L-Cysteinesulfinic acid (BioDeep_00000399895)
Main id: BioDeep_00000001365
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
L-Cysteinesulfinic acid
化学式: C3H7NO4S (153.0096)
中文名称: L-半胱氨酸亚磺酸, L-半胱亚磺酸 一水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(=O)O)N)S(=O)O
InChI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/t2-/m0/s1
描述信息
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:16345
- KEGG: C00606
- PubChem: 1549098
- DrugBank: DB02153
- ChEMBL: CHEMBL1160508
- CAS: 1115-65-7
- MoNA: CCMSLIB00005720377
- MoNA: CCMSLIB00005720667
- MoNA: CCMSLIB00000578166
- MoNA: CCMSLIB00000577930
- PubChem: 3881
- PDB-CCD: CSD
- 3DMET: B01293
- NIKKAJI: J36.785K
- medchemexpress: HY-100804
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-111
- KNApSAcK: 16345
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Francesco Vieceli Dalla Sega, Cecilia Prata, Laura Zambonin, Cristina Angeloni, Benedetta Rizzo, Silvana Hrelia, Diana Fiorentini. Intracellular cysteine oxidation is modulated by aquaporin-8-mediated hydrogen peroxide channeling in leukaemia cells.
BioFactors (Oxford, England).
2017 Mar; 43(2):232-242. doi:
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The international journal of biochemistry & cell biology.
2015 Sep; 66(?):141-8. doi:
10.1016/j.biocel.2015.07.016. [PMID: 26239309] - Glyn B Steventon, Stephen C Mitchell, Santigo Angulo, Coral Barbas. An investigation into possible xenobiotic-endobiotic inter-relationships involving the amino acid analogue drug, S-carboxymethyl-L-cysteine and plasma amino acids in humans.
Amino acids.
2012 May; 42(5):1967-73. doi:
10.1007/s00726-011-0926-y. [PMID: 21559953] - S G Rhee, W Jeong, T-S Chang, H A Woo. Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance.
Kidney international. Supplement.
2007 Aug; ?(106):S3-8. doi:
10.1038/sj.ki.5002380. [PMID: 17653208] - Olga Boudker, Renae M Ryan, Dinesh Yernool, Keiko Shimamoto, Eric Gouaux. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature.
2007 Jan; 445(7126):387-93. doi:
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Amino acids.
2006 Jul; 31(1):27-33. doi:
10.1007/s00726-005-0277-7. [PMID: 16680400] - Xian Peng Liu, Xue Ying Liu, Juan Zhang, Zong Liang Xia, Xin Liu, Huan Ju Qin, Dao Wen Wang. Molecular and functional characterization of sulfiredoxin homologs from higher plants.
Cell research.
2006 Mar; 16(3):287-96. doi:
10.1038/sj.cr.7310036. [PMID: 16541127] - J David Van Horn, Grzegorz Bulaj, David P Goldenberg, Cynthia J Burrows. The Cys-Xaa-His metal-binding motif: [N] versus [S] coordination and nickel-mediated formation of cysteinyl sulfinic acid.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2003 Jul; 8(6):601-10. doi:
10.1007/s00775-003-0454-7. [PMID: 12827456] - M J Croucher, L S Thomas, H Ahmadi, V Lawrence, J R Harris. Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system.
British journal of pharmacology.
2001 Jul; 133(6):815-24. doi:
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The Journal of nutrition.
1998 Apr; 128(4):751-7. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
1997 Dec; 704(1-2):83-8. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1997 Aug; 15(8):2800-6. doi:
10.1200/jco.1997.15.8.2800. [PMID: 9256122] - M E Suliman, B Anderstam, J Bergström. Evidence of taurine depletion and accumulation of cysteinesulfinic acid in chronic dialysis patients.
Kidney international.
1996 Nov; 50(5):1713-7. doi:
10.1038/ki.1996.490. [PMID: 8914041] - P Guérin, Y Ménézo. Hypotaurine and taurine in gamete and embryo environments: de novo synthesis via the cysteine sulfinic acid pathway in oviduct cells.
Zygote (Cambridge, England).
1995 Nov; 3(4):333-43. doi:
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Analytical biochemistry.
1994 Aug; 220(2):249-56. doi:
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Archives of biochemistry and biophysics.
1993 Aug; 304(2):392-401. doi:
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Neuroscience.
1992 Sep; 50(1):107-15. doi:
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The Journal of nutrition.
1990 May; 120(5):450-8. doi:
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Cancer biochemistry biophysics.
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Neuroscience letters.
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Methods in enzymology.
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Journal of neurochemistry.
1986 Oct; 47(4):1091-7. doi:
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1985 Oct; 343(2):303-13. doi:
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