Nonivamide (BioDeep_00000402548)

PANOMIX_OTCML-2023

代谢物信息卡片

Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-

化学式: C17H27NO3 (293.1990832)
中文名称: 辣椒素(合成)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI: InChI=1S/C17H27NO3/c1-3-4-5-6-7-8-9-17(20)18-13-14-10-11-15(19)16(12-14)21-2/h10-12,19H,3-9,13H2,1-2H3,(H,18,20)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4374; ORIGINAL_PRECURSOR_SCAN_NO 4372
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4385; ORIGINAL_PRECURSOR_SCAN_NO 4381
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4393; ORIGINAL_PRECURSOR_SCAN_NO 4390
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4393; ORIGINAL_PRECURSOR_SCAN_NO 4391
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9273; ORIGINAL_PRECURSOR_SCAN_NO 9269
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9289; ORIGINAL_PRECURSOR_SCAN_NO 9288
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9279; ORIGINAL_PRECURSOR_SCAN_NO 9277
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9286; ORIGINAL_PRECURSOR_SCAN_NO 9284
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9306; ORIGINAL_PRECURSOR_SCAN_NO 9303
CONFIDENCE standard compound; INTERNAL_ID 964; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9298; ORIGINAL_PRECURSOR_SCAN_NO 9296
CONFIDENCE standard compound; INTERNAL_ID 8335
Nonivamide is a Nonivamide is a

同义名列表

65 个代谢物同义名

Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-; Nonanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-; N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide; N-((4-Hydroxy-3-methoxyphenyl)methyl)nonanamide; N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide; N-((Hydroxy-3-methoxyphenyl)methyl)4-nonanamide; Benzamide, 4-hydroxy-3-methoxy-N-(1-oxononyl)-; N-(4-hydroxy-3-methoxy-benzyl)pelargonamide; N-(4-Hydroxy-3-methoxybenzyl)nonanamide; Nonanoyl 4-hydroxy-3-methoxybenzylamide; Hydroxymethoxybenzyl pelargonamide; Nonanamide, N-vanillyl- (8CI); Pelargonic acid vanillylamide; Nonanoic acid vanillylamide; Nonylic acid vanillylamide; Vanillyl pelargonic amide; N-Nonanoyl vanillylamide; Nonivamida [INN-Spanish]; Pelargonyl vanillylamide; Nonivamidum [INN-Latin]; Nonanamide, N-vanillyl-; N-Vanillylpelargonamide; Vanillyl n-nonoylamide; vanillyl-N-nonylamide; Nonoyl vanillylamide; N-vanillylnonanamide; Capsaicin synthetic; N-Vanillylnonamide; Spectrum5_001853; Spectrum4_000916; Spectrum2_001091; EINECS 219-484-1; Nonivamide [INN]; NCGC00094463-02; SpecPlus_000799; Spectrum_000311; Pseudocapsaicin; SPECTRUM2300192; NCGC00094463-04; Nonylvanylamide; NCGC00016089-01; FEMA No. 2787; KBioGR_001412; KBioSS_000791; Lopac0_001218; DivK1c_006895; KBio1_001839; KBio2_003359; KBio2_000791; KBio2_005927; SPBio_001162; Lopac-V-9130; 76390_FLUKA; V9130_SIGMA; CHEBI:46936; BRN 2144300; EU-0101218; NSC 172795; 60806-29-3; C132_SIGMA; Nonivamide; NSC172795; ST5410300; 2444-46-4; 618-92-8

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:46936
KEGGdrug: D08282
PubChem: 2998
DrugBank: DB11324
ChEMBL: CHEMBL75124
CAS: 2444-46-4
CAS: 630-63-7
MoNA: LU096454
MoNA: LU096453
MoNA: LU096452
MoNA: LU096451
MoNA: LU096406
MoNA: LU096405
MoNA: LU096404
MoNA: LU096403
MoNA: LU096402
MoNA: LU096401
MoNA: SM833501
medchemexpress: HY-17568

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Christina M Hochkogler, Barbara Lieder, Petra Rust, David Berry, Samuel M Meier, Marc Pignitter, Alessandra Riva, Alina Leitinger, Anne Bruk, Simone Wagner, Joachim Hans, Sabine Widder, Jakob P Ley, Gerhard E Krammer, Veronika Somoza. A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects. Molecular nutrition & food research. 2017 05; 61(5):. doi: 10.1002/mnfr.201600731. [PMID: 28012242]
Qingqing Yang, Jianguo Zhu, Fei Ma, Peiwu Li, Liangxiao Zhang, Wen Zhang, Xiaoxia Ding, Qi Zhang. Quantitative determination of major capsaicinoids in serum by ELISA and time-resolved fluorescent immunoassay based on monoclonal antibodies. Biosensors & bioelectronics. 2016 Jul; 81(?):229-235. doi: 10.1016/j.bios.2016.02.074. [PMID: 26954788]
Barbara Rohm, Annett Riedel, Jakob P Ley, Sabine Widder, Gerhard E Krammer, Veronika Somoza. Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells. Food & function. 2015 Jan; 6(1):173-85. doi: 10.1039/c4fo00435c. [PMID: 25422952]
Christina M Hochkogler, Barbara Rohm, Karin Hojdar, Marc Pignitter, Sabine Widder, Jakob P Ley, Gerhard E Krammer, Veronika Somoza. The capsaicin analog nonivamide decreases total energy intake from a standardized breakfast and enhances plasma serotonin levels in moderately overweight men after administered in an oral glucose tolerance test: a randomized, crossover trial. Molecular nutrition & food research. 2014 Jun; 58(6):1282-90. doi: 10.1002/mnfr.201300821. [PMID: 24753478]
Min Gi Kim, Beom Soo Shin, Yohan Choi, Jae Kuk Ryu, Seung Woo Shin, Hyun Wook Choo, Sun Dong Yoo. Determination and pharmacokinetics of [6]-gingerol in mouse plasma by liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2012 May; 26(5):660-5. doi: 10.1002/bmc.1712. [PMID: 22095468]
Antonella Rosa, Giovanni Appendino, M Paola Melis, Monica Deiana, Angela Atzeri, Incani Alessandra, Alberto Minassi, M Assunta Dessì. Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation. Chemico-biological interactions. 2009 Jul; 180(2):183-92. doi: 10.1016/j.cbi.2009.01.002. [PMID: 19497416]
Karen C Thomas, Ashwini S Sabnis, Mark E Johansen, Diane L Lanza, Philip J Moos, Garold S Yost, Christopher A Reilly. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. The Journal of pharmacology and experimental therapeutics. 2007 Jun; 321(3):830-8. doi: 10.1124/jpet.107.119412. [PMID: 17332266]
Maj-Britt Angarano, Robert F McMahon, Doyle L Hawkins, John A Schetz. Exploration of structure-antifouling relationships of capsaicin-like compounds that inhibit zebra mussel (Dreissena polymorpha) macrofouling. Biofouling. 2007; 23(5-6):295-305. doi: 10.1080/08927010701371439. [PMID: 17852065]
Xiu-Yu Yi, Victoria X Li, Fan Zhang, Fan Yi, Daniel R Matson, Ming Tao Jiang, Pin-Lan Li. Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle. American journal of physiology. Heart and circulatory physiology. 2006 Mar; 290(3):H1136-44. doi: 10.1152/ajpheart.00296.2005. [PMID: 16227345]
Mark E Johansen, Christopher A Reilly, Garold S Yost. TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1-mediated toxicities in human lung epithelial cells. Toxicological sciences : an official journal of the Society of Toxicology. 2006 Jan; 89(1):278-86. doi: 10.1093/toxsci/kfi292. [PMID: 16120755]
Nobuyuki Kozukue, Jae-Sook Han, Etsuko Kozukue, Sin-Jung Lee, Joung-Ae Kim, Kap-Rang Lee, Carol E Levin, Mendel Friedman. Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry. Journal of agricultural and food chemistry. 2005 Nov; 53(23):9172-81. doi: 10.1021/jf050469j. [PMID: 16277419]
Robert Q Thompson, Karen W Phinney, Michael J Welch, Edward White. Quantitative determination of capsaicinoids by liquid chromatography-electrospray mass spectrometry. Analytical and bioanalytical chemistry. 2005 Apr; 381(7):1441-51. doi: 10.1007/s00216-005-3102-y. [PMID: 15803309]
Edyta Niemczyk, Anna Majczak, Anna Hallmann, Jakub Kedzior, Michał Woźniak, Takashi Wakabayashi. A possible involvement of plasma membrane NAD(P)H oxidase in the switch mechanism of the cell death mode from apoptosis to necrosis in menadione-induced cell injury. Acta biochimica Polonica. 2004; 51(4):1015-22. doi: 0451041015. [PMID: 15625573]
H Tsuchiya. Biphasic membrane effects of capsaicin, an active component in Capsicum species. Journal of ethnopharmacology. 2001 May; 75(2-3):295-9. doi: 10.1016/s0378-8741(01)00200-8. [PMID: 11297867]
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P A Durant, T L Yaksh. Micturition in the unanesthetized rat: effects of intrathecal capsaicin, N-vanillylnonanamide, 6-hydroxydopamine and 5,6-dihydroxytryptamine. Brain research. 1988 Jun; 451(1-2):301-8. doi: 10.1016/0006-8993(88)90775-5. [PMID: 3150817]
G Skofitsch, J Donnerer, F Lembeck. Comparison of nonivamide and capsaicin with regard to their pharmacokinetics and effects on sensory neurons. Arzneimittel-Forschung. 1984; 34(2):154-6. doi: NULL. [PMID: 6202305]