L-Cystathionine (BioDeep_00000399916)
Main id: BioDeep_00000001337
natural product PANOMIX_OTCML-2023
代谢物信息卡片
L-Cystathionine
化学式: C7H14N2O4S (222.0674244)
中文名称: L-胱硫醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CSCC(C(=O)O)N)C(C(=O)O)N
InChI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)
描述信息
A modified amino acid generated by enzymic means from L-homocysteine and L-serine.
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].
同义名列表
1 个代谢物同义名
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:17482
- KEGG: C02291
- PubChem: 439258
- MeSH: Cystathionine
- CAS: 56-88-2
- MoNA: EMBL-MCF_spec112852
- MoNA: EMBL-MCF_spec41597
- MoNA: MoNA016889
- MoNA: HMDB0000099_ms_ms_158
- MoNA: HMDB0000099_ms_ms_157
- MoNA: HMDB0000099_ms_ms_156
- MoNA: PM000962
- MoNA: CCMSLIB00000578190
- MoNA: CCMSLIB00000577955
- MetaboLights: MTBLC17482
- PubChem: 5347
- KNApSAcK: C00007498
- 3DMET: B01559
- NIKKAJI: J4.574H
- medchemexpress: HY-W009749
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alan Cunningham, Lieve Oudejans, Marjan Geugien, Diego A Pereira-Martins, Albertus Tj Wierenga, Ayşegül Erdem, Dominique Sternadt, Gerwin A Huls, Jan Jacob Schuringa. The 'non-essential' amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia.
Blood advances.
2023 Oct; ?(?):. doi:
10.1182/bloodadvances.2023010786. [PMID: 37906522] - Rafael Rosell, Anisha Jain, Jordi Codony-Servat, Eloisa Jantus-Lewintre, Blake Morrison, Jordi Barretina Ginesta, María González-Cao. Biological insights in non-small cell lung cancer.
Cancer biology & medicine.
2023 Jun; ?(?):. doi:
10.20892/j.issn.2095-3941.2023.0108. [PMID: 37381723] - Elena C Tore, Simone J P M Eussen, Nasser E Bastani, Pieter C Dagnelie, Amany K Elshorbagy, Pol Grootswagers, Viktor Kožich, Thomas Olsen, Helga Refsum, Kjetil Retterstøl, Coen DA Stehouwer, Emma T K Stolt, Kathrine J Vinknes, Marleen M J van Greevenbroek. The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study.
The Journal of nutrition.
2023 May; ?(?):. doi:
10.1016/j.tjnut.2023.05.008. [PMID: 37164267] - Chau M Tran, Shoko Mihara, Keisuke Yoshida, Toru Hisabori. Cystathionine-β-synthase X proteins negatively regulate NADPH-thioredoxin reductase C activity.
Biochemical and biophysical research communications.
2023 04; 653(?):47-52. doi:
10.1016/j.bbrc.2023.02.055. [PMID: 36857899] - Fei Duan, Man-Man Li, Wei-Xia Li, Jin-Fa Tang, Zhi-Wan Wang. [Serum metabolomics of chronic obstructive pulmonary disease with lung-Qi deficiency syndrome].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Apr; 47(8):2251-2256. doi:
10.19540/j.cnki.cjcmm.20211203.501. [PMID: 35531742] - N Mota-Martorell, M Jové, R Berdún, R Pamplona. Plasma methionine metabolic profile is associated with longevity in mammals.
Communications biology.
2021 06; 4(1):725. doi:
10.1038/s42003-021-02254-3. [PMID: 34117367] - Ferran Comas, Jèssica Latorre, Francisco Ortega, Núria Oliveras-Cañellas, Aina Lluch, Wifredo Ricart, José Manuel Fernández-Real, José María Moreno-Navarrete. Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.
Redox biology.
2021 06; 42(?):101668. doi:
10.1016/j.redox.2020.101668. [PMID: 32800520] - Ingrid Kvestad, Adrian McCann, Ram K Chandyo, Lasse M Giil, Merina Shrestha, Manjeswori Ulak, Mari Hysing, Per M Ueland, Tor A Strand. One-Carbon Metabolism in Nepalese Infant-Mother Pairs and Child Cognition at 5 Years Old.
The Journal of nutrition.
2021 04; 151(4):883-891. doi:
10.1093/jn/nxaa403. [PMID: 33484134] - Laurent Ouerdane, Eszter Borbála Both, Jiqian Xiang, Hongqing Yin, Yu Kang, Shuxun Shao, Katalin Kiszelák, Zsuzsa Jókai, Mihály Dernovics. Water soluble selenometabolome of Cardamine violifolia.
Metallomics : integrated biometal science.
2020 12; 12(12):2032-2048. doi:
10.1039/d0mt00216j. [PMID: 33165451] - Mads M Svenningsson, Gard F T Svingen, Vegard Lysne, Per M Ueland, Grethe S Tell, Eva R Pedersen, Indu Dhar, Dennis W Nilsen, Ottar Nygård. Transsulfuration metabolites and the association with incident atrial fibrillation - An observational cohort study among Norwegian patients with stable angina pectoris.
International journal of cardiology.
2020 Oct; 317(?):75-80. doi:
10.1016/j.ijcard.2020.05.010. [PMID: 32389762] - Yasuyuki Matoba, Masafumi Noda, Tomoki Yoshida, Kosuke Oda, Yuka Ezumi, Chiaki Yasutake, Hisae Izuhara-Kihara, Narandarai Danshiitsoodol, Takanori Kumagai, Masanori Sugiyama. Catalytic specificity of the Lactobacillus plantarum cystathionine γ-lyase presumed by the crystallographic analysis.
Scientific reports.
2020 09; 10(1):14886. doi:
10.1038/s41598-020-71756-7. [PMID: 32913258] - X M Yuan, B Zhuan, P Li, X Zhao, T Wang, Z Yang. [Expression of nicotinamide adenine dinucleotide phosphate-reduced oxidase-4/reactive oxygen species and cystathionine-γ-lyase/hydrogen sulfide in patients with chronic obstructive pulmonary disease-related pulmonary hypertension].
Zhonghua nei ke za zhi.
2019 Oct; 58(10):770-776. doi:
10.3760/cma.j.issn.0578-1426.2019.10.009. [PMID: 31594176] - Laura Kasak, Constantina Bakolitsa, Zhiqiang Hu, Changhua Yu, Jasper Rine, Dago F Dimster-Denk, Gaurav Pandey, Greet De Baets, Yana Bromberg, Chen Cao, Emidio Capriotti, Rita Casadio, Joost Van Durme, Manuel Giollo, Rachel Karchin, Panagiotis Katsonis, Emanuela Leonardi, Olivier Lichtarge, Pier Luigi Martelli, David Masica, Sean D Mooney, Ayodeji Olatubosun, Predrag Radivojac, Frederic Rousseau, Lipika R Pal, Castrense Savojardo, Joost Schymkowitz, Janita Thusberg, Silvio C E Tosatto, Mauno Vihinen, Jouni Väliaho, Susanna Repo, John Moult, Steven E Brenner, Iddo Friedberg. Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants.
Human mutation.
2019 09; 40(9):1530-1545. doi:
10.1002/humu.23868. [PMID: 31301157] - Maria F Mujica-Coopman, Dayana R Farias, Ana B Franco-Sena, Juliana S Vaz, Gilberto Kac, Yvonne Lamers. Maternal Plasma Pyridoxal 5'-Phosphate Concentration Is Inversely Associated with Plasma Cystathionine Concentration across All Trimesters in Healthy Pregnant Women.
The Journal of nutrition.
2019 08; 149(8):1354-1362. doi:
10.1093/jn/nxz082. [PMID: 31098628] - Antonio Belardo, Federica Gevi, Lello Zolla. The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children.
The Journal of nutritional biochemistry.
2019 08; 70(?):38-46. doi:
10.1016/j.jnutbio.2019.04.004. [PMID: 31151052] - Indu Dhar, Vegard Lysne, Gard F T Svingen, Per M Ueland, Jesse F Gregory, Kaare H Bønaa, Ottar K Nygård. Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease.
The American journal of clinical nutrition.
2019 06; 109(6):1546-1554. doi:
10.1093/ajcn/nqy391. [PMID: 31005968] - Lili Shi, Chao Han, Shuai Liu, Yiqun Liu, Xuesong Xiang. [Effects of methionine on the activity of cystathionine-β-synthase].
Wei sheng yan jiu = Journal of hygiene research.
2019 May; 48(3):463-467. doi:
. [PMID: 31133135] - Thomas Olsen, Bente Øvrebø, Cheryl Turner, Nasser E Bastani, Helga Refsum, Kathrine J Vinknes. Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial.
Nutrients.
2018 Nov; 10(12):. doi:
10.3390/nu10121822. [PMID: 30477080] - Indu Dhar, Gard F T Svingen, Per M Ueland, Vegard Lysne, Mads M Svenningsson, Grethe S Tell, Ottar K Nygård. Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris.
Journal of the American Heart Association.
2018 09; 7(17):e008824. doi:
10.1161/jaha.118.008824. [PMID: 30371177] - Indu Dhar, Gard F T Svingen, Eva R Pedersen, Barbara DeRatt, Arve Ulvik, Elin Strand, Per M Ueland, Kaare H Bønaa, Jesse F Gregory, Ottar K Nygård. Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: Results from two independent cohorts.
International journal of cardiology.
2018 Sep; 266(?):24-30. doi:
10.1016/j.ijcard.2018.04.083. [PMID: 29728335] - Shozo Tomonaga, Hirofumi Okuyama, Tetsuya Tachibana, Ryosuke Makino. Effects of high ambient temperature on plasma metabolomic profiles in chicks.
Animal science journal = Nihon chikusan Gakkaiho.
2018 Feb; 89(2):448-455. doi:
10.1111/asj.12951. [PMID: 29154397] - Barbara N DeRatt, Maria A Ralat, Vegard Lysne, Fariba Tayyari, Indu Dhar, Arthur S Edison, Timothy J Garrett, Øivind Midttun, Per Magne Ueland, Ottar Kjell Nygård, Jesse F Gregory. Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris.
The Journal of nutrition.
2017 09; 147(9):1658-1668. doi:
10.3945/jn.117.254029. [PMID: 28794210] - Yasuyuki Matoba, Tomoki Yoshida, Hisae Izuhara-Kihara, Masafumi Noda, Masanori Sugiyama. Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum.
Protein science : a publication of the Protein Society.
2017 04; 26(4):763-783. doi:
10.1002/pro.3123. [PMID: 28127810] - Wupeng Yan, Everett Stone, Yan Jessie Zhang. Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry.
2017 02; 56(6):876-885. doi:
10.1021/acs.biochem.6b01172. [PMID: 28106980] - Angelo D'Alessandro, Travis Nemkov, Lori K Bogren, Sandra L Martin, Kirk C Hansen. Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.
Journal of proteome research.
2017 02; 16(2):958-969. doi:
10.1021/acs.jproteome.6b00884. [PMID: 27991798] - Han Li, Mu Wang, Qiande Liang, Shuna Jin, Xiaojie Sun, Yangqian Jiang, Xingyun Pan, Yanqiu Zhou, Yang Peng, Bin Zhang, Aifen Zhou, Yiming Zhang, Zhong Chen, Jiangxia Cao, Hongling Zhang, Wei Xia, Tongzhang Zheng, Zongwei Cai, Yuanyuan Li, Shunqing Xu. Urinary metabolomics revealed arsenic exposure related to metabolic alterations in general Chinese pregnant women.
Journal of chromatography. A.
2017 Jan; 1479(?):145-152. doi:
10.1016/j.chroma.2016.12.007. [PMID: 27988079] - Zheng Zhou, Mario Vailati-Riboni, Daniel N Luchini, Juan J Loor. Methionine and Choline Supply during the Periparturient Period Alter Plasma Amino Acid and One-Carbon Metabolism Profiles to Various Extents: Potential Role in Hepatic Metabolism and Antioxidant Status.
Nutrients.
2016 Dec; 9(1):. doi:
10.3390/nu9010010. [PMID: 28036059] - Mélanie Pouget, Marie Perrot, Philippe Denis, Jacques Vuichoud, Dominique Dardevet, Karine Vidal, Denis Breuillé, Isabelle Papet. Long-term dietary supplementation with cystathionine improves tissue glutathione in ageing rats.
Aging clinical and experimental research.
2016 Aug; 28(4):781-5. doi:
10.1007/s40520-015-0465-6. [PMID: 26514972] - Viktor Kožich, Jakub Krijt, Jitka Sokolová, Petra Melenovská, Pavel Ješina, Roman Vozdek, Tomáš Majtán, Jan P Kraus. Thioethers as markers of hydrogen sulfide production in homocystinurias.
Biochimie.
2016 Jul; 126(?):14-20. doi:
10.1016/j.biochi.2016.01.001. [PMID: 26791043] - Clemens C Stoffregen, Elisabeth A Odin, Göran U Carlsson, Göran K Kurlberg, Hillevi G Björkqvist, Maria T Tångefjord, Bengt G Gustavsson. Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B12 supplementation.
Anti-cancer drugs.
2016 Jun; 27(5):439-46. doi:
10.1097/cad.0000000000000345. [PMID: 26825869] - Rima Obeid, Susanne H Kirsch, Sarah Dilmann, Cosima Klein, Rudolf Eckert, Jürgen Geisel, Wolfgang Herrmann. Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial.
European journal of nutrition.
2016 Apr; 55(3):1021-8. doi:
10.1007/s00394-015-0916-z. [PMID: 25943647] - Lei Yin, Kevin Shengyang Yu, Kun Lu, Xiaozhong Yu. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis.
Toxicology in vitro : an international journal published in association with BIBRA.
2016 Apr; 32(?):297-309. doi:
10.1016/j.tiv.2016.01.010. [PMID: 26820058] - Shyamchand Mayengbam, Sara Raposo, Michel Aliani, James D House. A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6-Deficient Male Rats.
The Journal of nutrition.
2016 Jan; 146(1):14-20. doi:
10.3945/jn.115.219378. [PMID: 26581680] - Kim M Holwerda, M Susanne Weedon-Fekjær, Anne C Staff, Ilja M Nolte, Harry van Goor, A Titia Lely, Marijke M Faas. The association of single nucleotide polymorphisms of the maternal cystathionine-β-synthase gene with early-onset preeclampsia.
Pregnancy hypertension.
2016 Jan; 6(1):60-5. doi:
10.1016/j.preghy.2015.12.001. [PMID: 26955774] - Luisa Rios-Avila, Bonnie Coats, Maria Ralat, Yueh-Yun Chi, Øivind Midttun, Per M Ueland, Peter W Stacpoole, Jesse F Gregory. Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
The American journal of clinical nutrition.
2015 Sep; 102(3):616-25. doi:
10.3945/ajcn.115.113159. [PMID: 26201817] - Shoichiro Funatsu, Takashi Kondoh, Takahiro Kawase, Hiromi Ikeda, Mao Nagasawa, D Michael Denbow, Mitsuhiro Furuse. Long-term consumption of dried bonito dashi (a traditional Japanese fish stock) reduces anxiety and modifies central amino acid levels in rats.
Nutritional neuroscience.
2015 Aug; 18(6):256-64. doi:
10.1179/1476830514y.0000000124. [PMID: 24701973] - Shyamchand Mayengbam, Sara Raposo, Michel Aliani, James D House. Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B₆ deficient rats.
The Journal of nutritional biochemistry.
2015 Mar; 26(3):241-9. doi:
10.1016/j.jnutbio.2014.10.014. [PMID: 25524630] - P Alcaide, J Krijt, P Ruiz-Sala, P Ješina, M Ugarte, V Kožich, B Merinero. Enzymatic diagnosis of homocystinuria by determination of cystathionine-ß-synthase activity in plasma using LC-MS/MS.
Clinica chimica acta; international journal of clinical chemistry.
2015 Jan; 438(?):261-5. doi:
10.1016/j.cca.2014.09.009. [PMID: 25218699] - Josef Bártl, Petr Chrastina, Jakub Krijt, Jakub Hodík, Karolína Pešková, Viktor Kožich. Simultaneous determination of cystathionine, total homocysteine, and methionine in dried blood spots by liquid chromatography/tandem mass spectrometry and its utility for the management of patients with homocystinuria.
Clinica chimica acta; international journal of clinical chemistry.
2014 Nov; 437(?):211-7. doi:
10.1016/j.cca.2014.07.028. [PMID: 25086281] - Noriyuki Akahoshi, Shotaro Kamata, Masashi Kubota, Takako Hishiki, Yoshiko Nagahata, Tomomi Matsuura, Chiho Yamazaki, Yuka Yoshida, Hidenori Yamada, Yasuki Ishizaki, Makoto Suematsu, Tadashi Kasahara, Isao Ishii. Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.
American journal of physiology. Renal physiology.
2014 Jun; 306(12):F1462-76. doi:
10.1152/ajprenal.00623.2013. [PMID: 24761004] - Vanessa R da Silva, Luisa Rios-Avila, Yvonne Lamers, Maria A Ralat, Øivind Midttun, Eoin P Quinlivan, Timothy J Garrett, Bonnie Coats, Meena N Shankar, Susan S Percival, Yueh-Yun Chi, Keith E Muller, Per Magne Ueland, Peter W Stacpoole, Jesse F Gregory. Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
The Journal of nutrition.
2013 Nov; 143(11):1719-27. doi:
10.3945/jn.113.180588. [PMID: 23966327] - Heather B Roman, Lawrence L Hirschberger, Jakub Krijt, Alessandro Valli, Viktor Kožich, Martha H Stipanuk. The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
Antioxidants & redox signaling.
2013 Oct; 19(12):1321-36. doi:
10.1089/ars.2012.5010. [PMID: 23350603] - K J Vinknes, J M Dekker, C A Drevon, H Refsum, E Nurk, G Nijpels, C D A Stehouwer, T Teerlink, G S Tell, O Nygård, S E Vollset, P M Ueland, A K Elshorbagy. Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two Caucasian populations.
Prostaglandins, leukotrienes, and essential fatty acids.
2013 Oct; 89(5):297-303. doi:
10.1016/j.plefa.2013.09.007. [PMID: 24120123] - Young Suk Jung, Kang Uk Yun, Chang Seon Ryu, Jung Min Oh, Hui Chan Kwak, Ji-Yoon Lee, Song-Kyu Park, Bong Hee Kim, Soo Jin Oh, Sang Kyum Kim. Alterations in hepatic metabolism of sulfur amino acids in non-obese type-2 diabetic Goto-Kakizaki rats.
Chemico-biological interactions.
2013 Jul; 204(2):80-7. doi:
10.1016/j.cbi.2013.04.014. [PMID: 23665415] - Moemen S Hanafy, Shaikh M Rahman, Yumi Nakamoto, Toru Fujiwara, Satoshi Naito, Kyo Wakasa, Masao Ishimoto. Differential response of methionine metabolism in two grain legumes, soybean and azuki bean, expressing a mutated form of Arabidopsis cystathionine γ-synthase.
Journal of plant physiology.
2013 Feb; 170(3):338-45. doi:
10.1016/j.jplph.2012.10.018. [PMID: 23286999] - Jesse F Gregory, Youngja Park, Yvonne Lamers, Nirmalya Bandyopadhyay, Yueh-Yun Chi, Kichen Lee, Steven Kim, Vanessa da Silva, Nikolas Hove, Sanjay Ranka, Tamer Kahveci, Keith E Muller, Robert D Stevens, Christopher B Newgard, Peter W Stacpoole, Dean P Jones. Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.
PloS one.
2013; 8(6):e63544. doi:
10.1371/journal.pone.0063544. [PMID: 23776431] - Kenneth N Maclean, Lori S Greiner, Jeffrey R Evans, Sudesh K Sood, Sarka Lhotak, Neil E Markham, Sally P Stabler, Robert H Allen, Richard C Austin, Vivek Balasubramaniam, Hua Jiang. Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.
The Journal of biological chemistry.
2012 Sep; 287(38):31994-2005. doi:
10.1074/jbc.m112.355172. [PMID: 22854956] - Niikee C Schoendorfer, Rima Obeid, Leith Moxon-Lester, Nita Sharp, Luis Vitetta, Roslyn N Boyd, Peter S W Davies. Methylation capacity in children with severe cerebral palsy.
European journal of clinical investigation.
2012 Jul; 42(7):768-76. doi:
10.1111/j.1365-2362.2011.02644.x. [PMID: 22299647] - Romain Vuillefroy de Silly, Flora Coulon, Nicolas Poirier, Vojislav Jovanovic, Sophie Brouard, Véronique Ferchaud-Roucher, Gilles Blancho, Bernard Vanhove. Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses.
Blood.
2012 Mar; 119(11):2633-43. doi:
10.1182/blood-2011-04-350546. [PMID: 22262763] - Sara R Zwart, C Robert Gibson, Thomas H Mader, Karen Ericson, Robert Ploutz-Snyder, Martina Heer, Scott M Smith. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism.
The Journal of nutrition.
2012 Mar; 142(3):427-31. doi:
10.3945/jn.111.154245. [PMID: 22298570] - Amany K Elshorbagy, Viktor Kozich, A David Smith, Helga Refsum. Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies.
Current opinion in clinical nutrition and metabolic care.
2012 Jan; 15(1):49-57. doi:
10.1097/mco.0b013e32834d199f. [PMID: 22108094] - Yvonne Lamers, Bonnie Coats, Maria Ralat, Eoin P Quinlivan, Peter W Stacpoole, Jesse F Gregory. Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women.
The Journal of nutrition.
2011 May; 141(5):835-42. doi:
10.3945/jn.110.134197. [PMID: 21430249] - Amany K Elshorbagy, Maria Valdivia-Garcia, Helga Refsum, A David Smith, Dwight A L Mattocks, Carmen E Perrone. Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia.
Nutrition (Burbank, Los Angeles County, Calif.).
2010 Nov; 26(11-12):1201-4. doi:
10.1016/j.nut.2009.09.017. [PMID: 20080389] - Kenneth N Maclean, Jakub Sikora, Viktor Kožich, Hua Jiang, Lori S Greiner, Eva Kraus, Jakub Krijt, Katherine H Overdier, Renata Collard, Gary L Brodsky, Lynne Meltesen, Linda S Crnic, Robert H Allen, Sally P Stabler, Milan Elleder, Rima Rozen, David Patterson, Jan P Kraus. A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.
Molecular genetics and metabolism.
2010 Oct; 101(2-3):153-62. doi:
10.1016/j.ymgme.2010.06.010. [PMID: 20638879] - Valentina Medici, Janet M Peerson, Sally P Stabler, Samuel W French, Jesse F Gregory, Maria Catrina Virata, Antony Albanese, Christopher L Bowlus, Sridevi Devaraj, Edward A Panacek, Nazir Rahim, John R Richards, Lorenzo Rossaro, Charles H Halsted. Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease.
Journal of hepatology.
2010 Sep; 53(3):551-7. doi:
10.1016/j.jhep.2010.03.029. [PMID: 20561703] - Tom G Holt, Bernard K Choi, Neil S Geoghagen, Kristian K Jensen, Qi Luo, William A LaMarr, Gergely M Makara, Lorraine Malkowitz, Can C Ozbal, Yusheng Xiong, Claude Dufresne, Ming-Juan Luo. Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications.
Assay and drug development technologies.
2009 Oct; 7(5):495-506. doi:
10.1089/adt.2009.0200. [PMID: 19715455] - Srinivasan Dasarathy, Takhar Kasumov, John M Edmison, Lourdes L Gruca, Carole Bennett, Clarita Duenas, Susan Marczewski, Arthur J McCullough, Richard W Hanson, Satish C Kalhan. Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Sep; 297(3):G567-75. doi:
10.1152/ajpgi.00042.2009. [PMID: 19571235] - Jan P Kraus, Jindrich Hasek, Viktor Kozich, Renata Collard, Sarah Venezia, Bohumila Janosíková, Jian Wang, Sally P Stabler, Robert H Allen, Cornelis Jakobs, Christine T Finn, Yin-Hsiu Chien, Wuh-Liang Hwu, Robert A Hegele, S Harvey Mudd. Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies.
Molecular genetics and metabolism.
2009 Aug; 97(4):250-9. doi:
10.1016/j.ymgme.2009.04.001. [PMID: 19428278] - Øivind Midttun, Steinar Hustad, Per M Ueland. Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2009 May; 23(9):1371-9. doi:
10.1002/rcm.4013. [PMID: 19337982] - Yvonne Lamers, Jerry Williamson, Maria Ralat, Eoin P Quinlivan, Lesa R Gilbert, Christine Keeling, Robert D Stevens, Christopher B Newgard, Per M Ueland, Klaus Meyer, Ase Fredriksen, Peter W Stacpoole, Jesse F Gregory. Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.
The Journal of nutrition.
2009 Mar; 139(3):452-60. doi:
10.3945/jn.108.099184. [PMID: 19158217] - J E Baggott, T Tamura. Iron-dependent formation of homocysteine from methionine and other thioethers.
European journal of clinical nutrition.
2007 Dec; 61(12):1359-63. doi:
10.1038/sj.ejcn.1602665. [PMID: 17299471] - Inga Kwiecień, Maria Sokołowska, Lidia Włodek. Nephroprotective effect of cystathionine is due to its diverse action on the kidney and Ehrlich ascites tumor cells.
Pharmacological reports : PR.
2007 Sep; 59(5):553-64. doi:
. [PMID: 18048956] - Øivind Midttun, Steinar Hustad, Jørn Schneede, Stein E Vollset, Per M Ueland. Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study.
The American journal of clinical nutrition.
2007 Jul; 86(1):131-8. doi:
10.1093/ajcn/86.1.131. [PMID: 17616772] - Rima Obeid, Panagiotis Kostopoulos, Jean-Pierre Knapp, Mariz Kasoha, George Becker, Klaus Fassbender, Wolfgang Herrmann. Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid.
Clinical chemistry.
2007 Feb; 53(2):326-33. doi:
10.1373/clinchem.2006.076448. [PMID: 17200133] - Inga Kwiecień, Magdalena Michalska, Lidia Włodek. The selective effect of cystathionine on doxorubicin hepatotoxicity in tumor-bearing mice.
European journal of pharmacology.
2006 Nov; 550(1-3):39-46. doi:
10.1016/j.ejphar.2006.09.001. [PMID: 17034787] - Shin-ichiro Fukada, Yasuhiko Shimada, Tatsuya Morita, Kimio Sugiyama. Suppression of methionine-induced hyperhomocysteinemia by glycine and serine in rats.
Bioscience, biotechnology, and biochemistry.
2006 Oct; 70(10):2403-9. doi:
10.1271/bbb.60130. [PMID: 17031061] - Dan Liao, Hongmei Tan, Rutai Hui, Zhaohui Li, Xiaohua Jiang, John Gaubatz, Fan Yang, William Durante, Lawrence Chan, Andrew I Schafer, Henry J Pownall, Xiaofeng Yang, Hong Wang. Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance.
Circulation research.
2006 Sep; 99(6):598-606. doi:
10.1161/01.res.0000242559.42077.22. [PMID: 16931800] - Rie Shimooka, Kido Yasuhiro, Naoko Chiba, Junko Tanaka, Kazuhito Rokutan, Harumi Furochi, Katsuya Hirasaka, Takeshi Nikawa, Kyoichi Kishi. Soy protein diet prevents hypermethioninemia caused by portacaval shunt in rats.
The journal of medical investigation : JMI.
2006 Aug; 53(3-4):255-63. doi:
10.2152/jmi.53.255. [PMID: 16953062] - Sakino Toue, Riho Kodama, Michiko Amao, Yasuko Kawamata, Takeshi Kimura, Ryosei Sakai. Screening of toxicity biomarkers for methionine excess in rats.
The Journal of nutrition.
2006 06; 136(6 Suppl):1716S-1721S. doi:
10.1093/jn/136.6.1716s. [PMID: 16702345] - Peter J Garlick. Toxicity of methionine in humans.
The Journal of nutrition.
2006 06; 136(6 Suppl):1722S-1725S. doi:
10.1093/jn/136.6.1722s. [PMID: 16702346] - Steven R Davis, Eoin P Quinlivan, Peter W Stacpoole, Jesse F Gregory. Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women.
The Journal of nutrition.
2006 Feb; 136(2):373-8. doi:
10.1093/jn/136.2.373. [PMID: 16424114] - David A Geier, Mark R Geier. A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders.
Hormone research.
2006; 66(4):182-8. doi:
10.1159/000094467. [PMID: 16825783] - C D Campbell, J Ganesh, C Ficicioglu. Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency.
Haematologica.
2005 Dec; 90(12 Suppl):ECR45. doi:
. [PMID: 16464760] - Venu T Tadiboyina, Anthony Rupar, Paul Atkison, Annette Feigenbaum, Jonathan Kronick, Jian Wang, Robert A Hegele. Novel mutation in DGUOK in hepatocerebral mitochondrial DNA depletion syndrome associated with cystathioninuria.
American journal of medical genetics. Part A.
2005 Jun; 135(3):289-91. doi:
10.1002/ajmg.a.30748. [PMID: 15887277] - Wolfgang Herrmann, Heike Schorr, Rima Obeid, Julia Makowski, Brian Fowler, Martin K Kuhlmann. Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes.
Clinical chemistry.
2005 May; 51(5):891-7. doi:
10.1373/clinchem.2004.044453. [PMID: 15774574] - Sagar Doshi, Ian McDowell, Jonathan Goodfellow, Sally Stabler, Rainer Boger, Robert Allen, Robert Newcombe, Malcolm Lewis, Stuart Moat. Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.
Metabolism: clinical and experimental.
2005 Mar; 54(3):351-60. doi:
10.1016/j.metabol.2004.09.015. [PMID: 15736113] - Rima Obeid, Martin K Kuhlmann, Hans Köhler, Wolfgang Herrmann. Response of homocysteine, cystathionine, and methylmalonic acid to vitamin treatment in dialysis patients.
Clinical chemistry.
2005 Jan; 51(1):196-201. doi:
10.1373/clinchem.2004.041210. [PMID: 15528294] - Rima Obeid, Martin Kuhlmann, Carl-Martin Kirsch, Wolfgang Herrmann. Cellular uptake of vitamin B12 in patients with chronic renal failure.
Nephron. Clinical practice.
2005; 99(2):c42-8. doi:
10.1159/000083132. [PMID: 15637428] - S Jill James, Paul Cutler, Stepan Melnyk, Stefanie Jernigan, Laurette Janak, David W Gaylor, James A Neubrander. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
The American journal of clinical nutrition.
2004 Dec; 80(6):1611-7. doi:
10.1093/ajcn/80.6.1611. [PMID: 15585776] - Bendik F Terjesen, Kwan Park, Marcelo B Tesser, Maria C Portella, Yongfang Zhang, Konrad Dabrowski. Lipoic acid and ascorbic acid affect plasma free amino acids selectively in the teleost fish pacu (Piaractus mesopotamicus).
The Journal of nutrition.
2004 Nov; 134(11):2930-4. doi:
10.1093/jn/134.11.2930. [PMID: 15514254] - Øyvind Bleie, Helga Refsum, Per Magne Ueland, Stein Emil Vollset, Anne Berit Guttormsen, Ebba Nexo, Jørn Schneede, Jan Erik Nordrehaug, Ottar Nygård. Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention.
The American journal of clinical nutrition.
2004 Sep; 80(3):641-8. doi:
10.1093/ajcn/80.3.641. [PMID: 15321804] - C Chiarla, I Giovannini, J H Siegel. The relationship between plasma cholesterol, amino acids and acute phase proteins in sepsis.
Amino acids.
2004 Aug; 27(1):97-100. doi:
10.1007/s00726-004-0064-x. [PMID: 15309577] - A Klemm, C Franke, M Busch, A Müller, S Franke, D Lang, J Passlick-Deetjen, G Stein. Influence of hemodialysis membrane permeability on serum levels of advanced glycation end products (AGEs) and homocysteine metabolites.
Clinical nephrology.
2004 Mar; 61(3):191-7. doi:
10.5414/cnp61191. [PMID: 15077870] - Emi Nakano, Mike P Williamson, Nick H Williams, Hilary J Powers. Copper-mediated LDL oxidation by homocysteine and related compounds depends largely on copper ligation.
Biochimica et biophysica acta.
2004 Jan; 1688(1):33-42. doi:
10.1016/j.bbadis.2003.10.005. [PMID: 14732479] - Wolfgang Herrmann, Ulrich Hübner, Ines Koch, Rima Obeid, Ulrich Retzke, Jürgen Geisel. Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency.
Clinical chemistry and laboratory medicine.
2004; 42(10):1109-16. doi:
10.1515/cclm.2004.228. [PMID: 15552268] - Anne B Guttormsen, Einar Solheim, Helga Refsum. Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24-h observation period.
The American journal of clinical nutrition.
2004 Jan; 79(1):76-9. doi:
10.1093/ajcn/79.1.76. [PMID: 14684400] - Robert H White. The biosynthesis of cysteine and homocysteine in Methanococcus jannaschii.
Biochimica et biophysica acta.
2003 Dec; 1624(1-3):46-53. doi:
10.1016/j.bbagen.2003.09.005. [PMID: 14642812] - Sang K Kim, Kwon H Choi, Young C Kim. Effect of acute betaine administration on hepatic metabolism of S-amino acids in rats and mice.
Biochemical pharmacology.
2003 May; 65(9):1565-74. doi:
10.1016/s0006-2952(03)00115-1. [PMID: 12732369] - Jian Wang, Robert A Hegele. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH).
Human genetics.
2003 Apr; 112(4):404-8. doi:
10.1007/s00439-003-0906-8. [PMID: 12574942] - S Franke, A Müller, M Sommer, M Busch, R Kientsch-Engel, G Stein. Serum levels of total homocysteine, homocysteine metabolites and of advanced glycation end-products (AGEs) in patients after renal transplantation.
Clinical nephrology.
2003 Feb; 59(2):88-97. doi:
10.5414/cnp59088. [PMID: 12608551] - S H Mudd, A Tangerman, S P Stabler, R H Allen, C Wagner, S H Zeisel, H L Levy. Maternal methionine adenosyltransferase I/III deficiency: reproductive outcomes in a woman with four pregnancies.
Journal of inherited metabolic disease.
2003; 26(5):443-58. doi:
10.1023/a:1025121326959. [PMID: 14518826] - Sally P Stabler, Clemens Steegborn, Markus C Wahl, Jana Oliveriusova, Jan P Kraus, Robert H Allen, Conrad Wagner, S Harvey Mudd. Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
Metabolism: clinical and experimental.
2002 Aug; 51(8):981-8. doi:
10.1053/meta.2002.34017. [PMID: 12145770] - Sze Chung Clive Lo, Lisbeth Hamer, John E Hamer. Molecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea.
Eukaryotic cell.
2002 Apr; 1(2):311-4. doi:
10.1128/ec.1.2.311-314.2002. [PMID: 12455965] - Kwang-Hwan Jhee, Dimitri Niks, Peter McPhie, Michael F Dunn, Edith Wilson Miles. Yeast cystathionine beta-synthase reacts with L-allothreonine, a non-natural substrate, and L-homocysteine to form a new amino acid, 3-methyl-L-cystathionine.
Biochemistry.
2002 Feb; 41(6):1828-35. doi:
10.1021/bi011756t. [PMID: 11827527] - C G Ruaux, J M Steiner, D A Williams. Metabolism of amino acids in cats with severe cobalamin deficiency.
American journal of veterinary research.
2001 Dec; 62(12):1852-8. doi:
10.2460/ajvr.2001.62.1852. [PMID: 11763170] - S Maimann, R Hoefgen, H Hesse. Enhanced cystathionine beta-lyase activity in transgenic potato plants does not force metabolite flow towards methionine.
Planta.
2001 Dec; 214(2):163-70. doi:
10.1007/s004250100651. [PMID: 11800379] - M P Look, R Riezler, H K Berthold, S P Stabler, K Schliefer, R H Allen, T Sauerbruch, J K Rockstroh. Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviral therapy.
Metabolism: clinical and experimental.
2001 Nov; 50(11):1275-81. doi:
10.1053/meta.2001.27201. [PMID: 11699044] - K H Jhee, D Niks, P McPhie, M F Dunn, E W Miles. The reaction of yeast cystathionine beta-synthase is rate-limited by the conversion of aminoacrylate to cystathionine.
Biochemistry.
2001 Sep; 40(36):10873-80. doi:
10.1021/bi011087j. [PMID: 11535064] - J Geisel, I Zimbelmann, H Schorr, J P Knapp, M Bodis, U Hübner, W Herrmann. Genetic defects as important factors for moderate hyperhomocysteinemia.
Clinical chemistry and laboratory medicine.
2001 Aug; 39(8):698-704. doi:
10.1515/cclm.2001.115. [PMID: 11592436]