Cytochalasin E (BioDeep_00000403596)
natural product
代谢物信息卡片
化学式: C28H33NO7 (495.22569080000005)
中文名称: 细胞松驰素 E
谱图信息:
最多检出来源 Escherichia coli(natural_products) 12.5%
分子结构信息
SMILES: CC1CC=CC2C3C(O3)(C(C4C2(C(=O)NC4CC5=CC=CC=C5)OC(=O)OC=CC(C1=O)(C)O)C)C
InChI: InChI=1S/C28H33NO7/c1-16-9-8-12-19-23-27(4,35-23)17(2)21-20(15-18-10-6-5-7-11-18)29-24(31)28(19,21)36-25(32)34-14-13-26(3,33)22(16)30/h5-8,10-14,16-17,19-21,23,33H,9,15H2,1-4H3,(H,29,31)/t16-,17-,19-,20-,21-,23-,26+,27+,28+/m0/s1
描述信息
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D006133 - Growth Substances > D006131 - Growth Inhibitors
A natural product found in Arthrinium sacchari.
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:68201
- PubChem: 5458385
- PubChem: 6711190
- Metlin: METLIN44249
- ChEMBL: CHEMBL494856
- CAS: 36011-19-5
- MoNA: CCMSLIB00000855309
- MoNA: CCMSLIB00000855305
- MoNA: CCMSLIB00000855307
- MoNA: CCMSLIB00000850187
- MoNA: CCMSLIB00000850190
- MetaboLights: MTBLC68201
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Sarmina Dangol, Yafei Chen, Byung Kook Hwang, Nam-Soo Jwa. Iron- and Reactive Oxygen Species-Dependent Ferroptotic Cell Death in Rice-Magnaporthe oryzae Interactions.
The Plant cell.
2019 01; 31(1):189-209. doi:
10.1105/tpc.18.00535
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Mycotoxin research.
2018 May; 34(2):91-97. doi:
10.1007/s12550-017-0303-0
. [PMID: 29236246] - Yasukazu Takanezawa, Ryosuke Nakamura, Yuka Kojima, Yuka Sone, Shimpei Uraguchi, Masako Kiyono. Cytochalasin E increased the sensitivity of human lung cancer A549 cells to bortezomib via inhibition of autophagy.
Biochemical and biophysical research communications.
2018 04; 498(3):603-608. doi:
10.1016/j.bbrc.2018.03.029
. [PMID: 29524420] - Maria Lund Nielsen, Thomas Isbrandt, Lene Maj Petersen, Uffe Hasbro Mortensen, Mikael Rørdam Andersen, Jakob Blæsbjerg Hoof, Thomas Ostenfeld Larsen. Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering.
PloS one.
2016; 11(8):e0161199. doi:
10.1371/journal.pone.0161199
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Cell motility and the cytoskeleton.
2009 Mar; 66(3):142-55. doi:
10.1002/cm.20337
. [PMID: 19137584] - Yuhei Goto, Tetsuhiro Asada. Excessive expression of the plant kinesin TBK5 converts cortical and perinuclear microtubules into a radial array emanating from a single focus.
Plant & cell physiology.
2007 May; 48(5):753-61. doi:
10.1093/pcp/pcm045
. [PMID: 17452343] - Birgit Jarosch, Nicholas C Collins, Nina Zellerhoff, Ulrich Schaffrath. RAR1, ROR1, and the actin cytoskeleton contribute to basal resistance to Magnaporthe grisea in barley.
Molecular plant-microbe interactions : MPMI.
2005 May; 18(5):397-404. doi:
10.1094/mpmi-18-0397
. [PMID: 15915638] - Qing-Yi Lu, Yu-Sheng Jin, Allan Pantuck, Zuo-Feng Zhang, David Heber, Arie Belldegrun, Mai Brooks, Robert Figlin, Jianyu Rao. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Feb; 11(4):1675-83. doi:
10.1158/1078-0432.ccr-04-1608
. [PMID: 15746073] - Kenny M Hansson, Pentti Tengvall, Ingemar Lundström, Mats Rånby, Tomas L Lindahl. Comparative studies with surface plasmon resonance and free oscillation rheometry on the inhibition of platelets with cytochalasin E and monoclonal antibodies towards GPIIb/IIIa.
Biosensors & bioelectronics.
2002 Sep; 17(9):761-71. doi:
10.1016/s0956-5663(02)00049-0
. [PMID: 12191924] - Denny G Mellersh, Inge V Foulds, Verna J Higgins, Michele C Heath. H2O2 plays different roles in determining penetration failure in three diverse plant-fungal interactions.
The Plant journal : for cell and molecular biology.
2002 Feb; 29(3):257-68. doi:
10.1046/j.0960-7412.2001.01215.x
. [PMID: 11844104] - H Tomoda, I Namatame, N Tabata, K Kawaguchi, S Si, S Omura. Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages.
The Journal of antibiotics.
1999 Oct; 52(10):857-61. doi:
10.7164/antibiotics.52.857
. [PMID: 10604754] - E Tzima, P J Trotter, M A Orchard, J H Walker. Annexin V binds to the actin-based cytoskeleton at the plasma membrane of activated platelets.
Experimental cell research.
1999 Aug; 251(1):185-93. doi:
10.1006/excr.1999.4553
. [PMID: 10438584] - J Z Zhang, F Ismail-Beigi. Activation of Glut1 glucose transporter in human erythrocytes.
Archives of biochemistry and biophysics.
1998 Aug; 356(1):86-92. doi:
10.1006/abbi.1998.0760
. [PMID: 9681995] - B L Dixit, C M Gupta. Role of the actin cytoskeleton in regulating the outer phosphatidylethanolamine levels in yeast plasma membrane.
European journal of biochemistry.
1998 May; 254(1):202-6. doi:
10.1046/j.1432-1327.1998.2540202.x
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Parasitology.
1992 Aug; 105 ( Pt 1)(?):55-62. doi:
10.1017/s0031182000073686
. [PMID: 1437276] - M A Kolber, K O Broschat, B Landa-Gonzalez. Cytochalasin B induces cellular DNA fragmentation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1990 Sep; 4(12):3021-7. doi:
10.1096/fasebj.4.12.2394319
. [PMID: 2394319] - Y Sasaki, K Iwata, Y Sasaki. Concanavalin A- and fetal-calf-serum-induced rounding and myosin light chain phosphorylation in cultured smooth muscle cells.
Journal of cellular physiology.
1990 Aug; 144(2):183-9. doi:
10.1002/jcp.1041440202
. [PMID: 2116423] - S R Chen, T C Lo. Genetic evidence indicating the identity of the cytochalasin B photolabelled components in rat myoblasts.
Biochemistry international.
1990; 20(4):747-59. doi:
NULL
. [PMID: 2353924] - A Janoshazi, J L Seifter, A K Solomon. Interactions between anion exchange and other membrane proteins in rabbit kidney medullary collecting duct cells.
The Journal of membrane biology.
1989 Nov; 112(1):39-49. doi:
10.1007/bf01871162
. [PMID: 2593138] - P T Cheung, M R Hammerman. Cytochalasin B binding to rabbit proximal tubular basolateral membranes.
Kidney international.
1989 Jun; 35(6):1290-4. doi:
10.1038/ki.1989.124
. [PMID: 2770109] - M Scanlon, S M Laster, J G Wood, L R Gooding. Cytolysis by tumor necrosis factor is preceded by a rapid and specific dissolution of microfilaments.
Proceedings of the National Academy of Sciences of the United States of America.
1989 Jan; 86(1):182-6. doi:
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. [PMID: 2643096] - F Mollinedo, D L Schneider. Intracellular organelle motility and membrane fusion processes in human neutrophils upon cell activation.
FEBS letters.
1987 Jun; 217(2):158-62. doi:
10.1016/0014-5793(87)80655-5
. [PMID: 3036578] - T Glinsukon, W Suvitayawat, S Sahaphong, P Piyachaturawat. Effects of cytochalasin E on H+ and volume secretion in gastric fistula rats.
Toxicology letters.
1987 Mar; 36(1):95-103. doi:
10.1016/0378-4274(87)90046-4
. [PMID: 3564075] - J C Pinder, A G Weeds, W B Gratzer. Study of actin filament ends in the human red cell membrane.
Journal of molecular biology.
1986 Oct; 191(3):461-8. doi:
10.1016/0022-2836(86)90141-5
. [PMID: 3029384] - N Alavi, E Lianos, J B Van Liew, B K Mookerjee, C J Bentzel. Peritoneal permeability in the rat: modulation by microfilament-active agents.
Kidney international.
1985 Feb; 27(2):411-9. doi:
10.1038/ki.1985.25
. [PMID: 4039387] - S Sriurairatana, T Glinsukon. Ultrastructural changes in mouse dermal capillaries induced by cytochalasin E.
Research communications in chemical pathology and pharmacology.
1984 Sep; 45(3):379-87. doi:
NULL
. [PMID: 6505378] - B K Mookerjee, C Y Jung. Effects of cytochalasins on lymphocytes: mechanism of inhibition of rosette formation.
Journal of immunology (Baltimore, Md. : 1950).
1983 Sep; 131(3):1126-30. doi:
NULL
. [PMID: 6684138] - J D Axelrod, P F Pilch. Unique cytochalasin B binding characteristics of the hepatic glucose carrier.
Biochemistry.
1983 Apr; 22(9):2222-7. doi:
10.1021/bi00278a025
. [PMID: 6683102] - R D Estensen, K Zustiak, A Chuang, P Schultheiss, J Ditmanson. Action of 12-O-tetradecanoylphorbol-13-acetate on Y1 adrenal cells apparently requires the regulatory subunit of type 1 cyclic AMP dependent protein kinase.
Journal of experimental pathology.
1983; 1(1):49-60. doi:
NULL
. [PMID: 6100978] - T Glinsukon, A Suvannapura. Changes in plasma volume and protein concentration induced by cytochalasin E in the rat: a time-course study.
Toxicology letters.
1982 Dec; 14(3-4):157-62. doi:
10.1016/0378-4274(82)90045-5
. [PMID: 7167973] - R A Heyneman. Cytochalasin E-induced oxidative metabolism in polymorphonuclear leukocytes.
Archives internationales de physiologie et de biochimie.
1979 Dec; 87(5):925-34. doi:
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. [PMID: 94823]