Cefatrizine (BioDeep_00000405777)

   


代谢物信息卡片


Cefatrizine

化学式: C18H18N6O5S2 (462.078)
中文名称: 头孢他嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)CSC4=NNN=C4
InChI: InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

1 个代谢物同义名

Cefatrizine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • N Papantoniou, G Ismailos, G Daskalakis, C Karabinas, S Mesogitis, A Papapanagiotou, A Antsaklis. Pharmacokinetics of oral cefatrizine in pregnant and non-pregnant women with reference to fetal distribution. Fetal diagnosis and therapy. 2007; 22(2):100-6. doi: 10.1159/000097105. [PMID: 17135753]
  • Han-Gon Choi, H Won Jun, Dae-Duk Kim, Hongkee Sah, Bong Kyu Yoo, Chul Soon Yong. Simultaneous determination of cefatrizine and clavulanic acid in dog plasma by HPLC. Journal of pharmaceutical and biomedical analysis. 2004 Apr; 35(1):221-31. doi: 10.1016/j.jpba.2004.01.010. [PMID: 15030898]
  • David G Levitt. The pharmacokinetics of the interstitial space in humans. BMC clinical pharmacology. 2003 Jul; 3(?):3. doi: 10.1186/1472-6904-3-3. [PMID: 12890292]
  • K Matsuda, H Yuasa, J Watanabe. Dose dependency in the gastrointestinal absorption of cefatrizine: correlation between in vivo and in situ. Biological & pharmaceutical bulletin. 1998 Jun; 21(6):604-9. doi: 10.1248/bpb.21.604. [PMID: 9657046]
  • L X Yu, G L Amidon. Saturable small intestinal drug absorption in humans: modeling and interpretation of cefatrizine data. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 1998 Mar; 45(2):199-203. doi: 10.1016/s0939-6411(97)00088-x. [PMID: 9704917]
  • R Sheng, A Wang, X Liu. [Lyme neuroborreliosis with acute meningitis as the presenting manifestation: report of a case]. Zhonghua nei ke za zhi. 1997; 36(1):21-4. doi: NULL. [PMID: 9812556]
  • P Plantin, P Milochau, D Dubois. [Drug-induced serum sickness after ingestion of cefatrizine. First reported case]. Presse medicale (Paris, France : 1983). 1992 Nov; 21(40):1915. doi: NULL. [PMID: 1293606]
  • W R Couet, B G Reigner, J P Guedes, T N Tozer. Theoretical model for both saturable rate and extent of absorption: simulations of cefatrizine data. Journal of pharmacokinetics and biopharmaceutics. 1991 Jun; 19(3):271-85. doi: 10.1007/bf03036251. [PMID: 1875282]
  • W Couet, J P Fauvel, M Laville, N Pozet, J B Fourtillan. Pharmacokinetics of oral cefatrizine in patients with impaired renal function. International journal of clinical pharmacology, therapy, and toxicology. 1991 Jun; 29(6):213-7. doi: NULL. [PMID: 1869342]
  • B G Reigner, W Couet, J P Guedes, J B Fourtillan, T N Tozer. Saturable rate of cefatrizine absorption after oral administration to humans. Journal of pharmacokinetics and biopharmaceutics. 1990 Feb; 18(1):17-34. doi: 10.1007/bf01063620. [PMID: 2329468]
  • W Couet, B G Reigner, M A Lefebvre, J Bizouard, J B Fourtillan. [Pharmacokinetics of cefatrizine administered in repeated doses]. Pathologie-biologie. 1988 May; 36(5):513-6. doi: NULL. [PMID: 3043350]
  • S Soback, G Ziv, B Kurtz, R Paz. Clinical pharmacokinetics of five oral cephalosporins in calves. Research in veterinary science. 1987 Sep; 43(2):166-72. doi: 10.1016/s0034-5288(18)30767-7. [PMID: 3317582]
  • V Mastrandrea, S Ripa, F La Rosa, A Ghezzi. Pharmacokinetics of cefatrizine after oral administration in human volunteers. International journal of clinical pharmacology research. 1985; 5(5):319-23. doi: NULL. [PMID: 4066082]
  • M Pfeffer, R C Gaver, J Ximenez. Human intravenous pharmacokinetics and absolute oral bioavailability of cefatrizine. Antimicrobial agents and chemotherapy. 1983 Dec; 24(6):915-20. doi: 10.1128/aac.24.6.915. [PMID: 6660858]
  • A J Weinstein. The cephalosporins: activity and clinical use. Drugs. 1980 Aug; 20(2):137-54. doi: 10.2165/00003495-198020020-00007. [PMID: 6995096]
  • R C Gaver, G Deeb. Disposition of 14C-cefatrizine in man. Drug metabolism and disposition: the biological fate of chemicals. 1980 May; 8(3):157-62. doi: NULL. [PMID: 6104579]
  • E Crombez, G Van der Weken, W Van den Bossche, P De Moerloose. Quantitative liquid chromatographic determination of cefatrizine in serum and urine by fluorescence detection after post-column derivatization. Journal of chromatography. 1979 Sep; 177(2):323-32. doi: 10.1016/s0021-9673(01)96328-9. [PMID: 528641]
  • E Crombez, G Van der Weken, W Van den Bossche, P De Moerloose. Determination of cefatrizine in serum and urine by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1979 May; 173(1):165-73. doi: 10.1016/s0021-9673(01)80456-8. [PMID: 546870]