuchi, Ayami Hosoda, Shohei Sugano, Eri Morisaki, Akihiro Ohishi, Kazuki Nagasawa. Ergothioneine ameliorates oxaliplatin-induced peripheral neuropathy in rats.
Life sciences.
2018 Aug; 207(?):516-524. doi:
10.1016/j.lfs.2018.07.006. [PMID: 29981320] - Robert N Kerley, Cathal McCarthy, Douglas B Kell, Louise C Kenny. The potential therapeutic effects of ergothioneine in pre-eclampsia.
Free radical biology & medicine.
2018 03; 117(?):145-157. doi:
10.1016/j.freeradbiomed.2017.12.030. [PMID: 29284116] - Richard Ming Yi Tang, Irwin Kee-Mun Cheah, Terry Shze Keong Yew, Barry Halliwell. Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues.
Scientific reports.
2018 01; 8(1):1601. doi:
10.1038/s41598-018-20021-z. [PMID: 29371632] - Ming-Tsung Yen, Yuan-Hua Chang, Shih-Jeng Huang, Ming-Ching Cheng, Jeng-Leun Mau. Extraction of Ergothioneine from Pleurotus eryngii and P. citrinopileatus (Agaricomycetes) and Preparation of Its Product.
International journal of medicinal mushrooms.
2018; 20(4):381-392. doi:
10.1615/intjmedmushrooms.2018025953. [PMID: 29953398] - Yasuyuki Shinozaki, Kengo Furuichi, Tadashi Toyama, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Shuichi Kaneko, Noriyoshi Isozumi, Shushi Nagamori, Yoshikatsu Kanai, Tomoko Sugiura, Yukio Kato, Takashi Wada. Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease.
Kidney international.
2017 12; 92(6):1356-1369. doi:
10.1016/j.kint.2017.04.032. [PMID: 28754554] - Christopher Stoffels, Mhmd Oumari, Aris Perrou, Andreas Termath, Waldemar Schlundt, Hans-Günther Schmalz, Mathias Schäfer, Vera Wewer, Sabine Metzger, Edgar Schömig, Dirk Gründemann. Ergothioneine stands out from hercynine in the reaction with singlet oxygen: Resistance to glutathione and TRIS in the generation of specific products indicates high reactivity.
Free radical biology & medicine.
2017 12; 113(?):385-394. doi:
10.1016/j.freeradbiomed.2017.10.372. [PMID: 29074402] - Jade Pahila, Hisayuki Kaneda, Reiko Nagasaka, Tomoyuki Koyama, Toshiaki Ohshima. Effects of ergothioneine-rich mushroom extracts on lipid oxidation and discoloration in salmon muscle stored at low temperatures.
Food chemistry.
2017 Oct; 233(?):273-281. doi:
10.1016/j.foodchem.2017.04.130. [PMID: 28530575] - Michael D Kalaras, John P Richie, Ana Calcagnotto, Robert B Beelman. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione.
Food chemistry.
2017 Oct; 233(?):429-433. doi:
10.1016/j.foodchem.2017.04.109. [PMID: 28530594] - Hiroshi Arakawa, Ikumi Washio, Natsumi Matsuoka, Hikaru Kubo, Angelina Yukiko Staub, Noritaka Nakamichi, Naoki Ishiguro, Yukio Kato, Takeo Nakanishi, Ikumi Tamai. Usefulness of kidney slices for functional analysis of apical reabsorptive transporters.
Scientific reports.
2017 10; 7(1):12814. doi:
10.1038/s41598-017-12828-z. [PMID: 28993647] - Irwin K Cheah, Richard M Y Tang, Terry S Z Yew, Keith H C Lim, Barry Halliwell. Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation.
Antioxidants & redox signaling.
2017 02; 26(5):193-206. doi:
10.1089/ars.2016.6778. [PMID: 27488221] - Rao-Chi Chien, Yu-Chieh Lin, Jeng-Leun Mau. Apoptotic Effect of Taiwanofungus salmoneus (Agaricomycetes) Mycelia and Solid-State Fermented Products on Cancer Cells.
International journal of medicinal mushrooms.
2017; 19(9):777-495. doi:
10.1615/intjmedmushrooms.2017024264. [PMID: 29199553] - Irwin K Cheah, Lei Feng, Richard M Y Tang, Keith H C Lim, Barry Halliwell. Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?.
Biochemical and biophysical research communications.
2016 09; 478(1):162-167. doi:
10.1016/j.bbrc.2016.07.074. [PMID: 27444382] - Palma Ann Marone, Jan Trampota, Steven Weisman. A Safety Evaluation of a Nature-Identical l-Ergothioneine in Sprague Dawley Rats.
International journal of toxicology.
2016 09; 35(5):568-83. doi:
10.1177/1091581816653375. [PMID: 27306320] - Mona S Calvo, Anita Mehrotra, Robert B Beelman, Girish Nadkarni, Lingzhi Wang, Weijing Cai, Boon Cher Goh, Michael D Kalaras, Jaime Uribarri. A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms).
Plant foods for human nutrition (Dordrecht, Netherlands).
2016 Sep; 71(3):245-51. doi:
10.1007/s11130-016-0552-7. [PMID: 27193019] - Marta Frigeni, Francesco Iacobazzi, Xue Yin, Nicola Longo. Wide tolerance to amino acids substitutions in the OCTN1 ergothioneine transporter.
Biochimica et biophysica acta.
2016 Jun; 1860(6):1334-42. doi:
10.1016/j.bbagen.2016.03.021. [PMID: 26994919] - Noritaka Nakamichi, Keigo Nakayama, Takahiro Ishimoto, Yusuke Masuo, Tomohiko Wakayama, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Shoichi Iseki, Yukio Kato. Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice.
Brain and behavior.
2016 06; 6(6):e00477. doi:
10.1002/brb3.477. [PMID: 27134772] - Ya-yun Weng, Li-sha Jin, Yu-qing Wang, Fei-feng Song, Li-ping Li, Hui Zhou, Su Zeng, Hui-di Jiang. [Establishment and application of cell models with stable expression of hOCTN1/2].
Yao xue xue bao = Acta pharmaceutica Sinica.
2016 06; 51(6):931-7. doi:
NULL. [PMID: 29879347] - Emil Andreev, Nicolas Brosseau, Euridice Carmona, Anne-Marie Mes-Masson, Dindial Ramotar. The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin.
Scientific reports.
2016 Feb; 6(?):20508. doi:
10.1038/srep20508. [PMID: 26861753] - Angelo Zinellu, Alessandro Giuseppe Fois, Salvatore Sotgia, Elisabetta Zinellu, Fabiana Bifulco, Gianfranco Pintus, Arduino A Mangoni, Ciriaco Carru, Pietro Pirina. Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease.
European journal of clinical investigation.
2016 Feb; 46(2):181-8. doi:
10.1111/eci.12582. [PMID: 26681451] - Vikram Saini, Bridgette M Cumming, Loni Guidry, Dirk A Lamprecht, John H Adamson, Vineel P Reddy, Krishna C Chinta, James H Mazorodze, Joel N Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J C Steyn. Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.
Cell reports.
2016 Jan; 14(3):572-585. doi:
10.1016/j.celrep.2015.12.056. [PMID: 26774486] - Shital P Shah, John E Duda. Dietary modifications in Parkinson's disease: A neuroprotective intervention?.
Medical hypotheses.
2015 Dec; 85(6):1002-5. doi:
10.1016/j.mehy.2015.08.018. [PMID: 26364043] - Takuya Shimizu, Yusuke Masuo, Saki Takahashi, Noritaka Nakamichi, Yukio Kato. Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice.
Drug metabolism and pharmacokinetics.
2015 Jun; 30(3):231-9. doi:
10.1016/j.dmpk.2015.02.003. [PMID: 26003890] - Carolin Pfeiffer, Markus Bach, Tim Bauer, Julia Campos da Ponte, Edgar Schömig, Dirk Gründemann. Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels.
Free radical biology & medicine.
2015 Jun; 83(?):178-85. doi:
10.1016/j.freeradbiomed.2015.02.026. [PMID: 25746775] - Allegra Vit, Laëtitia Misson, Wulf Blankenfeldt, Florian P Seebeck. Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis.
Chembiochem : a European journal of chemical biology.
2015 Jan; 16(1):119-25. doi:
10.1002/cbic.201402522. [PMID: 25404173] - Shin-Yi Lin, Shih-Chang Chien, Sheng-Yang Wang, Jeng-Leun Mau. Submerged Cultivation of Mycelium with High Ergothioneine Content from the Culinary-Medicinal Golden Oyster Mushroom, Pleurotus citrinopileatus (Higher Basidiomycetes).
International journal of medicinal mushrooms.
2015; 17(8):749-61. doi:
10.1615/intjmedmushrooms.v17.i8.50. [PMID: 26559861] - Shih-Jeng Huang, Chun-Ping Lin, Jeng-Leun Mau, Yu-Shan Li, Shu-Yao Tsai. Effect of UV-B Irradiation on Physiologically Active Substance Content and Antioxidant Properties of the Medicinal Caterpillar Fungus Cordyceps militaris (Ascomycetes).
International journal of medicinal mushrooms.
2015; 17(3):241-53. doi:
10.1615/intjmedmushrooms.v17.i3.40. [PMID: 25954908] - Marco H Bello, John C Mogannam, Dexter Morin, Lynn Epstein. Endogenous ergothioneine is required for wild type levels of conidiogenesis and conidial survival but does not protect against 254 nm UV-induced mutagenesis or kill.
Fungal genetics and biology : FG & B.
2014 Dec; 73(?):120-7. doi:
10.1016/j.fgb.2014.10.007. [PMID: 25446508] - Luyun Cai, Xiaosa Wu, Zhijian Dong, Xuepeng Li, Shumin Yi, Jianrong Li. Physicochemical responses and quality changes of red sea bream (Pagrosomus major) to gum arabic coating enriched with ergothioneine treatment during refrigerated storage.
Food chemistry.
2014 Oct; 160(?):82-9. doi:
10.1016/j.foodchem.2014.03.093. [PMID: 24799212] - T-Y Song, H-C Lin, C-L Chen, J-H Wu, J-W Liao, M-L Hu. Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose.
Free radical research.
2014 Sep; 48(9):1049-60. doi:
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PloS one.
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Reproductive sciences (Thousand Oaks, Calif.).
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Free radical biology & medicine.
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Journal of agricultural and food chemistry.
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