trazodone hydrochloride (BioDeep_00000399092)
natural product
代谢物信息卡片
Trazodone hydrochloride (Desyrel)
化学式: C19H23Cl2N5O (407.1279568)
中文名称: 曲唑酮 盐酸盐
谱图信息:
最多检出来源 Escherichia coli(natural_products) 13.33%
分子结构信息
SMILES: C1(=CC=C(C=C1Cl)N2CCN(CC2)CCCN3C(N4C(=N3)C=CC=C4)=O).Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
Trazodone hydrochloride (AF-1161) is a serotonin receptor antagonist and reuptake inhibitor. Trazodone hydrochloride can be used for the research of major depressive disorder. Trazodone hydrochloride also has potential for sleep disorder research[1].
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:9655
- KEGGdrug: D00820
- KEGGdrug: D97808
- PubChem: 62935
- ChEMBL: CHEMBL1200798
- MeSH: Trazodone
- CAS: 25332-39-2
- CAS: 19666-36-5
- MoNA: CCMSLIB00000078519
- medchemexpress: HY-B0478
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
Medicine.
2024 Mar; 103(11):e37612. doi:
10.1097/md.0000000000037612. [PMID: 38489675] - Marta Balog, Allison Anderson, Thiago C Genaro-Mattos, Zeljka Korade, Karoly Mirnics. Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain.
Journal of lipid research.
2022 08; 63(8):100249. doi:
10.1016/j.jlr.2022.100249. [PMID: 35839864] - Marianna Mazza, Emanuele Caroppo, Giuseppe Marano, Georgios D Kotzalidis, Carla Avallone, Giovanni Camardese, Delfina Janiri, Lorenzo Moccia, Alessio Simonetti, Luigi Janiri, Gabriele Sani. Trazodone Prolonged-Release Monotherapy in Cannabis Dependent Patients during Lockdown Due to COVID-19 Pandemic: A Case Series.
International journal of environmental research and public health.
2022 06; 19(12):. doi:
10.3390/ijerph19127397. [PMID: 35742646] - Jing Ding, Yan Zhang, Xiaohua Cui, Caiping Zhao, Suo Zhang. Development of a Novel Analytical Method for Determining Trazodone in Human Plasma by Liquid Chromatography Coupled With Mass Spectrometry Coupled With Automatic 2-Dimensional Liquid Chromatograph-Mass Spectrometer Coupler 9500 and Its Application to Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2022 06; 44(3):465-473. doi:
10.1097/ftd.0000000000000921. [PMID: 34469419] - Udo Bonnet, Georg Juckel. COVID-19 Outcomes: Does the Use of Psychotropic Drugs Make a Difference? Accumulating Evidence of a Beneficial Effect of Antidepressants-A Scoping Review.
Journal of clinical psychopharmacology.
2022 May; 42(3):284-292. doi:
10.1097/jcp.0000000000001543. [PMID: 35420565] - Isabel Seguro, Patrícia Rebelo, João G Pacheco, Cristina Delerue-Matos. Electropolymerized, Molecularly Imprinted Polymer on a Screen-Printed Electrode-A Simple, Fast, and Disposable Voltammetric Sensor for Trazodone.
Sensors (Basel, Switzerland).
2022 Apr; 22(7):. doi:
10.3390/s22072819. [PMID: 35408433] - Basar Cenik, Jayme M Palka, Bonne M Thompson, Jeffrey G McDonald, Carol A Tamminga, Can Cenik, E Sherwood Brown. Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone.
Translational psychiatry.
2022 04; 12(1):139. doi:
10.1038/s41398-022-01903-3. [PMID: 35379782] - Sun-A Kim, Michelle R Borchardt, Kyuyoung Lee, Elizabeth A Stelow, Melissa J Bain. Effects of trazodone on behavioral and physiological signs of stress in dogs during veterinary visits: a randomized double-blind placebo-controlled crossover clinical trial.
Journal of the American Veterinary Medical Association.
2022 03; 260(8):876-883. doi:
10.2460/javma.20.10.0547. [PMID: 35333743] - Gauthier Nendumba, Lidvine Boland, Vincent Haufroid, Pierre-François Laterre, Philippe Hantson. Intravenous Lipid Emulsion in a Case of Trazodone Overdose.
The primary care companion for CNS disorders.
2022 03; 24(2):. doi:
10.4088/pcc.21cr02994. [PMID: 35768021] - Naglaa F Khedr, Rehab H Werida. l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity.
Life sciences.
2022 Feb; 290(?):120025. doi:
10.1016/j.lfs.2021.120025. [PMID: 34637798] - Jumpei Saito, Mariko Ishii, Asako Mito, Naho Yakuwa, Hiroyo Kawasaki, Yoshiyuki Tachibana, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Trazodone Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2021 11; 16(11):922-925. doi:
10.1089/bfm.2021.0191. [PMID: 34348038] - Zeljka Korade, Luke B Allen, Allison Anderson, Keri A Tallman, Thiago C Genaro-Mattos, Ned A Porter, Karoly Mirnics. Trazodone effects on developing brain.
Translational psychiatry.
2021 02; 11(1):85. doi:
10.1038/s41398-021-01217-w. [PMID: 33526772] - Alexandra L Moss, Rachel L Hritz, Rachel C Hector, Kathryn L Wotman. Investigation of the effects of orally administered trazodone on intraocular pressure, pupil diameter, physical examination variables, and sedation level in healthy equids.
American journal of veterinary research.
2021 Feb; 82(2):138-143. doi:
10.2460/ajvr.82.2.138. [PMID: 33480276] - Alessandro Ruggieri, Rossella Picollo, Alessandra Del Vecchio, Fabrizio Calisti, Patrizia Dragone, Alessandro Comandini, Maria T Rosignoli, Agnese Cattaneo, Frank Donath, Ralph-Steven Wedemeyer, Marina Todorova-Sanjari, André Warnke, Henning H Blume. Investigations on dose proportionality and drug-drug interaction for a fixed-dose combination of trazodone and gabapentin.
International journal of clinical pharmacology and therapeutics.
2021 Jan; 59(1):71-86. doi:
10.5414/cp203845. [PMID: 33040841] - Yasmeen Prud'homme, Shannon T Ferrell, Francis Beaudry, Guy Beauchamp, Sylvain Nichols, Marion Desmarchelier. PHARMACOKINETICS AND CLINICAL EFFECTS OF A SINGLE ORAL DOSE OF TRAZODONE IN THE DOMESTIC GOAT (CAPRA HIRCUS) AS A MODEL FOR WILD RUMINANTS.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Jan; 51(4):896-904. doi:
10.1638/2019-0242. [PMID: 33480570] - Fitri Fareez Ramli, Muhammad Hasif Azizi, Syed Alhafiz Syed Hashim. Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis.
International journal of medical sciences.
2021; 18(11):2372-2380. doi:
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2020 12; 16(1):88-97. doi:
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Journal of clinical pharmacology.
2020 11; 60(11):1483-1495. doi:
10.1002/jcph.1640. [PMID: 32488885] - Sung Il Bae, Ju-Tae Sohn. Lipid Emulsion Treatment for Trazodone Toxicity-Induced Coma.
Clinical neuropharmacology.
2020 Nov; 43(6):201. doi:
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2020 10; 21(1):443. doi:
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American journal of veterinary research.
2020 Sep; 81(9):739-746. doi:
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Scientific reports.
2020 02; 10(1):1964. doi:
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Clinical neuropharmacology.
2020 Jan; 43(1):31-33. doi:
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Headache.
2020 01; 60(1):269-270. doi:
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The Journal of clinical endocrinology and metabolism.
2019 10; 104(10):4619-4625. doi:
10.1210/jc.2018-02362. [PMID: 31265070] - Jia-Lian Zhu, Yi Gong, Wen-Wen Luo, Qi-Zhi Zhang, Rong-Hua Zhu, Wen-Xing Peng. Pharmacokinetics of trazodone sustained-release tablets in healthy subjects: Three open-label, randomized crossover studies
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2019 Oct; 57(10):520-530. doi:
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Annales pharmaceutiques francaises.
2019 Jul; 77(4):286-294. doi:
10.1016/j.pharma.2019.02.003. [PMID: 31027753] - O Atli, V Kilic, M Baysal, G Kilic, G Gormus, S Ucarcan, B Korkut, S Ilgin. Assessment of trazodone-induced cardiotoxicity after repeated doses in rats.
Human & experimental toxicology.
2019 Jan; 38(1):45-55. doi:
10.1177/0960327118769717. [PMID: 29774748] - Marion R Desmarchelier, Francis Beaudry, Shannon T Ferrell, Diane Frank. Determination of the pharmacokinetics of a single oral dose of trazodone and its effect on the activity level of domestic pigeons (Columba livia).
American journal of veterinary research.
2019 Jan; 80(1):102-109. doi:
10.2460/ajvr.80.1.102. [PMID: 30605036] - Silvana Olivieri, Graziella Bovi, Vanessa Petrucci, Anna Alfieri, Laura Oggianu, Rossella Picollo, Carolina Devastato, Patrizia Dragone, Fabio Garofolo, Serena Tongiani. Juvenile rat and pediatric trazodone studies: how to gain extra sensitivity to overcome bioanalytical challenges.
Bioanalysis.
2019 Jan; 11(1):21-32. doi:
10.4155/bio-2018-0236. [PMID: 30525928] - J L Davis, J Schirmer, E Medlin. Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.
Journal of veterinary pharmacology and therapeutics.
2018 Jun; 41(3):393-401. doi:
10.1111/jvp.12477. [PMID: 29333613] - Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W Klampfl, Wolfgang Buchberger. Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model.
Electrophoresis.
2018 05; 39(9-10):1301-1308. doi:
10.1002/elps.201700482. [PMID: 29427324] - Sinem Ilgın, Gözde Aydoğan-Kılıç, Merve Baysal, Volkan Kılıç, Mina Ardıç, Şeyda Uçarcan, Özlem Atlı. Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress.
Oxidative medicine and cellular longevity.
2018; 2018(?):7196142. doi:
10.1155/2018/7196142. [PMID: 30151072] - Zeljka Korade, Thiago C Genaro-Mattos, Keri A Tallman, Wei Liu, Krassimira A Garbett, Katalin Koczok, Istvan Balogh, Karoly Mirnics, Ned A Porter. Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone exposure.
Journal of lipid research.
2017 11; 58(11):2139-2146. doi:
10.1194/jlr.m079475. [PMID: 28972118] - Miriam Saiz-Rodríguez, Carmen Belmonte, Nieves Derqui-Fernández, Teresa Cabaleiro, Manuel Román, Dolores Ochoa, María Talegón, María C Ovejero-Benito, Francisco Abad-Santos. Pharmacogenetics of trazodone in healthy volunteers: association with pharmacokinetics, pharmacodynamics and safety.
Pharmacogenomics.
2017 Nov; 18(16):1491-1502. doi:
10.2217/pgs-2017-0116. [PMID: 29061081] - Heather K Knych, Khursheed R Mama, Eugene P Steffey, Scott D Stanley, Philip H Kass. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training.
American journal of veterinary research.
2017 Oct; 78(10):1182-1192. doi:
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Journal of the American Animal Hospital Association.
2017 Mar; 53(2):111-118. doi:
10.5326/jaaha-ms-6385. [PMID: 28282233] - A Najibi, R Heidari, J Zarifi, A Jamshidzadeh, N Firoozabadi, H Niknahad. Evaluating the Role of Drug Metabolism and Reactive Intermediates in Trazodone-Induced Cytotoxicity toward Freshly-Isolated Rat Hepatocytes.
Drug research.
2016 Nov; 66(11):592-596. doi:
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Human & experimental toxicology.
2016 May; 35(5):501-10. doi:
10.1177/0960327115595683. [PMID: 26187900] - Cynthia M Cooper, Jason M Baron. Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis.
The New England journal of medicine.
2015 Jan; 372(5):465-73. doi:
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Journal of pharmacological and toxicological methods.
2014 Nov; 70(3):276-82. doi:
10.1016/j.vascn.2014.07.008. [PMID: 25091319] - Dilek Yonar, M Maral Sünnetçioğlu. Spectroscopic and calorimetric studies on trazodone hydrochloride-phosphatidylcholine liposome interactions in the presence and absence of cholesterol.
Biochimica et biophysica acta.
2014 Oct; 1838(10):2369-79. doi:
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2014 Jan; 944(?):43-8. doi:
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Clinical chemistry.
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Clinical chemistry.
2012 Dec; 58(12):1635. doi:
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Drug and alcohol dependence.
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Archives of internal medicine.
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Pediatric emergency care.
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Talanta.
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Methods and findings in experimental and clinical pharmacology.
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Analytical and bioanalytical chemistry.
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Pharmacological reports : PR.
2008 Sep; 60(5):664-72. doi:
. [PMID: 19066412] - Laura Mercolini, Carolina Colliva, Mario Amore, Salvatore Fanali, Maria Augusta Raggi. HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.
Journal of pharmaceutical and biomedical analysis.
2008 Aug; 47(4-5):882-7. doi:
10.1016/j.jpba.2008.02.028. [PMID: 18400445] - Bhavin N Patel, Naveen Sharma, Mallika Sanyal, Pranav S Shrivastav. High throughput and sensitive determination of trazodone and its primary metabolite, m-chlorophenylpiperazine, in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Aug; 871(1):44-54. doi:
10.1016/j.jchromb.2008.06.046. [PMID: 18621591] - Malay K Das, Saroj K Ghosal. Ex vivo and in vivo evaluation of transdermal formulation of trazodone hydrochloride.
Acta poloniae pharmaceutica.
2008 Jul; 65(4):481-6. doi:
NULL. [PMID: 19051591] - Benjamin Chanrion, Clotilde Mannoury la Cour, Sophie Gavarini, Mathieu Seimandi, Laurent Vincent, Jean-François Pujol, Joël Bockaert, Philippe Marin, Mark J Millan. Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction.
Molecular pharmacology.
2008 Mar; 73(3):748-57. doi:
10.1124/mol.107.041574. [PMID: 18083778] - S Carda-Broch, M T Gil-Agustí, M Rambla-Alegre, Ll Monferrer-Pons, J S Esteve-Romero. Determination of trazodone in urine and pharmaceuticals using micellar liquid chromatography with fluorescence detection.
Journal of chromatography. A.
2007 Jul; 1156(1-2):254-8. doi:
10.1016/j.chroma.2007.02.112. [PMID: 17451726] - Kuo-Ping Shen, Shu-Fen Liou, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu. Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2.
The Journal of pharmacy and pharmacology.
2007 Jun; 59(6):879-89. doi:
10.1211/jpp.59.6.0015. [PMID: 17637181] - Xuejun Kang, Cao Pan, Qian Xu, Yingfang Yao, Yian Wang, Dongjin Qi, Zhongze Gu. The investigation of electrospun polymer nanofibers as a solid-phase extraction sorbent for the determination of trazodone in human plasma.
Analytica chimica acta.
2007 Mar; 587(1):75-81. doi:
10.1016/j.aca.2007.01.021. [PMID: 17386756] - Malay K Das, Asokangshu Bhattacharya, Saroj K Ghosal. Effect of penetration enhancers on skin permeation of trazodone hydrochloride from matrix type transdermal formulation through mouse and human cadaver epidermis.
Acta poloniae pharmaceutica.
2006 Nov; 63(6):535-41. doi:
NULL. [PMID: 17438871] - Seva E Kostrubsky, Stephen C Strom, Amit S Kalgutkar, Shaila Kulkarni, James Atherton, Rouchelle Mireles, Bo Feng, Raylene Kubik, Janean Hanson, Ellen Urda, Abdul E Mutlib. Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.
Toxicological sciences : an official journal of the Society of Toxicology.
2006 Apr; 90(2):451-9. doi:
10.1093/toxsci/kfj095. [PMID: 16410371] - Xuejun Kang, Jing Xiao, Xiao Huang, Zhongze Gu. Optimization of dansyl derivatization and chromatographic conditions in the determination of neuroactive amino acids of biological samples.
Clinica chimica acta; international journal of clinical chemistry.
2006 Apr; 366(1-2):352-6. doi:
10.1016/j.cca.2005.11.011. [PMID: 16406032] - O O Melkadze, Z A Zurabashvili. [Dynamics of Trazodone adsorption on the surface of erythrocytes].
Georgian medical news.
2006 Feb; ?(131):88-90. doi:
NULL. [PMID: 16575142] - Joseph A Zirrolli, Erica L Bradshaw, Michael E Long, Daniel L Gustafson. Rapid and sensitive LC/MS/MS analysis of the novel tyrosine kinase inhibitor ZD6474 in mouse plasma and tissues.
Journal of pharmaceutical and biomedical analysis.
2005 Sep; 39(3-4):705-11. doi:
10.1016/j.jpba.2005.04.024. [PMID: 15935603] - Kuo-Pyng Shen, Yi-Ching Lo, Rei-Cheng Yang, Hong-Wen Liu, Ing-Jun Chen, Bin-Nan Wu. Antioxidant eugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice.
The Journal of pharmacy and pharmacology.
2005 Jan; 57(1):117-25. doi:
10.1211/0022357055137. [PMID: 15639000] - Beom Soo Shin, John Kim, Chi Ho Yoon, Chul Hwan Kim, Eun Hye Park, Jeung-Whan Han, Sun Dong Yoo. Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a pharmacokinetic study.
Rapid communications in mass spectrometry : RCM.
2005; 19(3):408-14. doi:
10.1002/rcm.1805. [PMID: 15645510] - Edgar Zitron, Claudia Kiesecker, Eberhard Scholz, Sonja Lück, Ramona Bloehs, Sven Kathöfer, Dierk Thomas, Johann Kiehn, Volker A W Kreye, Hugo A Katus, Wolfgang Schoels, Christoph A Karle. Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone.
Naunyn-Schmiedeberg's archives of pharmacology.
2004 Aug; 370(2):146-56. doi:
10.1007/s00210-004-0952-3. [PMID: 15322737] - M Prapotnik, R Waschgler, P König, W Moll, A Conca. Therapeutic drug monitoring of trazodone: are there pharmacokinetic interactions involving citalopram and fluoxetine?.
International journal of clinical pharmacology and therapeutics.
2004 Feb; 42(2):120-4. doi:
10.5414/cpp42120. [PMID: 15180173] - Tetsuya Suhara, Yota Fujimura. [Biological pathophysiology of mood disorders special reference to the neurotransmitter receptors].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica.
2004; 106(8):1032-6. doi:
NULL. [PMID: 15655900] - Roland F Staack, Hans H Maurer. Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone.
Journal of analytical toxicology.
2003 Nov; 27(8):560-8. doi:
10.1093/jat/27.8.560. [PMID: 14670134] - David J Greenblatt, Lisa L von Moltke, Jerold S Harmatz, Steven M Fogelman, Gengsheng Chen, Jennifer A Graf, Polyxane Mertzanis, Susan Byron, Kerry E Culm, Brian W Granda, Johanna P Daily, Richard I Shader. Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone.
Journal of clinical pharmacology.
2003 Apr; 43(4):414-22. doi:
10.1177/0091270003251864. [PMID: 12723462] - Ali Ahmadi, Edward C Lauterbach, Nasreen Malik, John Gonzales. Unexplained transient hyperphosphatemia is more common in acute psychiatric disorders than in acute medical-surgical conditions.
Psychiatry research.
2003 Mar; 117(3):237-43. doi:
10.1016/s0165-1781(03)00021-0. [PMID: 12686366] - Bengi Uslu, Sibel A Ozkan. Electroanalytical characteristics of piribedil and its differential pulse and square wave voltammetric determination in pharmaceuticals and human serum.
Journal of pharmaceutical and biomedical analysis.
2003 Mar; 31(3):481-9. doi:
10.1016/s0731-7085(02)00725-2. [PMID: 12615235] - Amit S Kalgutkar, Timothy J Taylor, Karthik Venkatakrishnan, Emre M Isin. Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.
Drug metabolism and disposition: the biological fate of chemicals.
2003 Mar; 31(3):243-9. doi:
10.1124/dmd.31.3.243. [PMID: 12584149] - R Waschgler, M R Hubmann, A Conca, W Moll, P König. Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis.
International journal of clinical pharmacology and therapeutics.
2002 Dec; 40(12):554-9. doi:
10.5414/cpp40554. [PMID: 12503813] - N EL-Enany, F Belal, M Rizk. Voltammetric analysis of trazodone HCl in pharmaceuticals and biological fluids.
Journal of pharmaceutical and biomedical analysis.
2002 Sep; 30(2):219-26. doi:
10.1016/s0731-7085(02)00327-8. [PMID: 12191706] - Kazuo Mihara, Norio Yasui-Furukori, Tsuyoshi Kondo, Masayuki Ishida, Shingo Ono, Tadashi Ohkubo, Takako Osanai, Kazunobu Sugawara, Koichi Otani, Sunao Kaneko. Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients.
Therapeutic drug monitoring.
2002 Aug; 24(4):563-6. doi:
10.1097/00007691-200208000-00016. [PMID: 12142643] - Isao Fukunishi, Tateki Kitaoka, Tetsuo Shirai, Kyono Kino, Emiko Kanematsu, Yoshikazu Sato. A hemodialysis patient with trazodone-induced parkinsonism.
Nephron.
2002 Feb; 90(2):222-3. doi:
10.1159/000049048. [PMID: 11818711] - G W Caldwell, W N Wu, J A Masucci. Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man.
Xenobiotica; the fate of foreign compounds in biological systems.
2001 Nov; 31(11):823-39. doi:
10.1080/00498250110091758. [PMID: 11765144] - K Mihara, T Kondo, A Suzuki, N Yasui-Furukori, S Ono, K Otani, S Kaneko. Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients.
Pharmacology & toxicology.
2001 May; 88(5):267-70. doi:
10.1034/j.1600-0773.2001.d01-115.x. [PMID: 11393588] - R J Roberge, J R Luellen, S Reed. False-positive amphetamine screen following a trazodone overdose.
Journal of toxicology. Clinical toxicology.
2001; 39(2):181-2. doi:
10.1081/clt-100103839. [PMID: 11407508] - M G Ripple, J P Pestaner, B S Levine, J E Smialek. Lethal combination of tramadol and multiple drugs affecting serotonin.
The American journal of forensic medicine and pathology.
2000 Dec; 21(4):370-4. doi:
10.1097/00000433-200012000-00015. [PMID: 11111800] - P Enzlin, D Vanderschueren, L Bonte, W Vanderborght, G Declercq, K Demyttenaere. Trazodone: a double-blind, placebo-controlled, randomized study of its effects in patients with erectile dysfunction without major organic findings.
International journal of impotence research.
2000 Aug; 12(4):223-8. doi:
10.1038/sj.ijir.3900550. [PMID: 11079363]