Cocaethylene (BioDeep_00000405786)

   


代谢物信息卡片


Cocaethylene

化学式: C18H23NO4 (317.1626998)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C(C(OC(=O)c(c3)cccc3)1)C(C2)N(C)C(C2)C1
InChI: InChI=1S/C18H23NO4/c1-3-22-18(21)16-14-10-9-13(19(14)2)11-15(16)23-17(20)12-7-5-4-6-8-12/h4-8,13-16H,3,9-11H2,1-2H3/t13-,14+,15-,16+/m0/s1

描述信息

D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

Cocaethylene



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Javier A Tamargo, Kenneth E Sherman, Rafick-Pierre Sékaly, Rebeka Bordi, Daniela Schlatzer, Shenghan Lai, Jag H Khalsa, Raul N Mandler, Richard L Ehman, Marianna K Baum. Cocaethylene, simultaneous alcohol and cocaine use, and liver fibrosis in people living with and without HIV. Drug and alcohol dependence. 2022 03; 232(?):109273. doi: 10.1016/j.drugalcdep.2022.109273. [PMID: 35033954]
  • Teresa Huertas, Carmen Jurado, Manuel Salguero, Teresa Soriano, Joaquin Gamero. Stability of Cocaine Compounds in Biological Fluids During Post-Analytical Sample Storage. Journal of analytical toxicology. 2020 Dec; 44(8):864-870. doi: 10.1093/jat/bkaa044. [PMID: 33313886]
  • João Francisco Allochio Filho, Nayara A Dos Santos, Keyller Bastos Borges, Valdemar Lacerda, Fabrício Souza Pelição, Wanderson Romão. Fiber spray ionization mass spectrometry in forensic chemistry: A screening of drugs of abuse and direct determination of cocaine in urine. Rapid communications in mass spectrometry : RCM. 2020 Sep; 34 Suppl 3(?):e8747. doi: 10.1002/rcm.8747. [PMID: 32056289]
  • Fritz Pragst, Franziska Krumbiegel, Denise Thurmann, Lena Westendorf, Maximilian Methling, André Niebel, Sven Hartwig. Positive findings of ethyl glucuronide in hair of young children from families with addiction background. International journal of legal medicine. 2020 Mar; 134(2):523-532. doi: 10.1007/s00414-019-02236-5. [PMID: 31965236]
  • Roberto Mandrioli, Laura Mercolini, Michele Protti. Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption. Molecules (Basel, Switzerland). 2020 Feb; 25(5):. doi: 10.3390/molecules25051046. [PMID: 32110941]
  • Lilian de Lima Feltraco Lizot, Anne Caroline Cezimbra da Silva, Marcos Frank Bastiani, Tales Fernando Maurer, Roberta Zilles Hahn, Magda Susana Perassolo, Marina Venzon Antunes, Rafael Linden. Simultaneous Determination of Cocaine and Metabolites in Human Plasma Using Solid Phase Micro-Extraction Fiber Tips C18 and UPLC-MS/MS. Journal of analytical toxicology. 2020 Jan; 44(1):49-56. doi: 10.1093/jat/bkz042. [PMID: 31095712]
  • N C Rubio, F Krumbiegel, F Pragst, D Thurmann, A Nagel, E Zytowski, M Aranguren, J C Gorlelo, N Poliansky. Discrimination between chewing of coca leaves or drinking of coca tea and smoking of "paco" (coca paste) by hair analysis. A preliminary study of possibilities and limitations. Forensic science international. 2019 Apr; 297(?):171-176. doi: 10.1016/j.forsciint.2019.01.040. [PMID: 30798102]
  • Alan Wayne Jones. Forensic Drug Profile: Cocaethylene. Journal of analytical toxicology. 2019 Apr; 43(3):155-160. doi: 10.1093/jat/bkz007. [PMID: 30796807]
  • Liron Shemesh-Darvish, Doron Shinar, Hussein Hallak, Aviva Gross, Moti Rosenstock. TV-1380 attenuates cocaine-induced changes in cardiodynamic parameters in monkeys and reduces the formation of cocaethylene. Drug and alcohol dependence. 2018 07; 188(?):295-303. doi: 10.1016/j.drugalcdep.2018.01.033. [PMID: 29807217]
  • Juan Sánchez-González, Sara García-Carballal, Pamela Cabarcos, María Jesús Tabernero, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro. Determination of cocaine and its metabolites in plasma by porous membrane-protected molecularly imprinted polymer micro-solid-phase extraction and liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2016 Jun; 1451(?):15-22. doi: 10.1016/j.chroma.2016.05.003. [PMID: 27207577]
  • Juan Sánchez-González, María Jesús Tabernero, Ana María Bermejo, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro. Development of magnetic molecularly imprinted polymers for solid phase extraction of cocaine and metabolites in urine before high performance liquid chromatography - tandem mass spectrometry. Talanta. 2016 Jan; 147(?):641-9. doi: 10.1016/j.talanta.2015.10.034. [PMID: 26592657]
  • Michael R Fettiplace, Adrian Pichurko, Richard Ripper, Bocheng Lin, Katarzyna Kowal, Kinga Lis, David Schwartz, Douglas L Feinstein, Israel Rubinstein, Guy Weinberg. Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2015 May; 22(5):508-17. doi: 10.1111/acem.12657. [PMID: 25908403]
  • Morten Karlsen, Huiling Liu, Jon Eigill Johansen, Bård Helge Hoff. Economical synthesis of 13C-labeled opiates, cocaine derivatives and selected urinary metabolites by derivatization of the natural products. Molecules (Basel, Switzerland). 2015 Mar; 20(4):5329-45. doi: 10.3390/molecules20045329. [PMID: 25816077]
  • Nelida Cristina Rubio, Martin Hastedt, Jorge Gonzalez, Fritz Pragst. Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios. International journal of legal medicine. 2015 Jan; 129(1):69-84. doi: 10.1007/s00414-014-1061-6. [PMID: 25138383]
  • Hanna N Wetzel, Michael R Tabet, William J Ball, Andrew B Norman. The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice. International immunopharmacology. 2014 Dec; 23(2):387-90. doi: 10.1016/j.intimp.2014.10.025. [PMID: 25445957]
  • Enrico Gerace, Michele Petrarulo, Fabrizio Bison, Alberto Salomone, Marco Vincenti. Toxicological findings in a fatal multidrug intoxication involving mephedrone. Forensic science international. 2014 Oct; 243(?):68-73. doi: 10.1016/j.forsciint.2014.04.038. [PMID: 24846124]
  • Shurong Hou, Max Zhan, Xirong Zheng, Chang-Guo Zhan, Fang Zheng. Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene. The Biochemical journal. 2014 Jun; 460(3):447-57. doi: 10.1042/bj20140360. [PMID: 24870023]
  • O López-Guarnido, I Álvarez, F Gil, L Rodrigo, H C Cataño, A M Bermejo, M J Tabernero, A Pla, A F Hernández. Hair testing for cocaine and metabolites by GC/MS: criteria to quantitatively assess cocaine use. Journal of applied toxicology : JAT. 2013 Aug; 33(8):838-44. doi: 10.1002/jat.2741. [PMID: 22407992]
  • William E Hobbs, Emily E Moore, Rebecca A Penkala, Douglas D Bolgiano, José A López. Cocaine and specific cocaine metabolites induce von Willebrand factor release from endothelial cells in a tissue-specific manner. Arteriosclerosis, thrombosis, and vascular biology. 2013 Jun; 33(6):1230-7. doi: 10.1161/atvbaha.113.301436. [PMID: 23539221]
  • Jennifer L Pilgrim, Noel Woodford, Olaf H Drummer. Cocaine in sudden and unexpected death: a review of 49 post-mortem cases. Forensic science international. 2013 Apr; 227(1-3):52-9. doi: 10.1016/j.forsciint.2012.08.037. [PMID: 22981213]
  • Věra Hezinová, Zeineb Aturki, Karel Klepárník, Giovanni D'Orazio, František Foret, Salvatore Fanali. Simultaneous analysis of cocaine and its metabolites in urine by capillary electrophoresis-electrospray mass spectrometry using a pressurized liquid junction nanoflow interface. Electrophoresis. 2012 Feb; 33(4):653-60. doi: 10.1002/elps.201100410. [PMID: 22451058]
  • Muthu Ramakrishnan, Fernando Alves De Melo, Berma M Kinsey, John E Ladbury, Thomas R Kosten, Frank M Orson. Probing cocaine-antibody interactions in buffer and human serum. PloS one. 2012; 7(7):e40518. doi: 10.1371/journal.pone.0040518. [PMID: 22859949]
  • Ellen D Herbst, Debra S Harris, E Thomas Everhart, John Mendelson, Peyton Jacob, Reese T Jones. Cocaethylene formation following ethanol and cocaine administration by different routes. Experimental and clinical psychopharmacology. 2011 Apr; 19(2):95-104. doi: 10.1037/a0022950. [PMID: 21463066]
  • Laura Mercolini, Roberto Mandrioli, Gilberto Gerra, Maria Augusta Raggi. Analysis of cocaine and two metabolites in dried blood spots by liquid chromatography with fluorescence detection: a novel test for cocaine and alcohol intake. Journal of chromatography. A. 2010 Nov; 1217(46):7242-8. doi: 10.1016/j.chroma.2010.09.037. [PMID: 20934184]
  • Sage E Wiener, Darrell Sutijono, Cynthia H Moon, Ramanand A Subramanian, Jim Calaycay, Julie I Rushbrook, Shahriar Zehtabchi. Patients with detectable cocaethylene are more likely to require intensive care unit admission after trauma. The American journal of emergency medicine. 2010 Nov; 28(9):1051-5. doi: 10.1016/j.ajem.2009.06.014. [PMID: 20825763]
  • Geraldine Dowling, Liam Regan, Julie Tierney, Michael Nangle. A hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer. Journal of chromatography. A. 2010 Oct; 1217(44):6857-66. doi: 10.1016/j.chroma.2010.08.043. [PMID: 20855077]
  • Nima Majlesi, Richard Shih, Frederick W Fiesseler, Oliver Hung, Renato Debellonio. Cocaine-associated seizures and incidence of status epilepticus. The western journal of emergency medicine. 2010 May; 11(2):157-60. doi: NULL. [PMID: 20823966]
  • Robert B Parker, S Casey Laizure. The effect of ethanol on oral cocaine pharmacokinetics reveals an unrecognized class of ethanol-mediated drug interactions. Drug metabolism and disposition: the biological fate of chemicals. 2010 Feb; 38(2):317-22. doi: 10.1124/dmd.109.030056. [PMID: 19920055]
  • Diaa M Shakleya, Riet Dams, Robin E Choo, Hendree Jones, Marilyn A Huestis. Simultaneous liquid chromatography-mass spectrometry quantification of urinary opiates, cocaine, and metabolites in opiate-dependent pregnant women in methadone-maintenance treatment. Journal of analytical toxicology. 2010 Jan; 34(1):17-25. doi: 10.1093/jat/34.1.17. [PMID: 20109298]
  • Scott Kriger, Josh Gunn, Andrea R Terrell. Identification and quantitation of cocaine, benzoylecgonine, and cocaethylene in blood, serum, and plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):157-64. doi: 10.1007/978-1-60761-459-3_15. [PMID: 20077068]
  • Steven W Fleming, Amitava Dasgupta, Uttam Garg. Quantitation of cocaine, benzoylecgonine, ecgonine methyl ester, and cocaethylene in urine and blood using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):145-56. doi: 10.1007/978-1-60761-459-3_14. [PMID: 20077067]
  • Loralie J Langman, Matthew W Bjergum, Christopher L Williamson, Frank W Crow. Sensitive method for detection of cocaine and associated analytes by liquid chromatography-tandem mass spectrometry in urine. Journal of analytical toxicology. 2009 Oct; 33(8):447-55. doi: 10.1093/jat/33.8.447. [PMID: 19874651]
  • Yao Lu, Ryan M O'Donnell, Peter B Harrington. Detection of cocaine and its metabolites in urine using solid phase extraction-ion mobility spectrometry with alternating least squares. Forensic science international. 2009 Aug; 189(1-3):54-9. doi: 10.1016/j.forsciint.2009.04.007. [PMID: 19457629]
  • Debra S Harris, Thomas Everhart, Peyton Jacob, Emil Lin, John E Mendelson, Reese T Jones. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. BMC clinical pharmacology. 2009 Aug; 9(?):13. doi: 10.1186/1472-6904-9-13. [PMID: 19646280]
  • José Luiz da Costa, Fernando Gustavo Tonin, Luiz Antonio Zanolli, Alice Aparecida da Matta Chasin, Marina Franco Maggi Tavares. Simple method for determination of cocaine and main metabolites in urine by CE coupled to MS. Electrophoresis. 2009 Jun; 30(12):2238-44. doi: 10.1002/elps.200900032. [PMID: 19582724]
  • Eshwar Jagerdeo, Mohamed Abdel-Rehim. Screening of cocaine and its metabolites in human urine samples by direct analysis in real-time source coupled to time-of-flight mass spectrometry after online preconcentration utilizing microextraction by packed sorbent. Journal of the American Society for Mass Spectrometry. 2009 May; 20(5):891-9. doi: 10.1016/j.jasms.2009.01.010. [PMID: 19264505]
  • Robin M Whyatt, Robin Garfinkel, Lori A Hoepner, Howard Andrews, Darrell Holmes, Megan K Williams, Andria Reyes, Diurka Diaz, Frederica P Perera, David E Camann, Dana B Barr. A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy. Environmental health perspectives. 2009 Apr; 117(4):559-67. doi: 10.1289/ehp.0800041. [PMID: 19440494]
  • Hsiu-Li Su, Lan-Ing Feng, Hsiu-Ping Jen, You-Zung Hsieh. Determination of cocaine and its metabolites using cation-selective exhaustive injection and sweeping-MEKC. Electrophoresis. 2008 Nov; 29(20):4270-6. doi: 10.1002/elps.200800167. [PMID: 18924106]
  • Paul P Robandt, Louis J Reda, Kevin L Klette. Complete automation of solid-phase extraction with subsequent liquid chromatography-tandem mass spectrometry for the quantification of benzoylecgonine, m-hydroxybenzoylecgonine, p-hydroxybenzoylecgonine, and norbenzoylecgonine in urine--application to a high-throughput urine analysis laboratory. Journal of analytical toxicology. 2008 Oct; 32(8):577-85. doi: 10.1093/jat/32.8.577. [PMID: 19007506]
  • Purificación Fernández, Marta Lago, Rosa Antonia Lorenzo, Antonia María Carro, Ana María Bermejo, María Jesús Tabernero. Microwave-assisted extraction and HPLC-DAD determination of drugs of abuse in human plasma. Journal of analytical toxicology. 2007 Sep; 31(7):388-93. doi: 10.1093/jat/31.7.388. [PMID: 17725887]
  • Thomas Kraemer, Liane D Paul. Bioanalytical procedures for determination of drugs of abuse in blood. Analytical and bioanalytical chemistry. 2007 Aug; 388(7):1415-35. doi: 10.1007/s00216-007-1271-6. [PMID: 17468860]
  • Purificación Fernández, Marta Lago, Rosa Antonia Lorenzo, Antonia María Carro, Ana María Bermejo, María Jesús Tabernero. Microwave assisted extraction of drugs of abuse from human urine. Journal of applied toxicology : JAT. 2007 Jul; 27(4):373-9. doi: 10.1002/jat.1216. [PMID: 17265433]
  • Maria Caterina Grassi, Anna Maria Cioce, Franco Dei Giudici, Letizia Antonilli, Paolo Nencini. Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: a pilot study. Pharmacological research. 2007 Feb; 55(2):117-21. doi: 10.1016/j.phrs.2006.11.005. [PMID: 17174102]
  • Iván Alvarez, Ana María Bermejo, María Jesús Tabernero, Purificación Fernández, Patricia López. Determination of cocaine and cocaethylene in plasma by solid-phase microextraction and gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jan; 845(1):90-4. doi: 10.1016/j.jchromb.2006.07.061. [PMID: 16935038]
  • Jennifer Baker, Peter Jatlow, Patricia Pade, Viswanathan Ramakrishnan, Elinore F McCance-Katz. Acute cocaine responses following cocaethylene infusion. The American journal of drug and alcohol abuse. 2007; 33(4):619-25. doi: 10.1080/00952990701407694. [PMID: 17668348]
  • Elin Lehrmann, Carlo Colantuoni, Amy Deep-Soboslay, Kevin G Becker, Ross Lowe, Marilyn A Huestis, Thomas M Hyde, Joel E Kleinman, William J Freed. Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. PloS one. 2006 Dec; 1(?):e114. doi: 10.1371/journal.pone.0000114. [PMID: 17205118]
  • Mauricio Yonamine, Alessandro Morais Saviano. Determination of cocaine and cocaethylene in urine by solid-phase microextraction and gas chromatography-mass spectrometry. Biomedical chromatography : BMC. 2006 Oct; 20(10):1071-5. doi: 10.1002/bmc.643. [PMID: 16583460]
  • P Fernández, L Morales, C Vázquez, A M Bermejo, M J Tabernero. HPLC-DAD determination of opioids, cocaine and their metabolites in plasma. Forensic science international. 2006 Aug; 161(1):31-5. doi: 10.1016/j.forsciint.2005.10.016. [PMID: 16300917]
  • Yara Ilias, Stefan Bieri, Philippe Christen, Jean-Luc Veuthey. Evaluation of solid-phase microextraction desorption parameters for fast GC analysis of cocaine in coca leaves. Journal of chromatographic science. 2006 Aug; 44(7):394-8. doi: 10.1093/chromsci/44.7.394. [PMID: 16925937]
  • Patrick S Cardona, Arvind K Chaturvedi, John W Soper, Dennis V Canfield. Simultaneous analyses of cocaine, cocaethylene, and their possible metabolic and pyrolytic products. Forensic science international. 2006 Feb; 157(1):46-56. doi: 10.1016/j.forsciint.2005.04.001. [PMID: 16428007]
  • Buddha D Paul, Shairose Lalani, Thomas Bosy, Aaron J Jacobs, Marilyn A Huestis. Concentration profiles of cocaine, pyrolytic methyl ecgonidine and thirteen metabolites in human blood and urine: determination by gas chromatography-mass spectrometry. Biomedical chromatography : BMC. 2005 Nov; 19(9):677-88. doi: 10.1002/bmc.495. [PMID: 15841503]
  • Alan L Myers, Heather E Williams, James C Kraner, Patrick S Callery. Identification of anhydroecgonine ethyl ester in the urine of a drug overdose victim. Journal of forensic sciences. 2005 Nov; 50(6):1481-5. doi: NULL. [PMID: 16382849]
  • Michael Schaffer, Virginia Hill, Thomas Cairns. Hair analysis for cocaine: the requirement for effective wash procedures and effects of drug concentration and hair porosity in contamination and decontamination. Journal of analytical toxicology. 2005 Jul; 29(5):319-26. doi: 10.1093/jat/29.5.319. [PMID: 16105256]
  • P Fernández, C Vázquez, L Morales, A M Bermejo. Analysis of opiates, cocaine and metabolites in urine by high-performance liquid chromatography with diode array detection (HPLC-DAD). Journal of applied toxicology : JAT. 2005 May; 25(3):200-4. doi: 10.1002/jat.1052. [PMID: 15895479]
  • Thomas Cairns, Virginia Hill, Michael Schaffer, William Thistle. Levels of cocaine and its metabolites in washed hair of demonstrated cocaine users and workplace subjects. Forensic science international. 2004 Oct; 145(2-3):175-81. doi: 10.1016/j.forsciint.2004.04.033. [PMID: 15451090]
  • Debra S Harris, E Thomas Everhart, John Mendelson, Reese T Jones. The pharmacology of cocaethylene in humans following cocaine and ethanol administration. Drug and alcohol dependence. 2003 Nov; 72(2):169-82. doi: 10.1016/s0376-8716(03)00200-x. [PMID: 14636972]
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  • N Nath, M Eldefrawi, J Wright, D Darwin, M Huestis. A rapid reusable fiber optic biosensor for detecting cocaine metabolites in urine. Journal of analytical toxicology. 1999 Oct; 23(6):460-7. doi: 10.1093/jat/23.6.460. [PMID: 10517551]
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