Deacetyldiltiazem (BioDeep_00000405541)
代谢物信息卡片
Deacetyldiltiazem
化学式: C20H24N2O3S (372.1507554)
中文名称: 地尔硫卓杂质F
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCN1C2=CC=CC=C2SC(C(C1=O)O)C3=CC=C(C=C3)OC
InChI: InChI=1S/C20H24N2O3S/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14/h4-11,18-19,23H,12-13H2,1-3H3/t18-,19+/m1/s1
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:169833
- PubChem: 91638
- Metlin: METLIN2271
- CAS: 42399-40-6
- MoNA: HMDB0002873_ms_ms_2150
- MoNA: HMDB0002873_ms_ms_2151
- MoNA: HMDB0002873_ms_ms_2149
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dong-Hyun Choi, Jin-Seok Choi, Cheng Li, Jun-Shik Choi. Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin.
Pharmacological reports : PR.
2011; 63(6):1574-82. doi:
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The Journal of pharmacy and pharmacology.
2011 Jan; 63(1):129-35. doi:
10.1111/j.2042-7158.2010.01160.x. [PMID: 21189658] - Nicolas Bertrand, Céline Bouvet, Pierre Moreau, Jean-Christophe Leroux. Transmembrane pH-gradient liposomes to treat cardiovascular drug intoxication.
ACS nano.
2010 Dec; 4(12):7552-8. doi:
10.1021/nn101924a. [PMID: 21067150] - Young-Ah Cho, Dong-Hyun Choi, Jun-Shik Choi. Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats.
The Journal of pharmacy and pharmacology.
2009 Jun; 61(6):825-9. doi:
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Die Pharmazie.
2008 Nov; 63(11):815-8. doi:
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Cardiovascular therapeutics.
2008; 26(4):269-75. doi:
10.1111/j.1755-5922.2008.00060.x. [PMID: 19035878] - Soon-Pyo Hong, Kyoung-Sig Chang, Dong-Hyun Choi, Jun-Shik Choi. Effect of atorvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats.
Archives of pharmacal research.
2007 Jan; 30(1):90-5. doi:
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International journal of pharmaceutics.
2005 Nov; 305(1-2):122-8. doi:
10.1016/j.ijpharm.2005.09.004. [PMID: 16226412] - Hyun Jin Choi, Jun-Shik Choi. Effects of morin pretreatment on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem in rats.
Archives of pharmacal research.
2005 Aug; 28(8):970-6. doi:
10.1007/bf02973885. [PMID: 16178425] - Jun Shik Choi, Jin Pil Burm. The influence of cimetidine on the pharmacokinetics of diltiazem and its main metabolite in rabbits.
Archives of pharmacal research.
2004 Feb; 27(2):254-8. doi:
10.1007/bf02980114. [PMID: 15022730] - Suryanarayana Sista, John Chi-Keung Lai, Okponanabofa Eradiri, Kenneth S Albert. Pharmacokinetics of a novel diltiazem HCl extended-release tablet formulation for evening administration.
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2003 Oct; 43(10):1149-57. doi:
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Clinical pharmacology and therapeutics.
2002 Sep; 72(3):333-42. doi:
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2002 Apr; 23(3):115-20. doi:
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1998 Nov; 50(11):1247-53. doi:
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The Annals of pharmacotherapy.
1996 Jun; 30(6):608-11. doi:
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Journal of chromatography. A.
1995 Nov; 717(1-2):235-43. doi:
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Polish journal of pharmacology.
1995 Sep; 47(5):429-34. doi:
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Pharmaceutical research.
1995 Apr; 12(4):609-14. doi:
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Journal of pharmaceutical and biomedical analysis.
1994 Jan; 12(1):135-40. doi:
10.1016/0731-7085(94)80022-7. [PMID: 8161601] - V Hutt, F Janik, J Kappler, G Pabst, V Ravelli, M Maccari, H Jaeger. Evaluation of pharmacokinetics, bioavailability and dose linearity of diltiazem in healthy volunteers.
Arzneimittel-Forschung.
1993 Jul; 43(7):737-43. doi:
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1993 Jul; 33(7):612-22. doi:
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1993 May; 615(1):111-6. doi:
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Therapeutic drug monitoring.
1992 Dec; 14(6):485-92. doi:
10.1097/00007691-199212000-00009. [PMID: 1485371] - Y H Lee, M H Lee, C K Shim. Decreased systemic clearance of diltiazem with increased hepatic metabolism in rats with uranyl nitrate-induced acute renal failure.
Pharmaceutical research.
1992 Dec; 9(12):1599-606. doi:
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Biopharmaceutics & drug disposition.
1992 Oct; 13(7):521-37. doi:
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Biopharmaceutics & drug disposition.
1991 Oct; 12(7):515-23. doi:
10.1002/bdd.2510120705. [PMID: 1932613] - P Hubert, P Chiap, J Crommen. Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC--Part I: Optimization of the HPLC system and method validation.
Journal of pharmaceutical and biomedical analysis.
1991; 9(10-12):877-82. doi:
10.1016/0731-7085(91)80017-4. [PMID: 1822207] - P Hubert, P Chiap, J Crommen. Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC--Part II: Optimization of liquid-solid extraction.
Journal of pharmaceutical and biomedical analysis.
1991; 9(10-12):883-7. doi:
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1990 Mar; 18(2):180-2. doi:
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1990 Mar; 11(2):137-47. doi:
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