2,4-Toluene diisocyanate (BioDeep_00000402545)

   


代谢物信息卡片


2,4-Diisocyanato-1-methylbenzene

化学式: C9H6N2O2 (174.0429)
中文名称: 甲苯-2,4-二异氰酸酯, 甲苯二异氰酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C=C(C=C1)N=C=O)N=C=O
InChI: InChI=1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 8323

同义名列表

4 个代谢物同义名

2,4-Diisocyanato-1-methylbenzene; 2,4-Toluene diisocyanate; toluene 2,4-diisocyanate; Toluene diisocyanate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Lidong Chen, Jin Wu, Gaojian Zhu, Chao Liu, Tingting Xu, Liulian Huang, Weibing Wu, Jiaqi Guo, Huining Xiao, Hongqi Dai, Chen Huang, Zhen Zhang, Huiyang Bian. Comparison of hydrophobic cellulose nanofibrils modified with different diisocyanates for circulating oil absorption. International journal of biological macromolecules. 2024 Feb; 258(Pt 2):129107. doi: 10.1016/j.ijbiomac.2023.129107. [PMID: 38159705]
  • Manoj Yadav, Prem Prashant Chaudhary, Brandon N D'Souza, Grace Ratley, Jacquelyn Spathies, Sundar Ganesan, Jordan Zeldin, Ian A Myles. Diisocyanates influence models of atopic dermatitis through direct activation of TRPA1. PloS one. 2023; 18(3):e0282569. doi: 10.1371/journal.pone.0282569. [PMID: 36877675]
  • S Yang, W Zhao, X Peng, Z Lan, J Huang, H Han, Y Chen, S Cai, H Zhao. [Inhibition of TAK1 aggravates airway inflammation by increasing RIPK1 activity and promoting macrophage death in a mouse model of toluene diisocyanate-induced asthma]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2022 Feb; 42(2):181-189. doi: 10.12122/j.issn.1673-4254.2022.02.03. [PMID: 35365441]
  • Shuyu Chen, Zhuoyu Chen, Yao Deng, Shanshan Zha, Li Yu, Difei Li, Zhenyu Liang, Kai Yang, Shengming Liu, Rongchang Chen. Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma. Allergology international : official journal of the Japanese Society of Allergology. 2022 Jan; 71(1):73-82. doi: 10.1016/j.alit.2021.07.004. [PMID: 34332882]
  • Jong-Uk Lee, Ji-Yeon Jeong, Min Kyung Kim, Sun A Min, Jong-Sook Park, Choon-Sik Park. Association of GSTM1 and GSTT1 Null Genotypes with Toluene Diisocyanate-Induced Asthma. Canadian respiratory journal. 2022; 2022(?):7977937. doi: 10.1155/2022/7977937. [PMID: 35186174]
  • Bo Jiao, Yujun Chen, Yuting Yang, Linlin Sai, Gongchang Yu, Cunxiang Bo, Yu Zhang, Cheng Peng, Qiang Jia, Hua Shao. Toluene diisocyanate-induced inflammation and airway remodeling involves autophagy in human bronchial epithelial cells. Toxicology in vitro : an international journal published in association with BIBRA. 2021 Feb; 70(?):105040. doi: 10.1016/j.tiv.2020.105040. [PMID: 33127434]
  • Guohua Huang, Jinwei Su, Wenqu Zhao, Zhixuan Deng, Ping Wang, Hangming Dong, Haijin Zhao, Shaoxi Cai. JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma. Toxicology letters. 2021 Jan; 336(?):57-67. doi: 10.1016/j.toxlet.2020.10.002. [PMID: 33075463]
  • Haiyan Cui, Yuanxiong Cheng, Yi He, Weiying Cheng, Wenqu Zhao, Haijin Zhao, Fiona H Zhou, Liping Wang, Jianghui Dong, Shaoxi Cai. The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model. Molecular medicine reports. 2020 Nov; 22(5):3723-3734. doi: 10.3892/mmr.2020.11450. [PMID: 33000187]
  • Patrick M Plehiers, Anne H Chappelle, Mark W Spence. Practical learnings from an epidemiology study on TDI-related occupational asthma: Part I-Cumulative exposure is not a good indicator of risk. Toxicology and industrial health. 2020 Nov; 36(11):876-884. doi: 10.1177/0748233720947202. [PMID: 32862785]
  • Patrick M Plehiers, Anne H Chappelle, Mark W Spence. Practical learnings from an epidemiology study on TDI-related occupational asthma: Part II-Exposure without respiratory protection to TWA-8 values indicative of peak events is a good indicator of risk. Toxicology and industrial health. 2020 Nov; 36(11):885-891. doi: 10.1177/0748233720947203. [PMID: 32945732]
  • Bernice Scholten, Laura Kenny, Radu-Corneliu Duca, Anjoeka Pronk, Tiina Santonen, Karen S Galea, Miranda Loh, Katriina Huumonen, Anne Sleeuwenhoek, Matteo Creta, Lode Godderis, Kate Jones. Biomonitoring for Occupational Exposure to Diisocyanates: A Systematic Review. Annals of work exposures and health. 2020 07; 64(6):569-585. doi: 10.1093/annweh/wxaa038. [PMID: 32313948]
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  • Adam V Wisnewski, Jian Liu. Molecular Characterization and Experimental Utility of Monoclonal Antibodies with Specificity for Aliphatic Di- and Polyisocyanates. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2020 Jun; 39(3):66-73. doi: 10.1089/mab.2020.0006. [PMID: 32302507]
  • Ji Ho Lee, Sang Ha Kim, Youngwoo Choi, Hoang Kim Tu Trinh, Eun Mi Yang, Ga Young Ban, Yoo Seob Shin, Young Min Ye, Kenji Izuhara, Hae Sim Park. Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma. Yonsei medical journal. 2018 Dec; 59(10):1214-1221. doi: 10.3349/ymj.2018.59.10.1214. [PMID: 30450856]
  • Julia M Broström, Aram Ghalali, Huiyuan Zheng, Johan Högberg, Ulla Stenius, Margareta Littorin, Håkan Tinnerberg, Karin Broberg. Toluene diisocyanate exposure and autotaxin-lysophosphatidic acid signalling. Toxicology and applied pharmacology. 2018 09; 355(?):43-51. doi: 10.1016/j.taap.2018.06.019. [PMID: 29940203]
  • Mayumi Tsuji, Yasuhiro Ishihara, Toyohi Isse, Chihaya Koriyama, Megumi Yamamoto, Noriaki Kakiuchi, Hsu-Sheng Yu, Masayuki Tanaka, Takuto Tsuchiya, Masanori Ohta, Rie Tanaka, Toshihiro Kawamoto. Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory. Environmental health and preventive medicine. 2018 Jun; 23(1):24. doi: 10.1186/s12199-018-0713-4. [PMID: 29921217]
  • Jing Xiong, Wenqu Zhao, Yun Lin, Lihong Yao, Guohua Huang, Changhui Yu, Hangming Dong, Guanhua Xiao, Haijin Zhao, Shaoxi Cai. Phosphorylation of low density lipoprotein receptor-related protein 6 is involved in receptor for advanced glycation end product-mediated β-catenin stabilization in a toluene diisocyanate-induced asthma model. International immunopharmacology. 2018 Jun; 59(?):187-196. doi: 10.1016/j.intimp.2018.03.037. [PMID: 29656209]
  • Gil-Soon Choi, Hoang Kim Tu Trinh, Eun-Mi Yang, Young-Min Ye, Yoo Seob Shin, Seung-Hyun Kim, Hae-Sim Park. Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma. Experimental & molecular medicine. 2018 05; 50(5):1-10. doi: 10.1038/s12276-018-0085-2. [PMID: 29717106]
  • Duy L Pham, Tu Hk Trinh, Ga-Young Ban, Seung-Hyun Kim, Hae-Sim Park. Epithelial folliculin is involved in airway inflammation in workers exposed to toluene diisocyanate. Experimental & molecular medicine. 2017 11; 49(11):e395. doi: 10.1038/emm.2017.180. [PMID: 29147010]
  • Fien C Devos, Lore Pollaris, Jonathan Cremer, Sven Seys, Tomoaki Hoshino, Jan Ceuppens, Karel Talavera, Benoit Nemery, Peter H M Hoet, Jeroen A J Vanoirbeek. IL-13 is a central mediator of chemical-induced airway hyperreactivity in mice. PloS one. 2017; 12(7):e0180690. doi: 10.1371/journal.pone.0180690. [PMID: 28704401]
  • Qian Zhang, Ying Xiong, Guo-Bing Li, Qin Tang, Min Cao, Jing-Bin Huang, Mao Xing, Chang-Peng Hu, Ya Gong, Qing-Hua Wang, Ning Gao, Rong Zhang. Xinqin exhibits the anti-allergic effect through the JAK2/STAT5 signaling pathway. Journal of ethnopharmacology. 2016 Dec; 193(?):466-473. doi: 10.1016/j.jep.2016.09.045. [PMID: 27666014]
  • Lore Pollaris, Fien Devos, Vanessa De Vooght, Sven Seys, Benoit Nemery, Peter H M Hoet, Jeroen A J Vanoirbeek. Toluene diisocyanate and methylene diphenyl diisocyanate: asthmatic response and cross-reactivity in a mouse model. Archives of toxicology. 2016 Jul; 90(7):1709-17. doi: 10.1007/s00204-015-1606-6. [PMID: 26468151]
  • Morgen Mhike, Justin M Hettick, Itai Chipinda, Brandon F Law, Toni A Bledsoe, Angela R Lemons, Ajay P Nayak, Brett J Green, Donald H Beezhold, Reuben H Simoyi, Paul D Siegel. Characterization and comparative analysis of 2,4-toluene diisocyanate and 1,6-hexamethylene diisocyanate haptenated human serum albumin and hemoglobin. Journal of immunological methods. 2016 Apr; 431(?):38-44. doi: 10.1016/j.jim.2016.02.005. [PMID: 26853746]
  • Julia M Broström, Zhi-Wei Ye, Anna Axmon, Margareta Littorin, Håkan Tinnerberg, Christian H Lindh, Huiyuan Zheng, Aram Ghalali, Ulla Stenius, Bo A G Jönsson, Johan Högberg. Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms. Toxicology and applied pharmacology. 2015 Sep; 287(3):222-31. doi: 10.1016/j.taap.2015.06.006. [PMID: 26072274]
  • Jasia Bokhari, Muhammad Rashid Khan. Evaluation of anti-asthmatic and antioxidant potential of Boerhavia procumbens in toluene diisocyanate (TDI) treated rats. Journal of ethnopharmacology. 2015 Aug; 172(?):377-85. doi: 10.1016/j.jep.2015.06.049. [PMID: 26151242]
  • Dominika Świerczyńska-Machura, Sławomir Brzeźnicki, Ewa Nowakowska-Świrta, Jolanta Walusiak-Skorupa, Tomasz Wittczak, Wojciech Dudek, Marzena Bonczarowska, Wiktor Wesolowski, Sławomir Czerczak, Cezary Pałczyński. Occupational exposure to diisocyanates in polyurethane foam factory workers. International journal of occupational medicine and environmental health. 2015; 28(6):985-98. doi: 10.13075/ijomeh.1896.00284. [PMID: 26294200]
  • Wei Gui, Adam V Wisnewski, Iulia Neamtiu, Eugen Gurzau, Judith A Sparer, Meredith H Stowe, Jian Liu, Martin D Slade, Olivia A Rusu, Carrie A Redlich. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: initial one-year follow-up. American journal of industrial medicine. 2014 Nov; 57(11):1207-15. doi: 10.1002/ajim.22385. [PMID: 25266741]
  • Le Duy Pham, Mi-Ae Kim, Moon Gyung Yoon, Seung Ihm Lee, Yoo Seob Shin, Hae-Sim Park. Serum specific IgG response to toluene diisocyanate-tissue transglutaminase conjugate in toluene diisocyanate-induced occupational asthmatics. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2014 Jul; 113(1):48-54. doi: 10.1016/j.anai.2014.04.022. [PMID: 24950844]
  • Håkan Tinnerberg, Karin Broberg, Christian H Lindh, Bo A G Jönsson. Biomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates. International archives of occupational and environmental health. 2014 May; 87(4):365-72. doi: 10.1007/s00420-013-0872-y. [PMID: 23558852]
  • Jain Smita, U K Patil. Effect of Ipomea carnea Jacq. flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. Chinese journal of natural medicines. 2014 Mar; 12(3):161-6. doi: 10.1016/s1875-5364(14)60027-3. [PMID: 24702800]
  • Angela R Lemons, Toni A Bledsoe, Paul D Siegel, Donald H Beezhold, Brett J Green. Development of sandwich ELISAs for the detection of aromatic diisocyanate adducts. Journal of immunological methods. 2013 Nov; 397(1-2):66-70. doi: 10.1016/j.jim.2013.08.015. [PMID: 24012971]
  • Hui Liu, Yan-rang Wang, De-yi Yang. [Study on the metabolism of toluene diisocyanate in urine of rats and its dose-effect relationship]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2013 May; 31(5):380-2. doi: NULL. [PMID: 24079036]
  • Steven Haenen, Elke Clynen, Vanessa De Vooght, Liliane Schoofs, Benoit Nemery, Peter H M Hoet, Jeroen A J Vanoirbeek. Proteome changes in auricular lymph nodes and serum after dermal sensitization to toluene diisocyanate in mice. Proteomics. 2012 Dec; 12(23-24):3548-58. doi: 10.1002/pmic.201200264. [PMID: 23038679]
  • Seoung Ju Park, Kyung Sun Lee, So Ri Kim, Han Jung Chae, Wan Hee Yoo, Dong Im Kim, Myoung Shin Jeon, Yong Chul Lee. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2012 Oct; 61(10):1069-83. doi: 10.1007/s00011-012-0499-6. [PMID: 22692279]
  • G De Palma, Ilenia Cortesi, Roberta Ghitti, Denise Festa, R Bergonzi, P Apostoli. Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate. La Medicina del lavoro. 2012 Sep; 103(5):361-71. doi: NULL. [PMID: 23077796]
  • C Keen, M Coldwell, K McNally, P Baldwin, J McAlinden, J Cocker. A follow up study of occupational exposure to 4,4'-methylene-bis(2-chloroaniline) (MbOCA) and isocyanates in polyurethane manufacture in the UK. Toxicology letters. 2012 Aug; 213(1):3-8. doi: 10.1016/j.toxlet.2011.04.003. [PMID: 21501672]
  • Sung-Ho Kim, Gil-Soon Choi, Young-Hee Nam, Joo-Hee Kim, Gyu-Young Hur, Seung-Hyun Kim, Sang Myun Park, Hae-Sim Park. Role of vitamin D-binding protein in isocyanate-induced occupational asthma. Experimental & molecular medicine. 2012 May; 44(5):319-29. doi: 10.3858/emm.2012.44.5.036. [PMID: 22314196]
  • Tom Geens, Sandra Dugardin, Ann Schockaert, Geert De Cooman, Marc van Sprundel. Air exposure assessment of TDI and biological monitoring of TDA in urine in workers in polyurethane foam industry. Occupational and environmental medicine. 2012 Feb; 69(2):93-8. doi: 10.1136/oem.2011.064840. [PMID: 21725071]
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