Altrenogest (BioDeep_00000399143)
natural product
代谢物信息卡片
化学式: C21H26O2 (310.1932696)
中文名称: 四烯雌酮(烯丙孕素)
谱图信息:
最多检出来源 Homo sapiens(natural_products) 92.86%
分子结构信息
SMILES: C1C(C=C2C(C1)=C3[C@@](CC2)([C@]4([C@](C=C3)([C@](CC4)(CC=C)O)C)[H])[H])=O
InChI: InChI=1S/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:191255
- KEGGdrug: D02840
- PubChem: 10041070
- DrugBank: DB11372
- ChEMBL: CHEMBL1315492
- CAS: 850-52-2
- MoNA: CCMSLIB00000078596
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Sabrina Liesenfeld, Panagiotis Steliopoulos, Svenja Wenig, Vera Gottstein, Gerd Hamscher. Comprehensive LC-HRMS metabolomics analyses for the estimation of environmental inputs of altrenogest in pig breeding.
Chemosphere.
2022 Jan; 287(Pt 3):132353. doi:
10.1016/j.chemosphere.2021.132353
. [PMID: 34826959] - Rafael Dal Forno Gianluppi, Matheus Schardong Lucca, Monike Quirino, Ana Paula Gonçalves Mellagi, Rafael da Rosa Ulguim, Fernando Pandolfo Bortolozzo. Altrenogest treatment during the last week of lactation on ovarian traits and subsequent reproductive performance of primiparous and multiparous sows.
Theriogenology.
2021 Dec; 176(?):122-127. doi:
10.1016/j.theriogenology.2021.09.027
. [PMID: 34601236] - Yanyan Li, Haifeng Yang, Liangyou Xia, Shuang Wang, Shijin Bu. Comparative pharmacokinetic study of two kinds of altrenogest oral solutions for sows.
Animal biotechnology.
2021 Aug; 32(4):479-485. doi:
10.1080/10495398.2020.1723608
. [PMID: 32180500] - Yanyan Li, Haifeng Yang, Shulei Qiu, Shuang Wang, Liangyou Xia, Shijin Bu. Investigations on residual elimination of altrenogest oral solution in pigs and the withdrawal time.
Animal biotechnology.
2021 Jun; 32(3):310-317. doi:
10.1080/10495398.2019.1689989
. [PMID: 31814507] - Ashley Gillon, Emmie N M Ho, George H M Chan, Alexia Kauff, Gillian Hughes, Rachel A Lund, Zoe Ashley, Terence S M Wan, Alison K Heather. Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay.
Drug testing and analysis.
2021 Mar; 13(3):523-528. doi:
10.1002/dta.2941
. [PMID: 33037724] - Ruoxin Jia, Xiaoyu Chen, Zhiwei Zhu, Jing Huang, Fuxian Yu, Liang Zhang, Atsuo Ogura, Jianzhi Pan. Improving ovulation in gilts using anti-inhibin serum treatment combined with fixed-time artificial insemination.
Reproduction in domestic animals = Zuchthygiene.
2021 Jan; 56(1):112-119. doi:
10.1111/rda.13854
. [PMID: 33152153] - Hongzhi Xiao, Pan Sun, Feifei Sun, Jicheng Qiu, Jie Wang, Jianzhong Wang, Yalong Lin, Xiaohui Gong, Lu Zhang, Suxia Zhang, Xingyuan Cao. Pharmacokinetics of altrenogest in gilts.
Journal of veterinary pharmacology and therapeutics.
2019 Nov; 42(6):660-664. doi:
10.1111/jvp.12755
. [PMID: 31222770] - Paweena Thuwanut, Janine L Brown, Pierre Comizzoli, Adrienne E Crosier. Responsiveness of the cheetah (Acinonyx jubatus) ovary to exogenous gonadotropins after preemptive oral progestin treatment.
Theriogenology.
2019 Oct; 138(?):39-46. doi:
10.1016/j.theriogenology.2019.07.001
. [PMID: 31284220] - Katie L Bidne, Matthew R Romoser, Jason W Ross, Lance H Baumgard, Aileen F Keating. Heat stress during the luteal phase decreases luteal size but does not affect circulating progesterone in gilts1.
Journal of animal science.
2019 Oct; 97(10):4314-4322. doi:
10.1093/jas/skz251
. [PMID: 31372640] - Katelyn E Ellis, R McAlister Council-Troche, Karen A Von Dollen, Theresa M Beachler, C Scott Bailey, Jennifer L Davis, Sara K Lyle. Pharmacokinetics of Intrarectal Altrenogest in Horses.
Journal of equine veterinary science.
2019 01; 72(?):41-46. doi:
10.1016/j.jevs.2018.10.001
. [PMID: 30929782] - Vitória Müller, Bruna R Curcio, Ramiro E Toribio, Lorena S Feijó, Luciana A Borba, Igor F Canisso, Carlos E W Nogueira. Cortisol, progesterone, 17αOHprogesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis.
Theriogenology.
2019 Jan; 123(?):139-144. doi:
10.1016/j.theriogenology.2018.06.024
. [PMID: 30308389] - Katie L Bidne, Sara S Kvidera, Jason W Ross, Lance H Baumgard, Aileen F Keating. Impact of repeated lipopolysaccharide administration on ovarian signaling during the follicular phase of the estrous cycle in post-pubertal pigs.
Journal of animal science.
2018 Sep; 96(9):3622-3634. doi:
10.1093/jas/sky226
. [PMID: 29982469] - A J Ziecik, J Klos, E Przygrodzka, R Milewski, B Jana. Aberrant effects of altrenogest and exposure to exogenous gonadotropins on follicular cysts appearance in gilts.
Theriogenology.
2017 Feb; 89(?):250-254. doi:
10.1016/j.theriogenology.2016.10.028
. [PMID: 28043359] - F F McConaghy, L A Green, S Colgan, L H Morris. Studies of the pharmacokinetic profile, in vivo efficacy and safety of injectable altrenogest for the suppression of oestrus in mares.
Australian veterinary journal.
2016 Jul; 94(7):248-55. doi:
10.1111/avj.12459
. [PMID: 27349885] - Tatiane Micheletti, Janine L Brown, Susan L Walker, Zalmir S Cubas, Priscila V Furtado, Sarah B Putman, Wanderlei de Moraes, Marcos J de Oliveira, Claudio A de Oliveira, Nei Moreira. The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus).
Theriogenology.
2015 Sep; 84(4):575-82. doi:
10.1016/j.theriogenology.2015.04.015
. [PMID: 26001599] - C Wynne Collins, Steven L Monfort, Mandi M Vick, Barbara A Wolfe, Rachael B Weiss, Carol L Keefer, Nucharin Songsasen. Oral and injectable synthetic progestagens effectively manipulate the estrous cycle in the Przewalski's horse (Equus ferus przewalskii).
Animal reproduction science.
2014 Jul; 148(1-2):42-52. doi:
10.1016/j.anireprosci.2014.03.018
. [PMID: 24856195] - Monica A Stoops, Gary D West, Terri L Roth, Nancy P Lung. Use of urinary biomarkers of ovarian function and altrenogest supplementation to enhance captive breeding success in the Indian rhinoceros (Rhinoceros unicornis).
Zoo biology.
2014 Mar; 33(2):83-8. doi:
10.1002/zoo.21106
. [PMID: 24375460] - E S M Silva, S C F Frade, F S Ignácio, J C F Pantoja, J N P Puoli Filho, C Meira. Supplementary corpora lutea monitoring allows progestin treatment interruption on day 70 of pregnancy in non-cyclic recipient mares.
Animal reproduction science.
2014 Jan; 144(3-4):122-8. doi:
10.1016/j.anireprosci.2013.12.004
. [PMID: 24380787] - Kenji Korosue, Harutaka Murase, Fumio Sato, Mutsuki Ishimaru, Takehiro Harada, Gen Watanabe, Kazuyoshi Taya, Yasuo Nambo. Successful induction of lactation in a barren Thoroughbred mare: growth of a foal raised on induced lactation and the corresponding maternal hormone profiles.
The Journal of veterinary medical science.
2012 Aug; 74(8):995-1002. doi:
10.1292/jvms.12-0035
. [PMID: 22467072] - Todd R Robeck, Claudia Gill, Bethany M Doescher, Jay Sweeney, Piet De Laender, Cornelis E Van Elk, Justine K O'Brien. Altrenogest and progesterone therapy during pregnancy in bottlenose dolphins (Tursiops truncatus) with progesterone insufficiency.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2012 Jun; 43(2):296-308. doi:
10.1638/2011-0166.1
. [PMID: 22779233] - J Clapper, A Taylor. Components of the porcine anterior pituitary insulin-like growth factor system throughout the estrous cycle.
Domestic animal endocrinology.
2011 Feb; 40(2):67-76. doi:
10.1016/j.domaniend.2010.09.001
. [PMID: 21055896] - Conrad Willmann, Gerhard Schuler, Bernd Hoffmann, Nahid Parvizi, Christine Aurich. Effects of age and altrenogest treatment on conceptus development and secretion of LH, progesterone and eCG in early-pregnant mares.
Theriogenology.
2011 Feb; 75(3):421-8. doi:
10.1016/j.theriogenology.2010.05.009
. [PMID: 21144568] - Franziska M Palm, Ina Schenk, Stefanie Neuhauser, Daniel Schubert, Marc Machnik, Wilhelm Schänzer, Christine Aurich. Concentrations of altrenogest in plasma of mares and foals and in allantoic and amniotic fluid at parturition.
Theriogenology.
2010 Jul; 74(2):229-35. doi:
10.1016/j.theriogenology.2010.02.006
. [PMID: 20452000] - A Foisnet, C Farmer, C David, H Quesnel. Altrenogest treatment during late pregnancy did not reduce colostrum yield in primiparous sows.
Journal of animal science.
2010 May; 88(5):1684-93. doi:
10.2527/jas.2009-2751
. [PMID: 20118420] - R A Stewart, K M Pelican, J L Brown, D E Wildt, M A Ottinger, J G Howard. Oral progestin induces rapid, reversible suppression of ovarian activity in the cat.
General and comparative endocrinology.
2010 Apr; 166(2):409-16. doi:
10.1016/j.ygcen.2009.12.016
. [PMID: 20051246] - B Biancani, L Da Dalt, G Lacave, S Romagnoli, G Gabai. Measuring fecal progestogens as a tool to monitor reproductive activity in captive female bottlenose dolphins (Tursiops truncatus).
Theriogenology.
2009 Dec; 72(9):1282-92. doi:
10.1016/j.theriogenology.2009.07.025
. [PMID: 19783290] - T R Robeck, K J Steinman, M Greenwell, K Ramirez, W Van Bonn, M Yoshioka, E Katsumata, L Dalton, S Osborn, J K O'Brien. Seasonality, estrous cycle characterization, estrus synchronization, semen cryopreservation, and artificial insemination in the Pacific white-sided dolphin (Lagenorhynchus obliquidens).
Reproduction (Cambridge, England).
2009 Aug; 138(2):391-405. doi:
10.1530/rep-08-0528
. [PMID: 19494046] - S Neuhauser, F Palm, F Ambuehl, E Möstl, I Schwendenwein, C Aurich. Effect of altrenogest-treatment of mares in late gestation on adrenocortical function, blood count and plasma electrolytes in their foals.
Equine veterinary journal.
2009 Jul; 41(6):572-7. doi:
10.2746/042516409x394481
. [PMID: 19803053] - Mario Thevis, Sven Guddat, Wilhelm Schänzer. Doping control analysis of trenbolone and related compounds using liquid chromatography-tandem mass spectrometry.
Steroids.
2009 Mar; 74(3):315-21. doi:
10.1016/j.steroids.2008.10.004
. [PMID: 19007801] - Darin M Madson, Sheela Ramamoorthy, Chris Kuster, Narinder Pal, Xiang-Jin Meng, Patrick G Halbur, Tanja Opriessnig. Infectivity of porcine circovirus type 2 DNA in semen from experimentally-infected boars.
Veterinary research.
2009 Jan; 40(1):10. doi:
10.1051/vetres:2008048
. [PMID: 18973743] - K L Degenstein, R O'Donoghue, J L Patterson, E Beltranena, D J Ambrose, G R Foxcroft, M K Dyck. Synchronization of ovulation in cyclic gilts with porcine luteinizing hormone (pLH) and its effects on reproductive function.
Theriogenology.
2008 Oct; 70(7):1075-85. doi:
10.1016/j.theriogenology.2008.06.027
. [PMID: 18656251] - S Neuhauser, F Palm, F Ambuehl, C Aurich. Effects of altrenogest treatment of mares in late pregnancy on parturition and on neonatal viability of their foals.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2008 Jul; 116(7):423-8. doi:
10.1055/s-2008-1065367
. [PMID: 18484066] - M Machnik, I Hegger, M Kietzmann, M Thevis, S Guddat, W Schänzer. Pharmacokinetics of altrenogest in horses.
Journal of veterinary pharmacology and therapeutics.
2007 Feb; 30(1):86-90. doi:
10.1111/j.1365-2885.2007.00820.x
. [PMID: 17217407] - K-P Brüssow, F Schneider, A Tuchscherer, J Rátky, R R Kraeling, W Kanitz. Luteinizing hormone release after administration of the gonadotropin-releasing hormone agonist Fertilan (goserelin) for synchronization of ovulation in pigs.
Journal of animal science.
2007 Jan; 85(1):129-37. doi:
10.2527/jas.2006-281
. [PMID: 17179548] - Bruce W Christensen, Mats H T Troedsson, Tracy A Murchie, Margorzata A Pozor, Margo L Macpherson, Amara H Estrada, Natalie A Carrillo, Robert J Mackay, Gregory D Roberts, John Langlois. Management of hydrops amnion in a mare resulting in birth of a live foal.
Journal of the American Veterinary Medical Association.
2006 Apr; 228(8):1228-33. doi:
10.2460/javma.228.8.1228
. [PMID: 16618227] - Matilda Lampinen-Salomonsson, Elin Beckman, Ulf Bondesson, Mikael Hedeland. Detection of altrenogest and its metabolites in post administration horse urine using liquid chromatography tandem mass spectrometry--increased sensitivity by chemical derivatisation of the glucuronic acid conjugate.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Apr; 833(2):245-56. doi:
10.1016/j.jchromb.2006.02.014
. [PMID: 16520102] - T R Robeck, K J Steinman, M Yoshioka, E Jensen, J K O'Brien, E Katsumata, C Gili, J F McBain, J Sweeney, S L Monfort. Estrous cycle characterisation and artificial insemination using frozen-thawed spermatozoa in the bottlenose dolphin (Tursiops truncatus).
Reproduction (Cambridge, England).
2005 May; 129(5):659-74. doi:
10.1530/rep.1.00516
. [PMID: 15855629] - T R Robeck, K J Steinman, S Gearhart, T R Reidarson, J F McBain, S L Monfort. Reproductive physiology and development of artificial insemination technology in killer whales (Orcinus orca).
Biology of reproduction.
2004 Aug; 71(2):650-60. doi:
10.1095/biolreprod.104.027961
. [PMID: 15115725] - Brett S Glazar, Patrick M McCue, Jason E Bruemmer, Edward L Squires. Deslorelin on Day 8 or 12 postovulation does not luteinize follicles during an artificially maintained diestrous phase in the mare.
Theriogenology.
2004 Jul; 62(1-2):57-64. doi:
10.1016/j.theriogenology.2003.07.024
. [PMID: 15159101] - P Chavatte-Palmer, G Arnaud, C Duvaux-Ponter, L Brosse, S Bougel, P Daels, D Guillaume, F Clément, E Palmer. Quantitative and qualitative assessment of milk production after pharmaceutical induction of lactation in the mare.
Journal of veterinary internal medicine.
2002 Jul; 16(4):472-7. doi:
10.1892/0891-6640(2002)016<0472:qaqaom>2.3.co;2
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Animal reproduction science.
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Equine veterinary journal.
2000 Jul; 32(4):301-6. doi:
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Journal of reproduction and fertility. Supplement.
2000; ?(56):305-15. doi:
NULL
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Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
1999 Dec; 30(4):497-503. doi:
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Journal of the American Veterinary Medical Association.
1998 May; 212(9):1419-22. doi:
NULL
. [PMID: 9589129] - H D Guthrie, V G Pursel, R J Wall. Porcine follicle-stimulating hormone treatment of gilts during an altrenogest-synchronized follicular phase: effects on follicle growth, hormone secretion, ovulation, and fertilization.
Journal of animal science.
1997 Dec; 75(12):3246-54. doi:
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Domestic animal endocrinology.
1993 Apr; 10(2):127-40. doi:
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Biology of reproduction.
1992 Nov; 47(5):736-45. doi:
10.1095/biolreprod47.5.736
. [PMID: 1477200] - P F Daels, G H Stabenfeldt, J P Hughes, K Odensvik, H Kindahl. Evaluation of progesterone deficiency as a cause of fetal death in mares with experimentally induced endotoxemia.
American journal of veterinary research.
1991 Feb; 52(2):282-8. doi:
NULL
. [PMID: 2012339] - J Naden, E L Squires, T M Nett. Effect of maternal treatment with altrenogest on age at puberty, hormone concentrations, pituitary response to exogenous GnRH, oestrous cycle characteristics and fertility of fillies.
Journal of reproduction and fertility.
1990 Jan; 88(1):185-95. doi:
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Journal of reproduction and fertility.
1990 Jan; 88(1):177-83. doi:
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Journal of animal science.
1989 May; 67(5):1154-9. doi:
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The Veterinary record.
1989 Feb; 124(8):186-9. doi:
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Biology of reproduction.
1988 May; 38(4):750-5. doi:
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. [PMID: 3135851] - H D Guthrie, P E Meckley, E P Young, T G Hartsock. Effect of altrenogest and Lutalyse on parturition control, plasma progesterone, unconjugated estrogen and 13,14-dihydro-15-keto-prostaglandin F2 alpha in sows.
Journal of animal science.
1987 Jul; 65(1):203-11. doi:
10.2527/jas1987.651203x
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Journal of animal science.
1987 Apr; 64(4):1134-43. doi:
10.2527/jas1987.6441134x
. [PMID: 3571022] - H D Guthrie, D J Bolt, G H Kiracofe, K F Miller. Effect of charcoal-extracted porcine follicular fluid and 17 beta-estradiol on follicular growth and plasma gonadotropins in gilts fed a progesterone agonist, altrenogest.
Journal of animal science.
1987 Mar; 64(3):816-26. doi:
10.2527/jas1987.643816x
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Journal of reproduction and fertility. Supplement.
1987; 35(?):433-8. doi:
NULL
. [PMID: 3479598] - J R Diehl, L D Stuart, K L Goodrowe, D E Wildt. Effects of altrenogest and exogenous gonadotropins on ovarian function and embryo recovery in swine leukocyte antigen inbred miniature swine as influenced by cystic endometrial hyperplasia.
Biology of reproduction.
1986 Dec; 35(5):1261-8. doi:
10.1095/biolreprod35.5.1261
. [PMID: 3103703] - E F Kluber, D S Pollmann, D L Davis, J S Stevenson. Body growth and testicular characteristics of boars fed a synthetic progestogen, altrenogest.
Journal of animal science.
1985 Dec; 61(6):1441-7. doi:
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Biology of reproduction.
1985 Oct; 33(3):679-89. doi:
10.1095/biolreprod33.3.679
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Journal of animal science.
1985 Aug; 61(2):480-6. doi:
10.2527/jas1985.612480x
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Journal of animal science.
1981 Oct; 53(4):1088-94. doi:
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