secobarbital (BioDeep_00000402549)

   


代谢物信息卡片


secobarbital

化学式: C12H18N2O3 (238.1317358)
中文名称: 司可巴比妥
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(C)C1(C(=O)NC(=O)NC1=O)CC=C
InChI: InChI=1S/C12H18N2O3/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CA - Barbiturates, plain
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
CONFIDENCE standard compound; INTERNAL_ID 2307
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 8346

同义名列表

1 个代谢物同义名

secobarbital



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Naoki Yoshioka, Migiwa Asano, Azumi Kuse, Takeshi Kondo, Motonori Takahashi, Mai Morichika, Kanako Nakagawa, Makoto Sakurada, Yasuhiro Ueno. Quantitative analysis of thiamylal and its metabolite secobarbital using liquid chromatography-tandem mass spectrometry in adipose tissue, serum, and liver. Journal of forensic sciences. 2022 May; 67(3):1241-1249. doi: 10.1111/1556-4029.14965. [PMID: 34970733]
  • Shun Mizuno, Xiao-Pen Lee, Masaya Fujishiro, Takaaki Matsuyama, Miho Yamada, Yuki Sakamoto, Maiko Kusano, Kei Zaitsu, Chika Hasegawa, Iwao Hasegawa, Takeshi Kumazawa, Akira Ishii, Keizo Sato. High-throughput determination of valproate in human samples by modified QuEChERS extraction and GC-MS/MS. Legal medicine (Tokyo, Japan). 2018 Mar; 31(?):66-73. doi: 10.1016/j.legalmed.2018.01.002. [PMID: 29413992]
  • Yang-Lai Gao, Jun-Han Yao, Jun-Xiong Guo. [Clinical observation on fire needles at bones combined with cupping and Tuina for knee osteoarthritistis]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2013 Aug; 33(8):697-9. doi: ". [PMID: 24195209]
  • Tong Wang, Zhong-Chao Wu, Tian-Rong Zhu, Wen-Yan Wang. [Impacts on biomechanics of senile osteoporosis of kidney deficiency pattern treated with acupuncture and Tuina therapy]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2012 Aug; 32(8):685-8. doi: NULL. [PMID: 23072081]
  • Ning Li, Feng-Wei Tian, Cheng-Wei Wang, Peng-Ming Yu, Xi Zhou, Qian Wen, Xiu-Lan Qiao, Lu Huang. [Double-center randomized controlled trial on post-stroke shoulder pain treated by electroacupuncture combined with Tuina]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2012 Feb; 32(2):101-5. doi: ". [PMID: 22493908]
  • Tong Wang, Li Pang, Hui Huang, Wen-Yan Wang. [Observation on influence of bone metabolism biochemical indices of senile osteoporosis treated with distant acupuncture and nearby tuina]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2012 Jan; 32(1):13-6. doi: NULL. [PMID: 22295813]
  • Dean Fritch, Kristen Blum, Sheena Nonnemacher, Keith Kardos, August R Buchhalter, Edward J Cone. Barbiturate detection in oral fluid, plasma, and urine. Therapeutic drug monitoring. 2011 Feb; 33(1):72-9. doi: 10.1097/ftd.0b013e3182018151. [PMID: 21099741]
  • Leonard L Johnson, Uttam Garg. Quantitation of amobarbital, butalbital, pentobarbital, phenobarbital, and secobarbital in urine, serum, and plasma using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):65-74. doi: 10.1007/978-1-60761-459-3_7. [PMID: 20077060]
  • Young-Sihn Sihn, Hee-Sun Chung. Interpretations of the TDxFLx calibration data of the abused drugs. Forensic science international. 2003 Jan; 131(1):1-7. doi: 10.1016/s0379-0738(02)00345-6. [PMID: 12505464]
  • C Quiñones-Torrelo, Y Martín-Biosca, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Determination of amobarbital and secobarbital in plasma samples using micellar liquid chromatography. Biomedical chromatography : BMC. 2000 Aug; 14(5):287-92. doi: 10.1002/1099-0801(200008)14:5<287::aid-bmc1>3.0.co;2-c. [PMID: 10960826]
  • R D Cannon, S H Wong, S B Gock, J J Jentzen. Comparison of the serum barbiturate fluorescence polarization immunoassay by the COBAS INTEGRA to a GC/MS method. Therapeutic drug monitoring. 1999 Oct; 21(5):553-8. doi: 10.1097/00007691-199910000-00012. [PMID: 10519455]
  • A Namera, M Yashiki, Y Iwasaki, M Ohtani, T Kojima. Automated procedure for determination of barbiturates in serum using the combined system of PrepStation and gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1998 Sep; 716(1-2):171-6. doi: 10.1016/s0378-4347(98)00265-5. [PMID: 9824230]
  • K Srinivasan, W Zhang, M G Bartlett. Rapid simultaneous capillary electrophoretic determination of (R)- and (S)-secobarbital from serum and prediction of hydroxypropyl-gamma-cyclodextrin-secobarbital stereoselective interaction using molecular mechanics simulation. Journal of chromatographic science. 1998 Feb; 36(2):85-90. doi: 10.1093/chromsci/36.2.85. [PMID: 9487672]
  • F H Qiu, L Liu, Y Luo, Y Q Lu. [A double column double pH solid phase extraction and capillary GC/FID method for rapid simultaneous determination of acidic and basic drugs in human plasma]. Yao xue xue bao = Acta pharmaceutica Sinica. 1996; 31(3):205-8. doi: NULL. [PMID: 9206267]
  • H Hanioka, M Hamamura, K Kakino, H Ogata, H Jinno, A Takahashi, T Nishimura, M Ando. Dog liver microsomal P450 enzyme-mediated toluene biotransformation. Xenobiotica; the fate of foreign compounds in biological systems. 1995 Nov; 25(11):1207-17. doi: 10.3109/00498259509046677. [PMID: 8592870]
  • F H Qiu, L Liu, L Guo, Y Luo, Y Q Lu. [Rapid identification and quantitation of barbiturates in plasma using solid-phase extraction combined with GC-FID and GC-MS method]. Yao xue xue bao = Acta pharmaceutica Sinica. 1995; 30(5):372-7. doi: NULL. [PMID: 7660805]
  • R H Liu, A M McKeehan, C Edwards, G Foster, W D Bensley, J G Langner, A S Walia. Improved gas chromatography/mass spectrometry analysis of barbiturates in urine using centrifuge-based solid-phase extraction, methylation, with d5-pentobarbital as internal standard. Journal of forensic sciences. 1994 Nov; 39(6):1504-14. doi: NULL. [PMID: 7815030]
  • G Quatrehomme, F Bourret, Z Liao, A Ollier. An experimental methodology for the study of postmortem changes in toxic concentrations of drugs, using secobarbital as an example. Journal of forensic sciences. 1994 Sep; 39(5):1300-4. doi: NULL. [PMID: 7964567]
  • T Kojima, T Taniguchi, M Yashiki, T Miyazaki, Y Iwasaki, T Mikami, M Ohtani. A rapid method for detecting barbiturates in serum using EI-SIM. International journal of legal medicine. 1994; 107(1):21-4. doi: 10.1007/bf01247269. [PMID: 7999642]
  • R Pocci, V Dixit, V M Dixit. Solid-phase extraction and GC/MS confirmation of barbiturates from human urine. Journal of analytical toxicology. 1992 Jan; 16(1):45-7. doi: 10.1093/jat/16.1.45. [PMID: 1353548]
  • C C Duncan, J A Ruth. Correlation of sedative effects with brain levels of barbiturates in LS and SS mice. Alcohol (Fayetteville, N.Y.). 1991 Nov; 8(6):461-6. doi: 10.1016/s0741-8329(91)90136-k. [PMID: 1781923]
  • D S Deshmukh, S Kuizon, H Brockerhoff. Barbiturates inhibit intracellular Ca2+ rise induced by thrombin in rat platelets. Cell calcium. 1991 Oct; 12(9):645-54. doi: 10.1016/0143-4160(91)90061-i. [PMID: 1959128]
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  • A J Robinson-White, S M Muldoon, L Elson, D M Collado-Escobar. Evidence that barbiturates inhibit antigen-induced responses through interactions with a GTP-binding protein in rat basophilic leukemia (RBL-2H3) cells. Anesthesiology. 1990 Jun; 72(6):996-1004. doi: 10.1097/00000542-199006000-00009. [PMID: 2161623]
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  • C D Lox. Effects of acute and chronic exposure to secobarbital on the activity of hepatic synthesized clotting factors. Life sciences. 1984 Apr; 34(14):1357-63. doi: 10.1016/0024-3205(84)90007-9. [PMID: 6708735]
  • T L Kuo, W Y Chen, J M Fong, S W How. Studies on serum barbiturate levels of acute intoxication. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association. 1984 Feb; 83(2):135-41. doi: NULL. [PMID: 6586994]
  • D D Koblin, F W Lurz, B O'Connor, N T Nelson, E I Eger, C R Bainton. Potencies of barbiturates in mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia. Anesthesia and analgesia. 1984 Jan; 63(1):35-9. doi: . [PMID: 6691562]
  • N Sade, G P Jacobs. Radiosensitization of Staphylococcus aureus by secobarbital sodium and other barbiturates. Radiation research. 1983 Oct; 96(1):41-50. doi: 10.2307/3576162. [PMID: 6622654]
  • M Saito, S Ikegami, T Aizawa, S Innami. Effect of the degradation of cytochrome P-450 heme by secobarbital on polychlorinated biphenyls (PCB)-induced hepatic vitamin A reduction and lipid peroxide formation in rats. Journal of nutritional science and vitaminology. 1983 Aug; 29(4):467-80. doi: 10.3177/jnsv.29.467. [PMID: 6417289]
  • M E Sharp, S M Wallace, K W Hindmarsh, H W Peel. Monitoring saliva concentrations of methaqualone, codeine, secobarbital, diphenhydramine and diazepam after single oral doses. Journal of analytical toxicology. 1983 Jan; 7(1):11-4. doi: 10.1093/jat/7.1.11. [PMID: 6834790]
  • C D Lox, N Frederick. Clotting activity in the rat following acute barbiturate treatment. General pharmacology. 1983; 14(5):529-31. doi: 10.1016/0306-3623(83)90114-3. [PMID: 6642193]
  • J A Paladino, N A Blumer, R R Maddox. Effect of secobarbital on theophylline clearance. Therapeutic drug monitoring. 1983; 5(1):135-9. doi: 10.1097/00007691-198303000-00016. [PMID: 6845397]
  • H L Levine, M E Cohen, P K Duffner, K A Kustas, D D Shen. An improved high-pressure liquid chromatographic assay for secobarbital in serum. Journal of pharmaceutical sciences. 1982 Nov; 71(11):1281-3. doi: 10.1002/jps.2600711123. [PMID: 7175723]
  • H Steudel, A Steudel, G E von Unruh. Assay for cyclo-, seco- and pentobarbital by multiple ion detection: kinetics after a single dose. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1982 Apr; 20(4):267-9. doi: . [PMID: 6122710]
  • H L Levine, M E Cohen, P K Duffner, D J Lacey, R Karpynec, D D Shen. Rectal absorption and disposition of secobarbital in epileptic children. Pediatric pharmacology (New York, N.Y.). 1982; 2(1):33-8. doi: NULL. [PMID: 7110754]
  • D D Koblin, J E Deady, N T Nelson, E I Eger, C R Bainton. Mice tolerant to nitrous oxide are not tolerant to barbiturates. Anesthesia and analgesia. 1981 Mar; 60(3):138-41. doi: NULL. [PMID: 7193990]
  • R G ten Berg, F P Nijkamp, W de Jong, G de Groot, R A Maes. Development of hypertension in spontaneously hypertensive rats after gonadectomy: effects of secobarbital anesthesia on the blood pressure. Clinical and experimental hypertension. 1981; 3(6):1207-17. doi: 10.3109/10641968109037434. [PMID: 7333198]
  • R G Taylor, J S Lieberman. Intraarterial secobarbital: muscle injury evaluated by electrodiagnosis in four cases. Archives of physical medicine and rehabilitation. 1980 Nov; 61(11):532-6. doi: NULL. [PMID: 7436715]
  • R A O'Reilly, W F Trager, C H Motley, W Howald. Interaction of secobarbital with warfarin pseudoracemates. Clinical pharmacology and therapeutics. 1980 Aug; 28(2):187-95. doi: 10.1038/clpt.1980.149. [PMID: 7398186]
  • M Werner, R J Mohrbacher, C J Riendeau. Gas-liquid chromatography of undervatized drugs after chromatographic extraction from blood. Clinical chemistry. 1979 Dec; 25(12):2020-5. doi: NULL. [PMID: 41649]
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  • H A Kordan, P M Mumford. Effects of oxybarbiturates on the germination behaviour of Impatiens bolstii pollen. European journal of cell biology. 1979 Aug; 19(3):299-302. doi: ". [PMID: 488129]
  • A E Robinson, R D McDowall. The distribution of amylobarbitone, butobarbitone, pentobarbitone and quinalbarbitone and the hydroxylated metabolites in man. The Journal of pharmacy and pharmacology. 1979 Jun; 31(6):357-65. doi: 10.1111/j.2042-7158.1979.tb13523.x. [PMID: 39132]
  • F Vincent, C Feuerstein, M Gavend, J Faure. Routine identification and determination of 11 barbiturates in biological samples. Clinica chimica acta; international journal of clinical chemistry. 1979 May; 93(3):391-9. doi: 10.1016/0009-8981(79)90290-0. [PMID: 445855]
  • D J Harvey, L Glazener, D B Johnson, C M Butler, M G Horning. Comparative metabolism of four allylic barbiturates and hexobarbital by the rat and guinea pig. Drug metabolism and disposition: the biological fate of chemicals. 1977 Nov; 5(6):527-46. doi: . [PMID: 21777]
  • W S Dalton, R Martz, B E Rodda, L Lemberger, R B Forney. Influence of cannabidiol on secobarbital effects and plasma kinetics. Clinical pharmacology and therapeutics. 1976 Dec; 20(6):695-700. doi: 10.1002/cpt1976206695. [PMID: 791563]
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  • D Churchill, J M Yacoub, K P Siu, A Symes, M H Gault. Toxic nephropathy after low-dose methoxyflurane anesthesia: drug interaction with secobarbital?. Canadian Medical Association journal. 1976 Feb; 114(4):326-8, 333. doi: NULL. [PMID: 1253070]
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