Isohumulone (BioDeep_00000400502)

   

natural product


代谢物信息卡片


Isohumulone

化学式: C21H30O5 (362.209313)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)=CCC(=O)C1(O)C(O)=C(C(=O)CC(C)C)C(=O)C1CC=C(C)C
InChI: InChI=1S/C21H30O5/c1-12(2)7-9-15-19(24)18(16(22)11-14(5)6)20(25)21(15,26)17(23)10-8-13(3)4/h7-8,14-15,25-26H,9-11H2,1-6H3

描述信息

同义名列表

1 个代谢物同义名

Isohumulone



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bernard P Kok, Andrea Galmozzi, Nicole K Littlejohn, Verena Albert, Cristina Godio, Woojoo Kim, Sean M Kim, Jeffrey S Bland, Neile Grayson, Mingliang Fang, Wolfgang Meyerhof, Gary Siuzdak, Supriya Srinivasan, Maik Behrens, Enrique Saez. Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits. Molecular metabolism. 2018 10; 16(?):76-87. doi: 10.1016/j.molmet.2018.07.013. [PMID: 30120064]
  • Junko Tomita, Seiichi Mochizuki, Sohachi Fujimoto, Naoki Kashihara, Takashi Akasaka, Mitsune Tanimoto, Kiyoshi Yoshida. Acute improvement of endothelial functions after oral ingestion of isohumulones, bitter components of beer. Biochemical and biophysical research communications. 2017 Mar; 484(4):740-745. doi: 10.1016/j.bbrc.2017.01.133. [PMID: 28131837]
  • Ko Cattoor, Jean-Paul Remon, Koen Boussery, Jan Van Bocxlaer, Marc Bracke, Denis De Keukeleire, Dieter Deforce, Arne Heyerick. Bioavailability of hop-derived iso-α-acids and reduced derivatives. Food & function. 2011 Jul; 2(7):412-22. doi: 10.1039/c1fo10009b. [PMID: 21894329]
  • Kuniaki Obara, Mai Mizutani, Yoshitaka Hitomi, Hiroaki Yajima, Keiji Kondo. Isohumulones, the bitter component of beer, improve hyperglycemia and decrease body fat in Japanese subjects with prediabetes. Clinical nutrition (Edinburgh, Scotland). 2009 Jun; 28(3):278-84. doi: 10.1016/j.clnu.2009.03.012. [PMID: 19395131]
  • Tamehachi Namikoshi, Naruya Tomita, Sohachi Fujimoto, Yoshisuke Haruna, Masahito Ohzeki, Norio Komai, Tamaki Sasaki, Aruto Yoshida, Naoki Kashihara. Isohumulones derived from hops ameliorate renal injury via an anti-oxidative effect in Dahl salt-sensitive rats. Hypertension research : official journal of the Japanese Society of Hypertension. 2007 Feb; 30(2):175-84. doi: 10.1291/hypres.30.175. [PMID: 17460388]
  • Masako Shimura, Akiko Hasumi, Toshiko Minato, Mayu Hosono, Yutaka Miura, Satoru Mizutani, Keiji Kondo, Shinichi Oikawa, Aruto Yoshida. Isohumulones modulate blood lipid status through the activation of PPAR alpha. Biochimica et biophysica acta. 2005 Sep; 1736(1):51-60. doi: 10.1016/j.bbalip.2005.06.008. [PMID: 16099209]
  • H Yajima, T Noguchi, E Ikeshima, M Shiraki, T Kanaya, N Tsuboyama-Kasaoka, O Ezaki, S Oikawa, K Kondo. Prevention of diet-induced obesity by dietary isomerized hop extract containing isohumulones, in rodents. International journal of obesity (2005). 2005 Aug; 29(8):991-7. doi: 10.1038/sj.ijo.0802965. [PMID: 15852044]
  • Yutaka Miura, Mayu Hosono, Chiaki Oyamada, Hideharu Odai, Shinichi Oikawa, Keiji Kondo. Dietary isohumulones, the bitter components of beer, raise plasma HDL-cholesterol levels and reduce liver cholesterol and triacylglycerol contents similar to PPARalpha activations in C57BL/6 mice. The British journal of nutrition. 2005 Apr; 93(4):559-67. doi: 10.1079/bjn20041384. [PMID: 15946420]
  • Hiroaki Yajima, Emiko Ikeshima, Maho Shiraki, Tomoka Kanaya, Daisuke Fujiwara, Hideharu Odai, Nobuyo Tsuboyama-Kasaoka, Osamu Ezaki, Shinichi Oikawa, Keiji Kondo. Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. The Journal of biological chemistry. 2004 Aug; 279(32):33456-62. doi: 10.1074/jbc.m403456200. [PMID: 15178687]