actinomycin D (BioDeep_00000405744)
natural product
代谢物信息卡片
化学式: C62H86N12O16 (1254.6284436)
中文名称: 放线菌素D
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChI: InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:27666
- ChEBI: CHEBI:131148
- PubChem: 44415057
- ChEMBL: CHEMBL412030
- MeSH: Dactinomycin
- CAS: 50-76-0
- MoNA: CCMSLIB00000006870
- MoNA: CCMSLIB00000006871
- MoNA: CCMSLIB00000223879
- MoNA: FiehnHILIC001042
- MoNA: FiehnHILIC000154
- MetaboLights: MTBLC27666
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Ting Liu, Tianqi Xu, Chen Hu, Dayuan Sun, Guangxiong Zhou. Hemiactinomycin, an undescribed intermediate of actinomycin biosynthesis from an actinomycetes strain Streptomyces antibioticus H41-55.
Natural product research.
2024 May; 38(9):1577-1582. doi:
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. [PMID: 36564053] - Liangliang Gao, Meiling Huang, Qin Xiong, Yan Liang, Lanfang Mi, Yueming Jiang, Jun Zhang. Antibacterial Mechanism, Control Efficiency, and Nontarget Toxicity Evaluation of Actinomycin X2 against Xanthomonas citri Subsp. citri.
Journal of agricultural and food chemistry.
2024 Mar; 72(9):4788-4800. doi:
10.1021/acs.jafc.3c08600
. [PMID: 38377546] - Yuan Zhang, Hao Li, Fang Wang, Chang Liu, Gadi V P Reddy, Hu Li, Zhihong Li, Yucheng Sun, Zihua Zhao. Discovery of a new highly pathogenic toxin involved in insect sepsis.
Microbiology spectrum.
2023 Dec; 11(6):e0142223. doi:
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Neuroscience.
2022 10; 501(?):103-130. doi:
10.1016/j.neuroscience.2022.08.009
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Journal of integrative bioinformatics.
2022 Sep; 19(3):. doi:
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Polish journal of microbiology.
2022 Sep; 71(3):381-394. doi:
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BMJ case reports.
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Annals of surgical oncology.
2022 May; 29(5):3252-3261. doi:
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European journal of cancer (Oxford, England : 1990).
2022 05; 166(?):1-7. doi:
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European journal of cancer (Oxford, England : 1990).
2022 03; 163(?):88-97. doi:
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Biochemical and biophysical research communications.
2022 01; 588(?):61-67. doi:
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PloS one.
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The journal of obstetrics and gynaecology research.
2021 Oct; 47(10):3737-3741. doi:
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Cancer medicine.
2021 09; 10(18):6428-6441. doi:
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Biochemistry and cell biology = Biochimie et biologie cellulaire.
2021 08; 99(4):508-518. doi:
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Scientific reports.
2021 07; 11(1):14539. doi:
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2020 Dec; 26(1):. doi:
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Bioscience, biotechnology, and biochemistry.
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Marine drugs.
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Journal of gynecologic oncology.
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Journal of pediatric hematology/oncology.
2020 04; 42(3):e193-e194. doi:
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European journal of cancer (Oxford, England : 1990).
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Pediatric blood & cancer.
2020 02; 67(2):e28039. doi:
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. [PMID: 31625685] - Louise Morris, Roly Squire, Beata Sznajder, Harm van Tinteren, Jan Godzinski, Mark Powis. Optimal neoadjuvant chemotherapy duration in Wilms tumour with intravascular thrombus: A literature review and evidence from SIOP WT 2001 trial.
Pediatric blood & cancer.
2019 11; 66(11):e27930. doi:
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. [PMID: 31339231] - Anne Mahringer, Alexandra Bernd, David S Miller, Gert Fricker. Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules.
Biological chemistry.
2019 09; 400(10):1335-1345. doi:
10.1515/hsz-2018-0425
. [PMID: 30913027] - Sandhya Chandrakar, Ashwini Kumar Gupta. Actinomycin-Producing Endophytic Streptomyces parvulus Associated with Root of Aloe vera and Optimization of Conditions for Antibiotic Production.
Probiotics and antimicrobial proteins.
2019 09; 11(3):1055-1069. doi:
10.1007/s12602-018-9451-6
. [PMID: 30058033] - Najat C Daw, Yueh-Yun Chi, Yeonil Kim, Elizabeth A Mullen, John A Kalapurakal, Jing Tian, Geetika Khanna, James I Geller, Elizabeth J Perlman, Peter F Ehrlich, Anne B Warwick, Paul E Grundy, Conrad V Fernandez, Jeffrey S Dome. Treatment of stage I anaplastic Wilms' tumour: a report from the Children's Oncology Group AREN0321 study.
European journal of cancer (Oxford, England : 1990).
2019 09; 118(?):58-66. doi:
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Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jun; 29(6):S31-S33. doi:
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. [PMID: 31142414] - Hong Zeng, Pei-Xian Feng, Chuan-Xing Wan. Antifungal effects of actinomycin D on Verticillium dahliae via a membrane-splitting mechanism.
Natural product research.
2019 Jun; 33(12):1751-1755. doi:
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. [PMID: 29382222] - Mengchan Liu, Yanxi Jia, Yunchang Xie, Chunyan Zhang, Junying Ma, Changli Sun, Jianhua Ju. Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073.
Marine drugs.
2019 Apr; 17(4):. doi:
10.3390/md17040240
. [PMID: 31018504] - Sabine Irtan, Boo Messahel, Veronica Moroz, Roger E Taylor, Richard Grundy, Anna Kelsey, Gordan Vujanic, Kathy Pritchard-Jones. Outcomes of non-anaplastic stage III and 'inoperable' Wilms tumour treated in the UKW3 trial.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
2019 02; 131(?):1-7. doi:
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. [PMID: 30773174] - Hai-Li Kang, Qun Zhao, Shu-Li Yang, Wei Duan. Efficacy of Combination Therapy with Actinomycin D and Methotrexate in the Treatment of Low-Risk Gestational Trophoblastic Neoplasia.
Chemotherapy.
2019; 64(1):42-47. doi:
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Pediatric blood & cancer.
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The Turkish journal of pediatrics.
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HLA.
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Journal of pediatric urology.
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Nuclear medicine communications.
2018 Dec; 39(12):1081-1090. doi:
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Journal of cancer research and clinical oncology.
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Pediatric blood & cancer.
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PLoS pathogens.
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Pediatric hematology and oncology.
2018 Apr; 35(3):218-224. doi:
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Menopause (New York, N.Y.).
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2018 01; 36(3):254-261. doi:
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Scientific reports.
2018 01; 8(1):1263. doi:
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PloS one.
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Pediatric blood & cancer.
2018 Jan; 65(1):. doi:
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Pediatric blood & cancer.
2018 Jan; 65(1):. doi:
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Prostaglandins & other lipid mediators.
2018 01; 134(?):141-147. doi:
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Nature reviews. Urology.
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Annals of surgery.
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Medicine.
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Biochimica et biophysica acta. Molecular and cell biology of lipids.
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Cell and tissue research.
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Oncotarget.
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Cellular signalling.
2017 01; 29(?):209-217. doi:
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Methods in molecular biology (Clifton, N.J.).
2017; 1601(?):71-77. doi:
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The Journal of steroid biochemistry and molecular biology.
2017 01; 165(Pt B):430-437. doi:
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Methods in molecular biology (Clifton, N.J.).
2017; 1520(?):107-118. doi:
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Journal of pediatric hematology/oncology.
2017 01; 39(1):50-55. doi:
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The European journal of neuroscience.
2016 12; 44(11):2958-2965. doi:
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Taiwanese journal of obstetrics & gynecology.
2016 Dec; 55(6):881-885. doi:
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Pediatric dermatology.
2016 Sep; 33(5):e278-9. doi:
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Journal of natural products.
2016 06; 79(6):1651-7. doi:
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International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2016 06; 26(5):977-83. doi:
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Journal of pharmacological and toxicological methods.
2016 May; 79(?):45-54. doi:
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British journal of clinical pharmacology.
2016 May; 81(5):989-98. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2016 05; 30(5):1712-23. doi:
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American journal of therapeutics.
2016 Mar; 23(2):e594-6. doi:
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Shock (Augusta, Ga.).
2016 Feb; 45(2):139-47. doi:
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Journal of medical case reports.
2016 Jan; 10(?):9. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2016 Jan; 310(2):G64-9. doi:
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European journal of gynaecological oncology.
2016; 37(3):417-9. doi:
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PloS one.
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PloS one.
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International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2016 Jan; 26(1):208-15. doi:
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2015 Nov; 37(8):e494-6. doi:
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Lancet (London, England).
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Journal of experimental botany.
2015 Jul; 66(13):4035-46. doi:
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PloS one.
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The FEBS journal.
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