Biocytin (BioDeep_00000405548)

   

Volatile Flavor Compounds


代谢物信息卡片


Biocytin

化学式: C16H28N4O4S (372.18311680000005)
中文名称: 生物胞素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCC(=O)NCCCC[C@@H](C(=O)O)N)C[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2
InChI: InChI=1S/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1

描述信息

A monocarboxylic acid amide that results from the formal condensation of the carboxylic acid group of biotin with the N(6)-amino group of L-lysine.

同义名列表

3 个代谢物同义名

Biocytin; Biocytin; Biocytin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kouta Nagoya, Shiro Nakamura, Keiko Ikeda, Hiroshi Onimaru, Atsushi Yoshida, Kiyomi Nakayama, Ayako Mochizuki, Masaaki Kiyomoto, Fumihiko Sato, Kiyoshi Kawakami, Koji Takahashi, Tomio Inoue. Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus. Neuroscience. 2017 09; 358(?):211-226. doi: 10.1016/j.neuroscience.2017.06.035. [PMID: 28673717]
  • Gulcan Akgul, Lonnie P Wollmuth. Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Jul; 33(31):12739-50. doi: 10.1523/jneurosci.0040-13.2013. [PMID: 23904610]
  • Antón Barreiro-Iglesias, Karolina Sandra Mysiak, Fátima Adrio, María Celina Rodicio, Catherina G Becker, Thomas Becker, Ramón Anadón. Distribution of glycinergic neurons in the brain of glycine transporter-2 transgenic Tg(glyt2:Gfp) adult zebrafish: relationship to brain-spinal descending systems. The Journal of comparative neurology. 2013 Feb; 521(2):389-425. doi: 10.1002/cne.23179. [PMID: 22736487]
  • Mattia Asti, Michele Iori, Paola A Erba, Giulia Atti, Daniela Farioli, Claudio Guidotti, Annibale Versari. Radiosynthesis of 68Ga-labelled DOTA-biocytin (68Ga-r-BHD) and assessment of its pharmaceutical quality for clinical use. Nuclear medicine communications. 2012 Nov; 33(11):1179-87. doi: 10.1097/mnm.0b013e3283573e05. [PMID: 22836735]
  • Meike V Beer, Claudia Rech, Sylvia Diederichs, Kathrin Hahn, Kristina Bruellhoff, Martin Möller, Lothar Elling, Jürgen Groll. A hydrogel-based versatile screening platform for specific biomolecular recognition in a well plate format. Analytical and bioanalytical chemistry. 2012 Apr; 403(2):517-26. doi: 10.1007/s00216-012-5850-9. [PMID: 22367247]
  • Michael P Weekes, Robin Antrobus, Suzanne Talbot, Simon Hör, Nikol Simecek, Duncan L Smith, Stuart Bloor, Felix Randow, Paul J Lehner. Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6. Journal of proteome research. 2012 Mar; 11(3):1475-84. doi: 10.1021/pr201135e. [PMID: 22292497]
  • Marylka Uusisaari, Thomas Knöpfel. Functional classification of neurons in the mouse lateral cerebellar nuclei. Cerebellum (London, England). 2011 Dec; 10(4):637-46. doi: 10.1007/s12311-010-0240-3. [PMID: 21116763]
  • Kirit Pindolia, Megan Jordan, Caiying Guo, Nell Matthews, Donald M Mock, Erin Strovel, Miriam Blitzer, Barry Wolf. Development and characterization of a mouse with profound biotinidase deficiency: a biotin-responsive neurocutaneous disorder. Molecular genetics and metabolism. 2011 Feb; 102(2):161-9. doi: 10.1016/j.ymgme.2010.10.005. [PMID: 21051254]
  • Ming J Wu, Frank M Clarke, Peter J Rogers, Paul Young, Narelle Sales, Patrick J O'Doherty, Vincent J Higgins. Identification of a protein with antioxidant activity that is important for the protection against beer ageing. International journal of molecular sciences. 2011; 12(9):6089-103. doi: 10.3390/ijms12096089. [PMID: 22016646]
  • Adam W Hantman, Thomas M Jessell. Clarke's column neurons as the focus of a corticospinal corollary circuit. Nature neuroscience. 2010 Oct; 13(10):1233-9. doi: 10.1038/nn.2637. [PMID: 20835249]
  • Michael P Weekes, Robin Antrobus, Jennie R Lill, Lidia M Duncan, Simon Hör, Paul J Lehner. Comparative analysis of techniques to purify plasma membrane proteins. Journal of biomolecular techniques : JBT. 2010 Sep; 21(3):108-15. doi: NULL. [PMID: 20808639]
  • Yu Luo, Cameron H Good, Oscar Diaz-Ruiz, YaJun Zhang, Alexander F Hoffman, Lufei Shan, Serena Y Kuang, Nasir Malik, Vladimir I Chefer, Andreas C Tomac, Carl R Lupica, Cristina M Bäckman. NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization. PloS one. 2010 Aug; 5(8):e12141. doi: 10.1371/journal.pone.0012141. [PMID: 20808436]
  • Marylka Uusisaari, Thomas Knöpfel. GlyT2+ neurons in the lateral cerebellar nucleus. Cerebellum (London, England). 2010 Mar; 9(1):42-55. doi: 10.1007/s12311-009-0137-1. [PMID: 19826891]
  • Tomonori Shinya, Tomohiko Osada, Yoshitake Desaki, Masahiro Hatamoto, Yuko Yamanaka, Hisashi Hirano, Ryota Takai, Fang-Sik Che, Hanae Kaku, Naoto Shibuya. Characterization of receptor proteins using affinity cross-linking with biotinylated ligands. Plant & cell physiology. 2010 Feb; 51(2):262-70. doi: 10.1093/pcp/pcp185. [PMID: 20032208]
  • Horacio F Olivo, Nury Perez-Hernandez, Dongmin Liu, Mary Iruthayanathan, Brianne O'Leary, Laurie L Homan, Joseph S Dillon. Synthesis and application of a photoaffinity analog of dehydroepiandrosterone (DHEA). Bioorganic & medicinal chemistry letters. 2010 Feb; 20(3):1153-5. doi: 10.1016/j.bmcl.2009.12.019. [PMID: 20031404]
  • Gregory P Robbins, Masaya Jimbo, Joe Swift, Michael J Therien, Daniel A Hammer, Ivan J Dmochowski. Photoinitiated destruction of composite porphyrin-protein polymersomes. Journal of the American Chemical Society. 2009 Mar; 131(11):3872-4. doi: 10.1021/ja808586q. [PMID: 19249827]
  • Harry Martin, Colleen Murray, John Christeller, Tony McGhie. A fluorescence polarization assay to quantify biotin and biotin-binding proteins in whole plant extracts using Alexa-Fluor 594 biocytin. Analytical biochemistry. 2008 Oct; 381(1):107-12. doi: 10.1016/j.ab.2008.06.025. [PMID: 18611389]
  • Kou Hayakawa, Noriyuki Katsumata, Masahiko Hirano, Kazuyuki Yoshikawa, Tsutomu Ogata, Toshiaki Tanaka, Takeaki Nagamine. Determination of biotin (vitamin H) by the high-performance affinity chromatography with a trypsin-treated avidin-bound column. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Jun; 869(1-2):93-100. doi: 10.1016/j.jchromb.2008.05.016. [PMID: 18514598]
  • Mohamed Salem, Jeff Silverstein, Caird E Rexroad, Jianbo Yao. Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss). BMC genomics. 2007 Sep; 8(?):328. doi: 10.1186/1471-2164-8-328. [PMID: 17880706]
  • Melissa A Fowler, Kyriaki Sidiropoulou, Emin D Ozkan, Christopher W Phillips, Donald C Cooper. Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PloS one. 2007 Jun; 2(6):e573. doi: 10.1371/journal.pone.0000573. [PMID: 17593972]
  • Zhixiong Chen, Zach Suntres, Jeffrey Palmer, Jorge Guzman, Asad Javed, Jianjing Xue, Jun-Ge Yu, Helen Cooke, Hamdy Awad, Hamdy H Hassanain, Arturo J Cardounel, Fievos L Christofi. Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation. International journal for parasitology. 2007 Jun; 37(7):743-61. doi: 10.1016/j.ijpara.2006.12.018. [PMID: 17307183]
  • Oluwafemi Oguntibeju, Wilhelmina Maria Jacoba van den Heever, Frances Elizabeth Van Schalkwyk. A locally produced nutritional supplement in community-based HIV and AIDS patients. International journal of palliative nursing. 2007 Apr; 13(4):154-62. doi: 10.12968/ijpn.2007.13.4.23485. [PMID: 17551418]
  • Nicholas Santoro, Teresa Brtva, Steve Vander Roest, Karen Siegel, Grover L Waldrop. A high-throughput screening assay for the carboxyltransferase subunit of acetyl-CoA carboxylase. Analytical biochemistry. 2006 Jul; 354(1):70-7. doi: 10.1016/j.ab.2006.04.006. [PMID: 16707089]
  • Shuanghui Luo, Viral S Kansara, Xiaodong Zhu, Nanda K Mandava, Dhananjay Pal, Ashim K Mitra. Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Molecular pharmaceutics. 2006 May; 3(3):329-39. doi: 10.1021/mp0500768. [PMID: 16749865]
  • Irina Sinakevitch, Mamiko Niwa, Nicholas J Strausfeld. Octopamine-like immunoreactivity in the honey bee and cockroach: comparable organization in the brain and subesophageal ganglion. The Journal of comparative neurology. 2005 Aug; 488(3):233-54. doi: 10.1002/cne.20572. [PMID: 15952163]
  • Laurent Dreesen, Yannick Sartenaer, Christophe Humbert, Alaa A Mani, Christophe Méthivier, Claire-Marie Pradier, Paul A Thiry, André Peremans. Probing ligand-protein recognition with sum-frequency generation spectroscopy: the avidin-biocytin case. Chemphyschem : a European journal of chemical physics and physical chemistry. 2004 Nov; 5(11):1719-25. doi: 10.1002/cphc.200400213. [PMID: 15580932]
  • Franziska Grafe, Wolfgang Wohlrab, Reinhard H Neubert, Matthias Brandsch. Transport of biotin in human keratinocytes. The Journal of investigative dermatology. 2003 Mar; 120(3):428-33. doi: 10.1046/j.1523-1747.2003.12058.x. [PMID: 12603856]
  • Albert E Telfeian, Henry C Tseng, Marianna Baybis, Peter B Crino, Marc A Dichter. Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. Epilepsia. 2003 Feb; 44(2):143-9. doi: 10.1046/j.1528-1157.2003.06102.x. [PMID: 12558566]
  • Sara C Rathman, Stephen Eisenschenk, Robert J McMahon. The abundance and function of biotin-dependent enzymes are reduced in rats chronically administered carbamazepine. The Journal of nutrition. 2002 Nov; 132(11):3405-10. doi: 10.1093/jn/132.11.3405. [PMID: 12421859]
  • Aysun Pabuçcuoğlu, Sema Aydoğdu, Meral Baş. Serum biotinidase activity in children with chronic liver disease and its clinical significance. Journal of pediatric gastroenterology and nutrition. 2002 Jan; 34(1):59-62. doi: 10.1097/00005176-200201000-00014. [PMID: 11753166]
  • J Hymes, C M Stanley, B Wolf. Mutations in BTD causing biotinidase deficiency. Human mutation. 2001 Nov; 18(5):375-81. doi: 10.1002/humu.1208. [PMID: 11668630]
  • K Kumasaka, M Muratsugu, T Fukui, M Kimura, Y Takagi, N Hashizume. A new quantitative analytical method of serum biotinidase activity using biocytin as a substrate and its clinical significance in Japan. Clinica chimica acta; international journal of clinical chemistry. 2001 Apr; 306(1-2):71-7. doi: 10.1016/s0009-8981(01)00395-3. [PMID: 11282096]
  • B Baur, E R Baumgartner. Biotin and biocytin uptake into cultured primary calf brain microvessel endothelial cells of the blood-brain barrier. Brain research. 2000 Mar; 858(2):348-55. doi: 10.1016/s0006-8993(00)01944-2. [PMID: 10708686]
  • S M Aamodt, J Shi, M T Colonnese, W Veras, M Constantine-Paton. Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus. Journal of neurophysiology. 2000 Mar; 83(3):1580-91. doi: 10.1152/jn.2000.83.3.1580. [PMID: 10712481]
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  • V Angevin, I Salecker, C Vaillant, J Le Guen, P Branchereau, F Tiaho, I Van Eyseren, Y Pichon. Quantitative morphological analysis of embryonic cockroach (Periplaneta americana) brain neurons developing in vitro. Cell and tissue research. 2000 Jan; 299(1):129-43. doi: 10.1007/s004419900106. [PMID: 10654076]
  • B Wolf, K Norrgard, R J Pomponio, D M Mock, J R McVoy, K Fleischhauer, S Shapiro, M G Blitzer, J Hymes. Profound biotinidase deficiency in two asymptomatic adults. American journal of medical genetics. 1997 Nov; 73(1):5-9. doi: 10.1002/(sici)1096-8628(19971128)73:1<5::aid-ajmg2>3.0.co;2-u. [PMID: 9375914]
  • J Hymes, B Wolf. Biotinidase and its roles in biotin metabolism. Clinica chimica acta; international journal of clinical chemistry. 1996 Nov; 255(1):1-11. doi: 10.1016/0009-8981(96)06396-6. [PMID: 8930409]
  • F K Athappilly, W A Hendrickson. Structure of the biotinyl domain of acetyl-coenzyme A carboxylase determined by MAD phasing. Structure (London, England : 1993). 1995 Dec; 3(12):1407-19. doi: 10.1016/s0969-2126(01)00277-5. [PMID: 8747466]
  • J Hymes, K Fleischhauer, B Wolf. Biotinylation of biotinidase following incubation with biocytin. Clinica chimica acta; international journal of clinical chemistry. 1995 Jan; 233(1-2):39-45. doi: 10.1016/0009-8981(94)05965-u. [PMID: 7758201]
  • T Suormala, V T Ramaekers, S Schweitzer, B Fowler, M C Laub, C Schwermer, J Bachmann, E R Baumgartner. Biotinidase Km-variants: detection and detailed biochemical investigations. Journal of inherited metabolic disease. 1995; 18(6):689-700. doi: 10.1007/bf02436758. [PMID: 8750606]
  • J C Sørensen, N Tønder, J Zimmer. Biocytin pellets: an alternative technique for massive anterograde labeling of neuronal pathways in vivo and in vitro. Brain research. 1993 Apr; 608(2):338-44. doi: 10.1016/0006-8993(93)91476-9. [PMID: 7684313]
  • J Oizumi, K Hayakawa. Biocytin-specific 110-kDa biotinidase from human serum. Clinica chimica acta; international journal of clinical chemistry. 1993 Apr; 215(1):63-71. doi: 10.1016/0009-8981(93)90249-4. [PMID: 8513569]
  • K Sheldon, R Baumal, A Marks. Targeting of [111In]biocytin to cultured ovarian adenocarcinoma cells using covalent monoclonal antibody-streptavidin conjugates. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. 1992 Nov; 43(11):1399-402. doi: 10.1016/0883-2889(92)90015-7. [PMID: 1333461]
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