Oxazol (BioDeep_00000402526)
代谢物信息卡片
OXAZOLE
化学式: C3H3NO (69.0214628)
中文名称: 噁唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=COC=N1
InChI: InChI=1S/C3H3NO/c1-2-5-3-4-1/h1-3H
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:35597
- PubChem: 9255
- ChEMBL: CHEMBL2171710
- MeSH: Oxazoles
- CAS: 288-42-6
- MoNA: SM809305
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kimberly N Karin, Mohammed A Mustafa, Justin L Poklis, Belle Buzzi, Joel E Schlosburg, Linda Parker, M Imad Damaj, Aron H Lichtman. N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice.
Drug and alcohol dependence.
2024 Jun; 259(?):111276. doi:
10.1016/j.drugalcdep.2024.111276. [PMID: 38676968] - Claudia Lowe, Nawaporn Onkokesung, Alina Goldberg, Roland Beffa, Paul Neve, Robert Edwards, David Comont. RNA and protein biomarkers for detecting enhanced metabolic resistance to herbicides mesosulfuron-methyl and fenoxaprop-ethyl in black-grass (Alopecurus myosuroides).
Pest management science.
2024 Jun; 80(6):2539-2551. doi:
10.1002/ps.7960. [PMID: 38375975] - Feng Zhao, Lu Lin, Yihao Zhao, Jingjing Wu, Junqi Zhu, Tengfei Zhang, Huihua Tan. Developmental toxicity and metabolomics analyses of zebrafish (Danio rerio) embryos exposed to Fenoxaprop-p-ethyl.
Environmental science and pollution research international.
2024 Mar; 31(13):20399-20408. doi:
10.1007/s11356-024-32507-7. [PMID: 38374504] - Livia Interdonato, Ylenia Marino, Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Enrico Gugliandolo, Gianluca Antonio Franco, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola. Oxidative stress and mitochondrial dysfunction in brain of vinclozolin exposed animals.
Neurochemistry international.
2024 Mar; 174(?):105681. doi:
10.1016/j.neuint.2024.105681. [PMID: 38341035] - Min Liao, Minghao Jiang, Xumiao Wang, Wei Hu, Ning Zhao, Haiqun Cao. The Cys-2088-Arg mutation in the ACCase gene and enhanced metabolism confer cyhalofop-butyl resistance in Chinese sprangletop (Leptochloa chinensis).
Pesticide biochemistry and physiology.
2024 Mar; 200(?):105826. doi:
10.1016/j.pestbp.2024.105826. [PMID: 38582590] - Fan Yin, Jinfang Jiang, Min Liao, Haiqun Cao, Zhaofeng Huang, Ning Zhao. Fenoxaprop-P-ethyl, mesosulfuron-ethyl, and isoproturon resistance status in Beckmannia syzigachne from wheat fields across Anhui Province, China.
Pesticide biochemistry and physiology.
2024 Jan; 198(?):105711. doi:
10.1016/j.pestbp.2023.105711. [PMID: 38225069] - Lan Cheng, Jing-Rui Liu, Jia-Mu Liu, Dale Guo, Fang Deng, Qiang Bian, Haifeng Zhang, Xinya Han, Abdallah S Ali, Wei-Hua Zhang, Ming-Zhi Zhang, Yu-Cheng Gu. Design, synthesis, antifungal activity and molecular docking of ring-opened pimprinine derivative containing (thio)amide structure.
Pest management science.
2023 Jun; 79(6):2220-2229. doi:
10.1002/ps.7400. [PMID: 36750400] - Joshua P Morrow, David Pizzi, Zihnil A I Mazrad, Ashley I Bush, Kristian Kempe. Bioactive poly(2-oxazoline)-based nanomaterials bearing arylalkylamine and benzamide motifs possess intrinsic radical trapping and anti-ferroptosis properties.
Biomaterials science.
2023 May; 11(9):3159-3171. doi:
10.1039/d2bm02087d. [PMID: 36919797] - Jing-Rui Liu, Ya Gao, Bing Jin, Dale Guo, Fang Deng, Qiang Bian, Hai-Feng Zhang, Xin-Ya Han, Abdallah S Ali, Ming-Zhi Zhang, Wei-Hua Zhang, Yu-Cheng Gu. Design, Synthesis, Antifungal Activity, and Molecular Docking of Streptochlorin Derivatives Containing the Nitrile Group.
Marine drugs.
2023 Jan; 21(2):. doi:
10.3390/md21020103. [PMID: 36827144] - Sucheta Kudrimoti, Jacob Machin, Adedamola S Arojojoye, Samuel G Awuah, Rodney Eisenberg, Clara Fenger, George Maylin, Andreas F Lehner, Thomas Tobin. Synthesis and characterization of d5 -barbarin for use in barbarin-related research.
Drug testing and analysis.
2023 Jan; 15(1):42-46. doi:
10.1002/dta.3357. [PMID: 35975356] - Ying Zhang, Ya-Nan Liu, Saili Xie, Xuegu Xu, Ren-Ai Xu. Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC-MS/MS assay.
Pharmaceutical biology.
2022 Dec; 60(1):621-626. doi:
10.1080/13880209.2022.2048862. [PMID: 35289238] - Jing-Rui Liu, Jia-Mu Liu, Ya Gao, Zhan Shi, Ke-Rui Nie, Dale Guo, Fang Deng, Hai-Feng Zhang, Abdallah S Ali, Ming-Zhi Zhang, Wei-Hua Zhang, Yu-Cheng Gu. Discovery of Novel Pimprinine and Streptochlorin Derivatives as Potential Antifungal Agents.
Marine drugs.
2022 Nov; 20(12):. doi:
10.3390/md20120740. [PMID: 36547887] - Jun Ma, Qijie Zou, Chunhua Wang, Guangwei Yin, Fangyi Li. Development of β,β-Dibrominated Secondary Enamides and Their Application to the Synthesis of 5-Br Oxazoles.
The Journal of organic chemistry.
2022 11; 87(22):15670-15678. doi:
10.1021/acs.joc.2c01927. [PMID: 36315618] - Xiang Cheng, Zonghan Xu, Huisheng Luo, Xihao Chang, Xianhai Lv. Design, Synthesis, and Biological Evaluation of Novel Pyrazol-5-yl-benzamide Derivatives Containing Oxazole Group as Potential Succinate Dehydrogenase Inhibitors.
Journal of agricultural and food chemistry.
2022 Nov; 70(43):13839-13848. doi:
10.1021/acs.jafc.2c04708. [PMID: 36270026] - Misono Tadatsu, Ryota Sakashita, Rafaela Panteleri, Vassilis Douris, John Vontas, Yushi Shimotsuma, Tatsuya Ishida, Masaaki Sudo, Thomas Van Leeuwen, Masahiro Osakabe. A mutation in chitin synthase I associated with etoxazole resistance in the citrus red mite Panonychus citri (Acari: Tetranychidae) and its uneven geographical distribution in Japan.
Pest management science.
2022 Oct; 78(10):4028-4036. doi:
10.1002/ps.7021. [PMID: 35639971] - Ramona D'Amico, Davide Di Paola, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro. Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2-Nf-kb Pathway Alterations.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911320. [PMID: 36232623] - Davide Di Paola, Ramona D'Amico, Tiziana Genovese, Rosalba Siracusa, Marika Cordaro, Rosalia Crupi, Alessio Filippo Peritore, Enrico Gugliandolo, Livia Interdonato, Daniela Impellizzeri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola. Chronic Exposure to Vinclozolin Induced Fibrosis, Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Mice Kidney.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911296. [PMID: 36232596] - Kun Gao, Yukun Qin, Linsong Wang, Xin Li, Song Liu, Ronge Xing, HuaHua Yu, Xiaolin Chen, Pengcheng Li. Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy.
Journal of agricultural and food chemistry.
2022 Aug; 70(30):9520-9535. doi:
10.1021/acs.jafc.2c02507. [PMID: 35877994] - Hao Sun, Kristen A Cardinal, Larry Wienkers, Alice Chin, Vineet Kumar, Calvin Neace, Clark Henderson, Christopher J Endres, Ariel Topletz-Erickson, Kelly Regal, Alex Vo, Stephen C Alley, Anthony J Lee. Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Cancer chemotherapy and pharmacology.
2022 06; 89(6):737-750. doi:
10.1007/s00280-022-04429-z. [PMID: 35435471] - Carmela Belardo, Nicola Alessio, Martina Pagano, Emanuela De Dominicis, Rosmara Infantino, Michela Perrone, Monica Iannotta, Umberto Galderisi, Barbara Rinaldi, Damiana Scuteri, Giacinto Bagetta, Enza Palazzo, Sabatino Maione, Livio Luongo. PEA-OXA ameliorates allodynia, neuropsychiatric and adipose tissue remodeling induced by social isolation.
Neuropharmacology.
2022 05; 208(?):108978. doi:
10.1016/j.neuropharm.2022.108978. [PMID: 35157898] - Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E Ortiz, Nicholas J Schnicker, Andrew Thurman, Alejandro A Pezzulo, Peter J Szachowicz, Pengfei Li, Ruangang Pan, Klaus Klumpp, Fred Aswad, Justin Rebo, Shuh Narumiya, Makoto Murakami, Sonia Zuniga, Isabel Sola, Luis Enjuanes, David K Meyerholz, Kristen Fortney, Paul B McCray, Stanley Perlman. Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
Nature.
2022 05; 605(7908):146-151. doi:
10.1038/s41586-022-04630-3. [PMID: 35314834] - Lalit K Golani, Branka Divović, Dishary Sharmin, Kamal P Pandey, Md Yeunus Mian, Rok Cerne, Nicolas M Zahn, Michelle J Meyer, Veera V N P B Tiruveedhula, Jodi L Smith, Xingjie Ping, Xiaoming Jin, Arnold Lippa, Jeffrey M Schkeryantz, Leggy A Arnold, James M Cook, Miroslav M Savić, Jeffrey M Witkin. Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81.
Biopharmaceutics & drug disposition.
2022 Apr; 43(2):66-75. doi:
10.1002/bdd.2313. [PMID: 35194800] - Tomohiro Sasaki, Elin M Svensson, Xiaofeng Wang, Yanlin Wang, Jeffrey Hafkin, Mats O Karlsson, Suresh Mallikaarjun. Population Pharmacokinetic and Concentration-QTc Analysis of Delamanid in Pediatric Participants with Multidrug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2022 02; 66(2):e0160821. doi:
10.1128/aac.01608-21. [PMID: 34843388] - Andrey Zakharchenko, Yingfei Xue, Samuel Keeney, Christopher A Rock, Ivan S Alferiev, Stanley J Stachelek, Hajime Takano, Tina Thomas, Chandrasekaran Nagaswami, Abba M Krieger, Michael Chorny, Giovanni Ferrari, Robert J Levy. Poly-2-methyl-2-oxazoline-modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration.
Proceedings of the National Academy of Sciences of the United States of America.
2022 02; 119(6):. doi:
10.1073/pnas.2120694119. [PMID: 35131859] - Neil A Miller, Rebecca H Graves, Chris D Edwards, Augustin Amour, Ed Taylor, Olivia Robb, Brett O'Brien, Aarti Patel, Andrew W Harrell, Edith M Hessel. Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Clinical pharmacokinetics.
2022 02; 61(2):281-293. doi:
10.1007/s40262-021-01066-2. [PMID: 34458976] - Hong-Liang Lu, Chun-Quan Kang, Qin-Yuan Meng, Jian-Rao Hu, Steven D Melvin. Functional and hepatic metabolite changes in aquatic turtle hatchlings exposed to the anti-androgenic fungicide vinclozolin.
Ecotoxicology and environmental safety.
2022 Feb; 231(?):113220. doi:
10.1016/j.ecoenv.2022.113220. [PMID: 35066435] - Florica Adriana Jerca, Valentin Victor Jerca, Richard Hoogenboom. In Vitro Assessment of the Hydrolytic Stability of Poly(2-isopropenyl-2-oxazoline).
Biomacromolecules.
2021 12; 22(12):5020-5032. doi:
10.1021/acs.biomac.1c00994. [PMID: 34753285] - Yue Gu, Mengxia Xue, Qizhi Wang, Xiaodan Hong, Xinyu Wang, Fang Zhou, Jianguo Sun, Guangji Wang, Ying Peng. Novel Strategy of Proxalutamide for the Treatment of Prostate Cancer through Coordinated Blockade of Lipogenesis and Androgen Receptor Axis.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413222. [PMID: 34948018] - Carlos Alberto Gonsiorkiewicz Rigon, Luan Cutti, Paula Sinigaglia Angonese, Estéfani Sulzbach, Catarine Markus, Todd A Gaines, Aldo Merotto. The safener isoxadifen does not increase herbicide resistance evolution in recurrent selection with fenoxaprop.
Plant science : an international journal of experimental plant biology.
2021 Dec; 313(?):111097. doi:
10.1016/j.plantsci.2021.111097. [PMID: 34763850] - Christine Huynh, Janneke M Brussee, Laetitia Pouzol, Marlene Fonseca, Henriette E Meyer Zu Schwabedissen, Jasper Dingemanse, Patricia N Sidharta. Target engagement of the first-in-class CXCR7 antagonist ACT-1004-1239 following multiple-dose administration in mice and humans.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Dec; 144(?):112363. doi:
10.1016/j.biopha.2021.112363. [PMID: 34794236] - Kiat Hwa Chan, John T Groves. Concise Modular Synthesis and NMR Structural Determination of Gallium Mycobactin T.
The Journal of organic chemistry.
2021 11; 86(21):15453-15468. doi:
10.1021/acs.joc.1c01966. [PMID: 34699221] - Huiping Li, Guohong Song, Qiaoxia Zhou, Ran Ran, Hanfang Jiang, Ruyan Zhang, Yaxin Liu, Jiayang Zhang, Luping Meng, Liandong Ma, Ye Sun, Meiyu Wang, Qingqing Zhou, Honghua Yan, Qianxiang Zhou, Xunwei Dong, Youzhi Tong. Activity of preclinical and phase I clinical trial of a novel androgen receptor antagonist GT0918 in metastatic breast cancer.
Breast cancer research and treatment.
2021 Oct; 189(3):725-736. doi:
10.1007/s10549-021-06345-x. [PMID: 34392453] - Qinglin Cheng, Junfang Chen, Qingjun Jia, Zijian Fang, Gang Zhao. Efficacy and safety of current medications for treating severe and non-severe COVID-19 patients: an updated network meta-analysis of randomized placebo-controlled trials.
Aging.
2021 09; 13(18):21866-21902. doi:
10.18632/aging.203522. [PMID: 34531332] - Courtney Nelson, Peter D Constable, Sara L Connolly. Comparison of selected serum biochemistry measurements between the Nova Prime Plus VET, Nova pHOx Ultra, and Beckman Coulter AU680 analyzers in dogs.
Veterinary clinical pathology.
2021 Sep; 50(3):327-341. doi:
10.1111/vcp.13010. [PMID: 34545580] - Micaela Tirri, Paolo Frisoni, Sabrine Bilel, Raffaella Arfè, Claudio Trapella, Anna Fantinati, Giorgia Corli, Beatrice Marchetti, Fabio De-Giorgio, Cristian Camuto, Monica Mazzarino, Rosa Maria Gaudio, Giovanni Serpelloni, Fabrizio Schifano, Francesco Botrè, Matteo Marti. Worsening of the Toxic Effects of (±)Cis-4,4'-DMAR Following Its Co-Administration with (±)Trans-4,4'-DMAR: Neuro-Behavioural, Physiological, Immunohistochemical and Metabolic Studies in Mice.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168771. [PMID: 34445476] - Masakazu Shibata, Masatoshi Masuda, Katsunori Sasahara, Hiroyuki Sasabe, Tomohiro Sasaki, Seongryul Kim, Kenji Takeuchi, Ken Umehara, Eiji Kashiyama. Prediction of Human Pharmacokinetic Profiles of the Antituberculosis Drug Delamanid from Nonclinical Data: Potential Therapeutic Value against Extrapulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
2021 07; 65(8):e0257120. doi:
10.1128/aac.02571-20. [PMID: 34097484] - Koichi Narita, Keisuke Suganuma, Toshihiro Murata, Ryutaro Kondo, Hiroka Satoh, Kazuhiro Watanabe, Kenroh Sasaki, Noboru Inoue, Yuichi Yoshimura. Synthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles.
Bioorganic & medicinal chemistry.
2021 07; 42(?):116253. doi:
10.1016/j.bmc.2021.116253. [PMID: 34130218] - Shichen Liu, Shingo Kobayashi, Toshiki Sonoda, Masaru Tanaka. Poly(tertiary amide acrylate) Copolymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States.
Biomacromolecules.
2021 06; 22(6):2718-2728. doi:
10.1021/acs.biomac.1c00411. [PMID: 34081446] - Gisela Ramirez, Anna C Pham, Andrew J Clulow, Malinda Salim, Adrian Hawley, Ben J Boyd. Sustained absorption of delamanid from lipid-based formulations as a path to reduced frequency of administration.
Drug delivery and translational research.
2021 06; 11(3):1236-1244. doi:
10.1007/s13346-020-00851-z. [PMID: 32935235] - Demin Cai, Yanwei Li, Kexin Zhang, Bo Zhou, Feilong Guo, Lena Holm, Hao-Yu Liu. Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis.
Journal of cellular physiology.
2021 06; 236(6):4387-4402. doi:
10.1002/jcp.30157. [PMID: 33184849] - Shuang Cui, Xiao-Jie Pan, Chao-Liang Ge, Yi-Tong Guo, Peng-Fei Zhang, Ting-Ting Yan, Ji-Yu Zhou, Qing-Xian He, Long-Hao Cheng, Guang-Ji Wang, Hai-Ping Hao, Hong Wang. Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α.
Chinese journal of natural medicines.
2021 Jun; 19(6):401-411. doi:
10.1016/s1875-5364(21)60039-0. [PMID: 34092291] - Brad Hayes, Scott Wiseman, Daniel E Snyder. Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) against natural intestinal nematode infections in dogs presented as veterinary patients in Europe.
Parasites & vectors.
2021 May; 14(1):258. doi:
10.1186/s13071-021-04766-7. [PMID: 34001223] - Jianliang Xu, P Jaya Kausalya, Noémi Van Hul, Matias J Caldez, Shiyi Xu, Alicia Ghia Min Ong, Wan Lu Woo, Safiah Mohamed Ali, Philipp Kaldis, Walter Hunziker. Protective Functions of ZO-2/Tjp2 Expressed in Hepatocytes and Cholangiocytes Against Liver Injury and Cholestasis.
Gastroenterology.
2021 05; 160(6):2103-2118. doi:
10.1053/j.gastro.2021.01.027. [PMID: 33465371] - Brian J Kirby, Justin D Lutz, Mun Sang Yue, Kimberly L Garrison, Ann Ran-Ran Qin, Lorraine Ampaw, Carine Beysen, Robert P Myers, Brian P Kearney, Anita Mathias. Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.
Clinical pharmacology and therapeutics.
2021 05; 109(5):1334-1341. doi:
10.1002/cpt.2105. [PMID: 33141923] - Wensheng Yu, Jian Liu, Dane Clausen, Younong Yu, Joseph L Duffy, Ming Wang, Shouning Xu, Lin Deng, Takao Suzuki, Christine C Chung, Robert W Myers, Daniel J Klein, James I Fells, M Katharine Holloway, Jin Wu, Guoxin Wu, Bonnie J Howell, Richard J O Barnard, Joseph Kozlowski. Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
Journal of medicinal chemistry.
2021 04; 64(8):4709-4729. doi:
10.1021/acs.jmedchem.0c02150. [PMID: 33797924] - Lauren Lee, Yoshiyuki Hizukuri, Paul Severson, Benjamin Powell, Chao Zhang, Yan Ma, Maiko Narahara, Hiroyuki Sumi, Daniela Hernandez, Trivikram Rajkhowa, Gideon Bollag, Mark Levis. A novel combination regimen of BET and FLT3 inhibition for FLT3-ITD acute myeloid leukemia.
Haematologica.
2021 04; 106(4):1022-1033. doi:
10.3324/haematol.2020.247346. [PMID: 33504139] - Ariel R Topletz-Erickson, Anthony J Lee, JoAl G Mayor, Evelyn L Rustia, Layth I Abdulrasool, Amanda L Wise, Ben Dailey, Sharon DeChenne, Luke N Walker, Stephen C Alley, Christopher J Endres. Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects.
Journal of clinical pharmacology.
2021 04; 61(4):461-471. doi:
10.1002/jcph.1750. [PMID: 32989831] - Antonio C Arrieta, Jocelyn Y Ang, Claudia Espinosa, Oleksandr Fofanov, Camilla Tøndel, Margaret Z Chou, Carisa S De Anda, Jason Y Kim, Dan Li, Philip Sabato, Pamela S Sears, John S Bradley. Pharmacokinetics and Safety of Single-dose Tedizolid Phosphate in Children 2 to <12 Years of Age.
The Pediatric infectious disease journal.
2021 04; 40(4):317-323. doi:
10.1097/inf.0000000000003030. [PMID: 33710976] - Ya Gao, Dai-Chuan Huang, Chang Liu, Zi-Long Song, Jing-Rui Liu, Shu-Ke Guo, Jun-Yang Tan, Run-Ling Qiu, Bing Jin, Haifeng Zhang, Nick Mulholland, Xinya Han, Qinfei Xia, Abdallah S Ali, Dale Guo, Yun Deng, Yu-Cheng Gu, Ming-Zhi Zhang. Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study.
Bioorganic & medicinal chemistry.
2021 04; 35(?):116073. doi:
10.1016/j.bmc.2021.116073. [PMID: 33610010] - Zhongfu Luo, Yu Deng, Bilan Luo, Yong Li, Qing Lan, Judi Fan, Wei Xue, Lei Tang, Lingling Fan. Design and synthesis of novel n-butyphthalide derivatives as promising botanical fungicides.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2021 Mar; 76(3-4):117-127. doi:
10.1515/znc-2020-0192. [PMID: 32975209] - Ashley M Kretsch, Gina L Morgan, Katie A Acken, Sarah A Barr, Bo Li. Pseudomonas Virulence Factor Pathway Synthesizes Autoinducers That Regulate the Secretome of a Pathogen.
ACS chemical biology.
2021 03; 16(3):501-509. doi:
10.1021/acschembio.0c00901. [PMID: 33595276] - Tatsuya Ohkawara, Naoto Okubo, Osamu Maehara, Jun Nishihira, Hiroshi Takeda. Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice.
Toxicology letters.
2021 Mar; 339(?):51-59. doi:
10.1016/j.toxlet.2020.12.015. [PMID: 33370591] - Wael A Alghamdi, Mohammad H Al-Shaer, Maia Kipiani, Ketevan Barbakadze, Lali Mikiashvili, Russell R Kempker, Charles A Peloquin. Pharmacokinetics of bedaquiline, delamanid and clofazimine in patients with multidrug-resistant tuberculosis.
The Journal of antimicrobial chemotherapy.
2021 03; 76(4):1019-1024. doi:
10.1093/jac/dkaa550. [PMID: 33378452] - Wang Zhang, Jing-Ya Li, Xiao-Chen Wei, Qian Wang, Ji-Yang Yang, Huan Hou, Zi-Wei Du, Xin-An Wu. Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Mar; 149(?):112029. doi:
10.1016/j.fct.2021.112029. [PMID: 33508418] - Flavio Cadegiani, Erica M Lin, Andy Goren, Carlos G Wambier. Potential risk for developing severe COVID-19 disease among anabolic steroid users.
BMJ case reports.
2021 Feb; 14(2):. doi:
10.1136/bcr-2021-241572. [PMID: 33637513] - Hua Sang, Yu Wang, Yunxi Zhong, Shiyin Gu, Guangji Wang, Jianguo Sun, Ying Peng. Quantitative determination of proxalutamide in rat plasma and tissues using liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2021 Feb; 35(3):e9003. doi:
10.1002/rcm.9003. [PMID: 33169448] - Serena Boccella, Francesca Guida, Monica Iannotta, Fabio Arturo Iannotti, Rosmara Infantino, Flavia Ricciardi, Claudia Cristiano, Rosa Maria Vitale, Pietro Amodeo, Ida Marabese, Carmela Belardo, Vito de Novellis, Salvatore Paino, Enza Palazzo, Antonio Calignano, Vincenzo Di Marzo, Sabatino Maione, Livio Luongo. 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.
Molecular brain.
2021 02; 14(1):28. doi:
10.1186/s13041-020-00724-z. [PMID: 33557888] - Zi-Long Song, Yun Zhu, Jing-Rui Liu, Shu-Ke Guo, Yu-Cheng Gu, Xinya Han, Hong-Qiang Dong, Qi Sun, Wei-Hua Zhang, Ming-Zhi Zhang. Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety.
Molecular diversity.
2021 Feb; 25(1):205-221. doi:
10.1007/s11030-020-10048-8. [PMID: 32056130] - Duhyeong Hwang, Taylor Dismuke, Andrey Tikunov, Elias P Rosen, John R Kagel, Jacob D Ramsey, Chaemin Lim, William Zamboni, Alexander V Kabanov, Timothy R Gershon, Marina Sokolsky-Papkov PhD. Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity.
Nanomedicine : nanotechnology, biology, and medicine.
2021 02; 32(?):102345. doi:
10.1016/j.nano.2020.102345. [PMID: 33259959] - Valéria Tékus, Ádám István Horváth, Kata Csekő, Krisztina Szabadfi, Andrea Kovács-Valasek, Bese Dányádi, László Deres, Róbert Halmosi, Éva Sághy, Zoltán V Varga, Ernest Adeghate, Tamás Kőszegi, Péter Mátyus, Róbert Gábriel, Péter Ferdinandy, Erika Pintér, Zsuzsanna Helyes. Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Feb; 134(?):111105. doi:
10.1016/j.biopha.2020.111105. [PMID: 33338750] - Z-Y Zeng, Q-Q Li, Y-Y Huo, C-J Chen, S-S Duan, F-R Xu, Y-X Cheng, X Dong. Inhibitory effects of essential oils from Asteraceae plant against pathogenic fungi of Panax notoginseng.
Journal of applied microbiology.
2021 Feb; 130(2):592-603. doi:
10.1111/jam.14606. [PMID: 32026569] - Naja Nyffenegger, Anna Flace, Cédric Doucerain, Franz Dürrenberger, Vania Manolova. The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia.
International journal of molecular sciences.
2021 Jan; 22(2):. doi:
10.3390/ijms22020873. [PMID: 33467196] - Charles H Hocart, Abdeljalil El Habti, Gabriel O James. One-Pot Extractive Transesterification of Fatty Acids Followed by DMOX Derivatization for Location of Double Bonds Using GC-EI-MS.
Methods in molecular biology (Clifton, N.J.).
2021; 2306(?):105-121. doi:
10.1007/978-1-0716-1410-5_8. [PMID: 33954943] - William A Fahy, Farshid Homayoun-Valiani, Anthony Cahn, Jon Robertson, Alison Templeton, Wilhelmine H Meeraus, Robert Wilson, Mike Lowings, Miriam Marotti, Sarah L West, Maggie Tabberer, Edith M Hessel. Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.
International journal of chronic obstructive pulmonary disease.
2021; 16(?):1637-1646. doi:
10.2147/copd.s309320. [PMID: 34113095] - Suzanna L Attia, Samir Softic, Marialena Mouzaki. Evolving Role for Pharmacotherapy in NAFLD/NASH.
Clinical and translational science.
2021 01; 14(1):11-19. doi:
10.1111/cts.12839. [PMID: 32583961] - Suresh Mallikaarjun, Moti L Chapagain, Tomohiro Sasaki, Norimitsu Hariguchi, Devyani Deshpande, Shashikant Srivastava, Alexander Berg, Kuniko Hirota, Yusuke Inoue, Makoto Matsumoto, Jeffrey Hafkin, Lawrence Geiter, Xiaofeng Wang, Tawanda Gumbo, Yongge Liu. Cumulative Fraction of Response for Once- and Twice-Daily Delamanid in Patients with Pulmonary Multidrug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2020 12; 65(1):. doi:
10.1128/aac.01207-20. [PMID: 33106263] - Xiaofeng Wang, Suresh Mallikaarjun, Ekaterina Gibiansky. Population Pharmacokinetic Analysis of Delamanid in Patients with Pulmonary Multidrug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2020 12; 65(1):. doi:
10.1128/aac.01202-20. [PMID: 33106258] - Rassol Bahreini, Medhat Nasr, Cassandra Docherty, Olivia de Herdt, Samantha Muirhead, David Feindel. Evaluation of potential miticide toxicity to Varroa destructor and honey bees, Apis mellifera, under laboratory conditions.
Scientific reports.
2020 12; 10(1):21529. doi:
10.1038/s41598-020-78561-2. [PMID: 33299084] - Zhiyan Liu, Jiangping Cao, Xiaoting Yan, Wanqing Cheng, Xiaoguang Wang, Ruige Yang, Yong Guo. Discovery of Natural Product-Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3-Phenylisoxazolines as Antifungal Agents.
Chemistry & biodiversity.
2020 Dec; 17(12):e2000763. doi:
10.1002/cbdv.202000763. [PMID: 33085165] - Pei Wan, Zhilin Chen, Weifeng Zhong, Huiming Jiang, Zhicheng Huang, Dong Peng, Qiang He, Nanhui Chen. BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma.
Oncology reports.
2020 12; 44(6):2475-2486. doi:
10.3892/or.2020.7796. [PMID: 33125143] - Blondelle Matio Kemkuignou, Laura Treiber, Haoxuan Zeng, Hedda Schrey, Rainer Schobert, Marc Stadler. Macrooxazoles A-D, New 2,5-Disubstituted Oxazole-4-Carboxylic Acid Derivatives from the Plant Pathogenic Fungus Phoma macrostoma.
Molecules (Basel, Switzerland).
2020 Nov; 25(23):. doi:
10.3390/molecules25235497. [PMID: 33255301] - Ali Alsalme, T Pooventhiran, Nabil Al-Zaqri, D Jagadeeswara Rao, Siriki Srinivasa Rao, Renjith Thomas. Modelling the structural and reactivity landscapes of tucatinib with special reference to its wavefunction-dependent properties and screening for potential antiviral activity.
Journal of molecular modeling.
2020 Nov; 26(12):341. doi:
10.1007/s00894-020-04603-1. [PMID: 33200284] - Xia Zhao, Xiao Yan Sheng, Christopher D Payne, Xin Zhang, Feng Wang, Yi Min Cui. Pharmacokinetics, Safety, and Tolerability of Single- and Multiple-Dose Once-Daily Baricitinib in Healthy Chinese Subjects: A Randomized Placebo-Controlled Study.
Clinical pharmacology in drug development.
2020 11; 9(8):952-960. doi:
10.1002/cpdd.868. [PMID: 32945153] - A B Sioofy-Khojine, A Honkimaa, H Hyöty. A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses.
Diabetic medicine : a journal of the British Diabetic Association.
2020 11; 37(11):1849-1853. doi:
10.1111/dme.14175. [PMID: 31705692] - Keyang Wu, Yang Li, Peipei Pan, Zengqiang Li, Yige Yu, Jianjian Huang, Feifei Ma, Lili Tian, Yinghui Fang, Yiyan Wang, Han Lin, Ren-Shan Ge. Gestational vinclozolin exposure suppresses fetal testis development in rats.
Ecotoxicology and environmental safety.
2020 Oct; 203(?):111053. doi:
10.1016/j.ecoenv.2020.111053. [PMID: 32888615] - Peili Jiao, Yuxi Wang, Beibei Mao, Bingding Wang, Yi Zhong, Hongwei Jin, Lihe Zhang, Liangren Zhang, Zhenming Liu. Discovery of 2-(2-aminobenzo[d]thiazol-6-yl) benzo[d]oxazol-5-amine derivatives that regulated HPV relevant cellular pathway and prevented cervical cancer from abnormal proliferation.
European journal of medicinal chemistry.
2020 Oct; 204(?):112556. doi:
10.1016/j.ejmech.2020.112556. [PMID: 32739649] - Jacob Machin, Taylor Childers, Sucheta Kudrimoti, Rod Eisenberg, Clara Fenger, Petra Hartmann, George Maylin, Theodore Shults, Thomas Tobin. Synthesis and characterization of barbarin, a possible source of unexplained aminorex identifications in forensic science.
Drug testing and analysis.
2020 Oct; 12(10):1477-1482. doi:
10.1002/dta.2883. [PMID: 32567235] - Kit Man Chan, Cherine Amoura, Amelia Whiteley, Julien Rouget, Hanieh Safizadeh Shirazi, Alex Cavallaro, Krasimir Vasilev, Melanie MacGregor. Functional nanothin films plasma-deposited from 2-isopropenyl-2-oxazoline for biosensor applications.
Biointerphases.
2020 09; 15(5):051005. doi:
10.1116/6.0000499. [PMID: 32972145] - Yong-Jiang Wang, Li Wang, Xin He, Dong-Dong Xu, Jun Tang, Ya-Tuan Ma, Yi-Jun Yan, Yu-Cheng Gu, Jing Yang, Sheng-Xiong Huang. Characterization of inthomycin biosynthetic gene cluster revealing new insights into carboxamide formation.
Chinese journal of natural medicines.
2020 Sep; 18(9):677-683. doi:
10.1016/s1875-5364(20)60006-1. [PMID: 32928511] - L Simon, N Marcotte, J M Devoisselle, S Begu, V Lapinte. Recent advances and prospects in nano drug delivery systems using lipopolyoxazolines.
International journal of pharmaceutics.
2020 Jul; 585(?):119536. doi:
10.1016/j.ijpharm.2020.119536. [PMID: 32531447] - Ping Zhang, Yuhan He, Sheng Wang, Dongmei Shi, Yangyang Xu, Furong Yang, Jianhao Wang, Lin He. Chiral Separation and Determination of Etoxazole Enantiomers in Vegetables by Normal-Phase and Reverse-Phase High Performance Liquid Chromatography.
Molecules (Basel, Switzerland).
2020 Jul; 25(14):. doi:
10.3390/molecules25143134. [PMID: 32659902] - Shaoyong Ke, Wei Fang, Wenbo Huang, Zhigang Zhang, Liqiao Shi, Zhongyi Wan, Kaimei Wang, Chunxia Cao, Daye Huang. Sulfur-containing natural hinduchelins derivatives as potential antifungal agents against Rhizoctonia solani.
Bioorganic & medicinal chemistry letters.
2020 07; 30(13):127245. doi:
10.1016/j.bmcl.2020.127245. [PMID: 32389528] - Su-Youn Cho, Wi-Young So, Hee-Tae Roh. Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22phox Subunit and Aerobic Fitness Levels on Redox State Biomarkers and DNA Damage Responses to Exhaustive Exercise: A Randomized Trial.
International journal of environmental research and public health.
2020 06; 17(12):. doi:
10.3390/ijerph17124215. [PMID: 32545655] - Paulina Knobloch, Hendrik Koliwer-Brandl, Fabian M Arnold, Nabil Hanna, Imre Gonda, Sophia Adenau, Nicolas Personnic, Caroline Barisch, Markus A Seeger, Thierry Soldati, Hubert Hilbi. Mycobacterium marinum produces distinct mycobactin and carboxymycobactin siderophores to promote growth in broth and phagocytes.
Cellular microbiology.
2020 05; 22(5):e13163. doi:
10.1111/cmi.13163. [PMID: 31945239] - Wenhui Jin, Longhe Yang, Zhiwei Yi, Hua Fang, Weizhu Chen, Zhuan Hong, Yiping Zhang, Guangya Zhang, Long Li. Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway.
Marine drugs.
2020 Apr; 18(4):. doi:
10.3390/md18040222. [PMID: 32326173] - L Simon, V Lapinte, L Lionnard, N Marcotte, M Morille, A Aouacheria, K Kissa, J M Devoisselle, S Bégu. Polyoxazolines based lipid nanocapsules for topical delivery of antioxidants.
International journal of pharmaceutics.
2020 Apr; 579(?):119126. doi:
10.1016/j.ijpharm.2020.119126. [PMID: 32070758] - Ya-Nan Wang, Bing Xu, Li-Hua Qiu, Ru Sun, Yu-Jie Xu, Jian-Feng Ge. The fluorescent markers based on oxazolopyridine unit for imaging organelles.
Bioorganic & medicinal chemistry letters.
2020 04; 30(7):126996. doi:
10.1016/j.bmcl.2020.126996. [PMID: 32033852] - Chun-Liu Han, Chang-Zhi Qu. Cardiovascular Risk and Safety Evaluation of a Dual Peroxisome Proliferator-Activated Receptor-Alpha/Gamma Agonist, Aleglitazar, in Patients With Type 2 Diabetes: A Meta-analysis.
Journal of cardiovascular pharmacology.
2020 04; 75(4):351-357. doi:
10.1097/fjc.0000000000000796. [PMID: 31929323] - Xunan Zheng, Wei Liu, Dawei Zhang. Recent Advances in the Synthesis of Oxazole-Based Molecules via van Leusen Oxazole Synthesis.
Molecules (Basel, Switzerland).
2020 Mar; 25(7):. doi:
10.3390/molecules25071594. [PMID: 32244317] - Alexandrina Volobueva, Anna Egorova, Anastasia Galochkina, Sean Ekins, Vladimir Zarubaev, Vadim Makarov. The Evolution of Pleconaril: Modified O-Alkyl Linker Analogs Have Biological Activity towards Coxsackievirus B3 Nancy.
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061345. [PMID: 32188089] - Abhinav Sharma, Neha J Pagidipati, Robert M Califf, Darren K McGuire, Jennifer B Green, Dave Demets, Jyothis Thomas George, Hertzel C Gerstein, Todd Hobbs, Rury R Holman, Francesca C Lawson, Lawrence A Leiter, Marc A Pfeffer, Jane Reusch, Jeffrey S Riesmeyer, Matthew T Roe, Yves Rosenberg, Robert Temple, Stephen Wiviott, John McMurray, Christopher Granger. Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions.
Circulation.
2020 03; 141(10):843-862. doi:
10.1161/circulationaha.119.041022. [PMID: 31992065] - Andrey A Ivashchenko, Yan A Ivanenkov, Angela G Koryakova, Ruben N Karapetian, Oleg D Mitkin, Vladimir A Aladinskiy, Dmitry V Kravchenko, Nikolai P Savchuk, Alexander V Ivashchenko. Synthesis, biological evaluation and in silico modeling of novel integrase strand transfer inhibitors (INSTIs).
European journal of medicinal chemistry.
2020 Mar; 189(?):112064. doi:
10.1016/j.ejmech.2020.112064. [PMID: 31972393] - Millissia Ben Maamar, Stephanie E King, Eric Nilsson, Daniel Beck, Michael K Skinner. Epigenetic transgenerational inheritance of parent-of-origin allelic transmission of outcross pathology and sperm epimutations.
Developmental biology.
2020 02; 458(1):106-119. doi:
10.1016/j.ydbio.2019.10.030. [PMID: 31682807] - Naim Alkhouri, Eric Lawitz, Mazen Noureddin, Ralph DeFronzo, Gerald I Shulman. GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH).
Expert opinion on investigational drugs.
2020 Feb; 29(2):135-141. doi:
10.1080/13543784.2020.1668374. [PMID: 31519114] - Frank Richard, Jan Jaap van Lier, Bernard Roubert, Teba Haboubi, Udo-Michael Göhring, Franz Dürrenberger. Oral ferroportin inhibitor VIT-2763: First-in-human, phase 1 study in healthy volunteers.
American journal of hematology.
2020 01; 95(1):68-77. doi:
10.1002/ajh.25670. [PMID: 31674058] - Mitsuharu Matsumoto, Hiroaki Yashiro, Hitomi Ogino, Kazunobu Aoyama, Tadahiro Nambu, Sayuri Nakamura, Mayumi Nishida, Xiaolun Wang, Derek M Erion, Manami Kaneko. Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.
PloS one.
2020; 15(1):e0228212. doi:
10.1371/journal.pone.0228212. [PMID: 31990961] - Xinjia Yan, Jing Wen, Lin Zhou, Lei Fan, Xiaobo Wang, Zhi Xu. Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity.
Current topics in medicinal chemistry.
2020; 20(21):1916-1937. doi:
10.2174/1568026620666200624161151. [PMID: 32579505] - Jeroen V Koomen, Hiddo J L Heerspink, Ilse C Schrieks, Gregory G Schwartz, A Michael Lincoff, Stephen J Nicholls, Anders Svensson, Hans Wedel, Arlette Weichert, Diederick E Grobbee, Jasper Stevens. Exposure and response analysis of aleglitazar on cardiovascular risk markers and safety outcomes: An analysis of the AleCardio trial.
Diabetes, obesity & metabolism.
2020 01; 22(1):30-38. doi:
10.1111/dom.13862. [PMID: 31468659] - Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen, Daowen Wang. PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis.
BMC cancer.
2019 Dec; 19(1):1166. doi:
10.1186/s12885-019-6379-5. [PMID: 31791289]