Indazole (BioDeep_00000402530)
代谢物信息卡片
1H-Indazole
化学式: C7H6N2 (118.05309559999999)
中文名称: 吲唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=NN2
InChI: InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9)
描述信息
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 8312
CONFIDENCE standard compound; INTERNAL_ID 8153
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:36670
- ChEBI: CHEBI:36669
- PubChem: 9221
- ChEMBL: CHEMBL86795
- MeSH: Indazoles
- CAS: 271-44-3
- CAS: 271-42-1
- MoNA: SM831203
- MoNA: SM815301
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zebo Hu, Qianwen Zhu, Ying Wang, Xue Deng, Hui Yang, Mingjun Zhou, Jiyuan Zhang, Hao Wang, Haosen Wang, Lin Wang, Cui Zhang, Shu Li. Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy.
Renal failure.
2024 Dec; 46(1):2347446. doi:
10.1080/0886022x.2024.2347446. [PMID: 38695335] - Mengni He, Jie Wang, Wenhua Deng, Xiaorui Han, Xiumei Wang, Lidan Pang, Jiateng Huang, Pingping Lan, Tiantian Wang, Zengtao Wang. Exploring novel indazole derivatives as ASK1 inhibitors: Design, synthesis, biological evaluation and docking studies.
Bioorganic chemistry.
2024 Jun; 147(?):107391. doi:
10.1016/j.bioorg.2024.107391. [PMID: 38677010] - Pengfei Chen, Chi Zhang, Liuliang He, Mingfei Li, Jie Rong, Pengfei Sun, Yingying Chen, Daifeng Li. A thermoresponsive nanocomposite integrates NIR-II-absorbing small molecule with lonidamine for pyroptosis-promoted synergistic immunotherapy.
Journal of nanobiotechnology.
2024 Apr; 22(1):163. doi:
10.1186/s12951-024-02424-5. [PMID: 38600506] - Karan Jadhav, Arvind Sirvi, Akash Janjal, Mahesh C Kashyap, Abhay T Sangamwar. Utilization of Lipophilic Salt and Phospholipid Complex in Lipid-Based Formulations to Modulate Drug Loading and Oral Bioavailability of Pazopanib.
AAPS PharmSciTech.
2024 Mar; 25(3):59. doi:
10.1208/s12249-024-02780-3. [PMID: 38472682] - Xianhua She, Donghong Yin, Qian Guo, Yang Tang, Shuyun Wang, Xuyan Wang. Electrolyte disorders induced by six multikinase inhibitors therapy for renal cell carcinoma: a large-scale pharmacovigilance analysis.
Scientific reports.
2024 03; 14(1):5592. doi:
10.1038/s41598-024-56335-4. [PMID: 38454105] - Ayşe Lafzi, Tuba Demirci, Neslihan Yüce, Ebru Annaç, Mustafa Çiçek, Turgay Şişman. A study on the possible neurotoxic effects of CUMYL-4CN-BINACA in Sprague Dawley rats.
Legal medicine (Tokyo, Japan).
2023 Dec; 67(?):102389. doi:
10.1016/j.legalmed.2023.102389. [PMID: 38185093] - Ying-Jie Cui, Yi Zhou, Xi-Wu Zhang, Bao-Kai Dou, Chen-Chen Ma, Jing Zhang. The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors.
European journal of medicinal chemistry.
2023 Dec; 262(?):115870. doi:
10.1016/j.ejmech.2023.115870. [PMID: 37890199] - Hao Jiang, Jian Liao, Liezhi Wang, Chong Jin, Jinggang Mo, Sheng Xiang. The multikinase inhibitor axitinib in the treatment of advanced hepatocellular carcinoma: the current clinical applications and the molecular mechanisms.
Frontiers in immunology.
2023; 14(?):1163967. doi:
10.3389/fimmu.2023.1163967. [PMID: 37325670] - Huizhen Li, Wan Xu, Fang Li, Ru Zeng, Xiuming Zhang, Xianwu Wang, Shaojun Zhao, Jian Weng, Zhu Li, Liping Sun. Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles.
Drug delivery.
2022 Dec; 29(1):192-202. doi:
10.1080/10717544.2021.2023697. [PMID: 34984953] - Chia-Lin Lee, Chien-Ming Wang, Hung-Rong Yen, Ying-Chyi Song, Chao-Jung Chen. Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect.
Natural product research.
2022 Dec; 36(23):5935-5939. doi:
10.1080/14786419.2022.2041633. [PMID: 35192387] - Cui Huo, Zongyuan Luo, Xiangli Ning, Xin Kang, Qin Yan, Yuying Guo, Guobo Li, Zhouyu Wang, Yuzhi Li, Shan Qian. 4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity.
European journal of medicinal chemistry.
2022 Nov; 241(?):114625. doi:
10.1016/j.ejmech.2022.114625. [PMID: 35952399] - Suvadeep Mal, Udita Malik, Monalisa Mahapatra, Abhishek Mishra, Dilipkumar Pal, Sudhir K Paidesetty. A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective.
Drug development research.
2022 11; 83(7):1469-1504. doi:
10.1002/ddr.21979. [PMID: 35971890] - Pierce Kavanagh, Alexandr Pechnikov, Ivan Nikolaev, Geraldine Dowling, Mariia Kolosova, Andrej Grigoryev. Detection of ADB-BUTINACA Metabolites in Human Urine, Blood, Kidney and Liver.
Journal of analytical toxicology.
2022 Jul; 46(6):641-650. doi:
10.1093/jat/bkab088. [PMID: 34341821] - Ryuta Uraki, Maki Kiso, Shun Iida, Masaki Imai, Emi Takashita, Makoto Kuroda, Peter J Halfmann, Samantha Loeber, Tadashi Maemura, Seiya Yamayoshi, Seiichiro Fujisaki, Zhongde Wang, Mutsumi Ito, Michiko Ujie, Kiyoko Iwatsuki-Horimoto, Yuri Furusawa, Ryan Wright, Zhenlu Chong, Seiya Ozono, Atsuhiro Yasuhara, Hiroshi Ueki, Yuko Sakai-Tagawa, Rong Li, Yanan Liu, Deanna Larson, Michiko Koga, Takeya Tsutsumi, Eisuke Adachi, Makoto Saito, Shinya Yamamoto, Masao Hagihara, Keiko Mitamura, Tetsuro Sato, Masayuki Hojo, Shin-Ichiro Hattori, Kenji Maeda, Riccardo Valdez, Moe Okuda, Jurika Murakami, Calvin Duong, Sucheta Godbole, Daniel C Douek, Ken Maeda, Shinji Watanabe, Aubree Gordon, Norio Ohmagari, Hiroshi Yotsuyanagi, Michael S Diamond, Hideki Hasegawa, Hiroaki Mitsuya, Tadaki Suzuki, Yoshihiro Kawaoka. Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.
Nature.
2022 07; 607(7917):119-127. doi:
10.1038/s41586-022-04856-1. [PMID: 35576972] - Shi-Guo Yuan, Hong-Ling Hu, Xin-Jia Wang, Jin-Cheng Yang, Rong-Ping Zhou, Xiao-Chun Bai, Ping-Lin Lai. Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF-κB Signaling Pathway.
Orthopaedic surgery.
2022 Jun; 14(6):1203-1216. doi:
10.1111/os.13252. [PMID: 35470579] - Matthew S Ernst, John T Lysack, Martin D Hyrcza, Shamir P Chandarana, Desiree Hao. TRK Inhibition with Entrectinib in Metastatic Salivary Secretory Carcinoma (SC): A Case Report.
Current oncology (Toronto, Ont.).
2022 05; 29(6):3933-3939. doi:
10.3390/curroncol29060314. [PMID: 35735423] - Yi Zhao, Yao Peng, Zhongzhen Yang, Jiaqi Lu, Ru Li, Yuesen Shi, Yaxin Du, Ze Zhao, Li Hai, Yong Wu. pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma.
European journal of medicinal chemistry.
2022 May; 235(?):114281. doi:
10.1016/j.ejmech.2022.114281. [PMID: 35344903] - Rafal Dziadziuszko, Tiffany Hung, Kun Wang, Voleak Choeurng, Alexander Drilon, Robert C Doebele, Fabrice Barlesi, Charlie Wu, Lucas Dennis, Joel Skoletsky, Ryan Woodhouse, Meijuan Li, Ching-Wei Chang, Brian Simmons, Todd Riehl, Timothy R Wilson. Pre- and post-treatment blood-based genomic landscape of patients with ROS1 or NTRK fusion-positive solid tumours treated with entrectinib.
Molecular oncology.
2022 05; 16(10):2000-2014. doi:
10.1002/1878-0261.13214. [PMID: 35338679] - Christian V Cabanlong, Lauren N Russell, William E Fantegrossi, Paul L Prather. Metabolites of Synthetic Cannabinoid 5F-MDMB-PINACA Retain Affinity, Act as High Efficacy Agonists and Exhibit Atypical Pharmacodynamic Properties at CB1 Receptors.
Toxicological sciences : an official journal of the Society of Toxicology.
2022 04; 187(1):175-185. doi:
10.1093/toxsci/kfac024. [PMID: 35201352] - Gabriel Levy, Paola Guglielmelli, Peter Langmuir, Stefan N Constantinescu. JAK inhibitors and COVID-19.
Journal for immunotherapy of cancer.
2022 04; 10(4):. doi:
10.1136/jitc-2021-002838. [PMID: 35459733] - Rui Yu, Mi Tian, Ping He, Jie Chen, Zixia Zhao, Yongzhe Zhang, Beiru Zhang. Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway.
Biochimica et biophysica acta. Molecular cell research.
2022 04; 1869(4):119200. doi:
10.1016/j.bbamcr.2021.119200. [PMID: 34968577] - Robert Kronstrand, Caitlyn Norman, Svante Vikingsson, Anoek Biemans, Bryan Valencia Crespo, Darren Edwards, Daniel Fletcher, Nicolas Gilbert, Mattias Persson, Robert Reid, Olga Semenova, Faisal Al Teneiji, Xiongyu Wu, Johan Dahlén, Niamh NicDaéid, Fuad Tarbah, Oliver B Sutcliffe, Craig McKenzie, Henrik Gréen. The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons.
Drug testing and analysis.
2022 Apr; 14(4):634-652. doi:
10.1002/dta.3203. [PMID: 34811926] - Di Chen, Tianyi Yuan, Yucai Chen, Huifang Zhang, Ziran Niu, Lianhua Fang, Guanhua Du. DL0805-1, a novel Rho-kinase inhibitor, attenuates lung injury and vasculopathy in a rat model of monocrotaline-induced pulmonary hypertension.
European journal of pharmacology.
2022 Mar; 919(?):174779. doi:
10.1016/j.ejphar.2022.174779. [PMID: 35092757] - Oktay Unsal, Osman Sütcüoğlu, Ozan Yazıcı. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: A case of acute pancreatitis.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2022 Mar; 28(2):486-488. doi:
10.1177/10781552211040725. [PMID: 34569860] - David Fabregat-Safont, María Mata-Pesquera, Manuela Barneo-Muñoz, Ferran Martinez-Garcia, Marie Mardal, Anders B Davidsen, Juan V Sancho, Félix Hernández, María Ibáñez. In-depth comparison of the metabolic and pharmacokinetic behaviour of the structurally related synthetic cannabinoids AMB-FUBINACA and AMB-CHMICA in rats.
Communications biology.
2022 02; 5(1):161. doi:
10.1038/s42003-022-03113-5. [PMID: 35210552] - Jiaqi Lu, Ru Li, Binsong Mu, Yao Peng, Yi Zhao, Yuesen Shi, Li Guo, Li Hai, Yong Wu. Multiple targeted doxorubicin-lonidamine liposomes modified with p-hydroxybenzoic acid and triphenylphosphonium to synergistically treat glioma.
European journal of medicinal chemistry.
2022 Feb; 230(?):114093. doi:
10.1016/j.ejmech.2021.114093. [PMID: 35007860] - Stefanie D Krens, Sasja F Mulder, Nielka P van Erp. Lost in third space: altered tyrosine-kinase inhibitor pharmacokinetics in a patient with malignant ascites.
Cancer chemotherapy and pharmacology.
2022 02; 89(2):271-274. doi:
10.1007/s00280-021-04377-0. [PMID: 34853912] - Christian Rolfo, Alexander Drilon, David Hong, Caroline McCoach, Afshin Dowlati, Jessica J Lin, Alessandro Russo, Alison M Schram, Stephen V Liu, Jorge J Nieva, Timmy Nguyen, Shahrooz Eshaghian, Michael Morse, Scott Gettinger, Mohammad Mobayed, Sarah Goldberg, Emilio Araujo-Mino, Neelima Vidula, Aditya Bardia, Janakiraman Subramanian, Deepa Sashital, Thomas Stinchcombe, Lesli Kiedrowski, Kristin Price, David R Gandara. NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types.
British journal of cancer.
2022 02; 126(3):514-520. doi:
10.1038/s41416-021-01536-1. [PMID: 34480094] - Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A F de Ligt, Elwin R Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén, Susanne Prothon. Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects.
Drug metabolism and disposition: the biological fate of chemicals.
2022 02; 50(2):150-157. doi:
10.1124/dmd.121.000632. [PMID: 34853068] - Neil A Miller, Rebecca H Graves, Chris D Edwards, Augustin Amour, Ed Taylor, Olivia Robb, Brett O'Brien, Aarti Patel, Andrew W Harrell, Edith M Hessel. Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Clinical pharmacokinetics.
2022 02; 61(2):281-293. doi:
10.1007/s40262-021-01066-2. [PMID: 34458976] - Brian A Costello, Nrupen A Bhavsar, Yousef Zakharia, Sumanta K Pal, Ulka Vaishampayan, Heather Jim, Mayer N Fishman, Ana M Molina, Christos E Kyriakopoulos, Che-Kai Tsao, Leonard J Appleman, Benjamin A Gartrell, Arif Hussain, Walter M Stadler, Neeraj Agarwal, Russell K Pachynski, Thomas E Hutson, Hans J Hammers, Christopher W Ryan, Jack Mardekian, Azah Borham, Daniel J George, Michael R Harrison. A Prospective Multicenter Evaluation of Initial Treatment Choice in Metastatic Renal Cell Carcinoma Prior to the Immunotherapy Era: The MaRCC Registry Experience.
Clinical genitourinary cancer.
2022 02; 20(1):1-10. doi:
10.1016/j.clgc.2021.07.002. [PMID: 34364796] - Bahadir Koylu, Fatih Tekin, Burak Yasin Aktas, Saadettin Kilickap, Deniz Koksal. Pazopanib-induced chylothorax in a patient with renal cell carcinoma.
Anti-cancer drugs.
2022 01; 33(1):e555-e557. doi:
10.1097/cad.0000000000001172. [PMID: 34387587] - Susanne Prothon, Magnus Aurivillius, Ulrika Tehler, Ulf G Eriksson, Ajay Aggarwal, Yingxue Chen. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator Velsecorat (AZD7594) Following Inhalation in Healthy Volunteers.
Drug design, development and therapy.
2022; 16(?):485-497. doi:
10.2147/dddt.s334960. [PMID: 35264846] - Chunling Zhou, Aiping He, Qiang Kang, Chensen Li, Tianzhu Liu, Wenting Cai, Lina Fang, Shuangcheng Ma. Development of a UPLC-MS/MS method for determination of a dual EZH1/2 inhibitor UNC1999 in rat plasma.
Bioanalysis.
2022 Jan; 14(2):67-74. doi:
10.4155/bio-2021-0227. [PMID: 34841882] - Mamoru Hashimoto, Takahito Nakayama, Saizo Fujimoto, Shunsuke Inoguchi, Mitsuhisa Nishimoto, Takashi Kikuchi, Shogo Adomi, Eri Banno, Marco A De Velasco, Yoshitaka Saito, Nobutaka Shimizu, Yasunori Mori, Takafumi Minami, Kazutoshi Fujita, Masahiro Nozawa, Kazuhiro Nose, Kazuhiro Yoshimura, Hirotsugu Uemura. Disseminated intravascular coagulation induced by pazopanib following combination therapy of nivolumab plus ipilimumab in a patient with metastatic renal cell carcinoma.
Anti-cancer drugs.
2022 01; 33(1):e818-e821. doi:
10.1097/cad.0000000000001230. [PMID: 34486537] - Alejandro Peralta-Garcia, Mariona Torrens-Fontanals, Tomasz Maciej Stepniewski, Judith Grau-Expósito, David Perea, Vikram Ayinampudi, Maria Waldhoer, Mirjam Zimmermann, María J Buzón, Meritxell Genescà, Jana Selent. Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413592. [PMID: 34948390] - Damiano Cirri, Tiziano Marzo, Iogann Tolbatov, Alessandro Marrone, Francesco Saladini, Ilaria Vicenti, Filippo Dragoni, Adele Boccuto, Luigi Messori. In Vitro Anti-SARS-CoV-2 Activity of Selected Metal Compounds and Potential Molecular Basis for Their Actions Based on Computational Study.
Biomolecules.
2021 12; 11(12):. doi:
10.3390/biom11121858. [PMID: 34944502] - Margarida L F Martins, Nancy H C Loos, Sümeyra Mucuk, Danielle de Jong, Maria C Lebre, Hilde Rosing, Matthijs Tibben, Jos H Beijnen, Alfred H Schinkel. P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib.
Molecular pharmaceutics.
2021 12; 18(12):4371-4384. doi:
10.1021/acs.molpharmaceut.1c00553. [PMID: 34730366] - Asami Matsumoto, Ken Shiraiwa, Yosuke Suzuki, Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ryota Tanaka, Ryosuke Tatsuta, Hiroshi Tsumura, Hiroki Itoh. Sensitive quantification of free pazopanib using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and assessment of clinical application.
Journal of pharmaceutical and biomedical analysis.
2021 Nov; 206(?):114348. doi:
10.1016/j.jpba.2021.114348. [PMID: 34509660] - Jin-Wook Choi, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim, Susie Chin. Pazopanib-induced severe acute liver injury: A case report.
Medicine.
2021 Nov; 100(46):e27731. doi:
10.1097/md.0000000000027731. [PMID: 34797298] - Nathan D Pfeifer, Arthur Lo, David L Bourdet, Kenneth Colley, Dave Singh. Phase I study in healthy participants to evaluate safety, tolerability, and pharmacokinetics of inhaled nezulcitinib, a potential treatment for COVID-19.
Clinical and translational science.
2021 11; 14(6):2556-2565. doi:
10.1111/cts.13123. [PMID: 34318597] - Cui-Mei Liu, Wei Jia, Xin Meng, Zhen-Dong Hua. Identification and quantification of 10 indole/indazole carboxamide synthetic cannabinoids in 36 herbal blends by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.
Journal of forensic sciences.
2021 Nov; 66(6):2156-2166. doi:
10.1111/1556-4029.14873. [PMID: 34431514] - Simon Chowdhury, Jeffery R Infante, Robert Hawkins, Martin H Voss, Rodolfo Perini, Tobias Arkenau, Mark Voskoboynik, Paola Aimone, Isabelle Naeije, Albert Reising, David F McDermott. A Phase I/II Study to Assess the Safety and Efficacy of Pazopanib and Pembrolizumab Combination Therapy in Patients with Advanced Renal Cell Carcinoma.
Clinical genitourinary cancer.
2021 10; 19(5):434-446. doi:
10.1016/j.clgc.2021.04.007. [PMID: 34006498] - Qian Liu, Hao Yan, Xuyong Zheng, Lili Fu, Yuyan Bao, Haibo Zheng, Zhiguo Liu, Xiuhua Zhang, Gaozhi Chen. A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation.
Toxicology and applied pharmacology.
2021 10; 428(?):115648. doi:
10.1016/j.taap.2021.115648. [PMID: 34280409] - Michal Kopczynski, Izabela Rumienczyk, Maria Kulecka, Małgorzata Statkiewicz, Kazimiera Pysniak, Zuzanna Sandowska-Markiewicz, Urszula Wojcik-Trechcinska, Krzysztof Goryca, Karolina Pyziak, Eliza Majewska, Magdalena Masiejczyk, Katarzyna Wojcik-Jaszczynska, Tomasz Rzymski, Karol Bomsztyk, Jerzy Ostrowski, Michal Mikula. Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910204. [PMID: 34638546] - Mustafa Erman, Bivas Biswas, Pongwut Danchaivijitr, Lingwu Chen, Yoke Fui Wong, Tarek Hashem, Chun Sen Lim, Bulent Karabulut, Hsiao-Jen Chung, Chandrasekhar Chikatapu, Sara Ingles, Khemaies Slimane, Ravindran Kanesvaran. Prospective observational study on Pazopanib in patients treated for advanced or metastatic renal cell carcinoma in countries in Asia Pacific, North Africa, and Middle East regions: PARACHUTE study.
BMC cancer.
2021 Sep; 21(1):1021. doi:
10.1186/s12885-021-08738-z. [PMID: 34521387] - Bulent Erdogan, Osman Kostek, Muhammet Bekir Hacioglu, Ali Gokyer, Ahmet Kucukarda, Erkan Ozcan, Ivo Gokmen, Sernaz Uzunoglu, Irfan Cicin. Is early change in systemic inflammatory markers associated with treatment response in patients who received pazopanib?.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 Sep; 26(5):2196-2201. doi:
NULL. [PMID: 34761635] - Ondřej Fiala, Pavel Ostašov, Aneta Rozsypalová, Milan Hora, Ondřej Šorejs, Jan Šustr, Barbora Bendová, Ivan Trávníček, Jan Filipovský, Jindřich Fínek, Tomáš Büchler. Impact of Concomitant Cardiovascular Medication on Survival of Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib or Pazopanib in the First Line.
Targeted oncology.
2021 09; 16(5):643-652. doi:
10.1007/s11523-021-00829-y. [PMID: 34363554] - Florian Janisch, Thomas Klotzbücher, Phillip Marks, Christina Kienapfel, Christian P Meyer, Hang Yu, Constantin Fühner, Tobias Hillemacher, Keiichiro Mori, Hadi Mostafei, Shahrokh F Shariat, Margit Fisch, Roland Dahlem, Michael Rink. Predictive value of De Ritis ratio in metastatic renal cell carcinoma treated with tyrosine-kinase inhibitors.
World journal of urology.
2021 Aug; 39(8):2977-2985. doi:
10.1007/s00345-021-03628-2. [PMID: 33649869] - Belal Haschimi, Katharina Elisabeth Grafinger, Benedikt Pulver, Evangelia Psychou, Sebastian Halter, Laura M Huppertz, Folker Westphal, Michael Pütz, Volker Auwärter. New synthetic cannabinoids carrying a cyclobutyl methyl side chain: Human Phase I metabolism and data on human cannabinoid receptor 1 binding and activation of Cumyl-CBMICA and Cumyl-CBMINACA.
Drug testing and analysis.
2021 Aug; 13(8):1499-1515. doi:
10.1002/dta.3038. [PMID: 33788409] - Aparna Sharma, Mayank Singh, Ravi Chauhan, Prabhat Singh Malik, Sachin Khurana, Sandeep Mathur, Sunesh Kumar, Vishnubhatla Sreenivas, Lalit Kumar. Pazopanib based oral metronomic therapy for platinum resistant/refractory epithelial ovarian cancer: A phase II, open label, randomized, controlled trial.
Gynecologic oncology.
2021 08; 162(2):382-388. doi:
10.1016/j.ygyno.2021.05.025. [PMID: 34088513] - M Eriksson, P Reichardt, H Joensuu, A Krarup-Hansen, O Hagberg, P Hohenberger, H Hagberg, L Hansson, T Foukakis, K Pulkkanen, S Bauer, D Goplen, P Blach Rossen, K Sundby Hall. Benefit of pazopanib in advanced gastrointestinal stromal tumours: results from a phase II trial (SSG XXI, PAGIST).
ESMO open.
2021 08; 6(4):100217. doi:
10.1016/j.esmoop.2021.100217. [PMID: 34271307] - Souradeep Basu, Tiffany Mak, Rachel Ulferts, Mary Wu, Tom Deegan, Ryo Fujisawa, Kang Wei Tan, Chew Theng Lim, Clovis Basier, Berta Canal, Joseph F Curran, Lucy S Drury, Allison W McClure, Emma L Roberts, Florian Weissmann, Theresa U Zeisner, Rupert Beale, Victoria H Cowling, Michael Howell, Karim Labib, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
The Biochemical journal.
2021 07; 478(13):2481-2497. doi:
10.1042/bcj20210219. [PMID: 34198328] - Nizar M Tannir, Kyriakos P Papadopoulos, Deborah J Wong, Raid Aljumaily, Annie Hung, Manuel Afable, Jong Seok Kim, David Ferry, Alexandra Drakaki, Johanna Bendell, Aung Naing. Pegilodecakin as monotherapy or in combination with anti-PD-1 or tyrosine kinase inhibitor in heavily pretreated patients with advanced renal cell carcinoma: Final results of cohorts A, G, H and I of IVY Phase I study.
International journal of cancer.
2021 07; 149(2):403-408. doi:
10.1002/ijc.33556. [PMID: 33709428] - Kayoko Minakata, Koutaro Hasegawa, Hideki Nozawa, Itaru Yamagishi, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe. Quantification of Major Metabolites of AB-FUBINACA in Solid Tissues Obtained from an Abuser.
Journal of analytical toxicology.
2021 Jul; 45(6):555-565. doi:
10.1093/jat/bkaa120. [PMID: 32886766] - Alper Topal, Sezin Sayın, Ali Gokyer, Ahmet Kucukarda, Osman Kostek, Muhammet Bekir Hacıoglu, Sernaz Uzunoglu, Bulent Erdogan, Irfan Cicin. Real-life data on first-line Sunitinib and Pazopanib therapy in metastatic renal cell carcinoma patients: a single center experience.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 Jul; 26(4):1628-1634. doi:
NULL. [PMID: 34565028] - Qin Yue, S Cyrus Khojasteh, Sungjoon Cho, Shuguang Ma, Teresa Mulder, John Chen, Jodie Pang, Xiao Ding, Alan Deese, Jackson D Pellet, Nicholas Siebers, Lori Joas, Laurent Salphati, Joseph A Ware. Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Jul; 51(7):796-810. doi:
10.1080/00498254.2021.1923859. [PMID: 33938357] - Nirmish Singla, Phillip Pierorazio, Mohamad Allaf, Yasser Ged. Re: Robert J. Motzer, Paul Russo, Naomi Haas, et al. Adjuvant Pazopanib Versus Placebo After Nephrectomy in Patients with Localized or Locally Advanced Renal Cell Carcinoma: Final Overall Survival Analysis of the Phase 3 PROTECT Trial. Eur Urol 2021;79:334-8: PROTECTing Patients with Locally Advanced Kidney Cancer.
European urology.
2021 07; 80(1):e33-e34. doi:
10.1016/j.eururo.2021.04.025. [PMID: 33962807] - Naoto Kanno, Kenta Nakahashi, Marina Shiikawa, Makoto Endo, Kenji Numahata, Satoshi Shiono. [Pneumothorax during Pazopanib Therapy in a Patient with Soft Tissue Sarcoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
2021 Jul; 48(7):975-977. doi:
NULL. [PMID: 34267040] - Cristian Solano, Shrinjaya Thapa, Mohammad Muhsin Chisti. Adult Xp11.2 translocation renal cell carcinoma managed effectively with pazopanib.
BMJ case reports.
2021 Jun; 14(6):. doi:
10.1136/bcr-2021-243058. [PMID: 34172479] - Xiang-Li Ning, Yu-Zhi Li, Cui Huo, Ji Deng, Cheng Gao, Kai-Rong Zhu, Miao Wang, Yu-Xiang Wu, Jun-Lin Yu, Ya-Li Ren, Zong-Yuan Luo, Gen Li, Yang Chen, Si-Yao Wang, Cheng Peng, Ling-Ling Yang, Zhou-Yu Wang, Yong Wu, Shan Qian, Guo-Bo Li. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Journal of medicinal chemistry.
2021 06; 64(12):8303-8332. doi:
10.1021/acs.jmedchem.1c00303. [PMID: 34110158] - Yao Peng, Jiaqi Lu, Ru Li, Yi Zhao, Li Hai, Li Guo, Yong Wu. Glucose and Triphenylphosphonium Co-Modified Redox-Sensitive Liposomes to Synergistically Treat Glioma with Doxorubicin and Lonidamine.
ACS applied materials & interfaces.
2021 Jun; 13(23):26682-26693. doi:
10.1021/acsami.1c02404. [PMID: 34061501] - Qihao Xu, Yanhua Mou, Siyuan Wang, Xiaoxiao Gao, Yulong Zhang, Zhi Wang, Xiangwei Xu, Yu Han, Wenlong Jia, Meihui Zhang, Linxiang Zhao, Dan Liu. Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif.
Bioorganic chemistry.
2021 06; 111(?):104910. doi:
10.1016/j.bioorg.2021.104910. [PMID: 33894432] - Darawan Rinchai, Elena Verzoni, Veronica Huber, Agata Cova, Paola Squarcina, Loris De Cecco, Filippo de Braud, Raffaele Ratta, Matteo Dugo, Luca Lalli, Viviana Vallacchi, Monica Rodolfo, Jessica Roelands, Chiara Castelli, Damien Chaussabel, Giuseppe Procopio, Davide Bedognetti, Licia Rivoltini. Integrated transcriptional-phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients.
Clinical and translational medicine.
2021 06; 11(6):e434. doi:
10.1002/ctm2.434. [PMID: 34185403] - Loïc Mourey, Félicien Le Louedec, Alain Ravaud, Marie-Noëlle Paludetto, Laurence Digue, Carlos Alberto Gomez-Roca, Thibaud Valentin, Laurent Balardy, Pascale Olivier, Bastien Cabarrou, Thomas Filleron, Etienne Chatelut. VOTRAGE study: Phase I dose-escalation study of pazopanib in unfit older patients.
Journal of geriatric oncology.
2021 06; 12(5):759-764. doi:
10.1016/j.jgo.2021.02.006. [PMID: 33715996] - Ken Shiraiwa, Yosuke Suzuki, Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Asami Matsumoto, Ryota Tanaka, Ryosuke Tatsuta, Hiroshi Tsumura, Hiroki Itoh. Development of a High-Throughput Quantification Method for Pazopanib Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Clinical Application in Patients With Soft Tissue Tumors.
Therapeutic drug monitoring.
2021 06; 43(3):416-421. doi:
10.1097/ftd.0000000000000821. [PMID: 33009287] - Jiyuan Chen, Fuzheng Ren, Wenfeng Cao, Zhengjie Wu, Guanqun Ju, Chengwu Xiao, Weijia Wu, Shen Gao, Chuanliang Xu, Yuan Gao. Photothermal therapy enhance the anti-mitochondrial metabolism effect of lonidamine to renal cell carcinoma in homologous-targeted nanosystem.
Nanomedicine : nanotechnology, biology, and medicine.
2021 06; 34(?):102370. doi:
10.1016/j.nano.2021.102370. [PMID: 33713859] - Yu V Vitruk, S L Semko, O A Voylenko, M V Pikul, T V Borikun, T V Zadvornyi, T M Yalovenko, E O Stakhovsky, O V Rossylna. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302а and -377 in tumor tissue.
Experimental oncology.
2021 06; 43(2):98-103. doi:
10.32471/exp-oncology.2312-8852.vol-43-no-2.16383. [PMID: 34190510] - Joaquim Bellmunt, Emilio Esteban, Xabier García Del Muro, Juan Manuel Sepúlveda, Pablo Maroto, Enrique Gallardo, Aranzazu González Del Alba, Olatz Etxaniz, Marta Guix, Jose Luis González Larriba, Jose A Arranz, Miriam Redrado, Alfonso Calvo. Pazopanib as Second-line Antiangiogenic Treatment in Metastatic Renal Cell Carcinoma After Tyrosine Kinase Inhibitor (TKI) Failure: A Phase 2 Trial Exploring Immune-related Biomarkers for Testing in the Post-immunotherapy/TKI Era.
European urology oncology.
2021 06; 4(3):502-505. doi:
10.1016/j.euo.2019.07.014. [PMID: 31477526] - Yasutomo Nakai, Ario Takeuchi, Takahiro Osawa, Takahiro Kojima, Tomohiko Hara, Mikio Sugimoto, Masatoshi Eto, Keita Minami, Kosuke Ueda, Michinobu Ozawa, Motohide Uemura, Yasuyuki Miyauchi, Kojiro Ohba, Akira Kashiwagi, Masaya Murakami, Tomokazu Sazuka, Hiroaki Yasumoto, Shuichi Morizane, Yoshihide Kawasaki, Daichi Morooka, Toru Shimazui, Yoshiaki Yamamoto, Hiroshi Nakagomi, Ryotaro Tomida, Yoichi M Ito, Sachiyo Murai, Hiroshi Kitamura, Hiroyuki Nishiyama, Nobuo Shinohara. Efficacy and safety of second-line axitinib in octogenarians with metastatic renal cell carcinoma.
Journal of geriatric oncology.
2021 06; 12(5):834-837. doi:
10.1016/j.jgo.2020.12.012. [PMID: 33388281] - Chunhua Rui, Shen-Nan Shi, Wenqing Ren, Xia Qin, Chunlin Zhuang, Xiaofei Chen, Gang Chen, Jianqiang Yu, Hong-Yang Wang, Zhenyu Cai. The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis.
Biochemical pharmacology.
2021 06; 188(?):114542. doi:
10.1016/j.bcp.2021.114542. [PMID: 33819469] - Kotaro Suzuki, Takuto Hara, Tomoaki Terakawa, Kenichi Harada, Masato Fujisawa. Efficacy of axitinib rechallenge in metastatic renal cell carcinoma.
International journal of urology : official journal of the Japanese Urological Association.
2021 06; 28(6):702-703. doi:
10.1111/iju.14529. [PMID: 33719092] - Georgina Meneses-Lorente, Darren Bentley, Elena Guerini, Karey Kowalski, Edna Chow-Maneval, Li Yu, Andreas Brink, Nassim Djebli, Francois Mercier, Vincent Buchheit, Alex Phipps. Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors.
Investigational new drugs.
2021 06; 39(3):803-811. doi:
10.1007/s10637-020-01047-5. [PMID: 33462752] - Stefanie Deinhardt-Emmer, Laura Jäckel, Clio Häring, Sarah Böttcher, Janine J Wilden, Brigitte Glück, Regine Heller, Michaela Schmidtke, Mirijam Koch, Bettina Löffler, Stephan Ludwig, Christina Ehrhardt. Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice.
Biomolecules.
2021 05; 11(6):. doi:
10.3390/biom11060808. [PMID: 34072389] - Anil Kumar Yadav, Byeong-Churl Jang. Inhibition of Lipid Accumulation and Cyclooxygenase-2 Expression in Differentiating 3T3-L1 Preadipocytes by Pazopanib, a Multikinase Inhibitor.
International journal of molecular sciences.
2021 May; 22(9):. doi:
10.3390/ijms22094884. [PMID: 34063048] - Pinar Efeoglu Ozseker, Nebile Daglioglu, Mete Korkut Gulmen, Ilknur Tolunay, Fehiman Efeoglu. Determination of AB-FUBINACA and 5F-NPB-22 in rats exposed to 'Bonsai' via inhalation and analysis of seized product.
Legal medicine (Tokyo, Japan).
2021 May; 50(?):101869. doi:
10.1016/j.legalmed.2021.101869. [PMID: 33713938] - Nellie N Nafissi, Nina Karlin, Mark R Pittelkow, David J Dicaudo, Aaron R Mangold. Panniculitis in a patient with metastatic renal cell carcinoma on a tyrosine kinase inhibitor.
Anti-cancer drugs.
2021 04; 32(4):474-475. doi:
10.1097/cad.0000000000000999. [PMID: 33290313] - Andrew L Laccetti, Benjamin Garmezy, Lianchun Xiao, Minas Economides, Aradhana Venkatesan, Jianjun Gao, Eric Jonasch, Paul Corn, Amado Zurita-Saavedra, Landon C Brown, Chester Kao, Emily N Kinsey, Rajan T Gupta, Michael R Harrison, Andrew J Armstrong, Daniel J George, Nizar Tannir, Pavlos Msaouel, Amishi Shah, Tian Zhang, Matthew T Campbell. Combination antiangiogenic tyrosine kinase inhibition and anti-PD1 immunotherapy in metastatic renal cell carcinoma: A retrospective analysis of safety, tolerance, and clinical outcomes.
Cancer medicine.
2021 04; 10(7):2341-2349. doi:
10.1002/cam4.3812. [PMID: 33650321] - Ilya Tsimafeyeu, Yulia Tishova, Ruslan Zukov, Pavel Borisov, Anastasia Bondarenko, Kristina Zakurdaeva. Testosterone for Managing Treatment-related Fatigue in Patients With Metastatic Renal Cell Carcinoma: A Phase 2 Randomized Study FARETES.
American journal of clinical oncology.
2021 04; 44(4):137-142. doi:
10.1097/coc.0000000000000797. [PMID: 33512910] - Jillian H Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A Lewis, Mark R Cookson, Adamantios Mamais. Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
Molecular neurodegeneration.
2021 03; 16(1):17. doi:
10.1186/s13024-021-00441-8. [PMID: 33741046] - Andrew M Brandon, Lysbeth H Antonides, Jennifer Riley, Ola Epemolu, Denise A McKeown, Kevin D Read, Craig McKenzie. A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market.
Molecules (Basel, Switzerland).
2021 Mar; 26(5):. doi:
10.3390/molecules26051396. [PMID: 33807614] - Agnieszka Dreas, Katarzyna Kucwaj-Brysz, Karolina Pyziak, Urszula Kulesza, Ewelina Wincza, Charles-Henry Fabritius, Kinga Michalik, Ewelina Gabor-Worwa, Aniela Gołas, Mariusz Milik, Magdalena Masiejczyk, Eliza Majewska, Kazimiera Pyśniak, Urszula Wójcik-Trechcińska, Zuzanna Sandowska-Markiewicz, Krzysztof Brzózka, Jerzy Ostrowski, Tomasz Rzymski, Michal Mikula. Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.
European journal of medicinal chemistry.
2021 Mar; 213(?):113057. doi:
10.1016/j.ejmech.2020.113057. [PMID: 33303237] - Alessandra Mosca, Ugo De Giorgi, Giuseppe Procopio, Umberto Basso, Giacomo Cartenì, Melissa Bersanelli, Emanuele Naglieri, Luca Galli, Orazio Caffo, Giuseppe Fornarini, Francesco Boccardo, Camillo Porta. An Italian, multicenter, real-world, retrospective study of first-line pazopanib in unselected metastatic renal-cell carcinoma patients: the 'Pamerit' study.
Japanese journal of clinical oncology.
2021 Mar; 51(3):484-491. doi:
10.1093/jjco/hyaa193. [PMID: 33212499] - Francesco Pierantoni, Umberto Basso, Marco Maruzzo, Evelina Lamberti, Davide Bimbatti, Giuseppina Tierno, Eleonora Bergo, Antonella Brunello, Vittorina Zagonel. Comprehensive geriatric assessment is an independent prognostic factor in older patients with metastatic renal cell cancer treated with first-line Sunitinib or Pazopanib: a single center experience.
Journal of geriatric oncology.
2021 03; 12(2):290-297. doi:
10.1016/j.jgo.2020.09.009. [PMID: 32972885] - Robert J Motzer, Paul Russo, Naomi Haas, Christian Doehn, Frede Donskov, Marine Gross-Goupil, Sergei Varlamov, Evgeny Kopyltsov, Jae Lyun Lee, Ho Yeong Lim, Bohuslav Melichar, Milada Zemanova, Brian Rini, Toni K Choueiri, Lori Wood, M Neil Reaume, Arnulf Stenzl, Simon Chowdhury, Ray McDermott, Agnieszka Michael, Miguel Izquierdo, Paola Aimone, Hong Zhang, Cora N Sternberg. Adjuvant Pazopanib Versus Placebo After Nephrectomy in Patients With Localized or Locally Advanced Renal Cell Carcinoma: Final Overall Survival Analysis of the Phase 3 PROTECT Trial.
European urology.
2021 03; 79(3):334-338. doi:
10.1016/j.eururo.2020.12.029. [PMID: 33461782] - Michael Staehler, Andrej Panic, Peter J Goebell, Marie Merling, Karin Potthoff, Edwin Herrmann, Patrick de Geeter, Corinne Vannier, Cathrin Hogrefe, Norbert Marschner, Viktor Grünwald. First-line pazopanib in intermediate- and poor-risk patients with metastatic renal cell carcinoma: Final results of the FLIPPER trial.
International journal of cancer.
2021 02; 148(4):950-960. doi:
10.1002/ijc.33238. [PMID: 32738823] - Leo L Tsai, Rupal S Bhatt, Meaghan F Strob, Opeyemi A Jegede, Maryellen R M Sun, David C Alsop, Paul Catalano, David McDermott, Philip M Robson, Michael B Atkins, Ivan Pedrosa. Arterial Spin Labeled Perfusion MRI for the Evaluation of Response to Tyrosine Kinase Inhibition Therapy in Metastatic Renal Cell Carcinoma.
Radiology.
2021 02; 298(2):332-340. doi:
10.1148/radiol.2020201763. [PMID: 33258745] - Kayoko Minakata, Koutaro Hasegawa, Itaru Yamagishi, Hideki Nozawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe. In Vivo Metabolites of AB-PINACA in Solid Tissues Obtained from Its Abuser: Comparison with In Vitro Experiment.
Journal of analytical toxicology.
2021 Jan; 44(9):1027-1035. doi:
10.1093/jat/bkaa031. [PMID: 32232365] - Shinya Takasaki, Yoshihide Kawasaki, Masafumi Kikuchi, Akihiro Ito, Hiroaki Yamaguchi, Nariyasu Mano. Clinical Importance of Plasma Drug Concentration of Oral Molecular Targeted Drugs for Renal Cell Carcinoma.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2021 ; 24(?):127-136. doi:
10.18433/jpps31816. [PMID: 34559626] - William A Fahy, Farshid Homayoun-Valiani, Anthony Cahn, Jon Robertson, Alison Templeton, Wilhelmine H Meeraus, Robert Wilson, Mike Lowings, Miriam Marotti, Sarah L West, Maggie Tabberer, Edith M Hessel. Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.
International journal of chronic obstructive pulmonary disease.
2021; 16(?):1637-1646. doi:
10.2147/copd.s309320. [PMID: 34113095] - Ibrahim A Darwish, Nasr Y Khalil, Nawaf A Alsaif, Rashed N Herqash, Ahmed Y A Sayed, Hamdy M Abdel-Rahman. Charge-Transfer Complex of Linifanib with 2,3-dichloro-3,5-dicyano-1,4-benzoquinone: Synthesis, Spectroscopic Characterization, Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay.
Drug design, development and therapy.
2021; 15(?):1167-1180. doi:
10.2147/dddt.s296502. [PMID: 33737805] - Hasan N Ahmadabad, Allireza Abbaspour, Yaser Panahi, Saeed Tahmasebi, Nikoo Hossein-Khannazer, Sanaz Afraei, Hosein Miladi, Mahdi Goudarzvand, Ali N Kamali, Yasser Bagheri, Reza Yazdani, Maria M Di Fiore, Gholamreza Azizi. Anti-Inflammatory Effect of KW-2449 on Autoimmune Encephalomyelitis: An Experimental Study on Mice.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(9):1590-1597. doi:
10.2174/1871530320666201106095808. [PMID: 33155932] - J Gomolčáková, B Brezinová, P Dubovan, S Jurišová, K Rejlekova, M Chovanec, J Mardiak, M Mego. Targeted therapy in Xp11 translocation renal cell carcinoma.
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti.
2021; 34(2):137-140. doi:
10.48095/ccko2021137. [PMID: 33906362] - Stefano Capri, Camillo Porta, Claudia Condorelli, Eleonora Premoli, Ankur Khare, Manik Kalra, Niraj Modi, Barbara Ratto. An updated cost-effectiveness analysis of pazopanib versus sunitinib as first-line treatment for locally advanced or metastatic renal cell carcinoma in Italy.
Journal of medical economics.
2020 Dec; 23(12):1579-1587. doi:
10.1080/13696998.2020.1839240. [PMID: 33079593] - Hélène Lazareth, Nicolas Delanoy, Raphaël Cohen, Emilie Boissier, Hamza Ayari, Pierre Combe, Céline Crespel, Elise Mercadier-Riaz, Alexandre Karras, Marie Courbebaisse, Eric Thervet, Nicolas Pallet. Nephrotoxicity Associated With Niraparib.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 12; 76(6):898-900. doi:
10.1053/j.ajkd.2020.05.021. [PMID: 32679152] - Jing Zeng, Daitze Wu, Hui Hu, John A T Young, Zhipeng Yan, Lu Gao. Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes.
Hepatology (Baltimore, Md.).
2020 12; 72(6):1935-1948. doi:
10.1002/hep.31217. [PMID: 32145089] - Ceyda Tuba Sengel-Turk, Mehmet Eray Alcigir, Okan Ekim, Filiz Bakar-Ates, Canan Hascicek. Clinicopathological and immunohistochemical evaluation of lonidamine-entrapped lipid-polymer hybrid nanoparticles in treatment of benign prostatic hyperplasia: An experimental rat model.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2020 Dec; 157(?):211-220. doi:
10.1016/j.ejpb.2020.10.016. [PMID: 33129926] - Christopher G Wood, James E Ferguson, Joel S Parker, Dominic T Moore, Jennifer G Whisenant, Susan J Maygarden, Eric M Wallen, William Y Kim, Mathew I Milowsky, Kathryn E Beckermann, Nancy B Davis, Scott M Haake, Jose A Karam, Dante S Bortone, Benjamin G Vincent, Thomas Powles, W Kimryn Rathmell. Neoadjuvant pazopanib and molecular analysis of tissue response in renal cell carcinoma.
JCI insight.
2020 11; 5(22):. doi:
10.1172/jci.insight.132852. [PMID: 33208553] - Qianqian Fan, Jie Ma, Bo Zhang, Qiuyue Li, Fang Liu, Bin Zhao. Assessment of acute kidney injury related to small-molecule protein kinase inhibitors using the FDA adverse event reporting system.
Cancer chemotherapy and pharmacology.
2020 11; 86(5):655-662. doi:
10.1007/s00280-020-04151-8. [PMID: 33001273]