Succinylacetone (BioDeep_00000405318)
Main id: BioDeep_00000020854
PANOMIX_OTCML-2023
代谢物信息卡片
4,6-Dioxoheptanoic acid
化学式: C7H10O4 (158.057906)
中文名称: 4,6-二氧代庚酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)CC(=O)CCC(=O)O
InChI: InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)
描述信息
D004791 - Enzyme Inhibitors
4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis.
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:87897
- PubChem: 5312
- Metlin: METLIN4154
- ChEMBL: CHEMBL222824
- CAS: 51568-18-4
- MoNA: HMDB0000635_ms_ms_868
- MoNA: HMDB0000635_ms_ms_869
- MoNA: HMDB0000635_ms_ms_867
- RefMet: Succinylacetone
- medchemexpress: HY-W010184
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Li Guo, Baoquan Jiao, Fang Liu. [Clinical and genetic analysis of a patient with tyrosinemia type I but without elevated succinylacetone].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.
2019 May; 36(5):472-476. doi:
10.3760/cma.j.issn.1003-9406.2019.05.014. [PMID: 31030436] - Tiantian Zhi, Zhou Zhou, Bo Qiu, Qi Zhu, Xingyao Xiong, Chunmei Ren. Loss of fumarylacetoacetate hydrolase causes light-dependent increases in protochlorophyllide and cell death in Arabidopsis.
The Plant journal : for cell and molecular biology.
2019 05; 98(4):622-638. doi:
10.1111/tpj.14235. [PMID: 30666736] - Jonas Sundberg, Flemming Wibrand, Allan Meldgaard Lund, Mette Christensen. Simultaneous quantification of succinylacetone and nitisinone for therapeutic drug monitoring in the treatment of Tyrosinemia type 1.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1072(?):259-266. doi:
10.1016/j.jchromb.2017.11.031. [PMID: 29195145] - Hao Yang, Walla Al-Hertani, Denis Cyr, Rachel Laframboise, Guy Parizeault, Shu Pei Wang, Francis Rossignol, Marie-Thérèse Berthier, Yves Giguère, Paula J Waters, Grant A Mitchell. Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency.
Journal of medical genetics.
2017 04; 54(4):241-247. doi:
10.1136/jmedgenet-2016-104289. [PMID: 27876694] - Faysal Elgilani, Shennen A Mao, Jaime M Glorioso, Meng Yin, Ianko D Iankov, Anisha Singh, Bruce Amiot, Piero Rinaldo, Ronald J Marler, Richard L Ehman, Markus Grompe, Joseph B Lillegard, Raymond D Hickey, Scott L Nyberg. Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1.
The American journal of pathology.
2017 Jan; 187(1):33-41. doi:
10.1016/j.ajpath.2016.09.013. [PMID: 27855279] - Fernando Alvarez, Suzanne Atkinson, Manon Bouchard, Catherine Brunel-Guitton, Daniela Buhas, Jean-François Bussières, Josée Dubois, Daphna Fenyves, Paul Goodyer, Martyne Gosselin, Ugur Halac, Patrick Labbé, Rachel Laframboise, Bruno Maranda, Serge Melançon, Aicha Merouani, Grant A Mitchell, John Mitchell, Guy Parizeault, Luc Pelletier, Véronique Phan, Jean-François Turcotte. The Québec NTBC Study.
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2017; 959(?):187-195. doi:
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2016 11; 62(11):1539-1541. doi:
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2016 Jul; 408(17):4661-7. doi:
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10.1016/j.clinbiochem.2009.10.004. [PMID: 19836366] - Stephane L Bourque, Carling D Benjamin, Michael A Adams, Kanji Nakatsu. Lack of hemodynamic effects after extended heme synthesis inhibition by succinylacetone in rats.
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Cell biology and toxicology.
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Clinica chimica acta; international journal of clinical chemistry.
1992 Sep; 210(3):227-9. doi:
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Biochemical and biophysical research communications.
1992 Aug; 187(1):340-6. doi:
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Biochemical medicine and metabolic biology.
1992 Aug; 48(1):86-9. doi:
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Clinical science (London, England : 1979).
1992 Jul; 83(1):81-7. doi:
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Biochimica et biophysica acta.
1991 Dec; 1070(2):300-4. doi:
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Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1991 Apr; 196(4):428-31. doi:
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Materia medica Polona. Polish journal of medicine and pharmacy.
1991 Apr; 23(2):136-8. doi:
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The Journal of pediatrics.
1991 Jan; 118(1):136-9. doi:
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Biochemical medicine and metabolic biology.
1990 Dec; 44(3):238-46. doi:
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Acta paediatrica Scandinavica.
1990 Nov; 79(11):1063-8. doi:
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European journal of pediatrics.
1990 Jun; 149(9):637-9. doi:
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Enzyme.
1990; 43(1):17-25. doi:
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Biochimica et biophysica acta.
1989 Dec; 987(1):38-46. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1989 Oct; 184(3):243-50. doi:
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Experimental hematology.
1989 Sep; 17(8):908-13. doi:
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Clinical and experimental pharmacology & physiology.
1989 Jun; 16(6):497-500. doi:
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European journal of biochemistry.
1988 Nov; 177(2):417-24. doi:
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Kidney international.
1988 Nov; 34(5):671-7. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1988 Feb; 171(2-3):223-31. doi:
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The Journal of pediatrics.
1987 Mar; 110(3):399-403. doi:
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Biochemical medicine and metabolic biology.
1987 Feb; 37(1):101-9. doi:
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Journal of inherited metabolic disease.
1986; 9(2):216-24. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1985 Nov; 152(3):271-9. doi:
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Biochimica et biophysica acta.
1985 Oct; 820(1):140-6. doi:
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The Journal of experimental medicine.
1985 Sep; 162(3):1060-74. doi:
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Biochimica et biophysica acta.
1985 Apr; 845(1):109-18. doi:
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Journal of the National Cancer Institute.
1985 Mar; 74(3):603-8. doi:
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Journal of inherited metabolic disease.
1985; 8(1):21-4. doi:
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Journal of chromatographic science.
1984 May; 22(5):211-5. doi:
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Lancet (London, England).
1983 Jun; 1(8336):1279. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1983 May; 130(2):231-8. doi:
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The Journal of clinical investigation.
1983 Mar; 71(3):625-34. doi:
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Neurobehavioral toxicology and teratology.
1982 Nov; 4(6):635-42. doi:
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Biomedical mass spectrometry.
1982 Oct; 9(10):419-24. doi:
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Biochimica et biophysica acta.
1982 Feb; 720(1):96-105. doi:
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