4-thiouridine (BioDeep_00000405718)
代谢物信息卡片
化学式: C9H12N2O5S (260.0467)
中文名称: 4-巯基尿苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C(=O)NC1=S)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D000345 - Affinity Labels
D009676 - Noxae > D000963 - Antimetabolites
4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response[1].
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:20480
- PubChem: 3032615
- MeSH: Thiouridine
- CAS: 13957-31-8
- MoNA: FiehnHILIC002542
- MoNA: FiehnHILIC001006
- MoNA: FiehnHILIC000112
- medchemexpress: HY-W011793
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Chen Yao, Daizhu Lv, Xueqing Zhou, Pengcheng Fu, Wen Sun, Jinlian Chen, Huan Lin. Exploring urinary modified nucleosides as biomarkers for diabetic retinopathy: Development and validation of a ultra performance liquid chromatography-tandem mass spectrometry method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2024 Jan; 1232(?):123968. doi:
10.1016/j.jchromb.2023.123968
. [PMID: 38150972] - Dimitrios G Anastasakis, Alexis Jacob, Parthena Konstantinidou, Kazuyuki Meguro, Duncan Claypool, Pavol Cekan, Astrid D Haase, Markus Hafner. A non-radioactive, improved PAR-CLIP and small RNA cDNA library preparation protocol.
Nucleic acids research.
2021 05; 49(8):e45. doi:
10.1093/nar/gkab011
. [PMID: 33503264] - Manish Kumar Jeengar, Sudeep Chenna Narendra, Dinesh Thummuri, Mattias Magnusson, V G M Naidu, Srinivas Uppugunduri. Local administration of 4-Thiouridine, a novel molecule with potent anti-inflammatory properties, protects against experimental colitis and arthritis.
International immunopharmacology.
2020 Aug; 85(?):106598. doi:
10.1016/j.intimp.2020.106598
. [PMID: 32442901] - Xiaohui Zhang, Ruiqi Gao, Depeng Li, Hongyan Yin, Juling Zhang, Hongyu Cao, Xuefang Zheng. Study on Interaction between 5-Bromo-4-thio-2'-deoxyuridine and human serum albumin by spectroscopy and molecular docking.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Feb; 136 Pt C(?):1775-81. doi:
10.1016/j.saa.2014.10.081
. [PMID: 25467669] - Mohd Ishtikhar, Gulam Rabbani, Rizwan Hasan Khan. Interaction of 5-fluoro-5'-deoxyuridine with human serum albumin under physiological and non-physiological condition: a biophysical investigation.
Colloids and surfaces. B, Biointerfaces.
2014 Nov; 123(?):469-77. doi:
10.1016/j.colsurfb.2014.09.044
. [PMID: 25448717] - Xiaohui Zhang, Hongxiu Zhai, Ruiqi Gao, Juling Zhang, Yue Zhang, Xuefang Zheng. Study on the interaction between 4-thio-5-methyluridine and human serum albumin by spectroscopy and molecular modeling.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014; 121(?):724-31. doi:
10.1016/j.saa.2013.11.113
. [PMID: 24374886] - D Brégeon, V Colot, M Radman, F Taddei. Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift.
Genes & development.
2001 Sep; 15(17):2295-306. doi:
10.1101/gad.207701
. [PMID: 11544186] - G B Chheda, H B Patrzyc, H A Tworek, S P Dutta. Isolation and characterization of 5-carbamoylmethyluridine and 5-carbamoylmethyl-2-thiouridine from human urine.
Nucleosides & nucleotides.
1999 Oct; 18(10):2155-73. doi:
10.1080/07328319908044873
. [PMID: 10616723] - A Favre, G Moreno, C Salet, F Vinzens. 4-Thiouridine incorporation into the RNA of monkey kidney cells (CV-1) triggers near-UV light long-term inhibition of DNA, RNA and protein synthesis.
Photochemistry and photobiology.
1993 Nov; 58(5):689-94. doi:
10.1111/j.1751-1097.1993.tb04953.x
. [PMID: 7506834] - E Weretilnyk, W Orr, T C White, B Iu, J Singh. Characterization of three related low-temperature-regulated cDNAs from winter Brassica napus.
Plant physiology.
1993 Jan; 101(1):171-7. doi:
10.1104/pp.101.1.171
. [PMID: 7904076] - A Favre, G Moreno, M O Blondel, J Kliber, F Vinzens, C Salet. 4-Thiouridine photosensitized RNA-protein crosslinking in mammalian cells.
Biochemical and biophysical research communications.
1986 Dec; 141(2):847-54. doi:
10.1016/s0006-291x(86)80250-9
. [PMID: 2432896] - R K Ralph, S J Wojcik. Inhibition of turnip yellow mosaic virus synthesis by pyrimidine analogues.
Biochimica et biophysica acta.
1976 Aug; 444(1):261-8. doi:
10.1016/0304-4165(76)90243-9
. [PMID: 989025] - E H Hamamura, K Sato, J G Moffatt. Preparation of a number of 5-butylpyrimidine nucleosides.
Journal of medicinal chemistry.
1972 Oct; 15(10):1061-5. doi:
10.1021/jm00280a016
. [PMID: 4344370]