Hexanoylglycine (BioDeep_00000405341)
代谢物信息卡片
N-caproylglycine
化学式: C8H15NO3 (173.1052)
中文名称: 己酰基甘氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(=O)NCC(=O)O
InChI: InChI=1S/C8H15NO3/c1-2-3-4-5-7(10)9-6-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:64390
- PubChem: 99463
- Metlin: METLIN5669
- CAS: 24003-67-6
- MoNA: MoNA037738
- MoNA: MoNA037037
- MoNA: MoNA034896
- MoNA: MoNA034893
- MoNA: MoNA034892
- MoNA: MoNA031873
- MoNA: MoNA031872
- MoNA: MoNA031871
- MoNA: HMDB0000701_ms_ms_980
- MoNA: HMDB0000701_ms_ms_978
- MoNA: HMDB0000701_ms_ms_979
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 7227 - Drosophila melanogaster: 10.1038/S41467-019-11933-Z
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kunio Yui, Nasoyuki Tanuma, Hiroshi Yamada, Yohei Kawasaki. Reduced endogenous urinary total antioxidant power and its relation of plasma antioxidant activity of superoxide dismutase in individuals with autism spectrum disorder.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2017 Aug; 60(?):70-77. doi:
10.1016/j.ijdevneu.2016.08.003. [PMID: 27554135] - Avalyn Stanislaus, Kevin Guo, Liang Li. Development of an isotope labeling ultra-high performance liquid chromatography mass spectrometric method for quantification of acylglycines in human urine.
Analytica chimica acta.
2012 Oct; 750(?):161-72. doi:
10.1016/j.aca.2012.05.006. [PMID: 23062437] - Lindsay Tomlinson, Mark A Tirmenstein, Evan B Janovitz, Nelly Aranibar, Karl-Heinz Ott, John C Kozlosky, Laura M Patrone, William E Achanzar, Karen A Augustine, Kimberly C Brannen, Kenneth E Carlson, Jeffrey H Charlap, Katherine M Dubrow, Liya Kang, Laura T Rosini, Julieta M Panzica-Kelly, Oliver P Flint, Frederic J Moulin, John R Megill, Haiying Zhang, Michael J Bennett, Joseph J Horvath. Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):268-79. doi:
10.1093/toxsci/kfs217. [PMID: 22821849] - Caroline H Johnson, Andrew D Patterson, Kristopher W Krausz, Christian Lanz, Dong Wook Kang, Hans Luecke, Frank J Gonzalez, Jeffrey R Idle. Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats.
Radiation research.
2011 Apr; 175(4):473-84. doi:
10.1667/rr2437.1. [PMID: 21309707] - Annet M Bosch, Nico G G M Abeling, Lodewijk Ijlst, Hennie Knoester, W Ludo van der Pol, Alida E M Stroomer, Ronald J Wanders, Gepke Visser, Frits A Wijburg, Marinus Duran, Hans R Waterham. Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment.
Journal of inherited metabolic disease.
2011 Feb; 34(1):159-64. doi:
10.1007/s10545-010-9242-z. [PMID: 21110228] - Hye In Woo, Hyung-Doo Park, Yong-Wha Lee, Dong Hwan Lee, Chang-Seok Ki, Soo-Youn Lee, Jong-Won Kim. Clinical, biochemical and genetic analyses in two Korean patients with medium-chain acyl-CoA dehydrogenase deficiency.
The Korean journal of laboratory medicine.
2011 Jan; 31(1):54-60. doi:
10.3343/kjlm.2011.31.1.54. [PMID: 21239873] - Juliet Oerton, Javaria M Khalid, Guy Besley, R Neil Dalton, Melanie Downing, Anne Green, Mick Henderson, Steve Krywawych, James Leonard, Brage S Andresen, Carol Dezateux. Newborn screening for medium chain acyl-CoA dehydrogenase deficiency in England: prevalence, predictive value and test validity based on 1.5 million screened babies.
Journal of medical screening.
2011; 18(4):173-81. doi:
10.1258/jms.2011.011086. [PMID: 22166308] - Shelley Kennedy, Beth K Potter, Kumanan Wilson, Lawrence Fisher, Michael Geraghty, Jennifer Milburn, Pranesh Chakraborty. The first three years of screening for medium chain acyl-CoA dehydrogenase deficiency (MCADD) by newborn screening ontario.
BMC pediatrics.
2010 Nov; 10(?):82. doi:
10.1186/1471-2431-10-82. [PMID: 21083904] - Emily H Smith, Cheryl Thomas, David McHugh, Dimitar Gavrilov, Kimiyo Raymond, Piero Rinaldo, Silvia Tortorelli, Dietrich Matern, W Edward Highsmith, Devin Oglesbee. Allelic diversity in MCAD deficiency: the biochemical classification of 54 variants identified during 5 years of ACADM sequencing.
Molecular genetics and metabolism.
2010 Jul; 100(3):241-50. doi:
10.1016/j.ymgme.2010.04.001. [PMID: 20434380] - M Downing, N J Manning, R N Dalton, S Krywawych, J Oerton. Detection of urinary hexanoylglycine in the diagnosis of MCAD deficiency from newborn screening.
Journal of inherited metabolic disease.
2008 Aug; 31(4):550. doi:
10.1007/s10545-008-9976-z. [PMID: 18649007] - John B Tyburski, Andrew D Patterson, Kristopher W Krausz, Josef Slavík, Albert J Fornace, Frank J Gonzalez, Jeffrey R Idle. Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice.
Radiation research.
2008 Jul; 170(1):1-14. doi:
10.1667/rr1265.1. [PMID: 18582157] - Y Matsumoto, M Dogru, E Goto, Y Sasaki, H Inoue, I Saito, J Shimazaki, K Tsubota. Alterations of the tear film and ocular surface health in chronic smokers.
Eye (London, England).
2008 Jul; 22(7):961-8. doi:
10.1038/eye.2008.78. [PMID: 18425058] - C M Westermann, L Dorland, D M Votion, M G M de Sain-van der Velden, I D Wijnberg, R J A Wanders, W G M Spliet, N Testerink, R Berger, J P N Ruiter, J H van der Kolk. Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy.
Neuromuscular disorders : NMD.
2008 May; 18(5):355-64. doi:
10.1016/j.nmd.2008.02.007. [PMID: 18406615] - Nicola Longo, Iris Schrijver, Hannes Vogel, Lynn M Pique, Tina M Cowan, Marzia Pasquali, Gary K Steinberg, Gary L Hedlund, Sharon L Ernst, Renata C Gallagher, Gregory M Enns. Progressive cerebral vascular degeneration with mitochondrial encephalopathy.
American journal of medical genetics. Part A.
2008 Feb; 146A(3):361-7. doi:
10.1002/ajmg.a.31841. [PMID: 18203188] - Yueying Zhen, Kristopher W Krausz, Chi Chen, Jeffrey R Idle, Frank J Gonzalez. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.
Molecular endocrinology (Baltimore, Md.).
2007 Sep; 21(9):2136-51. doi:
10.1210/me.2007-0150. [PMID: 17550978] - C M Westermann, M G M de Sain-van der Velden, J H van der Kolk, R Berger, I D Wijnberg, J P Koeman, R J A Wanders, J A Lenstra, N Testerink, A B Vaandrager, C Vianey-Saban, C Acquaviva-Bourdain, L Dorland. Equine biochemical multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of rhabdomyolysis.
Molecular genetics and metabolism.
2007 Aug; 91(4):362-9. doi:
10.1016/j.ymgme.2007.04.010. [PMID: 17540595] - Simon Platt, Yvonne L McGrotty, Carley J Abramson, Cornelis Jakobs. Refractory seizures associated with an organic aciduria in a dog.
Journal of the American Animal Hospital Association.
2007 May; 43(3):163-7. doi:
10.5326/0430163. [PMID: 17473023] - L Santos, A Patterson, S M Moreea, C M Lippiatt, J Walter, M Henderson. Acute liver failure in pregnancy associated with maternal MCAD deficiency.
Journal of inherited metabolic disease.
2007 Feb; 30(1):103. doi:
10.1007/s10545-006-0520-8. [PMID: 17186412] - D R de Assis, R C Maria, G C Ferreira, P F Schuck, A Latini, C S Dutra-Filho, C M D Wannmacher, A T S Wyse, M Wajner. Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats.
Experimental neurology.
2006 Jan; 197(1):143-9. doi:
10.1016/j.expneurol.2005.09.002. [PMID: 16203000] - Leigh Waddell, Veronica Wiley, Kevin Carpenter, Bruce Bennetts, Lyn Angel, Brage S Andresen, Bridget Wilcken. Medium-chain acyl-CoA dehydrogenase deficiency: genotype-biochemical phenotype correlations.
Molecular genetics and metabolism.
2006 Jan; 87(1):32-9. doi:
10.1016/j.ymgme.2005.09.020. [PMID: 16291504] - Ravi J Tolwani, Doug A Hamm, Liqun Tian, J Daniel Sharer, Jerry Vockley, Piero Rinaldo, Dietrich Matern, Trenton R Schoeb, Philip A Wood. Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice.
PLoS genetics.
2005 Aug; 1(2):e23. doi:
10.1371/journal.pgen.0010023. [PMID: 16121256] - I L Bykov. [Effect of L-carnitine on metabolic disorders in rats with experimental acyl-CoA dehydrogenase deficiency].
Eksperimental'naia i klinicheskaia farmakologiia.
2004 Nov; 67(6):48-52. doi:
NULL. [PMID: 15707016] - S Albers, H L Levy, M Irons, A W Strauss, D Marsden. Compound heterozygosity in four asymptomatic siblings with medium-chain acyl-CoA dehydrogenase deficiency.
Journal of inherited metabolic disease.
2001 Jun; 24(3):417-8. doi:
10.1023/a:1010533408635. [PMID: 11486912] - M Kimura, S Yamaguchi. Screening for fatty acid beta oxidation disorders. Acylglycine analysis by electron impact ionization gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Aug; 731(1):105-10. doi:
10.1016/s0378-4347(99)00208-x. [PMID: 10491995] - I L Bykov, E Shigematsu. [Effect of l-carnitine on the expression of glycine conjugates in rats in experimental B2-hypovitaminosis].
Voprosy pitaniia.
1997; ?(6):9-11. doi:
NULL. [PMID: 9541994] - A Bhala, M J Bennett, K L McGowan, D E Hale. Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency.
The Journal of pediatrics.
1993 Jan; 122(1):100-3. doi:
10.1016/s0022-3476(05)83499-7. [PMID: 8419594] - M J Bennett, A Bhala, S F Poirier, M C Ragni, S M Willi, D E Hale. When do gut flora in the newborn produce 3-phenylpropionic acid? Implications for early diagnosis of medium-chain acyl-CoA dehydrogenase deficiency.
Clinical chemistry.
1992 Feb; 38(2):278-81. doi:
. [PMID: 1541011] - P Rinaldo, J J O'Shea, R D Welch, K Tanaka. Stable isotope dilution analysis of n-hexanoylglycine, 3-phenylpropionylglycine and suberylglycine in human urine using chemical ionization gas chromatography/mass spectrometry selected ion monitoring.
Biomedical & environmental mass spectrometry.
1989 Jul; 18(7):471-7. doi:
10.1002/bms.1200180705. [PMID: 2775902] - P Rinaldo, J J O'Shea, P M Coates, D E Hale, C A Stanley, K Tanaka. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine.
The New England journal of medicine.
1988 Nov; 319(20):1308-13. doi:
10.1056/nejm198811173192003. [PMID: 3054550] - N Gregersen, S Kølvraa, K Rasmussen, P B Mortensen, P Divry, M David, N Hobolth. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases.
Clinica chimica acta; international journal of clinical chemistry.
1983 Aug; 132(2):181-91. doi:
10.1016/0009-8981(83)90246-2. [PMID: 6616873] - N Gregersen, F Rosleff, S Kølvraa, N Hobolth, K Rasmussen, R Lauritzen. Non-ketotic C6-C10-dicarboxylic aciduria: biochemical investigations of two cases.
Clinica chimica acta; international journal of clinical chemistry.
1980 Mar; 102(2-3):179-89. doi:
10.1016/0009-8981(80)90031-5. [PMID: 6892795] - B H Baretz, H S Ramsdell, K Tanaka. Identification of n-hexanoylglycine in urines from two patients with Jamaican vomiting sickness.
Clinica chimica acta; international journal of clinical chemistry.
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