Nicholin (BioDeep_00000400312)
Main id: BioDeep_00000000744
natural product PANOMIX_OTCML-2023
代谢物信息卡片
cytidine 5-diphosphocholine
化学式: C14H26N4O11P2 (488.10732659999996)
中文名称: 胞磷胆碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+](C)(C)CCOP(=O)(O)OP(=O)([O-])OCC1C(C(C(O1)N2C=CC(=NC2=O)N)O)O
InChI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
Citicoline (Cytidine diphosphate-choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
Citicoline (Cytidine diphosphate-choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:16436
- PubChem: 11583971
- ChEMBL: CHEMBL1231700
- MeSH: Cytidine Diphosphate Choline
- CAS: 987-78-0
- MoNA: PT107070
- medchemexpress: HY-B0739
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhenhua Wang, Meng Yang, Yufan Yang, Yonglin He, Hongwu Qian. Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1.
Nature communications.
2023 May; 14(1):2529. doi:
10.1038/s41467-023-38290-2. [PMID: 37137909] - Qin Zhang, Hong Zhang, Chun-Mei Yang, Bo Wang, Chen-Yang Li, Qi Li. [Mechanism of active ingredients in Periploca forrestii compound against rheumatoid arthritis based on integrative metabolomics and network pharmacology].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jan; 48(2):507-516. doi:
10.19540/j.cnki.cjcmm.20220913.702. [PMID: 36725240] - Cheng Zheng, Mingjin Qu, Yingmiao Liu, Junzhi Wang, Hanjie Ying. Design and optimizing a new CDP-choline in vitro multienzyme producing process starts from d-ribose.
Biotechnology and applied biochemistry.
2022 Jun; 69(3):1029-1035. doi:
10.1002/bab.2173. [PMID: 33885187] - Hussein M Eid, Adel A Ali, Ahmed M Abdelhaleem Ali, Essam M Eissa, Randa M Hassan, Fatma I Abo El-Ela, Amira H Hassan. Potential Use of Tailored Citicoline Chitosan-Coated Liposomes for Effective Wound Healing in Diabetic Rat Model.
International journal of nanomedicine.
2022; 17(?):555-575. doi:
10.2147/ijn.s342504. [PMID: 35153481] - Cheng Zheng, Rongxin Miao, Yingmiao Liu, Yang Cao, Dong Liu, Junzhi Wang, Hanjie Ying. A Procedure to Design One-Pot Multi-enzyme System for Industrial CDP-Choline Production.
Applied biochemistry and biotechnology.
2021 Sep; 193(9):2769-2780. doi:
10.1007/s12010-021-03564-2. [PMID: 34117628] - Lucia E Rosas, Lauren M Doolittle, Lisa M Joseph, Hasan El-Musa, Michael V Novotny, Judy M Hickman-Davis, R Duncan Hite, Ian C Davis. Postexposure Liponucleotide Prophylaxis and Treatment Attenuates Acute Respiratory Distress Syndrome in Influenza-infected Mice.
American journal of respiratory cell and molecular biology.
2021 06; 64(6):677-686. doi:
10.1165/rcmb.2020-0465oc. [PMID: 33606602] - O A Gromova, I Yu Torshin, T R Grishina, V I Demidov, T E Bogacheva. [Molecular and clinical aspects of the effect of cytidyndiphosphocholine on cognitive functions].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2021; 121(5):88-97. doi:
10.17116/jnevro202112105188. [PMID: 34184483] - Annagrazia Adornetto, Laura Rombolà, Luigi Antonio Morrone, Carlo Nucci, Maria Tiziana Corasaniti, Giacinto Bagetta, Rossella Russo. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma.
Nutrients.
2020 Oct; 12(10):. doi:
10.3390/nu12103158. [PMID: 33081127] - Xiguang Feng, Yi Chen, Min Zhang, Miaojie Fang, Cuimei Xiao, Junzhu Chen. Protective effect of citicoline on random flap survival in a rat mode.
International immunopharmacology.
2020 Jun; 83(?):106448. doi:
10.1016/j.intimp.2020.106448. [PMID: 32247268] - Azadeh Aminzadeh, Ayda Salarinejad. Citicoline protects against lead-induced oxidative injury in neuronal PC12 cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2019 12; 97(6):715-721. doi:
10.1139/bcb-2018-0218. [PMID: 30925221] - Kamil Synoradzki, Paweł Grieb. Citicoline: A Superior Form of Choline?.
Nutrients.
2019 Jul; 11(7):. doi:
10.3390/nu11071569. [PMID: 31336819] - Mark B Plotnikov, Galina A Chernysheva, Oleg I Aliev, Vera I Smol'iakova, Tatiana I Fomina, Anton N Osipenko, Victoria S Rydchenko, Yana J Anfinogenova, Andrei I Khlebnikov, Igor A Schepetkin, Dmitriy N Atochin. Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091722. [PMID: 31058815] - Jing-Wen Yang, Guang-Xia Shi, Shuai Zhang, Jian-Feng Tu, Li-Qiong Wang, Chao-Qun Yan, Lu-Lu Lin, Bao-Zhen Liu, Jun Wang, San-Feng Sun, Bo-Feng Yang, Li-Yu Wu, Cheng Tan, Sheng Chen, Zhang-Jin Zhang, Marc Fisher, Cun-Zhi Liu. Effectiveness of acupuncture for vascular cognitive impairment no dementia: a randomized controlled trial.
Clinical rehabilitation.
2019 Apr; 33(4):642-652. doi:
10.1177/0269215518819050. [PMID: 30672317] - Su Myat Phyu, Chih-Chung Tseng, Tim Andrew Davies Smith. CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor.
Magma (New York, N.Y.).
2019 Apr; 32(2):227-235. doi:
10.1007/s10334-018-0719-3. [PMID: 30446846] - Cheng Zheng, Zhenjian Li, Haifeng Yang, Tianyi Zhang, Huanqing Niu, Dong Liu, Junzhi Wang, Hanjie Ying. Computation-aided rational design of a halophilic choline kinase for cytidine diphosphate choline production in high-salt condition.
Journal of biotechnology.
2019 Jan; 290(?):59-66. doi:
10.1016/j.jbiotec.2018.11.008. [PMID: 30445133] - Cecilia Zazueta, Mabel Buelna-Chontal, Arturo Macías-López, Nadia G Román-Anguiano, Héctor González-Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda-Frausto, Rafael Bojalil, Alejandro Silva-Palacios, Rodrigo Velázquez-Espejel, Sonia Galvan Arzate, Francisco Correa. Cytidine-5'-Diphosphocholine Protects the Liver From Ischemia/Reperfusion Injury Preserving Mitochondrial Function and Reducing Oxidative Stress.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2018 08; 24(8):1070-1083. doi:
10.1002/lt.25179. [PMID: 29679463] - M Castro-Gago, D Dacruz, C Gomez-Lado, J Eiris-Punal. [Treatment of choline kinase beta deficiency with citicoline].
Revista de neurologia.
2018 07; 67(1):40. doi:
. [PMID: 29923598] - Sapto Yuliani, Mustofa, Ginus Partadiredja. Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats.
Drug and chemical toxicology.
2018 Jan; 41(1):62-71. doi:
10.1080/01480545.2017.1293087. [PMID: 28440093] - Yixiong Chen, Bing Li, Kai Cen, Yuzhen Lu, Siwei Zhang, Chengshu Wang. Diverse effect of phosphatidylcholine biosynthetic genes on phospholipid homeostasis, cell autophagy and fungal developments in Metarhizium robertsii.
Environmental microbiology.
2018 01; 20(1):293-304. doi:
10.1111/1462-2920.13998. [PMID: 29159973] - Ahmed O Abdel-Zaher, Mostafa M Hamdy, Mahran S Abdel-Rahman, Doaa H Abd El-Hamid. Protective effect of citicoline against aluminum-induced cognitive impairments in rats.
Toxicology and industrial health.
2017 Apr; 33(4):308-317. doi:
10.1177/0748233716641869. [PMID: 27178312] - Yingmiao Liu, Junzhi Wang, Chongmao Xu, Yong Chen, Junjie Yang, Dong Liu, Huanqing Niu, Yu Jiang, Sheng Yang, Hanjie Ying. Efficient multi-enzyme-catalyzed CDP-choline production driven by an ATP donor module.
Applied microbiology and biotechnology.
2017 Feb; 101(4):1409-1417. doi:
10.1007/s00253-016-7874-0. [PMID: 27738720] - Parker S Woods, Lauren M Doolittle, Lucia E Rosas, Lisa M Joseph, Edward P Calomeni, Ian C Davis. Lethal H1N1 influenza A virus infection alters the murine alveolar type II cell surfactant lipidome.
American journal of physiology. Lung cellular and molecular physiology.
2016 12; 311(6):L1160-L1169. doi:
10.1152/ajplung.00339.2016. [PMID: 27836900] - L V Kuznetsova, M N Karpova, K A Zinkovski, N Yu Klishina. Аnticonvulsant effects of citicoline and diazepam at their combined application on model of the acute generalized convulsions induced by pentylenetetrazole in Wistar rats.
Patologicheskaia fiziologiia i eksperimental'naia terapiia.
2016 Oct; 60(4):20-3. doi:
". [PMID: 29244918] - E Yu Solovieva, K I Farrahova, A N Karneev, D T Chipova. [Phospholipids metabolism disorders in acute stroke].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2016; 116(1):104-112. doi:
10.17116/jnevro201611611104-112. [PMID: 27045147] - Alicia Contet, Emilie Pihan, Marina Lavigne, Kai Wengelnik, Sweta Maheshwari, Henri Vial, Dominique Douguet, Rachel Cerdan. Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening.
FEBS letters.
2015 Apr; 589(9):992-1000. doi:
10.1016/j.febslet.2015.03.003. [PMID: 25771858] - Martina Gsell, Ariane Fankl, Lisa Klug, Gerald Mascher, Claudia Schmidt, Claudia Hrastnik, Günther Zellnig, Günther Daum. A Yeast Mutant Deleted of GPH1 Bears Defects in Lipid Metabolism.
PloS one.
2015; 10(9):e0136957. doi:
10.1371/journal.pone.0136957. [PMID: 26327557] - Vid V Flis, Ariane Fankl, Claudia Ramprecht, Günther Zellnig, Erich Leitner, Albin Hermetter, Günther Daum. Phosphatidylcholine Supply to Peroxisomes of the Yeast Saccharomyces cerevisiae.
PloS one.
2015; 10(8):e0135084. doi:
10.1371/journal.pone.0135084. [PMID: 26241051] - Craig C Morton, Adam J Aitchison, Karsten Gehrig, Neale D Ridgway. A mechanism for suppression of the CDP-choline pathway during apoptosis.
Journal of lipid research.
2013 Dec; 54(12):3373-84. doi:
10.1194/jlr.m041434. [PMID: 24136823] - Gergely N Nagy, Lívia Marton, Balázs Krámos, Julianna Oláh, Ágnes Révész, Károly Vékey, Frédéric Delsuc, Éva Hunyadi-Gulyás, Katalin F Medzihradszky, Marina Lavigne, Henri Vial, Rachel Cerdan, Beáta G Vértessy. Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.
The FEBS journal.
2013 Jul; 280(13):3132-48. doi:
10.1111/febs.12282. [PMID: 23578277] - Paolo Fagone, Suzanne Jackowski. Phosphatidylcholine and the CDP-choline cycle.
Biochimica et biophysica acta.
2013 Mar; 1831(3):523-32. doi:
10.1016/j.bbalip.2012.09.009. [PMID: 23010477] - Mourad Chioua, David Sucunza, Elena Soriano, Dimitra Hadjipavlou-Litina, Alberto Alcázar, Irene Ayuso, María Jesús Oset-Gasque, María Pilar González, Leticia Monjas, María Isabel Rodríguez-Franco, José Marco-Contelles, Abdelouahid Samadi. Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.
Journal of medicinal chemistry.
2012 Jan; 55(1):153-68. doi:
10.1021/jm201105a. [PMID: 22126405] - Lorissa J Niebergall, René L Jacobs, Todd Chaba, Dennis E Vance. Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.
Biochimica et biophysica acta.
2011 Dec; 1811(12):1177-85. doi:
10.1016/j.bbalip.2011.06.021. [PMID: 21745592] - Ozge Guldali, Vahide Savci, Kansu Buyukafsar. CDP-choline-induced contractions in the mouse gastric fundus through purinoceptors and Rho/Rho-kinase signalling.
Life sciences.
2011 Mar; 88(11-12):473-9. doi:
10.1016/j.lfs.2011.01.002. [PMID: 21219915] - Christopher J Pynn, Neil G Henderson, Howard Clark, Grielof Koster, Wolfgang Bernhard, Anthony D Postle. Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo.
Journal of lipid research.
2011 Feb; 52(2):399-407. doi:
10.1194/jlr.d011916. [PMID: 21068006] - S Ghosh, N Das, A K Mandal, S R Dungdung, S Sarkar. Mannosylated liposomal cytidine 5' diphosphocholine prevent age related global moderate cerebral ischemia reperfusion induced mitochondrial cytochrome c release in aged rat brain.
Neuroscience.
2010 Dec; 171(4):1287-99. doi:
10.1016/j.neuroscience.2010.09.049. [PMID: 20883746] - Ahmet Menku, Mustafa Ogden, Recep Saraymen. The protective effects of propofol and citicoline combination in experimental head injury in rats.
Turkish neurosurgery.
2010 Jan; 20(1):57-62. doi:
. [PMID: 20066623] - Yesim Ozarda Ilcol, Zeki Yilmaz, Mehmet Cansev, Ismail H Ulus. Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: involvement of the peripheral nicotinic acetylcholine receptors.
Shock (Augusta, Ga.).
2009 Sep; 32(3):286-94. doi:
10.1097/shk.0b013e3181971b02. [PMID: 19060783] - Hemamalini Bommiasamy, Sung Hoon Back, Paolo Fagone, Kyungho Lee, Sasha Meshinchi, Elizabeth Vink, Rungtawan Sriburi, Matthew Frank, Suzanne Jackowski, Randal J Kaufman, Joseph W Brewer. ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.
Journal of cell science.
2009 May; 122(Pt 10):1626-36. doi:
10.1242/jcs.045625. [PMID: 19420237] - Jens Minnerup, Wolf-Rüdiger Schäbitz. Multifunctional actions of approved and candidate stroke drugs.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2009 Jan; 6(1):43-52. doi:
10.1016/j.nurt.2008.10.032. [PMID: 19110198] - Ya Liu, Ning Li, Xing-Wu Ran. [Clinical effect of ligustrazine combined with citicoline for treatment of diabetic peripheral neuropathy].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2008 Jul; 28(7):606-9. doi:
". [PMID: 18822909] - O Hurtado, J M Pradillo, D Fernández-López, J R Morales, T Sobrino, J Castillo, E Alborch, M A Moro, I Lizasoain. Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke.
Neurobiology of disease.
2008 Jan; 29(1):123-31. doi:
10.1016/j.nbd.2007.08.004. [PMID: 17884513] - William Harold Witola, Choukri Ben Mamoun. Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase.
Eukaryotic cell.
2007 Sep; 6(9):1618-24. doi:
10.1128/ec.00229-07. [PMID: 17644653] - William H Witola, Gabriella Pessi, Kamal El Bissati, Jennifer M Reynolds, Choukri Ben Mamoun. Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus.
The Journal of biological chemistry.
2006 Jul; 281(30):21305-21311. doi:
10.1074/jbc.m603260200. [PMID: 16704982] - Neslihan Yücel, Süleyman R Cayli, Ozkan Ateş, Neşe Karadağ, Serpil Firat, Yusuf Turköz. Evaluation of the neuroprotective effects of citicoline after experimental spinal cord injury: improved behavioral and neuroanatomical recovery.
Neurochemical research.
2006 Jun; 31(6):767-75. doi:
10.1007/s11064-006-9075-1. [PMID: 16794862] - Maria José Caballero, Germán Gallardo, Lidia Robaina, Daniel Montero, Antonio Fernández, Marisol Izquierdo. Vegetable lipid sources affect in vitro biosynthesis of triacylglycerols and phospholipids in the intestine of sea bream (Sparus aurata).
The British journal of nutrition.
2006 Mar; 95(3):448-54. doi:
10.1079/bjn20051529. [PMID: 16512929] - Jannapally Suresh Reddy, Vobalaboina Venkateswarlu, Gerben A Koning. Radioprotective effect of transferrin targeted citicoline liposomes.
Journal of drug targeting.
2006 Jan; 14(1):13-9. doi:
10.1080/10611860600613241. [PMID: 16603447] - Mario Fioravanti, Ann E Buckley. Citicoline (Cognizin) in the treatment of cognitive impairment.
Clinical interventions in aging.
2006; 1(3):247-51. doi:
10.2147/ciia.2006.1.3.247. [PMID: 18046877] - Ertugrul Cakir, Haydar Usul, Bekircan Peksoylu, Ozgur C Sayin, Ahmet Alver, Murat Topbas, Suleyman Baykal, Kayhan Kuzeyli. Effects of citicoline on experimental spinal cord injury.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2005 Nov; 12(8):923-6. doi:
10.1016/j.jocn.2005.03.013. [PMID: 16257217] - J Krupinski, M Slevin, L Badimon. Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia.
Neurochemical research.
2005 Aug; 30(8):1067-73. doi:
10.1007/s11064-005-7201-0. [PMID: 16258856] - Shang-qian Zhong, Li-jing Sun, Yu-zhen Yan, Yan-qin Sun, Yin-yuan Zhong. Effect of Xuesaitong soft capsule on hemorrheology and in auxiliarily treating patients with acute cerebral infarction.
Chinese journal of integrative medicine.
2005 Jun; 11(2):128-31. doi:
10.1007/bf02836469. [PMID: 16150200] - Rao Muralikrishna Adibhatla, J F Hatcher. Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders.
Neurochemical research.
2005 Jan; 30(1):15-23. doi:
10.1007/s11064-004-9681-8. [PMID: 15756928] - Magdalena Gewartowska, Waldemar L Olszewski. The new approaches to preservation of graft cell integrity in preservation for transplantation.
Annals of transplantation.
2005; 10(4):6-10. doi:
NULL. [PMID: 17037081] - Howard M Jernigan, Penny S Blum, Ipsit Chakrabarti, Yin Su, J Samuel Zigler. Effects of cataractogenesis on the CDP-choline pathway: increased phospholipid synthesis in lenses from galactosemic rats and 13/N guinea pigs.
Ophthalmic research.
2005 Jan; 37(1):7-12. doi:
10.1159/000082764. [PMID: 15604593] - Beth Ann Helmink, Jon A Friesen. Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster.
Biochimica et biophysica acta.
2004 Jul; 1683(1-3):78-88. doi:
10.1016/j.bbalip.2004.04.008. [PMID: 15238222] - Marcia M Wright, Alicia G Howe, Vanina Zaremberg. Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2004 Feb; 82(1):18-26. doi:
10.1139/o03-092. [PMID: 15052325] - Claudia Kent, Patricia Gee, Si Young Lee, Xuelin Bian, J Christopher Fenno. A CDP-choline pathway for phosphatidylcholine biosynthesis in Treponema denticola.
Molecular microbiology.
2004 Jan; 51(2):471-81. doi:
10.1046/j.1365-2958.2003.03839.x. [PMID: 14756787] - Rao Muralikrishna Adibhatla, James F Hatcher, Robert J Dempsey. Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia.
Antioxidants & redox signaling.
2003 Oct; 5(5):647-54. doi:
10.1089/152308603770310329. [PMID: 14580322] - Rao Muralikrishna Adibhatla, James F Hatcher. Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia.
Journal of neuroscience research.
2003 Aug; 73(3):308-15. doi:
10.1002/jnr.10672. [PMID: 12868064] - Neale D Ridgway, Thomas A Lagace. Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.
The Biochemical journal.
2003 Jun; 372(Pt 3):811-9. doi:
10.1042/bj20030252. [PMID: 12659631] - Henry A Boumann, Mirjam J A Damen, Cees Versluis, Albert J R Heck, Ben de Kruijff, Anton I P M de Kroon. The two biosynthetic routes leading to phosphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling.
Biochemistry.
2003 Mar; 42(10):3054-9. doi:
10.1021/bi026801r. [PMID: 12627972] - Rao Muralikrishna Adibhatla, J F Hatcher. Citicoline mechanisms and clinical efficacy in cerebral ischemia.
Journal of neuroscience research.
2002 Oct; 70(2):133-9. doi:
10.1002/jnr.10403. [PMID: 12271462] - Rao Muralikrishna Adibhatla, J F Hatcher, R J Dempsey. Citicoline: neuroprotective mechanisms in cerebral ischemia.
Journal of neurochemistry.
2002 Jan; 80(1):12-23. doi:
10.1046/j.0022-3042.2001.00697.x. [PMID: 11796739] - A N Hunt, G T Clark, G S Attard, A D Postle. Highly saturated endonuclear phosphatidylcholine is synthesized in situ and colocated with CDP-choline pathway enzymes.
The Journal of biological chemistry.
2001 Mar; 276(11):8492-9. doi:
10.1074/jbc.m009878200. [PMID: 11121419] - A M Rao, J F Hatcher, R J Dempsey. Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP-choline neuroprotection.
Journal of neurochemistry.
2000 Dec; 75(6):2528-35. doi:
10.1046/j.1471-4159.2000.0752528.x. [PMID: 11080206] - P Antony, J N Kanfer, L Freysz. Phosphatidylcholine metabolism in nuclei of phorbol ester-activated LA-N-1 neuroblastoma cells.
Neurochemical research.
2000 Aug; 25(8):1073-82. doi:
10.1023/a:1007613827552. [PMID: 11055744] - W Yu, F Shen, Z Ma. [Observation of therapeutic effect of Salviae miltiorrhiza and cytosine diphosphate-choline injection on patients with hypertensive cerebral hemorrhage].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2000 Feb; 20(2):94-6. doi:
". [PMID: 11783323] - A M Rao, J F Hatcher, R J Dempsey. CDP-choline: neuroprotection in transient forebrain ischemia of gerbils.
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