tinidazole (BioDeep_00000399176)
natural product
代谢物信息卡片
tinidazole
化学式: C8H13N3O4S (247.0627)
中文名称: 替硝唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1N=C(N(C=1[N+](=O)[O-])CCS(CC)(=O)=O)C
InChI: InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3
描述信息
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases > P01AB - Nitroimidazole derivatives
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01X - Other antibacterials > J01XD - Imidazole derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:63627
- KEGGdrug: D01426
- PubChem: 5479
- Metlin: METLIN2857
- DrugBank: DB00911
- ChEMBL: CHEMBL1220
- MeSH: Tinidazole
- CAS: 148159-84-6
- CAS: 19387-91-8
- MoNA: FiehnHILIC002365
- MoNA: FiehnHILIC000799
- MoNA: CCMSLIB00000078647
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Fereshteh Koohi, Hamid R Zare, Zahra Shekari. Decoration of titanium dioxide nanotubes with silver nanoparticles using the photochemical deposition method and their application as an electrocatalyst to determine tinidazole.
Analytical methods : advancing methods and applications.
2021 11; 13(44):5343-5350. doi:
10.1039/d1ay01179k. [PMID: 34730130] - Marouf Alhalabi, Mohammed Waleed Alassi, Kamal Alaa Eddin, Khaled Cheha. Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial.
BMC infectious diseases.
2021 Jul; 21(1):642. doi:
10.1186/s12879-021-06356-5. [PMID: 34218802] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Francesco Drago, Giulia Ciccarese, Alfredo Rebora, Aurora Parodi. Tinidazole: Another Therapeutic Option for Syphilis?.
Journal of clinical pharmacology.
2020 09; 60(9):1185-1188. doi:
10.1002/jcph.1629. [PMID: 32408379] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Mahmoud M Sebaiy, Wafaa S Hassan, Mostafa E Elhennawy. Developing a High-Performance Liquid Chromatography (HPLC) Method for Simultaneous Determination of Oxytetracycline, Tinidazole and Esomeprazole in Human Plasma.
Journal of chromatographic science.
2019 Aug; 57(8):724-729. doi:
10.1093/chromsci/bmz046. [PMID: 31251331] - Ni Deng, Lili Xie, Yongwei Li, Haishu Lin, Renhui Luo. Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1.
Acta cirurgica brasileira.
2018 Nov; 33(11):945-953. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Oct; 1097-1098(?):94-100. doi:
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2018 Jun; 121(?):115-124. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Jun; 89(?):94-104. doi:
10.1016/j.ejps.2016.04.022. [PMID: 27108116] - Noura Hemdan Abou-Taleb, Dalia Rashad El-Wasseef, Dina Tawfik El-Sherbiny, Saadia Mohamed El-Ashry. Multiobjective optimization strategy based on desirability functions used for the microemulsion liquid chromatographic separation and quantification of norfloxacin and tinidazole in plasma and formulations.
Journal of separation science.
2015 Mar; 38(6):901-8. doi:
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2015 Feb; 136 Pt C(?):1380-7. doi:
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2015 Jan; 20(1):44. doi:
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Journal of gastrointestinal and liver diseases : JGLD.
2014 Dec; 23(4):367-70. doi:
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2014 Dec; 84(6):1347-50. doi:
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Journal of chromatographic science.
2014 Apr; 52(4):298-309. doi:
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Journal of ethnopharmacology.
2014; 151(1):108-13. doi:
10.1016/j.jep.2013.08.054. [PMID: 24095700] - Sally A Helmy. Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, and gatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers.
Therapeutic drug monitoring.
2013 Dec; 35(6):770-7. doi:
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Indian journal of pharmacology.
2013 Sep; 45(5):470-3. doi:
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2013 Apr; 14(4):954-61. doi:
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10.1590/s0036-46652013000300008. [PMID: 23740012] - Liying Wu, Jianfang Liu, Yunhao Zhang, Yanning Hou. Development of a HPLC/MS/MS method for simultaneous determination of tinidazole, dyclonine and chlorhexidine in rat plasma and its application in the pharmacokinetic research of a film-forming solution.
Journal of pharmaceutical and biomedical analysis.
2012 Mar; 62(?):224-7. doi:
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2012 Mar; 26(3):363-70. doi:
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Journal of aging research.
2012; 2012(?):567143. doi:
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Korean journal of urology.
2011 Oct; 52(10):703-8. doi:
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2011 Sep; 879(25):2554-60. doi:
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International journal of analytical chemistry.
2011; 2011(?):840178. doi:
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BMC cancer.
2010 Sep; 10(?):469. doi:
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The Korean journal of parasitology.
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Postgraduate medical journal.
2010 May; 86(1015):272-8. doi:
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2010 Feb; 51(3):685-90. doi:
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European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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2009 Jul; 34(3-4):185-92. doi:
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Comparative medicine.
2009 Apr; 59(2):174-9. doi:
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Journal of the Egyptian Society of Parasitology.
2009 Apr; 39(1):47-58. doi:
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Saudi medical journal.
2009 Feb; 30(2):209-13. doi:
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2009; 12(2):175-80. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2009 Jan; 107(1):258-69. doi:
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Archives of gynecology and obstetrics.
2008 Oct; 278(4):341-7. doi:
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2008 Jul; 36(7):1385-405. doi:
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Helicobacter.
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