5-Methoxytryptophan (BioDeep_00000405525)

   


代谢物信息卡片


(R)-2-Amino-3-(5-methoxy-1H-indol-3-yl)propanoic acid

化学式: C12H14N2O3 (234.1004374)
中文名称: 5-甲氧基-DL-色氨酸, 5-甲氧基-L-色氨酸, (R)-2-氨基-3-(5-甲氧基-1H-吲哚-3-基)丙酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC2=C(C=C1)NC=C2CC(C(=O)O)N
InChI: InChI=1S/C12H14N2O3/c1-17-8-2-3-11-9(5-8)7(6-14-11)4-10(13)12(15)16/h2-3,5-6,10,14H,4,13H2,1H3,(H,15,16)

描述信息

An L-tryptophan derivative that is L-tryptophan with a methoxy substituent at position 5.

同义名列表

3 个代谢物同义名

5-Methoxy-dl-tryptophan; 5-Methoxytryptophan; (R)-2-Amino-3-(5-methoxy-1H-indol-3-yl)propanoic acid



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ting-Chun Lin, Cheng-Chin Kuo, Chao-Yi Wu, Kuo-Wei Yeh, Ming-Ling Kuo, Jing-Long Huang. The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: A retrospective cohort study. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2020 Oct; 53(5):797-802. doi: 10.1016/j.jmii.2018.12.003. [PMID: 30630711]
  • Kenneth K Wu, Cheng-Chin Kuo, Shaw-Fang Yet, Chii-Ming Lee, Jun-Yang Liou. 5-methoxytryptophan: an arsenal against vascular injury and inflammation. Journal of biomedical science. 2020 Jul; 27(1):79. doi: 10.1186/s12929-020-00671-w. [PMID: 32635910]
  • Dan-Qian Chen, Gang Cao, Hua Chen, Christos P Argyopoulos, Hui Yu, Wei Su, Lin Chen, David C Samuels, Shougang Zhuang, George P Bayliss, Shilin Zhao, Xiao-Yong Yu, Nosratola D Vaziri, Ming Wang, Dan Liu, Jia-Rong Mao, Shi-Xing Ma, Jin Zhao, Yuan Zhang, You-Quan Shang, Huining Kang, Fei Ye, Xiao-Hong Cheng, Xiang-Ri Li, Li Zhang, Mei-Xia Meng, Yan Guo, Ying-Yong Zhao. Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan. Nature communications. 2019 04; 10(1):1476. doi: 10.1038/s41467-019-09329-0. [PMID: 30931940]
  • Sarah McGarrity, Ósk Anuforo, Haraldur Halldórsson, Andreas Bergmann, Skarphéðinn Halldórsson, Sirus Palsson, Hanne H Henriksen, Pär Ingemar Johansson, Óttar Rolfsson. Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification. Scientific reports. 2018 05; 8(1):6811. doi: 10.1038/s41598-018-25015-5. [PMID: 29717213]
  • George M Anderson, Joshua T Eighmie. The determination of 5-methoxytryptophan in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Feb; 1074-1075(?):124-128. doi: 10.1016/j.jchromb.2018.01.008. [PMID: 29396377]
  • Yen-Hung Lin, Cheng-Chin Kuo, Chii-Ming Lee, Chia-Hung Chou, Ying-Hsien Chen, Ji-Fan Yeh, Ching-Chang Huang, Chi-Shen Hung, Li-Yu Daisy Liu, Yi-Lwun Ho, Kenneth K Wu. 5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure - a preliminary approach to clinical utility. International journal of cardiology. 2016 Nov; 222(?):895-900. doi: 10.1016/j.ijcard.2016.07.293. [PMID: 27526355]
  • Yi-Fu Wang, Yu-Juei Hsu, Hsu-Feng Wu, Guan-Lin Lee, Ya-Sung Yang, Jing-Yiing Wu, Shaw-Fang Yet, Kenneth K Wu, Cheng-Chin Kuo. Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation. Circulation research. 2016 07; 119(2):222-36. doi: 10.1161/circresaha.116.308559. [PMID: 27151398]
  • Yen-Chun Ho, Meng-Ling Wu, Chen-Hsuan Su, Chung-Huang Chen, Hua-Hui Ho, Guan-Lin Lee, Wei-Shiang Lin, Wen-Yu Lin, Yu-Juei Hsu, Cheng-Chin Kuo, Kenneth K Wu, Shaw-Fang Yet. A Novel Protective Function of 5-Methoxytryptophan in Vascular Injury. Scientific reports. 2016 05; 6(?):25374. doi: 10.1038/srep25374. [PMID: 27146795]
  • Jie Zhang, Xiaoli Mu, Yankai Xia, Francis L Martin, Wei Hang, Liangpo Liu, Meiping Tian, Qingyu Huang, Heqing Shen. Metabolomic analysis reveals a unique urinary pattern in normozoospermic infertile men. Journal of proteome research. 2014 Jun; 13(6):3088-99. doi: 10.1021/pr5003142. [PMID: 24796210]
  • G L Brammer. Duodenum is not a consistent source of melatonin in rats. Life sciences. 1994; 55(10):775-87. doi: 10.1016/0024-3205(94)00561-3. [PMID: 8072375]
  • D J Morton. Effect of methoxyindole administration on plasma cation levels in the rat. Journal of pineal research. 1989; 6(2):141-7. doi: 10.1111/j.1600-079x.1989.tb00411.x. [PMID: 2464684]
  • J van Benthem, J de Koning, I Ebels, M G Balemans. The effect of different photoperiods on the methylating capacity of the pineal gland of adult, male golden hamsters, with special reference to 5-methoxyindoles. Journal of neural transmission. 1986; 67(1-2):147-62. doi: 10.1007/bf01243367. [PMID: 3097253]
  • J A McNulty, M M Prechel, T K Audhya, D Taylor, L Fox, T A Dombrowski, W H Simmons. Pineal ultrastructure and indole profiles spanning the summer rise in arginine vasotocin immunoactivity. Endocrinology. 1985 Sep; 117(3):1035-42. doi: 10.1210/endo-117-3-1035. [PMID: 2410234]
  • K M Lovette, H Y Chuang, A F Mohammad, R G Mason. The subcellular distribution and partial characterization of cholinesterase activities of canine platelets. Biochimica et biophysica acta. 1976 Apr; 428(2):355-68. doi: 10.1016/0304-4165(76)90043-x. [PMID: 6047]