HOMATROPINE (BioDeep_00000003998)

   


代谢物信息卡片


HOMATROPINE

化学式: C16H21NO3 (275.1521356)
中文名称: 后马托品
谱图信息: 最多检出来源 Viridiplantae(plant) 94.12%

分子结构信息

SMILES: CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O
InChI: InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3

描述信息

S - Sensory organs > S01 - Ophthalmologicals > S01F - Mydriatics and cycloplegics > S01FA - Anticholinergics
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
Annotation level-1

同义名列表

1 个代谢物同义名

HOMATROPINE



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Zile Wang, Pimiao Zheng, Jianyi Wang, Shuang He, Zhenhui Ren, Yanfang Zhang, Jincheng Xiong, Haiyang Jiang. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours. Food chemistry. 2021 Feb; 337(?):127617. doi: 10.1016/j.foodchem.2020.127617. [PMID: 32799156]
  • Revathi Ponnuswamy, Arun Kumar Singh, Meenakshi Sundaram Raman, Lella Venkata Subbarao, Neeraja C N. Conversion of partial restorer Swarna into restorer by transferring fertility restorer Rf gene(s) through marker assisted back cross breeding (MABB) in rice. Scientific reports. 2020 01; 10(1):1101. doi: 10.1038/s41598-020-58019-1. [PMID: 31980666]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Jayabalan Nirmal, Thirumurthy Velpandian, Sundararajan Baskar Singh, Nihar Ranjan Biswas, Vasantha Thavaraj, Rajvardhan Azad, Supriyo Ghose. Development and validation of a highly sensitive LC-MS/MS method for organic cation transporter (OCT) substrate tetraethylammonium (TEA) in rabbits. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Mar; 879(9-10):585-90. doi: 10.1016/j.jchromb.2011.01.019. [PMID: 21317050]
  • Murat Oz, Vanaja Jaligam, Sehamuddin Galadari, George Petroianu, Yaroslav M Shuba, Toni S Shippenberg. The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. Journal of neurochemistry. 2010 Mar; 112(6):1454-64. doi: 10.1111/j.1471-4159.2009.06557.x. [PMID: 20050977]
  • Harald John, Tobias Binder, Hans Höchstetter, Horst Thiermann. LC-ESI MS/MS quantification of atropine and six other antimuscarinic tropane alkaloids in plasma. Analytical and bioanalytical chemistry. 2010 Jan; 396(2):751-63. doi: 10.1007/s00216-009-3209-7. [PMID: 19855962]
  • Samar K Basak, Partho K Bakshi, Sabitabrata Basu, Soham Basak. Keratouveitis caused by Euphorbia plant sap. Indian journal of ophthalmology. 2009 Jul; 57(4):311-3. doi: 10.4103/0301-4738.53060. [PMID: 19574703]
  • Tommaso R I Cataldi, Giuliana Bianco. Capillary electrophoresis of tropane alkaloids and glycoalkaloids occurring in Solanaceae plants. Methods in molecular biology (Clifton, N.J.). 2008; 384(?):171-203. doi: 10.1007/978-1-59745-376-9_9. [PMID: 18392571]
  • M H Al-Zubaidy, F K Mohammad. Metoclopramide protection of diazinon-induced toxicosis in chickens. Journal of veterinary science. 2007 Sep; 8(3):249-54. doi: 10.4142/jvs.2007.8.3.249. [PMID: 17679771]
  • Brian M Thome, Cornelius F Ivory. True moving bed electrophoresis using stepped electric field gradients. Electrophoresis. 2007 May; 28(10):1477-87. doi: 10.1002/elps.200600689. [PMID: 17492725]
  • Q Song, G M Greenway, T McCreedy. Tris(2,2'-bipyridine)ruthenium(II) electrogenerated chemiluminescence of alkaloid type drugs with solid phase extraction sample preparation. The Analyst. 2001 Jan; 126(1):37-40. doi: 10.1039/b006663j. [PMID: 11205508]
  • L J Jin, Y Wang, R Xu, M L Go, H K Lee, S F Li. Chiral resolution of atropine, homatropine and eight synthetic tropinyl and piperidinyl esters by capillary zone electrophoresis with cyclodextrin additives. Electrophoresis. 1999 Jan; 20(1):198-203. doi: 10.1002/(sici)1522-2683(19990101)20:1<198::aid-elps198>3.0.co;2-7. [PMID: 10065977]
  • S Auriola, A Martinsen, K M Oksman-Caldentey, T Naaranlahti. Analysis of tropane alkaloids with thermospray high-performance liquid chromatography-mass spectrometry. Journal of chromatography. 1991 Jan; 562(1-2):737-44. doi: 10.1016/0378-4347(91)80622-j. [PMID: 2026736]
  • C D Kay, J D Morrison. An evaluation of the effectiveness of intramuscular atropine or homatropine eyedrops in preventing the effects of physostigmine eyedrops on human vision. Quarterly journal of experimental physiology (Cambridge, England). 1988 Jul; 73(4):511-9. doi: 10.1113/expphysiol.1988.sp003171. [PMID: 3174912]
  • A Stojek, A Bilikiewicz, S Szewzyk, T Bartkiewicz. Reduction in plasma prolactin levels in depressed women after homatropine administration. The American journal of psychiatry. 1986 Nov; 143(11):1497. doi: 10.1176/ajp.143.11.1497a. [PMID: 3777265]
  • D A Willis, K M Unger, R A Tang. Angiotensin-converting enzyme in sarcoid perivasculitis. Annals of ophthalmology. 1983 Aug; 15(8):778-81. doi: NULL. [PMID: 6318638]
  • R G JANES, J P CALKINS. Effect of certain drugs on the iris vessels; the action of isoflurophate and homatropine on the rat's eye. A.M.A. archives of ophthalmology. 1957 Mar; 57(3):414-7. doi: 10.1001/archopht.1957.00930050426013. [PMID: 13410225]